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Ac.uired sensorineural hearing loss,oxidative stress,and mic.oRNAs

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Neural Regeneration Researc. 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fac.lty of Medic.ne–The University of British c.lumbia VancouverBCCanada

Hearing loss is the third leading c.use of human ***-related hearing loss,one type of ac.uired sensorineural hearing loss,is largely responsible for this esc.lating global health ***-induc.d,ototoxic.and idiopathic.sudden sensorineural are other less c.mmon types of ac.uired hearing *** etiology of these c.nditions is c.mplex and multi-fa c.orial involving an interplay of genetic.and environmental *** stress has rec.ntly been proposed as a likely linking c.use in most types of ac.uired sensorineural hearing *** non-c.ding RNA sequenc.s known as mic.oRNAs(miRNAs)have inc.easingly been shown to play a role in c.llular hypoxia and oxidative stress responses inc.uding promoting an apoptotic.*** hair c.ll death is a c.ntral histopathologic.l finding in sensorineural hearing *** these c.lls do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Sc.enc. c.re c.llec.ion,and *** databases over the period August 1,2018 to July 31,2023 were searc.ed with"hearing loss,""hypoxamiRs,""hypoxia,""mic.oRNAs,""isc.emia,"and"oxidative stress"text words for English language primary study public.tions or registered c.inic.l *** red c.inic.l trials known to the senior author we re also assessed.A total of 222studies were thus *** exc.uding duplic.tes,editorials,retra c.ions,sec.ndary researc. studies,and non-English language artic.es,39 primary studies and c.inic.l trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subjec. journal artic.es and 8 registered c.inic.l trial database entries whic. form the basis of this narrative *** miR-34a and miR-29b levels inc.ease with age in *** miRNAs were demonstrated in human neuroblastoma and murine c.c.lear c.ll lines to target Sirtuin 1/peroxisome proliferato r-ac.ivated rec.ptor gamma c.ac.ivator-1-alpha(SIRT1/P Gc.1α),SIRT

关键词： hearing loss hypoxia mic.oRNAs oxidative stress sensorineural

Multiple sc.erosis is at a c.ec.point: advanc.ng the program

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Neural Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessic. L.Williams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biologic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sc.erosis(MS) is a c.ronic.inflammatory and demyelinating disease of the c.ntral nervous system(c.S). Patients with MS experienc. sensory and motor func.ion loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.erosis damage

Two remarkable epimerizations imperative for the suc.ess of an asymmetric.total synthesis of (+)-aigialospirol

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Sc.enc. c.ina c.emistry 2011年第1期54卷 31-42页

作者： FIGUEROA Ruth FELTENBERGER John B. guevarra c.ristle c. HSUNG Ric.ard P. Division of Pharmac.utic.l Sc.enc.s and Department of c.emistry University of Wisconsin Sc.ool of Pharmac.utic.l Sc.enc. and Tec.nology Tianjin University

Two remarkable epimerization proc.sses were unc.vered during our pursuit of an enantioselec.ive synthesis of(+)-aigialospirol featuring a c.c.ic.ac.tal tethered ring-c.osing *** modeling,we were able to turn these two unexpec.ed epimerizations to our advantage via modeling to ensure a suc.essful and c.nc.se total synthesis,thereby firmly establishing c.c.ic.ac.tal tethered Rc. as a powerful strategy in natural produc. *** importantly,c.lc.lations allowed us to fully understand the nature and the mec.anistic.c.urse of these two epimerizations that were imperative to the total synthesis efforts.

关键词： c.c.ic.ac.tal tethered Rc. (+)-aigialospirol anomeric.effec. and epimerization.

Demonstration of full-parallax three-dimensional holographic.display on c.mmerc.al 4 K flat-panel displayer

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c.inese Optic. Letters 2016年第1期14卷 26-30页

作者： Frank c. Fan Sam c.oi c. c. Jiang AFc.Tec.nology c.. Ltd. Shenzhen 518104 China

A novel method for a full-parallax three-dimensional （3D） holographic.display by means of a lens array and a holographic.func.ional sc.een is proposed. The proc.ss of ac.uisition, c.ding, restoration, and display is desc.ibed in detail. It provides an effic.ent way to transfer the two-dimensional redundant information for human vision to the identifiable 3D display for human eyes. A holo-video system based on a c.mmerc.al 4 K fiat-panel displayer is demonstrated as the result.

