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2009 IEEE International Symposium on IT in Medicine & Education(ITME2009)

作者： COVA Gabriel guerrero esteban RICARDO Ricardo ESTEVEZ Jose School of Electronic Information Engineering Beijing University of Aeronautics ＆ Astronautics

E-Health applications require communications systems and user interfaces with high technical capabilities to match the demand of emerging technological developments in the medical field.This paper focuses on the analysis of recent satellite-based telemedicine networks,making emphasis in its technical characteristic,e-health applications and services.Gives an overview of the actual trends of the state-of-the art wireless technologies according to the guidelines of the Global Economics Forum and to different workgroup’s workshops of International Telecommunication Union （ITU）,and presents a perspective of network architecture to provide e-health applications and Services according with emerging state-of-the-art wireless technologies.Finally,an overview of some future applications is presented that takes advantage of the network capacity.

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Conservation and variability of hepatitis B core at different chronic hepatitis stages

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World Journal of Gastroenterology 2020年第20期26卷 2584-2598页

作者： Marcal Yll Maria Francesca Cortese Mercedes guerrero-Murillo Gerard Orriols Josep Gregori Rosario Casillas Carolina González Sara Sopena Cristina Godoy Marta Vila David Tabernero Josep Quer Ariadna Rando Rosa Lopez-Martinez Rafael esteban Mar Riveiro-Barciela Maria Buti Francisco Rodríguez-Frías Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d'Hebron Institut Recerca-Hospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Department of Microbiology Hospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Instituto de Salud Carlos ⅢMadrid 28029Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autónoma de BarcelonaBarcelona 08035Spain

BACKGROUND Since it is currently not possible to eradicate hepatitis B virus(HBV)infection with existing treatments,research continues to uncover new therapeutic strategies.HBV core protein,encoded by the HBV core gene(HBC),intervenes in both structural and functional processes,and is a key protein in the HBV life cycle.For this reason,both the protein and the gene could be valuable targets for new therapeutic and diagnostic strategies.Moreover,alterations in the protein sequence could serve as potential markers of disease progression.AIM To detect,by next-generation sequencing,HBC hyper-conserved regions that could potentially be prognostic factors and targets for new therapies.METHODS Thirty-eight of 45 patients with chronic HBV initially selected were included and grouped according to liver disease stage[chronic hepatitis B infection without liver damage(CHB,n=16),liver cirrhosis(LC,n=5),and hepatocellular carcinoma(HCC,n=17)].HBV DNA was extracted from patients’plasma.A region between nucleotide(nt)1863 and 2483,which includes HBC,was amplified and analyzed by next-generation sequencing(Illumina Mi Seq platform).Sequences were genotyped by distance-based discriminant analysis.General and intergroup nt and amino acid(aa)conservation was determined by sliding window analysis.The presence of nt insertion and deletions and/or aa substitutions in the different groups was determined by aligning the sequences with genotype-specific consensus sequences.RESULTS Three nt(nt 1900-1929,2249-2284,2364-2398)and 2 aa(aa 117-120,159-167)hyper-conserved regions were shared by all the clinical groups.All groups showed a similar pattern of conservation,except for five nt regions(nt 1946-1992,2060-2095,2145-2175,2230-2250,2270-2293)and one aa region(aa 140-160),where CHB and LC,respectively,were less conserved(P<0.05).Some group-specific conserved regions were also observed at both nt(2306-2334 in CHB and 1935-1976 and 2402-2435 in LC)and aa(between aa 98-103 in CHB and 28-30 and 51-54 in LC)levels.No differences in insertion an

关键词： Hepatitis B virus Hepatitis B core gene Next-generation sequencing Genetic conservation Amino acid substitution Gene therapy Small interfering RNA

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Formation of MEVEZUG Pure Ovino Reproducers in Tierra Caliente guerrero,Mexico

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Journal of Environmental Science and Engineering(A) 2020年第6期9卷 246-254页

作者： esteban Julián Mireles Martínez Adiel Catalán Robles Areli Hernández Rodríguez JoséAlonso Galeana Isidro Gutiérrez Segura MaTrinidad Valencia Almazan Rosendo Cuicas Huerta Facultad de Medicina Veterinaria y Zootecnia Universidad Autónoma de GuerreroCd.Altamirano 40660México Instituto de Ciencia Animal(ICA) San Joséde las Lajas 32700 MayabequeCuba

The objective of the present work was to obtain pure ovine reproducers.Starting 2010 work began with the sheep herd of the Faculty of Veterinary Medicine and Animal Science of the Universidad Autónoma de guerrero,located in the municipality of Pungarabato,guerrero State,México.The faculty is 250 meters above sea level.The climate of the region is warm subhumid,with average temperature between 24 and 30°C,but in the heat season maximum temperatures up to 46°down in the shade.The rainfall regimen is 800-1,200 mm of rainfall per year.The production of sheep in Mexico is characterized mainly by creole animals and crosses are made with pure breeds imported from several European countries and USA.Therefore,there is a need to form local breeds adapted to the climatic conditions and production systems of Mexico.The sheep herd initially had 100 animal of hair,with 70 sheep with their lambs and a reproducer.These animals had phenotype Pelibuey,Black Belly,Doper and Katahdin.As of May 2010,consanguineous crosses were established.During this period the parameters were registered:date and type of birth,weight and sex of the newborn.Data on BW(Birth Weight)of males and females were analyzed by ANOVA(Analysis of Variance)and multiple comparison test was used for the comparison of means(Duncan,1955),with a significance level of Pguerrero.From the crosses of these breeders to the females of these herds

关键词： MEVEZUG pure ovine reproducers

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