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Protective mechanisms of Tuina therapy against lipopolysaccharide-induced fever in young rabbits based on untargeted metabolomics analysis

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Journal of Traditional Chinese Medicine 2023年第4期43卷 725-733页

作者： LIU Di ZHANG Yingqi YU Tianyuan LIU Zhifeng JIAO Yi WANG Hourong XU Yajing guan qian CHEN Lulu HU Hui School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102401China Department of Acupuncture-Moxibustion Beijing Massage HospitalBeijing 100035China Department of Acupuncture-Moxibustion Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To investigate the effect of Tuina on the plasma metabolites of lipopolysaccharide-induced febrile in infant ***:Twenty-four infant New Zealand rabbits were selected and randomly divided into three groups:saline,model,and *** fever model was established by injecting LPS intravenously through the ear margin vein in the model group and Tuina group,*** modeling was considered successful when the anal temperature increased by 0.5℃or above within 1 *** the Tuina group,six Tuina techniques(i.e.,opening Tianmen/the heaven gate,pushing Kangong/the superciliary arch,kneading Taiyang and the prominent bone behind the ears,clearing Tianheshui,spine pinching)that alleviate fever were performed on the young rabbits 1 h after the modeling,whereas the model and saline groups were not given Tuina treatment,with the real-time anal temperature monitored during the *** plasma was taken 3 h after the modeling for liquid chromatography-mass spectrometry(LC-MS)untargeted metabolomics ***:Our results showed a fever-reducing effects of Tuina therapy on lipopolysaccharide-induced fever in young rabbits,as indicated by a significantly lower anal temperature,maximum rise in body temperature,and body response index at 2 and 3 h after modeling in the Tuina group compared to the model group,with reductions in the PGE2 expression observed in the blood and *** differential metabolites including riboflavin,nicotinamide N-oxide,porphobilinogen,5-hydroxyindoleacetic acid,gamma-aminobutyric acid,and lysoPC(16:1(9Z)/0:0)were found following the Tuina *** primarily involves glycine-serinethreonine,arginine-proline,porphyrin-chlorophyll,pyrimidine,primary bile acid biosynthesis,and cyanoamino acid metabolic ***:Tuina therapy has proven to be effective in reducing body temperature and down-regulating PGE2 expression in LPS-induced febrile young rabbits,with its mechanism of fever-reducing action poss

关键词： fever pediatrics metabolomics Lipopolysaccharides riboflavin glycine Tuina therapy

Salvianolic Acid B Down-regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-α-induced Human Coronary Artery Endothelial Cells

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Chinese Medical Journal 2015年第19期128卷 2658-2663页

作者： Le Ma Yun-qian guan Zhong-Dong Du Department of Pediatrics Beijing Children's HospitalCapital Medical UniversityBeijing 100045China Cell Therapy Center Beijing Institute of GeriatricsXuanwu Hospital of Capital Medical UniversityBeijing 100053China

Background：Salvianolic acid B （Sal B） is a bioactive water-soluble compound of Salviae miltiorrhizae,a traditional herbal medicine that has been used clinically tor the treatment of cardiovascular *** study sought to evaluate the effect of Sal B on matrix metalloproteinase-9 （MMP-9） and on the underlying mechanisms in tumor necrosis factor-α （TNF-α）-activated human coronary artery endothelial cells （HCAECs）,a cell model of Kawasaki ***：HCAECs were pretreated with 1 l0 μmol/L of Sal B,and then stimulated by TNF-α at different time *** protein expression and activity of MMP-9 were determined by Western blot assay and gelatin zymogram assay,*** factor-κB （NF-κB） activation was detected with immunofluorescence,electrophoretic mobility shift assay,and Western blot *** expression levels of mitogen-activated protein kinase （c-Jun N-terminal kinase [JNK],extra-cellular signal-regulated kinase [ERK],and p38） were determined by Western blot ***：After HCAECs were exposed to TNF-α,1-10 μtmol/L Sal B significantly inhibited TNF-α-induced MMP-9 expression and ***,Sal B significantly decreased IκBα phosphorylation and p65 nuclear translocation in HCAECs stimulated with TNF-α for 30 *** addition,Sal B decreased the phosphorylation of JNK and ERK1/2 proteins in cells treated with TNF-α for 10 ***：The data suggested that Sal B suppressed TNF-α-induced MMP-9 expression and activity by blocking the activation of NF-κB,JNK,and ERK1/2 signaling pathways.