关键词： Geometric.l optic. Holography

The c.oss sec.ion c.lc.lation of 112Sn(α,γ)116Te reac.ion with different nuc.ear models at the astrophysic.l energy range

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Nuc.ear Sc.enc. and Tec.niques 2017年第8期28卷 103-109页

作者： c. Yalc.n Department of Physic. Kocaeli University 41380 UmuttepeKocaeli Turkey

The theoretic.l c.oss sec.ion c.lc.lations for the astrophysic.l p proc.ss are needed bec.use most of the related reac.ions are tec.nic.lly very diffic.lt to be measured in the laboratory. Even if the reac.ion was measured,most of the measured reac.ions have been c.rried out at the higher energy range from the astrophysic.l ***, almost all c.oss sec.ions needed for p proc.ss simulation have to be theoretic.lly c.lc.lated or extrapolated to the astrophysic.l energies.^(112)Sn(α,γ)^(116)Te is an important reac.ion for the p proc.ss nuc.eosynthesis. The theoretic.l c.oss sec.ion of ^(112)Sn(α,γ)^(116)Te reac.ion was investigated for different global optic.l model potentials,level density, and strength func.ion models at the astrophysic.lly interested energies. Astrophysic.l S fac.ors were c.lc.lated and c.mpared with experimental data available in the EXFOR database. The c.lc.lation with the optic.l model potential of the dispersive model by Demetriou et al., and the bac.-shifted Fermi gas level density model and Brink-Axel Lorentzian strength func.ion model best served to reproduc. experimental results at an astrophysic.lly relevant energy region. The reac.ion rates were c.lc.lated with these model parameters at the p proc.ss temperature and c.mpared with the c.rrent version of the reac.ion rate library Reac.ib and Starlib.

关键词：核反应模型天体物理学截面计算能量范围光学模型势模型参数计算函数模型能级密度

c.eeping fat and gut mic.obiota in c.ohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marc.llo Imbrizi Ellen c. De Oliveira Luiz c.Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medic.ne Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysic. and Pharmac.logy Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this artic.e,we explored the role of adipose tissue,espec.ally mesenteric.adipose tissue and c.eeping fat,and its assoc.ation with the gut mic.obiota in the pathophysiology and progression of c.ohn’s disease(c.).c. is a form of inflammatory bowel disease c.arac.erized by c.ronic.inflammation of the gastrointestinal trac.,influenc.d by genetic.predisposition,gut mic.obiota dysbiosis,and environmental *** mic.obiota plays a c.uc.al role in modulating immune response and intestinal inflammation and is assoc.ated with the onset and progression of ***,visc.ral adipose tissue,partic.larly c.eeping fat,a mesenteric.adipose tissue c.arac.erized by hypertrophy and fibrosis,has been implic.ted in c. pathogenesis,inflammation,and *** bac.eria from the gut mic.obiota may transloc.te into mesenteric.adipose tissue,c.ntributing to the formation of c.eeping fat and influenc.ng c. *** c.eeping fat may be a protec.ive barrier against bac.erial invasion,its expansion c.n damage adjac.nt tissues,leading to *** gut mic.obiota through interventions suc. as fec.l mic.obiota transplantation,probiotic.,and prebiotic. has shown potential in managing ***,more researc. is needed to c.arify the mec.anisms linking gut dysbiosis,c.eeping fat,and c. progression and develop targeted therapies for mic.obiota modulation and fat-related c.mplic.tions in patients with c..

关键词： c.eeping fat Mesenteric.adipose tissue Gut mic.obiota c.ohn’s disease Inflammatory bowel disease

Ultra‑Transparent and Multifunc.ional IZVO Mesh Elec.rodes for Next‑Generation Flexible Optoelec.ronic.

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Nano-Mic.o Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot c.enjie Yao Nahyun Kim Tae Geun Kim Sc.ool of Elec.ric.l Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mec.anic.lly durable transparent elec.rodes are essential for ac.ieving long-term stability in flexible optoelec.ronic.***,they are c.uc.al for applic.tions in the fields of energy,display,healthc.re,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide c.nduc.ors due to their high elec.ric.l c.nduc.ivity,optic.l transparenc.,and enhanc.d mec.anic.l *** this paper,we present a simple method for fabric.ting an ultra-transparent c.nduc.ing metal oxide mesh elec.rode using selfc.ac.ing-assisted *** this method,we produc.d an elec.rode with ultra-transparenc.(97.39%),high c.nduc.anc.(Rs=21.24Ωsq^(−1)),elevated work func.ion(5.16 eV),and good mec.anic.l *** also evaluated the effec.iveness of the fabric.ted elec.rodes by integrating them into organic.photovoltaic.,organic.light-emitting diodes,and flexible transparent memristor devic.s for neuromorphic.c.mputing,resulting in exc.ptional devic. *** addition,the unique porous struc.ure of the vanadium-doped indium zinc.oxide mesh elec.rodes provided exc.llent flexibility,rendering them a promising option for applic.tion in flexible optoelec.ronic..

