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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

1995年

作者：中国证券监督管理委员会 Zhong Guo Zheng Quan Jian Du guan Li wei yuan Hui 编

来源：畅想之星图书光盘版（南... 评论

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li weiwei Guo Shuolong yuan Liangwei Xu Chang Lin Xi Shi wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： Yaping Li Zhi-Xin Liu Jia-wei Su Ya-Zhou yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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福建围头海域深水网箱养殖区污损生物

海洋学报 2007年第1期29卷 98-104页

作者：黄桂芳郑国富魏观渊丁兰戴天元福建省水产研究所福建厦门361012

2004年3月到2005年2月,在福建围头湾深水网箱养殖区开展污损生物周年挂网调查.共记录污损生物154种,隶属于12个生物门;全年网衣都有污损生物附着,冬季和春季优势种为细枝仙藻、中胚花筒螅和长颈麦杆虫,主要影响网箱内外水体交换,夏季和... 详细信息

2004年3月到2005年2月,在福建围头湾深水网箱养殖区开展污损生物周年挂网调查.共记录污损生物154种,隶属于12个生物门;全年网衣都有污损生物附着,冬季和春季优势种为细枝仙藻、中胚花筒螅和长颈麦杆虫,主要影响网箱内外水体交换,夏季和秋季优势种为网纹藤壶,容易导致网衣磨损,影响网箱安全;各月份附着生物量差异极大,平均附着生物量表层网片449.42 g/m2,最高峰出现在4月份,底层网片580.25 g/m2,最高峰出现在3月份.季度平均生物量表层网片3 142.30 g/m2,底层网片6 030.97 g/m2;春季表层网衣藻类特别多,中胚花筒螅、网纹藤壶和麦杆虫等数量远大于港湾内网衣或试板的污损生物量,呈现海区透明度大及抗动荡环境的特点,与港湾内网衣或试板有较大差别.

关键词：污损生物深水网箱养殖福建围头海域

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北美红杉人工林生长规律研究

浙江林业科技 2017年第3期37卷 54-58页

作者：关维元吴军钟志真董海日张少伟建德市林业技术推广中心浙江建德311600 建德市新安江林场浙江建德311605

2016年4月,在浙江省建德市新安江林场的35年生北美红杉Sequoia sempervirens人工林中设置20 m×30 m标准地进行每木调查,选取并测定解析木数据,对其胸径、树高及材积的生长规律进行研究。结果表明,随着树龄的增大,北美红杉树高和胸径生... 详细信息

2016年4月,在浙江省建德市新安江林场的35年生北美红杉Sequoia sempervirens人工林中设置20 m×30 m标准地进行每木调查,选取并测定解析木数据,对其胸径、树高及材积的生长规律进行研究。结果表明,随着树龄的增大,北美红杉树高和胸径生长表现为"直线形",而材积生长则表现为"S"型;35年生北美红杉平均树高、胸径、材积总生长量分别为23.00 m,30.6 cm,0.343 0 m^3,年平均生长量分别为0.70 m,0.93 cm,0.010 4 m^3;连年生长量和平均生长量曲线并没有交叉,该树种还处于速生阶段未达到数量成熟。将北美红杉与毗邻的同龄杉木Cunninghamia lanceolata纯林的平均胸径和平均树高生长量进行比较,结果表明其年平均胸径及树高生长量均比杉木多。

关键词：北美红杉胸径树高材积生长

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三种极危水韭孢子体发育及其生理特征

浙江林业科技 2015年第3期35卷 11-15页

作者：程树颖关维元徐永星刘保东关旸哈尔滨师范大学黑龙江哈尔滨150025 浙江省建德市林业科学研究所浙江建德311600

以人工繁殖的极度濒危植物中华水韭(Isoetes sinensis)、东方水韭(***)、云贵水韭(***)为试验材料,测定了三种水韭生长过程中光合参数、渗透调节物质及呼吸速率等生理指标,探讨了不同生长时期三种水韭的生理变化。结果显示:三种水韭可... 详细信息

以人工繁殖的极度濒危植物中华水韭(Isoetes sinensis)、东方水韭(***)、云贵水韭(***)为试验材料,测定了三种水韭生长过程中光合参数、渗透调节物质及呼吸速率等生理指标,探讨了不同生长时期三种水韭的生理变化。结果显示:三种水韭可溶性糖及可溶性蛋白含量在营养生长期有小幅下降,其后有所升高;叶绿素含量在营养生长期上升而过渡生长期上升缓慢趋于平缓,之后又逐渐上升;三种水韭光合参数均呈先升高再下降又升高的趋势;三种水韭在营养生长期净光合速率上升不显著,呼吸速率变化显著,气孔导度和蒸腾速率减小。

关键词：水韭孢子体发育生理特征

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农村幼儿教师队伍建设的现实问题及政策选择

陕西学前师范学院学报 2017年第10期33卷 12-16页

作者：曲正伟关添元东北师范大学教育学部吉林长春130024

构建覆盖城乡、布局合理的学前教育公共服务体系,加强农村幼儿教师队伍建设是今后一段时间我国学前教育政策关注的重点。目前我国农村幼儿教师队伍在数量、结构、质量等方面还存在诸多问题,应强化政府主体责任,建立多元开放教师补充机制... 详细信息