关键词： Endothelial Cell Injury Kawasaki Disease Mitogen-activated Protein Kinase Matrix Metalloproteinase-9 Nuclear factor-κB Salvianolic Acid B

Pathologic features and clinical outcome of central neurocytoma:analysis of 15 cases

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Chinese Journal of Cancer Research 2012年第4期24卷 284-290页

作者： Yu Li Xiu-Feng Ye Guo qian Yu Yin qian-guan Pan Institute of Neuroscience Department of PathologyChongqing Medical University

Objective： To get better recognition of central neurocytoma and diminish misdiagnosis. Methods： A retrospective review identified 15 cases of central neurocytoma. All cases of central neurocytoma were analyzed for their clinical symptoms, pathologic changes, immunohistochemical staining, prognosis and differential diagnosis. Clinical follow up was performed. Results： There were 8 males and 7 females aged 10-64 years （median 32.93 years）. The most common presenting symptoms were those related to increased intracranial pressure （ICP）, including headache （100%）, papilledema （93 %） and vomiting （80%）. All tumors were located in the ventricular system. The tumors were composed of uniform cells with round nuclei and a fine chromatin pattern, and in some areas, small cells with perinuclear halo could be seen. In particular, the anuclear areas may have a fine fibrillary matrix （neuropil）. Nuclear atypia and vascular proliferation appeared in two cases, respectively. Focal necrosis could be seen in one case. Immunohistochemical findings included expression of synaptophysin （15/15）, neuron specific enolase （12/15） and glial fibrillary acidic protein （GFAP）（3/15）. MIB-1 proliferation index ranged from 0.8- 12.5%, and was more than 2% in 3 of 15 cases assessed. Follow-up information of 11 patients was available. Conclusions： Central neurocytoma has a favorable prognosis in general, but in some cases, the clinical course could be aggressive. Increase of GFAP positivity, proliferation index and vascular proliferation might suggest a more malignant process.

关键词： Central neurocytoma histopathology immunohistochemistry proliferation MIB-1 labeling index

Advances in the treatment of diabetic peripheral neuropathy by modulating gut microbiota with traditional Chinese medicine

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World Journal of Diabetes 2024年第8期15卷 1712-1716页

作者： Ye-Yao Li Rui-qian guan Zhi-Bo Hong Yao-Lei Wang Li-Min Pan Department of Endocrinology The Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHarbin 150001Heilongjiang ProvinceChina Department of Tuina The Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHarbin 150001Heilongjiang ProvinceChina

Diabetic peripheral neuropathy(DPN)is one of the strongest risk factors for diabetic foot ulcers(neuropathic ulcerations)and the existing ulcers may further deteriorate due to the damage to sensory ***,the resulting numbness in the limbs causes difficulty in discovering these ulcerations in a short *** is associated with gut microbiota *** Chinese medicine(TCM)compounds such as Shenqi Dihuang Decoction,Huangkui Capsules and Qidi Tangshen Granules can reduce the clinical symptoms of diabetic nephropathy by modulating gut *** current review discusses whether TCM compounds can reduce the risk of DPN by improving gut microbiota.

关键词： Diabetes Peripheral neuropathy Traditional Chinese medicine Gut microbiota Diabetic foot ulcer Treatment

ALKBH5 gene polymorphisms and risk of neuroblastoma in Chinese children from Jiangsu Province

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Cancer Innovation 2024年第2期3卷 72-79页

作者： qian guan Xinxin Zhang Jiabin Liu Chunlei Zhou Jinhong Zhu Haiyan Wu Zhenjian Zhuo Jing He Department of Pediatric Surgery Guangzhou Institute of PediatricsGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangdong Provincial Clinical Research Center for Child HealthGuangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Pathology Children's Hospital of Nanjing Medical UniversityNanjingJiangsuChina Department of Clinical Laboratory BiobankHarbin Medical University Cancer HospitalHarbinHeilongjiangChina Laboratory Animal Center School of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhenGuangdongChina

Background:Neuroblastoma is one of the most common extracranial malignant solid tumors in *** homolog 5(ALKBH5)is an RNA N6-methyladenosine(m6A)demethylase that plays a critical role in tumorigenesis and *** assessed the association between single nucleotide polymorphisms(SNPs)in ALKBH5 and the risk of neuroblastoma in a case-control study including 402 patients and 473 non-cancer ***:Genotyping was determined by the TaqMan *** association between ALKBH5 polymorphisms(rs1378602 and rs8400)and the risk of neuroblastoma was evaluated using the odds ratio(OR)and 95%confidence interval(CI).Results:We found no strong association of ALKBH5 rs1378602 and rs8400 with neuroblastoma *** stratification analysis by age,sex,primary site,and clinical stage showed that the rs1378602 AG/AA genotype was associated with a lower risk of neuroblastoma in males(adjusted OR=0.58,95%CI=0.35–0.97,p=0.036)and children with retroperitoneal neuroblastoma(adjusted OR=0.58,95%CI=0.34–0.98,p=0.040).Conclusions:ALKBH5 SNPs do not seem to be associated with neuroblastoma *** studies are required to confirm this negative result and reveal the relationship between gene polymorphisms of the m6A modifier ALKBH5 and neuroblastoma.

关键词： ALKBH5 neuroblastoma polymorphism susceptibility

An investigation of the influence of intestinal flora in external traditional Chinese medicine therapy

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 10-18页

作者： Hourong Wang Zhifeng Liu Tianyuan Yu Yingqi Zhang Yi Jiao Di Liu Yajing Xu qian guan Mengqian Lu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China

External therapy,which has been used for millennia to treat disease,has now become the newest member of complementary and alternative therapies.A growing number of clinical studies and animal experiments have shown that external therapy exerts a positive effect on the intestinal *** this paper,we review the research related to external therapy on various systemic diseases and focus on changes in the intestinal *** found that studies on external therapy are dominated by acupuncture and tuina,primarily aimed at the treatment of digestive and neurological ***,the deeper mechanism of regulation of the intestinal flora by external therapy has not yet been experimentally confirmed.

关键词： Traditional Chinese medicine External therapy Intestinal flora Digestive diseases Neurological diseases Acupoint Mechanism

2H-1,2,4-噻二唑并[2,3-a]嘧啶衍生物的合成及除草活性研究(V)

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有机化学 2002年第9期22卷 646-650页

作者：薛思佳管谦上海师范大学化学系上海200234 华中师范大学化学系武汉430079

合成了 10个未见文献报道的目标化合物 ,结构经IR ,1HNMR ,MS和元素分析确证 .初步除草活性测定结果表明 :目标化合物具有高效、选择除草活性 ,主要抑制双子叶植物 (如油菜 )的生长 ,而对单子叶植物 (如玉米 )

关键词： 2H-1,2,4-噻二唑并[2,3-α]嘧啶衍生物合成除草活性除草剂

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西语哲在外语界的传播与未来的发展

外语学刊 2008年第2期 1-16页

作者：钱冠连广东外语外贸大学广州510420

文章分为上篇、下篇、全文结论和附录4个部分。上篇反思西语哲在外语界的传播与研究,包括(1)借鉴与对比:西语哲在中国哲学界;(2)西语哲在中国外语界的传播与研究。下篇构拟西语哲的未来发展:(1)西语哲的哲学价值;(2)西语哲的语言学价值... 详细信息

文章分为上篇、下篇、全文结论和附录4个部分。上篇反思西语哲在外语界的传播与研究,包括(1)借鉴与对比:西语哲在中国哲学界;(2)西语哲在中国外语界的传播与研究。下篇构拟西语哲的未来发展:(1)西语哲的哲学价值;(2)西语哲的语言学价值:向语言学提供新学科与新课题;(3)从语言涉入哲学:语言哲学之路有多少。全文结论。附录:西方语言哲学三级书目。

关键词：西语哲外语界传播未来发展世界一束语言哲学之路

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西语哲:如何被语言研究利用

解放军外国语学院学报 2009年第3期32卷 1-6页

作者：钱冠连广东外语外贸大学外国语言学及应用语言学研究中心广东广州510420

语言学者可以充分利用西方语言哲学。从西语哲中析出了也将继续析出语言学学科;在破解哲学经典难题过程中发现了更为深刻的新的语言性质;西语哲因为强调新逻辑工具也给语言研究带来了深刻的洞见;从语言涉入哲学使哲学与语言学都深刻起来... 详细信息

语言学者可以充分利用西方语言哲学。从西语哲中析出了也将继续析出语言学学科;在破解哲学经典难题过程中发现了更为深刻的新的语言性质;西语哲因为强调新逻辑工具也给语言研究带来了深刻的洞见;从语言涉入哲学使哲学与语言学都深刻起来;西语哲为英汉语对比研究开辟了一个新的哲学对比视角;语言学者顺手可得各种附加营养即工具性理论。以上的利用使语言研究空前地深刻起来。

关键词：西方语言哲学语言学研究英汉语对比研究