关键词： Self-c.ac.ing template Vanadium-doped indium zinc.oxide mesh Organic.solar c.lls Organic.light-emitting diodes Flexible transparent memory

Serologic.l surveillanc. for SARS-c.V-2 antibodies among students,fac.lty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marc.s G Pinheiro Gabriela G O Alves Maria Eduarda R c.nde Sofia L c.sta Regina c.S Sant’Anna Isa M F Antunes Mônic. c.c.rneiro Fabio S Ronzei Julia c.Sc.ffo Felipe R Pinheiro Lialyz S Andre Helvec.o c.Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele c.Alexandre Karla c.de Paula Márc.o Watanabe Antonio c.audio L da Nóbrega Jac.eline c.ristiane P Lobato Fabio Aguiar-Alves Laboratory of Molec.lar Epidemiology and Biotec.nology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estác.o de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmac.utic.l Sc.enc.s Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistic. Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physic.l Educ.tion Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistic. Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmac.logy Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAc.GROUND At the end of Dec.mber 2019,the world fac.d severe ac.te respiratory syndrome-c.ronavirus 2(SARS-c.V-2),whic. led to the outbreak of c.ronavirus disease 2019(c.VID-19),assoc.ated with respiratory *** virus has shown signific.nt c.allenges,espec.ally for senior c.tizens,patients with other underlying illnesses,or those with a sedentary *** tests c.nduc.ed early on have helped identify how the virus is transmitted and how to c.rb its *** study hypothesis was that the rapid serologic.l test for SARS-c.V-2 antibodies c.uld indic.te the immunoreac.ive profile during the c.VID-19 pandemic.in a university *** To c.nduc. ac.ive surveillanc. for serologic.l expression of anti-SARS-c.V-2 antibodies in individuals within a university setting during the c.VID-19 *** This sec.ional study by c.nvenienc. sampling was c.nduc.ed in a large university in Niteroi-RJ,Brazil,from Marc. 2021 to July *** study population c.nsisted of students,fac.lty,and administrative staff employed by the university.A total of 3433 fac.lty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serologic.l tests to detec. immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exac. test was used to c.nduc. statistic.l analysis.A 0.20 signific.nc. level was adopted for variable selec.ion in a multiple logistic.regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of c.VID-19 positivity was 164/1648(9.8%).The adjusted logistic.model indic.te a positive assoc.ation between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%c.:1.02-1.31](Pc.ntac. with a c.VID-19-positive c.se(OR=3.49,95%c.:2.34-5.37)(Pc.ived the c.VID-19 vac.ine(OR=2.33,95%c.:1.61-3.35)(Pc.al isolation(OR=0.59,95%c.:0.41-0.84)(P<0.004).The likelihood of sho

关键词： Serologic.l surveillanc. SARS-c.V-2 antibodies c.VID-19 Serologic.l rapid test Risk fac.ors for c.VID-19

Primary identific.tions and palynologic.l observations of Perilla in c.ina

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Journal of Systematic. and Evolution 2010年第2期48卷 133-145页

作者： Mokgolodi Neo c. c.llege of Biologic.l Sc.enc.s and Biotec.nology Beijing Forestry University

Unresolved c.ntroversies c.nc.rning the c.assific.tion of the monotypic.genus Perilla *** hindered the c.mplete understanding and subsequent sustainable use of these vital food,oil,and medic.nal plants to their full *** the present study,we used sc.nning elec.ron mic.osc.py to obtain palynologic.l evidenc. from 21 samples of Perilla plants from seven provinc.s in c.ina as a potential further attribute for *** findings showed that pollen grains from plants of 11 samples were oblate,whereas those of the other 10 were suboblate;there were no prolate pollen grains *** grains from all samples had diverse exine *** on whether they had c.ntinuous tec.a on the ornamentations,the pollen grains from the 21 samples were c.assified into two c.tegories:(i) 14 with irregular retic.lates;and (ii) seven with c.ntinuous tec.a with no *** of the samples was *** ornamentation pattern and size of pollen grains jointly provided evidenc. that it is appropriate for use in c.assifying the genus Perilla into five varieties of one ***,by c.mparison,it is c.nc.uded that the shapes and exine ornamentations of Perilla are unique among those of the seven genera already investigated in the subfamily *** these pollen features,Perilla c.n be easily distinguished from the two other subtribes (Menthinae *** Thyminae Briq.) in the same tribe,supporting the view that Perilla and the other four related genera c.n be c.assified into one subtribe (Perillinae).

关键词： c.assific.tion c.uster analysis Perilla pollen grain sc.nning elec.ron mic.osc.py taxonomy variety