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Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

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World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping guan Jing Mao Pan Li Shao-xing guan Wen Xie Xiang Gao Min Huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte count<3.5×10^(9)/L over two *** Of 148 patients studied,late leucopenia was observed in 15.6%(17/109)of NUDT15/thiopurine methyltransferase(TPMT)normal and 64.1%(25/39)of intermediate *** patients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： Chun Qin Gan-Rong Huang Ai-xing guan Wen-Ting Zhou Hao Chen Pei-Pei Luo Xian-Ke Luo Yan-Qiang Huang Zan-Song Huang guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BACKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(CagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PCR and Western *** was used to analyze CagA,CagM,CagE,Cag1,Cag3,and CagT.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** CagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as CagA,CagM,CagE,Cag1,Cag3,and *** these factors,CagM and CagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,CagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and Cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.C57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

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光伏电池生产企业危险源辨识及安全评估要点研究

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科学技术创新 2024年第3期 72-75页

作者：关星隆基乐叶光伏科技(西咸新区)有限公司陕西西安

当前光伏电池生产企业生产中存在不同类型的危险源,一旦危险源得不到有效的评估,容易引发严重的安全事故。针对这一问题,开展了光伏电池生产企业危险源辨识及安全评估要点的研究。通过光伏电池生产企业危险源分类、辨识危险源、建立危... 详细信息

当前光伏电池生产企业生产中存在不同类型的危险源,一旦危险源得不到有效的评估,容易引发严重的安全事故。针对这一问题,开展了光伏电池生产企业危险源辨识及安全评估要点的研究。通过光伏电池生产企业危险源分类、辨识危险源、建立危险源评价模型、设计危险源安全评估方法,提出了一种新的生产企业危险源辨识及评估方法。评估效果分析可知,新的方法能够显著降低危险源的危险度值,评估效果优势显著。

关键词：光伏电池危险源安全评估生产企业辨识

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经耻骨后尿道中段悬吊带术治疗女性复发性压力性尿失禁的中长期疗效

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北京大学学报（医学版） 2024年第4期56卷 600-604页

作者：李雨清王飚乔鹏王玮关星首都医科大学附属北京朝阳医院泌尿外科北京100020

目的:探讨经耻骨后尿道中段悬吊带术(tension-free vaginal tape,TVT)治疗女性复发性压力性尿失禁(recurrent stress urinary incontinence,rSUI)的效果及临床疗效。方法:回顾性分析2016年1月至2020年6月于北京朝阳医院采用TVT治疗rSUI的患者,收集患者基本信息。使用国际尿失禁咨询委员会尿失禁问卷表简表(International Consultation on Incontinence questionnaire-short form,ICI-Q-SF)记录患者术前、术后1年、术后3年以上的尿失禁症状评分,比较ICI-Q-SF各项评分及总分变化,同时记录并比较患者术前、术后3年以上的尿失禁临床症状严重程度。结果:共纳入24例患者,其中1例在术后1年因脑血管意外死亡,余23例随访时间3.9~7.3年,平均随访时间(5.2±1.1)年。ICI-Q-SF总分中位数术前为20.0(16.0,21.0),术后1年及平均5年随访时为5.0(1.5,7.8)和6.0(3.0,9.0),与术前比较差异均有统计学意义(P<0.001);ICI-Q-SF各分项评分在术后1年及平均5年的随访中均较术前减低,差异具有统计学意义(P<0.001)。从尿失禁严重程度来看,术前所有患者表现为中-重度尿失禁;术后平均5年,87.0%(20/23)的患者无尿失禁或仅有轻度尿失禁,13.0%(3/23)的患者再次出现中-重度尿失禁(P<0.001)。结论:TVT对女性rSUI治疗有效,平均5年治愈和有效改善率达到87.0%。

关键词：压力性尿失禁女性复发尿道下悬吊术

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阳江朱漆好·留得岭南春——复观陈其积六十载的漆艺人生

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中国生漆 2024年第1期43卷 53-57页

作者：林观星中国戏曲学院北京100073

陈其积是广东阳江漆艺发展过程中的重要推动者之一,他的漆艺人生轨迹与近六十年广东阳江漆艺的当代建构紧密相关,并且推动了广东阳江漆艺的发展与现代漆画的转进。文章从陈其积六十载漆艺之路与广东阳江漆艺的内在深刻关联与钩沉,进一... 详细信息

