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Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 52-63页

作者： Li Zhang Sai He Hao guan Yao Zhao Di Zhang Department of General Surgery the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Department of Breast Cancer Shaanxi Provincial Cancer HospitalXi’an 710000China

Background:Hepatocellular carcinoma(HCC),the most common type of primary liver cancer,is the fourth leading cause of cancer-related deaths *** evidence shows that the expression of circulating RNA ZFR(circZFR)is upregulated in HCC ***,the molecular mechanism of circZFR in HCC is ***:Quantitative reverse transcriptase polymerase chain reaction(qRT-PCR)was employed to detect the expression of circZFR,microRNA-624-3p(miR-624-3p)and WEE1 in HCC tissues and *** R assay and actinomycin D treatment assay were used to analyze the characteristics of *** functional analysis,the capacities of colony formation,cell proliferation,cell apoptosis,migration and invasion were assessed by colony formation assay,5-ethynyl-2-deoxyuridine(EdU)assay,flow cytometry assay and transwell *** blot was used to examine the protein levels of WEE1 and epithelial-mesenchymal transition(EMT)-related *** interactions between miR-624-3p and circZFR or WEE1 were validated by dual-luciferase reporter assay and RNA immunoprecipitation(RIP)*** models were established to determine the role of circZFR in ***:circZFR and WEE1 were upregulated,while miR-624-3p expression was reduced in HCC tissues and *** could sponge miR-624-3p,and WEE1 was a downstream gene of *** of circZFR significantly reduced the malignant behaviors of HCC and that co-transfection with miR624-3p inhibitor restored this *** of WEE1 abolished the inhibitory effect of miR624-3p mimic on HCC ***,circZFR acted as a competitive endogenous RNA(ceRNA)to regulate WEE1 expression by targeting ***,in vivo studies have illustrated that circZFR knockdown inhibited tumor ***:circZFR knockdown reduced HCC cell proliferation,migration and invasion and promoted apoptosis by regulating the miR-624-3p/WEE1 axis,suggesting that the circZFR/miR-624-3p/WEE1 axis might

关键词： Hepatocellular carcinoma circZFR miR-624-3p WEE1 Liver cancer

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Flotation separation of scheelite from calcite using luteolin as a novel depressant

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 462-472页

作者： Xiaokang Li Ying Zhang Haiyang He Yu Wu Danyu Wu Zhenhao guan Faculty of Land and Resources Engineering Kunming University of Science and TechnologyKunming 650093China State Key Laboratory of Clean Utilization of Complex Non-Ferrous Metal Resources Kunming University of Science and TechnologyKunming 650093China

This paper proposes luteolin(LUT)as a novel depressant for the flotation-based separation of scheelite and calcite in a sodium oleate(NaOL)*** suitability of LUT as a calcite depressant is confirmed through micro-flotation *** pH=9,with LUT concentration of 50 mg·L^(-1) and NaOL concentration of 50 mg·L^(-1),scheelite recovery reaches 80.3%.Calcite,on the other hand,exhibits a recovery rate of 17.6%,indicating a significant difference in floatability between the two ***,the surface modifica-tions of scheelite and calcite following LUT treatment are characterized using adsorption capacity testing,Zeta potential analysis,Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),and atomic force microscopy(AFM).The study in-vestigates the selective depressant mechanism of LUT on *** capacity testing and Zeta potential analysis demonstrate sub-stantial absorption of LUT on the surface of calcite,impeding the further adsorption of sodium oleate,while its impact on scheelite is ***-IR and XPS analyses reveal the selective adsorption of LUT onto the surface of calcite,forming strong chemisorption bonds between the hydroxyl group and calcium ions *** directly illustrates the distinct adsorption densities of LUT on the two miner-al ***,LUT can effectively serve as a depressant for calcite,enabling the successful separation of scheelite and calcite.