构建覆盖城乡、布局合理的学前教育公共服务体系,加强农村幼儿教师队伍建设是今后一段时间我国学前教育政策关注的重点。目前我国农村幼儿教师队伍在数量、结构、质量等方面还存在诸多问题,应强化政府主体责任,建立多元开放教师补充机制,完善教师管理制度,落实教师权益保障,建设一支高素质专业化的农村幼儿教师队伍,切实保障适龄儿童接受基本的、有质量的学前教育。

关键词：农村学前教育幼儿教师队伍

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多羽实蕨胚胎发育的研究

植物研究 2014年第6期34卷 736-740页

作者：赵二兰徐永星关维元刘保东哈尔滨师范大学黑龙江省普通高等学校植物生物学重点实验室哈尔滨150025 浙江省建德市林业科学研究所建德311600

利用人工培养和石蜡切片法研究了多羽实蕨(Bolbitis angustipinna(Hayata)***)胚胎发育过程。合子第一次分裂面垂直于原叶体纵轴且平行于颈卵器颈部;第二次分裂面平行于原叶体纵轴且垂直于颈卵器颈部;第三次分裂面同时平行于原叶体纵轴... 详细信息

利用人工培养和石蜡切片法研究了多羽实蕨(Bolbitis angustipinna(Hayata)***)胚胎发育过程。合子第一次分裂面垂直于原叶体纵轴且平行于颈卵器颈部;第二次分裂面平行于原叶体纵轴且垂直于颈卵器颈部;第三次分裂面同时平行于原叶体纵轴和颈卵器颈部。经多次分裂形成球形胚胎,球形胚胎的外上和外下区域几乎同时分别发育出第一叶顶端细胞和第一根顶端细胞,继而分别斜向分裂产生第一叶原基和第一根原基。随后,第一叶原基迅速分裂,最早突破帽状体形成第一幼叶;第一根原基的分裂速度稍慢,晚于第一叶突破帽状体形成第一根。并讨论了胚胎发育的系统学问题。

关键词：多羽实蕨胚胎发育

Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque

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Science China Chemistry 2025年

作者： Xinyu Xu yuan Ma Hui Cao Li Xu Haoming Chen Sulai Liu wei Sun Guosheng Song Xiaobing Zhang State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Department of Hepatobiliary Surgery/Central Laboratory Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University Shenzhen Research Institute of Hunan University

Atherosclerosis(AS) is a prevalent condition associated with cardiovascular and cerebrovascular diseases, featuring lipid-laden plaque; however, the insufficient resolution and low sensitivity of traditional medical imaging techniques limit their application in lipid imaging. Currently, the second near-infrared(NIR-II) fluorescence imaging offers promising sensitivity and convenience. However, existing probes have limitations in terms of signal-to-background ratio, penetration depth, and tissue scattering. Herein, we use a molecular regulatory strategy to design a lipid-activatable probe Rh-965 with high specificity and NIR-II emission for improved imaging potential in deep tissues. The potential of Rh-965 for imaging plaque lipids in mice with AS is demonstrated by localizing carotid artery plaques using NIR-II imaging. The development of more stable lipid-activated NIR-II probes can significantly enhance atherosclerosis diagnosis and facilitate in vivo imaging in deeper tissues.

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Performance enhancement of perovskite solar cells with Cs2PtI6-xBrx absorber layer based on numerical simulation

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Optoelectronics Letters 2025年

作者： Du Zuyan yuan Yujie Hou Guofu Xin Yupeng Bi Jinlian Li wei Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Integrated Circuit Science and Engineering， Tianjin University of Technology Institute of Photoelectronic Thin Film Devices and Technology， Nankai University

Cs2TiBr6， characterized as a lead-free vacancy-ordered double perovskite material， demonstrates notable stability and photoelectric performance， rendering it suitable for application in perovskite solar cells. However， the experimental efficiency of this material is currently limited， achieving only 3.12%. This efficiency limitation primarily stems from the material’s wide bandgap， which results in insufficient light absorption. To address this issue， this study utilized Cs2PtI6-xBrxfor band structure fine-tuning. By adjusting the bandgap of Cs2PtI6-xBrxthrough Br-doping， not only was the alignment of the energy bandgap in the absorption layer effectively adjusted， but the cutoff range of light absorption was also significantly expanded. Setting the Cs2PtI6-xBrxbandgap to 1.4 eV resulted in optimal device performance. Additionally， comparative analyses aimed at boosting solar cell efficiency were performed on both hole transport and electron transport layer materials. Subsequently， the structure of the perovskite solar cell was optimized using an FTO/TiO2/Cs2TiBr6/Cs2PtI6-xBrx/Cu2O/Au configuration. Furthermore， the influence of the absorber layer thickness and defect density on device performance was studied. Ultimately， this configuration enabled the Cs2TiBr6/Cs2PtI6-xBrxsolar cell to achieve a peak conversion efficiency of 29.69%.

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