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A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers

Biomedical and Environmental Sciences 2024年第5期37卷 445-456页

作者： HU Wei Qiong ZHOU Wei guang ZHOU guang Wei liAO Jia Xi SHI Jia Xing XIE FengYang li Shou Heng WANG Yong FENG Xian Hong gu xiu li CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Institute of WUT-AMU Wuhan University of TechnologyWuhan 430070HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People’s HospitalWuhan 430499HubeiChina Department of Reproductive Genetics Wuhan Huake Reproductive HospitalWuhan 430013HubeiChina

Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than ***,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer *** A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were *** of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger ***-four eligible studies were included in the *** After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the Hubei Chinese *** meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese *** The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关键词： LEPR gene rs1137101 Digestive system cancers Genetic susceptibility Meta-analysis

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Tunable VO_(2) cavity enables multispectral manipulation from visible to microwave frequencies

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light(Science & Applications) 2024年第3期13卷 510-518页

作者： Hang Wei Jinxin gu Tao Zhao Zhiyuan Yan He-xiu Xu Shuliang Dou Cheng-Wei Qiu Yao li Center for Composite Materials and Structure Harbin Institute of TechnologyHarbin 150001China National University of Singapore Department of Electrical&Computer EngineeringSingapore 117583Singapore School of Chemical Engineering and Technology Harbin Institute of TechnologyHarbin 150001China Suzhou Laboratory Suzhou 215123China

Optical materials capable of dynamically manipulating electromagnetic waves are an emerging field in memories,optical modulators,and thermal ***,their multispectral design preliminarily attracts much attention,aiming to enhance their efficiency and integration of ***,the multispectral manipulation based on these materials is challenging due to their ubiquitous wavelength dependence restricting their capacity to narrow *** this article,we cascade multiple tunable optical cavities with selective-transparent layers,enabling a universal approach to overcoming wavelength dependence and establishing a multispectral platform with highly integrated *** on it,we demonstrate the multispectral(ranging from 400 nm to 3 cm),fast response speed(0.9 s),and reversible manipulation based on a typical phase change material,vanadium *** platform involves tandem VO_(2)-based Fabry–Pérot(F-P)cavities enabling the customization of optical responses at target bands *** can achieve broadband color-changing capacity in the visible region(a shift of~60 nm in resonant wavelength)and is capable of freely switching between three typical optical models(transmittance,reflectance,and absorptance)in the infrared to microwave regions with drastic amplitude tunability exceeding *** work represents a state-of-art advance in multispectral optics and material science,providing a critical approach for expanding the multispectral manipulation ability of optical systems.

关键词： spectral microwave visible

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An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation

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Defence Technology（防务技术） 2024年第2期32卷 254-261页

作者： Benfeng gu Haiyuan li Baoming li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China

To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore *** this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried *** test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of *** the simulation results and experimental data,the damage condition of the contact surface is analyzed.

关键词： Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling Experimental validation PFN

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浮游板优化精液与密度梯度离心结合上游法的比较

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生殖医学杂志 2024年第8期33卷 1080-1086页

作者：张玲辜秀丽袁周金其贝张衷源叶臻孟天庆周慧李红钢熊承良华中科技大学同济医学院生殖健康研究所武汉430030 武汉华科生殖专科医院武汉430010

目的应用浮游板和密度梯度离心结合上游法优化人类精液,明确优化效果并比较两种方法优化后精子参数的差异。方法收集正常精液样本85例和轻中度少弱精子症精液样本59例,每例样本分为原液组、密梯组和浮游组各1 ml进行后续处理。原液组在... 详细信息