关键词： scheelite calcite luteolin flotation depressant separation

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Joint computation offloading and parallel scheduling to maximize delay-guarantee in cooperative MEC systems

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Digital Communications and Networks 2024年第3期10卷 693-705页

作者： Mian Guo Mithun Mukherjee Jaime Lloret Lei Li Quansheng guan Fei Ji School of Electronics and Information Guangdong Polytechnic Normal UniversityGuangzhouChina School of Artificial Intelligence Nanjing University of Information Science and TechnologyNanjingChina Universitat Politecnica de Valencia 46022ValenciaSpain South China University of Technology China

The growing development of the Internet of Things(IoT)is accelerating the emergence and growth of new IoT services and applications,which will result in massive amounts of data being generated,transmitted and pro-cessed in wireless communication *** Edge Computing(MEC)is a desired paradigm to timely process the data from IoT for value *** MEC,a number of computing-capable devices are deployed at the network edge near data sources to support edge computing,such that the long network transmission delay in cloud computing paradigm could be *** an edge device might not always have sufficient resources to process the massive amount of data,computation offloading is significantly important considering the coop-eration among edge ***,the dynamic traffic characteristics and heterogeneous computing capa-bilities of edge devices challenge the *** addition,different scheduling schemes might provide different computation delays to the offloaded ***,offloading in mobile nodes and scheduling in the MEC server are coupled to determine service *** paper seeks to guarantee low delay for computation intensive applica-tions by jointly optimizing the offloading and scheduling in such an MEC *** propose a Delay-Greedy Computation Offloading(DGCO)algorithm to make offloading decisions for new tasks in distributed computing-enabled mobile devices.A Reinforcement Learning-based Parallel Scheduling(RLPS)algorithm is further designed to schedule offloaded tasks in the multi-core MEC *** an offloading delay broadcast mechanism,the DGCO and RLPS cooperate to achieve the goal of delay-guarantee-ratio ***,the simulation results show that our proposal can bound the end-to-end delay of various *** under slightly heavy task load,the delay-guarantee-ratio given by DGCO-RLPS can still approximate 95%,while that given by benchmarked algorithms is reduced to intolerable *** simulation resul

关键词： Edge computing Computation offloading Parallel scheduling Mobile-edge cooperation Delay guarantee

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Grasp Detection with Hierarchical Multi-Scale Feature Fusion and Inverted Shuffle Residual

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Tsinghua Science and Technology 2024年第1期29卷 244-256页

作者： Wenjie Geng Zhiqiang Cao Peiyu guan Fengshui Jing Min Tan Junzhi Yu State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Department of Advanced Manufacturing and Robotics College of EngineeringPeking UniversityBeijing 100871China

Grasp detection plays a critical role for robot *** pixel-wise grasp detection networks with encoder-decoder structure receive much attention due to good accuracy and ***,they usually transmit the high-level feature in the encoder to the decoder,and low-level features are *** is noted that low-level features contain abundant detail information,and how to fully exploit low-level features remains ***,the channel information in high-level feature is also not well ***,the performance of grasp detection is *** solve these problems,we propose a grasp detection network with hierarchical multi-scale feature fusion and inverted shuffle *** low-level and high-level features in the encoder are firstly fused by the designed skip connections with attention module,and the fused information is then propagated to corresponding layers of the decoder for in-depth feature *** a hierarchical fusion guarantees the quality of grasp ***,an inverted shuffle residual module is created,where the high-level feature from encoder is split in channel and the resultant split features are processed in their respective *** such differentiation processing,more high-dimensional channel information is kept,which enhances the representation ability of the ***,an information enhancement module is added before the encoder to reinforce input *** proposed method attains 98.9%and 97.8%in image-wise and object-wise accuracy on the Cornell grasping dataset,respectively,and the experimental results verify the effectiveness of the method.

