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HUMAN MITOCHONDRIAL tRNA MUTATIONS IN MATERNALLY INHERITED DEAFNESS

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Journal of Otology 2013年第1期8卷 44-50页

作者： ZHENG Jing GONG Sha-sha TANG Xiao-wen ZHU Yi guan min-xin Department of Genetics College of Life SciencesZhejiang University Attardi Institute of Mitochondrial Biomedicine Wenzhou Medical University

Mutations in mitochondrial tRNA genes have been shown to be associated with maternally inherited syn-dromic and non-syndromic deafness. Among those, mutations such as tRNALeu(UUR) 3243A>G associated with syndromic deafness are often present in heteroplasmy, and the non-syndromic deafness-associated tRNA mu-tations including tRNASer(UCN) 7445A>G are often in homoplasmy or in high levels of heteroplasmy. These tRNA mutations are the primary factors underlying the development of hearing loss. However, other tRNA mutations such as tRNAThr 15927G>A and tRNASer(UCN) 7444G>A are insufficient to produce a deafness phe-notype, but always act in synergy with the primary mitochondrial DNA mutations, and can modulate their phenotypic manifestation. These tRNA mutations may alter the structure and function of the corresponding mitochondrial tRNAs and cause failures in tRNAs metabolism. Thereby, the impairment of mitochondrial protein synthesis and subsequent defects in respiration caused by these tRNA mutations, results in mitochon-drial dysfunctions and eventually leads to the development of hearing loss. Here, we summarized the deaf-ness-associated mitochondrial tRNA mutations and discussed the pathophysiology of these mitochondrial tRNA mutations, and we hope these data will provide a foundation for the early diagnosis, management, and treatment of maternally inherited deafness.

关键词： deafness mitochondria tRNA primary mutation secondary mutation maternally inherited

A GMDA clustering algorithm based on evidential reasoning architecture

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Chinese Journal of Aeronautics 2024年第1期37卷 300-311页

作者： Haibin WANG xin guan Xiao YI Shuangming LI Guidong SUN Naval Aviation University Yantai 264001China Unit 92941 of PLA Huludao 125001China Institute of Systems Engineering Beijing 100082China

The traditional clustering algorithm is difficult to deal with the identification and division of uncertain objects distributed in the overlapping region,and aimed at solving this problem,the Evidential Clustering based on General Mixture Decomposition Algorithm(GMDA-EC)is proposed.First,the belief classification of target cluster is carried out,and the sample category of target distribution overlapping region is extended.Then,on the basis of General Mixture Decomposition Algorithm(GMDA)clustering,the fusion model of evidence credibility and evidence relative entropy is constructed to generate the basic probability assignment of the target and achieve the belief division of the target.Finally,the performance of the algorithm is verified by the synthetic dataset and the measured dataset.The experimental results show that the algorithm can reflect the uncertainty of target clustering results more comprehensively than the traditional probabilistic partition clustering algorithm.

关键词： Evidential clustering Credal partition Evidential reasoning Mixed decomposition Gaussian mixture model

Grasp Detection with Hierarchical Multi-Scale Feature Fusion and Inverted Shuffle Residual

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Tsinghua Science and Technology 2024年第1期29卷 244-256页

作者： Wenjie Geng Zhiqiang Cao Peiyu guan Fengshui Jing min Tan Junzhi Yu State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijing 100871China

Grasp detection plays a critical role for robot manipulation.Mainstream pixel-wise grasp detection networks with encoder-decoder structure receive much attention due to good accuracy and efficiency.However,they usually transmit the high-level feature in the encoder to the decoder,and low-level features are neglected.It is noted that low-level features contain abundant detail information,and how to fully exploit low-level features remains unsolved.Meanwhile,the channel information in high-level feature is also not well mined.Inevitably,the performance of grasp detection is degraded.To solve these problems,we propose a grasp detection network with hierarchical multi-scale feature fusion and inverted shuffle residual.Both low-level and high-level features in the encoder are firstly fused by the designed skip connections with attention module,and the fused information is then propagated to corresponding layers of the decoder for in-depth feature fusion.Such a hierarchical fusion guarantees the quality of grasp prediction.Furthermore,an inverted shuffle residual module is created,where the high-level feature from encoder is split in channel and the resultant split features are processed in their respective branches.By such differentiation processing,more high-dimensional channel information is kept,which enhances the representation ability of the network.Besides,an information enhancement module is added before the encoder to reinforce input information.The proposed method attains 98.9%and 97.8%in image-wise and object-wise accuracy on the Cornell grasping dataset,respectively,and the experimental results verify the effectiveness of the method.