目的应用浮游板和密度梯度离心结合上游法优化人类精液,明确优化效果并比较两种方法优化后精子参数的差异。方法收集正常精液样本85例和轻中度少弱精子症精液样本59例,每例样本分为原液组、密梯组和浮游组各1 ml进行后续处理。原液组在精液液化后未做任何处理;密梯组精液液化后用密度梯度离心法结合上游法进行处理,浮游组则在精液液化后应用精子浮游板进行处理。比较原液组、密梯组、浮游组3个亚组间的精子浓度、前向运动精子百分率、正常形态精子百分率;应用流式细胞仪检测精子线粒体膜电位和精子DNA碎片指数,使用单精子活性氧分析仪检测单精子活性氧水平,使用电子显微镜观察精子超微结构并进行组间比较。结果无论是正常精液还是轻中度少弱精子症精液,与原液组比较,密梯组与浮游组的前向运动精子百分率、正常形态精子百分率及精子线粒体膜电位均显著升高(P0.05)。正常精液中,浮游组的精子浓度显著高于密梯组(P=0.029),单精子活性氧水平显著低于原液组(P=0.038)。轻中度少弱精子症精液中3亚组间的单精子活性氧水平均无显著性差异(P>0.05)。电子显微镜观察发现正常精液中3个亚组的精子均未见明显异常;轻中度少弱精子症精液中密梯组部分精子可观察到精子细胞膜断裂和线粒体肿胀等异常,而浮游组精子超微结构未见明显异常。结论密度梯度离心结合上游法和浮游板法用于精液的处理和优化,均可有效回收活力、形态和功能更好的精子。精子浮游板法的体外干预小,操作简便,可以获得活性氧更少、损伤更小的精子。

关键词：密度梯度离心法浮游板法单精子活性氧精子DNA碎片指数精子线粒体膜电位

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Rapid analysis of metal ions and organic compounds in strong acidic solutions by nano-ESI mass spectrometry

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Chinese Chemical Letters 2024年第2期35卷 516-520页

作者： Jiaquan Xu Ting li Zhendong Yu lili Song xiu-xiu Xu Hui li Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation East China University of TechnologyNanchang 330013China Department of Rehabilitation Medicine The First Affiliated Hospital of Nanchang UniversityNanchang 330006China

Rapid analysis of metal ions and organic compounds in strong acidic solutions is of sustainable interest in multiple ***,complicated and time-consuming pretreatments are always required for MS analysis of the compounds in strong acidic ***,it will result in a weak signal and cause serious damage to the mass ***,a simple method inherited from nano-ESI MS was developed for rapid analysis of strong acidic ***(nL)strong acidic solution was first loaded in the nano-ESI emitter,followed by evaporation to remove the H+and leave the analytes on the wall of the nano-ESI *** evaporation process can be completed within 1 min because of the extremely tiny volume(≤1 nL)of the loaded ***,the dried analytes on the wall of the nano-ESI emitter were redissolved by loading a new solvent,followed by nano-ESI MS *** using this method,metal ions and organic compounds in the strong acidic solution can be detected with low sample consumption(1 nL),high speed(limit of detection=0.2µg/L),and high accuracy(>90%).Proof-of-concept applications of the present method have been successfully achieved for the analysis of gastric juice(pH of the sample=1),monitoring reaction catalyzed by strong acid(pH of the system=0),and micro-area analysis of ores(pH of the extraction solvent=0),showing great application potential in multiple fields.

关键词： Strong acidic solutions Nano-ESI MS Rapid analysis Reaction monitoring Micro-area analysis Gastric juice analysis

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A Power Data Anomaly Detection Model Based on Deep Learning with Adaptive Feature Fusion

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Computers, Materials & Continua 2024年第6期79卷 4045-4061页

作者： xiu liu liang gu Xin Gong Long An Xurui Gao Juying Wu State Grid Information&Telecommunication Co.of SEPC Big Data CenterTaiyuan030000China