关键词： grasp detection hierarchical multi-scale feature fusion skip connections with attention inverted shuffle residual

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How Does Urban Shrinkage Affect Land Use Efficiency?A Case Study of Shrinking Cities in Northeast China

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Chinese Geographical Science 2024年第1期34卷 34-51页

作者： XIE Mingke FENG Zhangxian SONG Yang guan Haoming WANG Shijun School of Geographical Sciences Northeast Normal UniversityChangchun130024China

The effect of urban shrinkage has gradually become a new ***,urban shrinkage may exert great influence on land use efficiency(LUE)through various urban subsystems,but there is currently limited research examining these *** the Super-SBM-Undesirable model and the Structural Equation Model(SEM),this study calculates the LUE of shrinking cities in Northeast China and simulates the process of urban shrinkage affecting *** quantify the process of urban shrinkage affecting LUE,three mediation variables,namely the economy,public services,and innovation,are used as latent variables to apply *** results show that urban shrinkage will affect LUE through a direct path and indirect *** the direct path,urban shrinkage leads to an improvement in *** the indirect paths,the economy and innovation will transmit the negative effect of urban shrinkage on LUE,while public services will reverse this *** important contribution of this study is that it quantifies the paths of urban shrinkage affecting LUE,thereby expanding the understanding of urban shrinkage effect and laying a foundation for the sustainable development of shrinking cities.

关键词： urban shrinkage land use efficiency Super-SBM-Undesirable model Structural Equation Model(SEM) Northeast China

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Detection and isolation of false data injection attack via adaptive Kalman filter bank

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Journal of Control and Decision 2024年第1期11卷 60-72页

作者： Xiaoyuan Luo Minggao Zhu Xinyu Wang Xinping guan School of Electrical Engineering Yanshan UniversityQinhuangdaoPeople’s Republic of China Jiangsu Collaborative Innovation Center for Smart Distribution Network NanjingPeople’s Republic of China School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghaiPeople’s Republic of China

Due to the integration of cyber–physical systems,smart grids have faced the new security risks caused by false data injection attacks(FDIAs).FDIAs can bypass the traditional bad data detection techniques by falsifying the process of state *** this reason,this paper studies the detection and isolation problem of FDIAs based on the adaptive Kalman filter bank(AKFB)in smart *** the covert characteristics of FDIAs into account,a novel detection method is proposed based on the designed ***,the adaptive threshold is proposed to solve the detection delay caused by a priori threshold in the current detection *** the case of multiple attacked sensor nodes,the AKFB-based isolation method is *** reduce the number of isolation iterations,a logical decision matrix scheme is ***,the effectiveness of the proposed detection and isolation method is demonstrated on an IEEE 22-bus smart grids.

关键词： Smart grids false data inject attack detection and isolation Kalman filter bank

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Non-monotonic behavior of jam probability and stretchedexponential distribution in pedestrian counterflow

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Chinese Physics B 2024年第9期33卷 259-266页

作者： Ze-Hao Chen Zhi-Xi Wu Jian-Yue guan College of Physical Science and Technology Guangxi Normal UniversityGuilin 541004China Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Provinceand Key Laboratory for Quantum Theory and Applications of the Ministry of EducationLanzhou UniversityLanzhou 730000China

We adopt a floor field cellular automata model to study the statistical properties of bidirectional pedestrian flow movingin a straight corridor. We introduce a game-theoretic framework to deal with the conflict of multiple pedestrians tryingto move to the same target location. By means of computer simulations, we show that the complementary cumulative distributionof the time interval between two consecutive pedestrians leaving the corridor can be fitted by a stretched exponentialdistribution, and surprisingly, the statistical properties of the two types of pedestrian flows are affected differently by theflow ratio, i.e., the ratio of the pedestrians walking toward different directions. We also find that the jam probability exhibitsa non-monotonic behavior with the flow ratio, where the worst performance arises at an intermediate flow ratio of around0.2. Our simulation results are consistent with some empirical observations, which suggest that the peculiar characteristicsof the pedestrians may attributed to the anticipation mechanism of collision avoidance.

