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数据信托的内涵、生成逻辑与实现路径——基于数据流通视角的分析

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图书情报知识 2022年第5期39卷 109-119页

作者：夏义堃管茜李纲武汉大学信息资源研究中心武汉430072 武汉大学信息管理学院武汉430072

[目的/意义]作为新兴的数据监管模式和数据资产管理方式,数据信托对于促进数据流通和数据要素市场建设具有重要意义。[研究设计/方法]在文献调研和比较分析的基础上,结合数据权利理论、流通理论、公共信托理论等多学科思维,多角度分析... 详细信息

[目的/意义]作为新兴的数据监管模式和数据资产管理方式,数据信托对于促进数据流通和数据要素市场建设具有重要意义。[研究设计/方法]在文献调研和比较分析的基础上,结合数据权利理论、流通理论、公共信托理论等多学科思维,多角度分析数据信托的内涵、现实意义、理论基础和实施路径。[结论/发现]数据信托作为新兴中介机构、新型数据关系和监管工具,蕴含价值与安全并重的学理内涵、实施公平透明的运行机制、建设可信的生态环境,破解了传统数据流通的主体活力不足、信任危机、空间收缩等问题。数据信托的健康发展需要数据法规体系、数据安全治理、信托运营规则、可信数据生态等要素的协同治理。[创新/价值]厘清了数据信托的内涵框架,从数据流通而非个人数据管理视角分析数据信托的监管效用和市场价值,为我国数据要素市场建设、数据信托产业发展提供参考。

关键词：数据信托数据流通数据中介数据交易信任

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含面内刚性转角自由度的四边形广义协调膜元

重庆大学学报（自然科学版） 2009年第1期32卷 31-36页

作者：陈朝晖郭益蒋锐管前乾重庆大学土木工程学院重庆400030 成都基准方中建筑设计事务所四川成都610017

在常规4结点膜单元内增加独立的平面内刚体转角自由度,采用四边形等参元形式,基于广义协调理论建立了含转角自由度的四边形广义协调膜元,避免了常规平面膜元由于忽略平面内转动而引发转动零刚度、导致刚度阵奇异的缺陷。广义协调元法具... 详细信息

在常规4结点膜单元内增加独立的平面内刚体转角自由度,采用四边形等参元形式,基于广义协调理论建立了含转角自由度的四边形广义协调膜元,避免了常规平面膜元由于忽略平面内转动而引发转动零刚度、导致刚度阵奇异的缺陷。广义协调元法具有非协调元不要求精确协调的优点,且随着单元细分可趋近于协调元,保证了广义协调元的收敛性。应用于经典的Cook问题、悬臂梁问题和MacNeal梁问题,该单元计算精度高、收敛性好、无零能模式。网格畸变分析表明,该单元弱梯形闭锁、单元抗畸变性较好,与矩形单元相比,具有单元划分的灵活性和适应性。

关键词：有限元法广义协调理论转角自由度膜元网格畸变零能模式

Reduction of tumorigenicity of SMMC-7721 hepatoma cells by vascular endothelial growth factor antisense gene therapy

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World Journal of Gastroenterology 2001年第1期7卷 22-27页

作者： Yu Cheng Tang Yu Li guan Xiang qian Department of Biochemistry, Shanghai Second Medical University, Shanghai 200025, China Yu Cheng Tang Yu Li Guan Xiang Qian Department of Biochemistry Shanghai Second Medical University Shanghai 200025 China Yu Cheng Tang graduated in 2000 from Shanghai Second Medical University specialized in tumor biology.