With the popularisation of intelligent power,power devices have different shapes,numbers and *** means that the power data has distributional variability,the model learning process cannot achieve sufficient extraction of data features,which seriously affects the accuracy and performance of anomaly ***,this paper proposes a deep learning-based anomaly detection model for power data,which integrates a data alignment enhancement technique based on random sampling and an adaptive feature fusion method leveraging dimension *** at the distribution variability of power data,this paper developed a sliding window-based data adjustment method for this model,which solves the problem of high-dimensional feature noise and low-dimensional missing *** address the problem of insufficient feature fusion,an adaptive feature fusion method based on feature dimension reduction and dictionary learning is proposed to improve the anomaly data detection accuracy of the *** order to verify the effectiveness of the proposed method,we conducted effectiveness comparisons through elimination *** experimental results show that compared with the traditional anomaly detection methods,the method proposed in this paper not only has an advantage in model accuracy,but also reduces the amount of parameter calculation of the model in the process of feature matching and improves the detection speed.

关键词： Data alignment dimension reduction feature fusion data anomaly detection deep learning

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A bifunctional POM-based Cu-viologen complex with mixed octamolybdate clusters for rapid oxidation desulfurization and effective photogeneration of hydrogen

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Rare Metals 2024年第1期43卷 236-246页

作者： lin Yang Zhong Zhang Chao-Nan Zhang xiu-li Wang College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of liaoning Province for Conversion Materials of Solar Cell Bohai UniversityJinzhou 121013China

The design and synthesis of catalysts for the oxidation desulfurization and production of hydrogen are extremely important for solving environmental pollution and energy ***,a novel bifunctional [α-Mo_(8)O_(26)]^(4-)/[β-Mo_(8)O_(26)]^(4-)-based Cu-viologen complex H_(4)[Cu_(2)~ⅠCl_(2)(Hbcbpy)_(4)] [α-Mo_(8)O_(26)] [β-Mo8O_(26)]·H_(2)O(BHU-2,Hbcbpy=1-(4-carboxybenzyl)-4,4'-bipyridinium) was synthesized and characterized by single-crystal X-ray diffraction(XRD),infrared radiation spectra,powder X-ray diffraction(PXRD) and X-ray photoelectron spectroscopy(XPS) *** structural characteristic of BHU-2 is the presence of two types of octamolybdate clusters [α-Mo_(8)O_(26)]^(4-)/[β-Mo_(8)O_(26)]^(4-)and a new binuclear Cu~Ⅰ-Hbcbpy complex linked by Cl-bridges[Cu_(2)ⅠCl_(2)(Hbcbpy)_(4)]^(4+).BHU-2 as a heterogeneous catalyst exhibits excellent activities to the oxidation desulfurization and photocatalytic hydrogen *** room temperature,BHU-2 can catalyze 96% conversion of methyl phenyl sulfide with 98% selectivity,and the process obeys the pseudo-first-order reaction kinetic with the half-life of9.6 *** notorious 2-chloroethyl ethyl sulfide can achieve 99% conversion with 98% selectivity within only1 min at the presence of BHU-2,and the turnover frequency(TOF) is up to 7400 h^(-1).BHU-2 also exhibits high catalytic activity for the oxidation of other aromatic and aliphatic thioethers within short time at room ***,BHU-2 shows a high catalytic activity for visible-light-driven hydrogen evolution with an H_(2) evolution rate of 1677.85 μmol·g^(-1)·h^(-1) within 10 ***,the catalytic activities do not decrease evidently after three cycles,revealing the prominent structural stability and recyclability.

关键词： Polyoxometalate Metal-organic complex Viologen Oxidation desulfurization Photocatalytic hydrogen production

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Numerical Study on the Aerodynamic and Fluid−Structure Interaction of An NREL-5MW Wind Turbine

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China Ocean Engineering 2024年第3期38卷 363-378页

作者： ZHAO Mi YU Wan-li WANG Pi-guang QU Yang DU xiu-li Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China