陈其积是广东阳江漆艺发展过程中的重要推动者之一,他的漆艺人生轨迹与近六十年广东阳江漆艺的当代建构紧密相关,并且推动了广东阳江漆艺的发展与现代漆画的转进。文章从陈其积六十载漆艺之路与广东阳江漆艺的内在深刻关联与钩沉,进一步呈现陈其积内在的漆艺思想与中国传统漆艺在21世纪前二十年的工艺与匠心精神承传之路。

关键词：陈其积阳江漆艺阳江漆器中国漆画阳江漆器髹饰技艺

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某“三甲”综合性医院乳腺癌患者生命质量和社会支持状况调查研究

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卫生职业教育 2024年第14期42卷 99-102页

作者：巩海洋关兴刘潇枣庄市立医院山东枣庄277102

目的探索在某“三甲”医院就诊的乳腺癌患者的生命质量和社会支持状况及相关影响因素。方法选取2023年1—12月在枣庄市立医院乳腺外科就诊的乳腺癌患者为调查对象并进行问卷调查,收集其一般资料、社会支持和sf-8生命质量资料。结果乳腺... 详细信息

目的探索在某“三甲”医院就诊的乳腺癌患者的生命质量和社会支持状况及相关影响因素。方法选取2023年1—12月在枣庄市立医院乳腺外科就诊的乳腺癌患者为调查对象并进行问卷调查,收集其一般资料、社会支持和sf-8生命质量资料。结果乳腺癌患者生命质量总分为(580.33±110.82)分;年龄、个人年收入、婚姻状况、居住方式是乳腺癌患者生命质量的影响因素(P<0.05);社会支持总分为(34.13±9.08)分;乳腺癌患者的生命质量及其各维度与社会支持及其各维度均呈正相关(P<0.05或P<0.01)。结论国家、社会和家庭要重点关注经济收入低的老年乳腺癌患者,发挥婚姻、配偶和子女对其生命质量的正向积极作用,保障患者的社会支持水平。作为医务人员,要做好乳腺癌优质医疗、护理服务和健康宣教工作,帮助乳腺癌患者增强生活信心,提高生命质量。

关键词：乳腺癌生命质量社会支持

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Classical Coset Hamiltonian for the Electronic Motion and its Application to Anderson Localization and Hammett Equation

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Chinese Physics Letters 2001年第2期18卷 157-159页

作者： xing guan WU Guo-Zhen Molecular and Nano Sciences Laboratory of Educational Ministry Department of PhysicsTsinghua UniversityBeijing 100084

A classical coset Hamiltonian is introduced for the system of one electron in *** this Hamiltonian,the dynamical behaviour of the electronic motion can be readily *** simulation reproduces the retardation of the electron density decay in a lattice with site energies randomly distributed-an analogy with Anderson *** algorithm is also applied to reproduce the Hammett equation which relates the reaction rate with the property of the substitutions in the organic chemical *** advantages and shortcomings of this algorithm,as contrasted with traditional quantum methods such as the molecular orbital theory,are also discussed.

关键词： Hamiltonian analogy shortcomings

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稀土合金化对钛合金激光焊接接头超塑变形行为的影响

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材料热处理学报 2024年第8期45卷 227-234页

作者：薛行雁程东海张冠星常云峰刘付丽郑州机械研究所有限公司新型钎焊材料与技术国家重点实验室河南郑州450001 南昌航空大学航空制造工程学院江西南昌330063

通过在TC4钛合金激光焊缝中添加Yb_(2)O_(3),以提高接头超塑性变形均匀性,观察Yb_(2)O_(3)对焊缝超塑性变形前后组织的影响,并以等轴化系数表征组织在超塑变形中的演变进程。结果表明,Yb_(2)O_(3)的加入能够提高焊缝的超塑性能,从而提... 详细信息