关键词： traffic and crowd dynamics evolutionary game theory

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Analysis of conductance and interfacial polarisation behaviours of silicone rubber based on frequency domain spectroscopy

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High Voltage 2024年第1期9卷 56-65页

作者： Hao Hu Zhidong Jia Xilin Wang Ruiyang guan Weinan Fan Simin Luo Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhenChina guangzhou Power Supply China Southern Power Grid Company Ltd.GuangzhouChina

Silicone rubber(SR)is widely used for cable insulation and operates in multi-stress coupling *** dielectric properties and ageing performance are the essential factors affecting cable *** this study,the frequency domain spectroscopy of unaged SR and SR aged under various conditions is *** dielectric responses before and after ageing are analysed in depth by the conjoint analysis via multiple complex planes(permittivity,conductivity,and modulus).Typical conductivity and interfacial polarisation properties,as well as property changes resulting from thermal and tensile ageing,are *** results show that tensile ageing promotes conductance and interfacial polarisation,while thermal ageing shows the opposite *** on the multi-core model and charge carrier hopping transport model,thermal and tensile ageing mechanisms on the conductance and interfacial polarisation behaviours of SR are *** behaviours exhibit positively correlated changing characteristics,suggesting that the two behaviours may originate from a common *** carrier transport process,promoted by the tensile effect and slightly suppressed by the thermal effect,is the primary factor and considered an important indicator to evaluate the dielectric properties of SR insulation.

关键词： interfacial rubber insulation

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Microstructure evolution,mechanical properties and fracture behavior of Al-xSi/AZ91D bimetallic composites prepared by a compound casting

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Journal of Magnesium and Alloys 2024年第5期12卷 1944-1964页

作者： guangyu Li Wenming Jiang Feng guan Junwen Zhu Yang Yu Zitian Fan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

In this paper,the effect of the Si content on microstructure evolution,mechanical properties,and fracture behavior of the Al-xSi/AZ91D bimetallic composites prepared by compound casting was investigated *** obtained results showed that all the Al-xSi/AZ91D bimetallic composites had a metallurgical reaction layer(MRL),whose thickness increased with increasing Si content for the hypoeutectic Al-Si/AZ91D composites,while the hypereutectic Al-Si/AZ91D composites were *** MRL included eutectic layer(E layer),intermetallic compound layer(IMC layer)and transition region layer(T layer).In the IMC layer,the hypereutectic Al-Si/AZ91D composites contained some Si solid solution and flocculent Mg_(2)Si+Al-Mg IMCs phases not presented in the hypoeutectic Al-Si/AZ91D ***,increasing Si content,the thickness proportion of the T layer increased,forming an inconsistent preferred orientation of the *** shear strengths of the Al-xSi/AZ91D bimetallic composites enhanced with increasing Si content,and the Al-15Si/AZ91D composite obtained a maximum shear strength of 58.6 MPa,which was 73.4% higher than the Al-6Si/AZ91D *** fractures of the Al-xSi/AZ91D bimetallic composites transformed from the T layer into the E layer with the increase of the Si *** improvement of the shear strength of the Al-xSi/AZ91D bimetallic composites was attributed to the synergistic action of the Mg_(2)Si particle reinforcement,the reduction of oxidizing inclusions and the ratio of Al-Mg IMCs as well as the orientation change of the MRL.

关键词： Al/Mg bimetallic composites Si content Mg_(2)Si reinforcement Microstructure Mechanical properties Fracture behavior

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The story of a decade:Genomics,functional genomics,and molecular breeding in Brassica napus

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Plant Communications 2024年第4期5卷 94-111页

作者： Jianwei Gu Zhilin guan Yushun Jiao Kede Liu Dengfeng Hong National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Life Science and Technology Hubei Engineering UniversityXiaogan 432100 HubeiChina Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074 HubeiChina Yazhouwan National Laboratory Sanya 572024 HainanChina These authors contributed equally to this article.

Rapeseed(Brassica napus L.)is one of the major global sources of edible vegetable oil and is also used as a feed and pioneer crop and for sightseeing and industrial *** in genome sequencing and molecular marker technology have fueled a boom in functional genomic studies of major agronomic characters such as yield,quality,flowering time,and stress ***,introgression and pyra-miding of key functional genes have greatly accelerated the genetic improvement of important *** we summarize recent progress in rapeseed genomics and genetics,and we discuss effective molecular breeding strategies by exploring thesefindings in *** insights will extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture throughout the world.

关键词： Brassica napus functional genomics genomics molecular breeding agronomic traits

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