A 5-MW wind turbine has been modeled and analyzed for fluid-structure interaction and aerodynamic *** this study, a full-scale model of a 5-MW wind turbine is first developed based on a computational fluid dynamics(CFD) approach, in which the unsteady, noncompressible Reynolds Averaged Navier-Stokes(RANS) method is used. The main focus of the study is to analyze the tower shadow effect on the aerodynamic performance of the wind turbine under different inlet flow conditions. Subsequently, the finite element model is established by considering fluid/structure interactions to study the structural stress, displacement, strain distributions and flow field information of the structure under the uniform wind speed. Finally, the fluid-structure interaction model is established by considering turbulent wind and the tower shadow effect. The variation rules of the dynamic response of the one-way and two-way fluid-structure interaction(FSI) models under different wind speeds are analyzed, and the numerical calculation results are compared with those of the centralized mass model. The results show that the tower shadow effect and structural deformation are the main factors affecting the aerodynamic load fluctuation of the wind turbine, which in turn affects the aerodynamic performance and structural stability of the blades. The structural dynamic response of the coupled model shows significant similarity, while the structural displacement response of the former exhibits less fluctuation compared with the conventional centralized mass model. The one-way fluid-structure interaction(FSI)model shows a higher frequency of stress-strain and displacement oscillations on the blade compared with the two-way FSI model.

关键词： computational fluid dynamics methods(CFD) tower shadow effect aerodynamic performance fluidstructure interaction space flow field

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Experimental Investigation on Vertical Hydraulic Transport of Ores in Deepsea Mining

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China Ocean Engineering 2024年第1期38卷 42-53页

作者： liU Lei liU Jian-cheng li Xin XU li-xin ZHANG xiu-zhan State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Sanya Yazhou Bay Institution of Deep-sea Sci-Tech Shanghai Jiao Tong UniversitySanya 572000China China Merchants Marine And Offshore Research Institute Co. Ltd.Shenzhen 518067China China Merchants Deepsea Research Institute(Sanya)Co. Ltd.Sanya 572000China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on *** hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for industrial *** the present study,an indoor model test of the vertical hydraulic transport of particles was conducted.A noncontact optical method has been proposed to measure the local characteristics of the particles inside a vertical pipe,including the local concentration and particle *** hydraulic gradient of ore transport was evaluated with various particle size distributions,particle densities,feeding concentrations and mixture flow *** transport,the local concentration is larger than the feeding concentration,whereas the particle velocity is less than the mixture *** qualitative effects of the local concentration and local fluid velocity on the particle velocity and slip velocity were *** local fluid velocity contributes significantly to particle velocity and slip velocity,whereas the effect of the local concentration is marginal.A higher feeding concentration and mixture flow velocity result in an increased hydraulic *** effect of the particle size gradation is slight,whereas the particle density plays a crucial role in the transport.

关键词： deepsea mining vertical hydraulic transport experiment flow characteristics

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Research on concrete structure defect repair based on three-dimensional printing

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Frontiers of Structural and Civil Engineering 2024年第5期18卷 731-742页

作者： Yang gu Wei li Xupeng YAO guangjun liU School of Mechanical Engineering Tongji UniversityShanghai 201804China College of Civil Engineering Tongji UniversityShanghai 200092China Shanghai Engineering Research Center for Safety Intelligent Control of Building Machinery Shanghai 200032China

Quality assurance and maintenance play a crucial role in engineering construction,as they have a significant impact on project *** common issue in concrete structures is the presence of *** enhance the automation level of concrete defect repairs,this study proposes a computer vision-based robotic system,which is based on three-dimensional(3D)printing technology to repair *** system integrates multiple sensors such as light detection and ranging(liDAR)and *** is utilized to model concrete pipelines and obtain geometric parameters regarding their ***,a convolutional neural network(CNN)is employed with a depth camera to locate defects in concrete ***,a method for coordinate transformation is presented to convert the obtained coordinates into executable ones for a robotic ***,the feasibility of this concrete defect repair method is validated through simulation and experiments.

关键词： concrete defect detection 3D printing deep learning point cloud data

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