AIM: To test the hypothesis to block VEGF expression of SMMC-7721 hepatoma cells may inhibit tumor growth using the rat hepatoma model. METHODS: Amplify the 200 VEGF cDNA fragment and insert it into human U6 gene cassette in the reverse orientation transcribing small antisense RNA which could specifically interact with VEGF165, and VEGF121 mRNA. Construct the retroviral vector containing this antisense VEGF U6 cassette and package the replication-deficient recombinant retrovirus. SMMC-7721 cells were transduced with these virus and positive clones were selected with G418. PCR and Southern blot analysis were performed to determine if U6 cassette integrated into the genomic DNA of positive clone. Transfected tumor cells were evaluated for RNA expression by ribonuclease protection assays. The VEGF protein in the supernatant of parental tumor cells and genetically modified tumor cells was determined with ELISA. In vitro and in vivo growth properties of antisense VEGF cell clone in nude mice were analyzed. RESULTS: Restriction enzyme digestion and PCR sequencing verified that the antisense VEGF RNA retroviral vector was successfully *** G418 selection, resistant SMMC-7721 cell clone was picked up. PCR and Southern blot analysis suggested that U6 cassette was integrated into the cell genomic DNA. Stable SMMC-7721 cell clone transduced with U6 antisense RNA cassette could express 200 bp small antisense VEGF RNA and secrete reduced levels of VEGF in culture condition. Production of VEGF by antisense transgene-expressing cells was 65+/-10 ng/L per 10(6) cells, 42045 ng/L per 10(6) cells in sense group and 485+/-30 ng/L per 10(6) cells in the negative control group, (P< 0.05). The antisense-VEGF cell clone appeared phenotypically indistinguishable from SMMC-7721 cells and SMMC-7721 cells transfected sense VEGF. The growth rate of the antisense-VEGF cell clone was the same as the control cells. When S.C. was implanted into nude mice, growth of antisense-VEGF c

关键词： Gene Therapy Animals Carcinoma, Hepatocellular Cell Division DNA Polymerase III Endothelial Growth Factors Endothelium, Vascular Enzyme-Linked Immunosorbent Assay Gene Expression Humans Liver Neoplasms Lymphokines Mice Mice, Nude Neovascularization, Pathologic Promoter Regions (Genetics) RNA, Antisense Research Support, Non-U.S. Gov't Transduction, Genetic Tumor Cells, Cultured Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors

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乡村振兴背景下民族地区村庄治理的发展走向

贵州民族研究 2019年第2期40卷 50-55页

作者：管前程中央民族大学马克思主义学院北京100081

民族地区村庄治理,作为乡村政治建设的重要内容,是民族地区乡村振兴的基础前提和制度保障。改革开放以来我国民族地区村庄治理经历了税费时代、后税费时代和新时代三个不同阶段。从管理民主到治理有效是民族地区村庄治理的发展走向,影... 详细信息

民族地区村庄治理,作为乡村政治建设的重要内容,是民族地区乡村振兴的基础前提和制度保障。改革开放以来我国民族地区村庄治理经历了税费时代、后税费时代和新时代三个不同阶段。从管理民主到治理有效是民族地区村庄治理的发展走向,影响治理的有历史性因素和现实性因素,当前遇到一些新情况和新问题。提升民族地区村庄治理的几个着力点是:加强农村基层党建,重视人才队伍建设,深化村民自治,推进法治建设,提升德治水平。同时还要推进"三治融合",建立现代乡村社会治理体制。

关键词：管理民主治理有效民族地区村庄治理村民自治

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国外政府数据资产管理的主要做法与基本经验

信息资源管理学报 2022年第6期12卷 18-30页

作者：夏义堃管茜武汉大学信息资源研究中心武汉430072

数字化时代政府数据量的急剧扩张与技术手段的快速更新,特别是随着各国大数据战略、开放政府数据战略、人工智能战略、数字经济战略的持续推进,数据作为战略资产的重要价值已成为全球共识。本文以美国、英国、澳大利亚等代表性国家政府... 详细信息