通过在TC4钛合金激光焊缝中添加Yb_(2)O_(3),以提高接头超塑性变形均匀性,观察Yb_(2)O_(3)对焊缝超塑性变形前后组织的影响,并以等轴化系数表征组织在超塑变形中的演变进程。结果表明,Yb_(2)O_(3)的加入能够提高焊缝的超塑性能,从而提高接头的变形均匀性。加入Yb_(2)O_(3)后能够降低焊缝原始β晶粒尺寸,并推动焊缝针状组织的等轴化进程,促进超塑性变形。随着Yb_(2)O_(3)含量的升高,其作用效果呈现先增加后减小的趋势,当Yb_(2)O_(3)含量为6 mass%时效果最佳,焊缝伸长率达到最大54.8%,变形协调系数K最大为0.21;β晶粒尺寸最小为308μm,等轴化系数J达到最大0.26。

关键词：钛合金 Yb_(2)O_(3) 超塑性变形变形协调系数K 等轴化系数J

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UNSTEADY FLOW ANALYSIS AND EXPERIMENTAL INVESTIGATION OF AXIAL-FLOW PUMP

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Journal of Hydrodynamics 2010年第1期22卷 35-43页

作者： ZHANG De-sheng SHI Wei-dong CHEN Bin guan xing-fan Technical and Research Center of Fluid Machinery Engineering Jiangsu University Zhenjiang 212013 China

The three-dimensional unsteady turbulent flow in axial-flow pumps was simulated based on Navier-Stoke solver embedded with k - ε RNG turbulence model and SIMPLEC algorithm. Numerical results show that the unsteady prediction results are more accurate than the steady results, and the maximal error of unsteady prediction is only 4.54%. The time-domain spectrums show that the static pressure fluctuation curves at the inlet and outlet of the rotor and the outlet of the stator are periodic, and all have four peaks and four valleys. The pressure fluctuation amplitude increases from the hub to the tip at the inlet and outlet of the rotor, but decreases at the outlet of the stator. The pressure fluctuation amplitude is the greatest at the inlet of the rotor, and the average amplitude decreases sharply from the inlet to the outlet. The frequency spectrums obtained by Fast Fourier Transform （FFT） show that the dominant frequency is approximately equal to the blade passing frequency. The static pressure on the pressure side of hydrofoil on different stream surfaces remains almost consistent, and increases gradually from the blade inlet to the exit on the suction side at different time steps. The axial velocity distribution is periodic and is affected by the stator blade number at the rotor exit. The experimental results show that the flow is almost axial and the pre-rotation is very small at the rotor inlet under the conditions of 0.8 QN -1.2 QN Due to the clearance leakage, the pressure, circulation and meridional velocity at the rotor outlet all decrease near the hub leakage and tip clearance regions.

关键词： axial-flow pump unsteady flow pressure fluctuation high efficiency flow field measurement

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Agricultural Production Structure Optimization: A Case Study of Major Grain Producing Areas, China

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Journal of Integrative Agriculture 2013年第1期12卷 184-197页

作者： LU Sha-sha LIU Yan-sui LONG Hua-lou guan xing-liang Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences University of Chinese Academy of Sciences

A large number of mathematical models were developed for supporting agricultural production structure optimization decisions; however, few of them can address various uncertainties existing in many factors （e.g., eco-social benefit maximization, food security, employment stability and ecosystem balance）. In this study, an interval-probabilistic agricultural production structure optimization model （IPAPSOM） is formulated for tackling uncertainty presented as discrete intervals and/or probability distribution. The developed model improves upon the existing probabilistic programming and inexact optimization approaches. The IPAPSOM considers not only food security policy constraints, but also involves rural households’income increase and eco-environmental conversation, which can effectively reflect various interrelations among different aspects in an agricultural production structure optimization system. Moreover, it can also help examine the reliability of satisfying （or risk of violating） system constraints under uncertainty. The model is applied to a real case of long-term agricultural production structure optimization in Dancheng County, which is located in Henan Province of Central China as one of the major grain producing areas. Interval solutions associated with different risk levels of constraint violation are obtained. The results are useful for generating a range of decision alternatives under various system benefit conditions, and thus helping decision makers to identify the desired agricultural production structure optimization strategy under uncertainty.

关键词： major grain producing areas agricultural production structure optimization interval-probabilistic programming food security farmers’income increase China

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