关键词： grasp detection hierarchical multi-scale feature fusion skip connections with attention inverted shuffle residual

Clinical practice of sepsis-induced immunosuppression:Current immunotherapy and future options

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维普期刊数据库

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Chinese Journal of Traumatology 2024年第2期27卷 63-70页

作者： Fei Pei Bin Gu Shu-min Miao Xiang-Dong guan Jian-Feng Wu Department of Critical Care Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China guangdong Clinical Research Center for Critical Care Medicine Guangzhou510080China

Sepsis is a potentially fatal condition characterized by the failure of one or more organs due to a disordered host response to infection.The development of sepsis is closely linked to immune dysfunction.As a result,immunotherapy has gained traction as a promising approach to sepsis treatment,as it holds the potential to reverse immunosuppression and restore immune balance,thereby improving the prognosis of septic patients.However,due to the highly heterogeneous nature of sepsis,it is crucial to carefully select the appropriate patient population for immunotherapy.This review summarizes the current and evolved treatments for sepsis-induced immunosuppression to enhance clinicians'understanding and practical application of immunotherapy in the management of sepsis.

关键词： Sepsis Sepsis-induced immunosuppression Immunotherapy Enrichment Classifier

Multi-scale data joint inversion of minerals and porosity in altered igneous reservoirs—A case study in the South China Sea

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Petroleum Science 2024年第1期21卷 206-220页

作者： xin-Ru Wang Bao-Zhi Pan Yu-Hang Guo Qing-Hui Wang Yao guan College of Geo-exploration Science and Technology Jilin UniversityChangchun130046JilinChina Research Institute CNOOC Ltd.-ShenzhenShenzhen518000GuangdongChina

There are abundant igneous gas reservoirs in the South China Sea with significant value of research,and lithology classification,mineral analysis and porosity inversion are important links in reservoir evaluation.However,affected by the diverse lithology,complicated mineral and widespread alteration,conventional logging lithology classification and mineral inversion become considerably difficult.At the same time,owing to the limitation of the wireline log response equation,the quantity and accuracy of minerals can hardly meet the exploration requirements of igneous formations.To overcome those issues,this study takes the South China Sea as an example,and combines multi-scale data such as micro rock slices,petrophysical experiments,wireline log and element cutting log to establish a set of joint inversion methods for minerals and porosity of altered igneous rocks.Specifically,we define the lithology and mineral characteristics through core slices and mineral data,and establish an igneous multi-mineral volumetric model.Then we determine element cutting log correction method based on core element data,and combine wireline log and corrected element cutting log to perform the lithology classification and joint inversion of minerals and porosity.However,it is always difficult to determine the elemental eigenvalues of different minerals in inversion.This paper uses multiple linear regression methods to solve this problem.Finally,an integrated inversion technique for altered igneous formations was developed.The results show that the corrected element cutting log are in good agreement with the core element data,and the mineral and porosity results obtained from the joint inversion based on the wireline log and corrected element cutting log are also in good agreement with the core data from X-ray diffraction.The results demonstrate that the inversion technique is applicable and this study provides a new direction for the mineral inversion research of altered igneous formations.

关键词： Joint inversion Altered igneous rock Element correction method Lithology identification Multi mineral volume model

Volume-averaged modeling of multiphase solidification with equiaxed crystal sedimentation in a steel ingot

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China Foundry 2024年第3期21卷 229-238页

作者： Xiao-lei Zhu Shuang Cao Rui guan Ji Yang Zhe Ning xin-gang Ai Sheng-li Li xin-cheng Miao The key Laboratory of Material Forming and Structure Property Control Anshan 114051LiaoningChina State Key Laboratory of Metal Material for Marine Equipment and Application Anshan 114009LiaoningChina School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051LiaoningChina

Macrosegregation is a critical factor that limits the mechanical properties of materials.The impact of equiaxed crystal sedimentation on macrosegregation has been extensively studied,as it plays a significant role in determining the distribution of alloying elements and impurities within a material.To improve macrosegregation in steel connecting shafts,a multiphase solidification model that couples melt flow,heat transfer,microstructure evolution,and solute transport was established based on the volume-averaged Eulerian-Eulerian approach.In this model,the effects of liquid phase,equiaxed crystals,columnar dendrites,and columnar-to-equiaxed transition(CET)during solidification and evolution of microstructure can be considered simultaneously.The sedimentation of equiaxed crystals contributes to negative macrosegregation,where regions between columnar dendrites and equiaxed crystals undergo significant A-type positive macrosegregation due to the CET.Additionally,noticeable positive macrosegregation occurs in the area of final solidification in the ingot.The improvement in macrosegregation is beneficial for enhancing the mechanical properties of connecting shafts.To mitigate the thermal convection of molten steel resulting from excessive superheating,reducing the superheating during casting without employing external fields or altering the design of the ingot mold is indeed an effective approach to control macrosegregation.

关键词： ingot casting multiphase solidification model equiaxed crystal sedimentation microstructure macrosegregation

Genetically controlled humanized microenvironment in mice for pre-clinical study

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Genetically controlled humanized microenvironment in mice fo...