数字化时代政府数据量的急剧扩张与技术手段的快速更新,特别是随着各国大数据战略、开放政府数据战略、人工智能战略、数字经济战略的持续推进,数据作为战略资产的重要价值已成为全球共识。本文以美国、英国、澳大利亚等代表性国家政府数据资产管理相关战略、政策及实践举措为研究对象,以政府数据价值实现和风险平衡为核心,分析政府数据资产管理的共性特征与基本经验,即宏观上树立全面的数据资产观、推进数据资产管理的统筹布局,中观上以政策内容强化数据资产的过程管理,微观上以技术、多元伙伴、能力等要素的综合应用全面支持数据资产管理水平的提升。

关键词：数据资产管理政府数据数据管理数据治理数据价值

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东庞煤矿软岩硐室加固技术研究

煤炭工程 2010年第10期42卷 23-25页

作者：韩关桥中国矿业大学(北京)资源与安全工程学院北京100083 冀中能源股份有限公司矿山安全部河北邢台054200

分析了东庞煤矿"工程软岩"硐室-300m水平水泵房破坏现状及破坏原因,经过加固方案比较,决定采用锚注加固技术,对该技术作用机理进行了分析,介绍了锚注加固技术应用施工参数及使用材料,加固工程结束后,通过设置测点对水泵房加固效果进行... 详细信息

分析了东庞煤矿"工程软岩"硐室-300m水平水泵房破坏现状及破坏原因,经过加固方案比较,决定采用锚注加固技术,对该技术作用机理进行了分析,介绍了锚注加固技术应用施工参数及使用材料,加固工程结束后,通过设置测点对水泵房加固效果进行了测试,测试结果证明了锚注加固技术应用于软岩硐室的良好效果。

关键词：工程软岩破坏机理锚注加固注浆锚杆

Plasma RANTES level is correlated with cardio-cerebral atherosclerosis burden in patients with ischemic cerebrovascular disease

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Chronic Diseases and Translational Medicine 2020年第1期6卷 46-54页

作者： Kong Qi Ma Xin Lyu Jun-Xuan Wang Chen Du Xiang-Ying guan Yun-qian Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Clinical Center for Cardio-cerebrovascular Disease Capital Medical UniversityBeijing 100053China Department of Radiology Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Cell Biology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Background::Regulated upon activation, normal T-cell expressed, and secreted (RANTES) is a chemokine actively involved in the initiation and progression of atherosclerosis (AS), which is the major cause of ischemic cerebrovascular disease (ICVD). This study aimed to determine the associations between circulating RANTES level and overall AS conditions of cardiac and cerebral vessel beds in patients with ***::Patients with ICVD admitted to the department of neurology of Xuanwu Hospital from April 1, 2019 to June 30, 2019 were prospectively enrolled in the study. Plasma RANTES level was measured by enzyme-linked immunosorbent assay to represent the circulating RANTES level. The integrated AS burden of the cervicocephalic and coronary arteries was examined using computed tomography angiography and reflected by "cardio-cerebral AS burden (CCAB)" as a continuous variable. Then, the relationship of plasma RANTES level and CCAB in patients with ICVD was analyzed by correlation analyses and general linear ***::A total of 40 patients with ICVD were included in the study. There was a significant positive correlation between CCAB and plasma RANTES level in ICVD ( r = 0.786, P < 0.001), independent of age, sex, acute or chronic phase of ICVD, and mono or dual antiplatelet therapy (adjusted B for ln RANTES, 12.063;95% confidence interval, 7.572-16.533). The association of plasma RANTES level with AS conditions (burden, severity, and extent) in single cardiac or cerebral vessel bed was similar to that with CCAB, but the correlation coefficient for CCAB was higher (increment ranged from 0.126 to 0.397). Conclusions::Plasma RANTES level was an independent indicator for the integrated AS burden of the cervicocephalic and coronary arteries in ICVD. Comprehensive evaluation of AS conditions using the novel continuous index CCAB might be important in revealing the systematic relationship between circulating RANTES and AS in patients with ICVD.

