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Protective Effects and Potential Mechanism of Tongxinluo on Mice with Thromboangiitis Obliterans Induced by Sodium Laurate

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Chinese Journal of Integrative Medicine 2023年第7期29卷 608-616页

作者： gu jiao-jiao WEI Ya-ru MA Ku WANG Xiao-qi GAO Huai-lin Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Department of Endocrinology Hebei Yiling HospitalShijiazhuang050091China

Objective To investigate the effects of Tongxinluo(TXL)on thromboangiitis obliterans(TAO)and the underlying *** Ninety male C57/BL6J mice were randomly divided into 6 groups according to a random number table:the sham group,TAO model group,Compound Danshen Tablet(CDT)group,and the high-,medium-,and low-dose TXL *** mice except the sham group were injected with sodium laurate(0.1 mL,5 mg/mL)in the femoral artery to establish TAO mouse *** modeling,mice in the sham and TAO model groups were intragastrically administered 0.5%(w/v)sodium carboxymethylcellulose,mice in the CDT group were intragastrically administered 0.52 g/kg CDT,and mice in the TXL-H,TXL-M,and TXL-L groups were intragastrically administered 1.5,0.75,and 0.38 g/kg TXL,*** 4 weeks of gavage,the recovery of blood flow in the lower limbs of mice was detected by Laser Doppler *** pathological changes and thrombosis of the femoral artery were observed by morphological *** expressions of tumor necrosis factorα(TNF-α)and inducible nitric oxide synthase(iNOS)in the femoral artery wall were detected by HE *** of thromboxane B2(TXB2),6-keto-prostaglandin F1α(6-keto-PGF1α),endothelin-1(ET-1),interleukin(IL)-1βand IL-6 were measured using enzyme-linked immunosorbent assay(ELISA).Levels of activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT)and fibrinogen(FIB)were detected by a fully automated biochemical *** TXL promoted the restoration of blood flow in the lower limbs,reduced the area of thrombosis in the femoral artery,and alleviated the pathological changes in the femoral artery ***,the levels of TXB2,ET-1,IL-6,IL-1β,TNF-αand iNOS were significantly lower in the TXL groups compared with the model group(P<0.05 or P<0.01),while the level of 6-keto-PGF1αwas significantly higher(P<0.01).In addition,APTT,PT,and TT were significantly prolonged in TXL groups compared with the model group(P<0

关键词： Tongxinluo thromboangitis obliterans thrombosis inflammation

Effects of Variant Rates and Noise on Epidemic Spreading

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Chinese Physics Letters 2011年第5期28卷 282-284页

作者： LI Wei GAO Zong-Mao gu jiao Complexity Science Center and Institute of Particle Physics Huazhong Normal UniversityWuhan 430079 Max-Planck-Institute for Mathematics in the Sciences

We introduce variant rates,for both infection and recovery and noise into the susceptible-infected-removed(SIR)modelfor epidemic *** changing rates are taken mainly due to the changing profiles of an epidemic during its ***,the noise parameter which is taken from a given distribution,*** can describe the fluctuations of the infection and recovery *** numerical simulations show that the SIR model with variant rates and noise and can improve the fitting with real SARS data in the near-stationary stage.

关键词： evolution infection epidemic

Epidemic Spreading in a Multi-compartment System

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Chinese Physics Letters 2012年第2期29卷 233-236页

作者： GAO Zong-Mao gu jiao LI Wei College of Physical Science and Technology Huazhong Normal UniversityWuhan 430079 Max-Planck-Institute for Mathematics in the Sciences Leipzig 04103Germany Complexity Science Center&Institute of Particle Physics Huazhong Normal UniversityWuhan 430079

We introduce the variant rate and white noise into the susceptible-infected-removed (SIR) model for epidemics,discuss the epidemic dynamics of a multiple-compartment system,and describe this system by using master *** both the local epidemic spreading system and the whole multiple-compartment system,we find that a threshold could be useful in forecasting when the epidemic ***,numerical simulations show that a model with the variant infection rate and white noise can improve fitting with real SARS data.