Emulsifying property,antioxidant activity,and bitterness of soybean protein isolate hydrolysate obtained by Corolase PP under high hydrostatic pressure

中国遗传学会第九次全国会员代表大会暨学术研讨会

作者： CHEN Ye JACAMO Rodrigo KONOPLEVA Marina guan min-xin ANDREEFF Michael Institute of Genetics College of Life SciencesZhejiang University Department of Leukemia The University of Texas M.D.Anderson Cancer Center

The importance of the microenvironment for cancer development,progression and resistance to treatment has recently been recognized.Our group was first to report the contribution of bone marrow(BM) derived mesenchymal stromal cells(MSC) for tumor development and metastasis.BM provides dynamic microenvironment(niche) for the maintenance of hematopoietic stem cells(HSC) quiescence and normal hematopoiesis with high local concentrations of growth factors,chemokines and cytokines.Accumulating evidence has also shown that the BM microenvironment plays a pivotal role in the pathophysiology and propagation of leukemia Leukemia cells undergo spontaneous apoptosis once they are removed from the in vivo microenvironment and placed in suspension cultures without supportive stroma.The understanding of the interactions between leukemia cells and their BM niche is critically important for leukemia therapy.We here describe a novel artificial bone and bone marrow model mimicking the human hematopoietic microenvironment by using human mesenchymal stromat cells(MSCs) and endothelial colony-forming cells(ECFCs).MSCs and ECFCs were isolated from heparinized human bone marrow or peripheral blood through an initial adhesion step,grown in specific media and then subcutaneously injected into the flanks of the NOD/SCID/IL-2rγ mice,where they developed into bone-like tissues with high osteoblast activity after 8 weeks.Histochemical stains confirmed the bone structures and also showed that these artificial bones contained typical bone marrow cavities constituting a robust hematopoietic environment.In vivo imaging with Osteosense confirmed the presence of hydroxylapatite and luciferase imaging of firefly luciferase labeled human leukemic cells the engraftment of MOLM13/Luc/GFP leukemic cells in the extramedullary BM sites,following i.***.injection with infiltration of the extramedullary and physiological medullary bone marrow space.Factors critical for MSC support of normal vs.leukemic hematopoiesis are largely unknown and cannot be studied si

关键词： Mouse model Genetically controlled humanized microenvironment Tumor engraftment

来源： cnki会议评论

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cnki会议

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Food Science and Human Wellness 2024年第3期13卷 1271-1278页

作者： Haining guan Chunmei Feng min Ren Xiaojun Xu Dengyong Liu Xiaoqin Diao College of Food Science and Technology Bohai UniversityJinzhou 121013China

Enzymatic hydrolysis of proteins can enhance their emulsifying properties and antioxidant activities.However,the problem related to the hydrolysis of proteins was the generation of the bitter taste.Recently,high hydrostatic pressure(HHP)treatment has attracted much interest and has been used in several studies on protein modification.Hence,the study aimed to investigate the effects of enzymatic hydrolysis by Corolase PP under different pressure treatments(0.1,100,200,and 300 MPa for 1-5 h at 50℃)on the emulsifying property,antioxidant activity,and bitterness of soybean protein isolate hydrolysate(SPIH).As observed,the hydrolysate obtained at 200 MPa for 4 h had the highest emulsifying activity index(47.49 m^(2)/g)and emulsifying stability index(92.98%),and it had higher antioxidant activities(44.77%DPPH free radical scavenging activity,31.12%superoxide anion radical scavenging activity,and 61.50%copper ion chelating activity).At the same time,the enhancement of emulsion stability was related to the increase of zeta potential and the decrease of mean particle size.In addition,the hydrolysate obtained at 200 MPa for 4 h had a lower bitterness value and showed better palatability.This study has a broad application prospect in developing food ingredients and healthy foods.

关键词： Soybean protein isolate High hydrostatic pressure Emulsification Antioxidant Bitter taste

Revealing the role of pyramidal slip in the high ductility of Mg-Li alloy

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Journal of Magnesium and Alloys 2024年第3期12卷 1021-1025页

作者： Jing Xu Bo guan Yunchang xin guangjie Huang Peidong Wu Qing Liu International Joint Laboratory for Light Alloys College of Materials Science and EngineeringChongqing UniversityChongqing 400030China Key Laboratory for Light-weight Materials Nanjing Tech UniversityNanjing 210009China Department of Mechanical Engineering McMaster UniversityHamiltonON L8S 4L7Canada

The high ductility of Mg-Li alloy has been mainly ascribed to a high activity of pyramidalslip to accommodate plastic strain.In the present study,however,a quantitative analysis reveals that Li-addition can only slightly stimulate the activation of pyramidalslip under compression along the normal direction of a hot-rolled Mg-4.5 wt.%Li plate,with a relative activity of approximately 18%.Although the limited activity of pyramidalslip alone cannot accommodate a large plastic strain,it effectively reduces the number of{10.11}−{10.12}double twins,which are believed to be favorable sites for crack initiation.The evidently reduced activity of double twins leads to a lower cracking tendency,and therefore improves ductility.

关键词： Mg alloy Plasticity Plastic deformation Slip Twinning.