关键词： Plasma RANTES Cardiocerebral atherosclerosis burden Ischemic cerebrovascular disease Cervicocephalic artery Coronary artery

中国南方两个革菌新种:中国丝皮革菌和棉絮丝皮革菌(丝皮革菌科,多孔菌目)

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菌物学报 2021年第3期40卷 447-461页

作者：官前鑫赵长林西南林业大学生物多样性保护学院云南昆明650224

依据形态学和分子系统学研究结果,描述了产自中国云南省的丝皮革菌属2个新种,即中国丝皮革菌Hyphoderma sinense和棉絮丝皮革菌***。中国丝皮革菌以光滑子实层体表面、被结晶和念珠状的囊状体及圆柱形至腊肠状的担孢子(8-11.5×3-5μm)... 详细信息

依据形态学和分子系统学研究结果,描述了产自中国云南省的丝皮革菌属2个新种,即中国丝皮革菌Hyphoderma sinense和棉絮丝皮革菌***。中国丝皮革菌以光滑子实层体表面、被结晶和念珠状的囊状体及圆柱形至腊肠状的担孢子(8-11.5×3-5μm)为主要识别特征。棉絮丝皮革菌具有棉絮状至粉状子实层体表面、管状和分隔状囊状体及椭圆形至腊肠状担孢子。对新种的ITS和nLSU片段进行了测序和分析,采用最大似然法、最大简约法和贝叶斯推断法对研究样本的ITS+nLSU nrRNA基因序列进行系统发育分析,结果显示两个新种隶属于丝皮革菌属,其中,中国丝皮革菌与变形丝皮革菌聚在一起;棉絮丝皮革菌与松生丝皮革菌、丝皮革菌和拟丝皮革菌聚为一类。本研究提供了两新种的详细描述、线条图、生态照片及与相似种的区别,同时编写了我国丝皮革菌属23个种的检索表。

关键词：担子菌门分子系统学新单元分类学木腐真菌

Endothelial progenitor cell down-regulation in a mouse model of Kawasaki disease

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Chinese Medical Journal 2012年第3期000卷 496-501页

作者： LIU Jun-feng DU Zhong-dong CHEN Zhi LU Dun-xiang LI Li guan Yun-qian WAN Sui-gui Department of Pediatrics Beijing Children's Hospital Capital Medical University Beijing 100045 China Laboratory of Cell Biology Xuanwu Hospital Capital Medical University Beijing 100053 China

Background Cardiovascular complications of Kawasaki disease （KD） are a common cause of heart disease in pediatric *** studies have suggested a role for endothelial progenitor cells （EPCs） in coronary artery lesions associated with ***,long-term observations of EPCs during the natural progression of this disorder are *** an experimental model of KD,we aimed to determine whether the coronary artery lesions are associated with down-regulation of *** To induce KD,C57BL/6 mice were administered an intraperitoneal injection of Lactobacillus casei cell wall extract （LCWE; phosphate buffered saline used as control vehicle）.Study groups included：group A （14 days following LCWE injection）,group B （56 days following LCWE injection） and group C （controls）.Numbers of circulating EPCs （positively staining for both CD34 and FIk-1 while staining negative for CD45） were evaluated using flow *** marrow mononuclear cells were cultured in vitro to expand EPCs for functional *** vitro EPC proliferation,adhesion and migration were *** The model was shown to exhibit similar coronary artery lesions to KD patients with coronary *** of circulating EPCs decreased significantly in the KD models （groups A and B） compared to controls （（0.017±0.008）% VS.（0.028±0.007）%,P〈0.05 and （0.016±0.007）% vs.（0.028±0.007）%,P 〈0.05）.Proliferative,adhesive and migratory properties of EPCs were markedly impaired in groups A and *** Coronary artery lesions in KD occur as a consequence of impaired vascular injury repair,resulting from excess consumption of EPCs together with a functional impairment of bone marrow EPCs and their precursors.

关键词： Kawasaki disease endothelial progenitor cells coronary aneurysm mouse model