关键词： equations system removed

Hypersonic sliding target tracking in near space

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Defence Technology（防务技术） 2015年第4期11卷 370-381页

作者： Xiang-yu ZHANG guo-hong WANG Zhen-yu SONG jiao-jiao gu Institute of Information Fusion NAAU Department of Scientific Research NAAU

To improve the tracking accuracy of hypersonic sliding target in near space,the influence of target hypersonic movement on radar detection and tracking is analyzed,and an IMM tracking algorithm is proposed based on radial velocity compensating and cancellation processing of high dynamic biases under the earth centered earth fixed(ECEF) *** on the analysis of effect of target hypersonic movement,a measurement model is constructed to reduce the filter divergence which is caused by the model *** high dynamic biases due to the target hypersonic movement are approximately compensated through radial velocity estimation to achieve the hypersonic target tracking at low systematic biases in near *** high dynamic biases are further eliminated by the cancellation processing of different radars,in which the track association problem can be solved when the dynamic biases are *** IMM algorithm based on constant acceleration(CA),constant turning(CT) and Singer models is used to achieve the hypersonic sliding target tracking in near *** results show that the target tracking in near space can be achieved more effectively by using the proposed algorithm.

关键词：高超声速流动目标跟踪空间滑翔动态偏差 IMM算法高超音速雷达探测

Delay Effect on Coherent Transfer of Optical Frequency Based on a Triple-Pass Scheme

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Chinese Physics Letters 2018年第8期35卷 9-13页

作者： Chao-qun Ma Li-Fei Wu jiao gu Yan-He Chen guo-Qing Chen School of Science Jiangnan UniversityWuxi 214122 Jiangsu Provincial Research Center of Light Industrial Optoelectronic Engineering and Technology Jiangnan UniversityWuxi 214122 State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062

We demonstrate a triple-pass scheme for coherent transfer of optical frequency and the delay effect on the fiber phase noise compensation. It is theoretically proved that the delay effect consists of both fiber delay and servo delay. The delay effect confines the servo bandwidth within 1/8 and induces a residual fiber phase noise after noise compensation. For a 25-km-long fiber, the servo bandwidth is found to be around 1 k Hz, and the fiber phase noise is suppressed approaching to the theoretical limitation. The triple-pass scheme enables the simultaneous transfer of optical frequency to multiple remote users. The performance of noise compensator in the triple-pass scheme can achieve a similar level result compared with that in the double-pass scheme.

关键词： Delay Effect on Coherent Transfer of Optical Frequency Based on a Triple-Pass Scheme AOM

Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WEI Ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi HAN Ning-xin WANG Zi-xuan LIU Lu WANG Xiao-qi HAO Yuan-jie MA Kun gu jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug Evaluation Center Shijiazhuang050035China Hebei Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Objective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was established by left anterior descending coronary artery ligation for 45 *** to a random number table,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the benazepril(BNPL)*** day after modeling,TXL and BNPL were administered by *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fibrosis in *** and quantitative analysis of endothelial mesenchymal transition(EndMT)after MIRI was performed by immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3K)and phospho protein kinase B(p-AKT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fibrosis,increased the expression of CD31 and inhibited the expression ofα-SMA,thus inhibited the occurrence of EndMT(P0.05).In addition,the use of the PI3K/AKT pathway-specific inhibitor LY-294002 to block this pathway and combination with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice.

关键词： myocardial fibrosis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway

Generic BOMA Processing System for Assembly-To-Order Production

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Journal of Systems Science and Systems Engineering 2001年第1期13卷 1-6页

作者： DU Jun, gu Peiliang, jiao Yuan\|yuan School of Management, Tianjin University, Tianjin 300072, China School of Management Tianjin University Tianjin 300072 China

：This paper discusses integrated product and production data management for assembly-to-orderproduction, which is characterized by a large number of product and process varieties. A data structure,called Bill-of-Materials-and-Assemblies (BOMA), is proposed for the purpose of unifying BOM and assembly routing data in order to accommodate a wide range of product variability and production variations.A generic BOMA concept is put forward to deal with variety effectively. A prototype system of the proposedgeneric BOMA is implemented using object-oriented modeling.

关键词： Bill-of-materials assembly-to-order variety

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian jiao Lai Xu Zhen gu Hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

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妇科手术损伤输尿管的防治要点探讨

中国实用妇科与产科杂志 2019年第1期35卷 12-14页

作者：顾美皎华中科技大学同济医学院附属同济医院妇产科湖北武汉430030

输尿管损伤是妇科手术中最严重并发症,发生率为1%~2%[1]。发生率与手术性质、解剖上复杂性和术者技巧有关,多年来虽经不懈努力试着通过改进手术方法以降低输尿管损伤率,但收效甚微,故有必要反复讨论。

关键词：妇科手术输尿管损伤保守治疗微创手术