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Design of artificial biomimetic channels with Na^(+)permeation rate and selectivity potentially outperforming the natural sodium channel

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Nano Research 2024年第9期17卷 8638-8646页

作者： Zhi Zhu Yan zhao Chao Chang Shaojian Yan Tingyu Sun Shiyu gu Yangmei Li Dengsong Zhang Chunlei Wang Xiao Cheng Zeng School of Optical-Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Innovation Laboratory of Terahertz Biophysics National Innovation Institute of Defense TechnologyBeijing 100071China School of Physics Peking UniversityBeijing 100871China International Joint Laboratory of Catalytic Chemistry College of SciencesShanghai UniversityShanghai 200444China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

Artificial ion channels that enable high-efficiency ion transport have important implications in nanofluidics and biomedical applications such as drug ***,we show a simulation-based chemical design of a biomimetic sodium channel that possesses permeation rate and selectivity potentially higher than those of the state-of-the-art natural vertebrate voltage-gated sodium ***,our theoretical findings have undergone empirical testing,aligning well with the Arrhenius law as derived from a diverse range of experimental *** high-efficiency ion transport is achieved by anchoring the carboxylate functional groups within the channel filter.A key chemical guiding principle underlying the ion channel design is that the free-energy barrier for the Na^(+)passage across the channel should be comparable to typical thermal energy at room *** the implementation of the chemical design,we found that the relatively low free-energy barrier can be attributed to the compensation effect of the carboxylate groups to the partially lost oxygen shell of the ion within the ion channel,as well as to the consonant vibration of the ions inside and outside the *** mechanistic understanding brings new insight,at the molecular level,into the high-efficiency ion transport across the designed membrane *** proof of principle achieved from the simulations will stimulate future experimental confirmation and potential applications of the high-performance artificial channels in nanofluidics and in bioinspired iontronics.

关键词： sodium channels anchoring carboxylate functional groups molecular dynamics simulations low free-energy barrier for ion passage thermal kinetic energy

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Fabrication of MXene-Bi_(2)WO_(6)heterojunction by Bi_(2)Ti_(2)O_(7)hinge for extraordinary LED-light-driven photocatalytic performance

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Nano Research 2024年第6期17卷 4729-4736页

作者： Zhiwen Li Liangliang Xu Zaheer Ud Din Babar Ali Raza Yifei Zhang Xinrui gu Yu-Xin Miao Zhen zhao Gao Li Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Scuola Superiore Meridionale(SSM) University of Naples Federico IILargo S.Marcellino1080138Italy Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea University of Chinese Academy of Sciences Beijing 100049China

Heterojunction composites with intimate interfaces can shorten the diffusion distance,which leads to a shorter path for photogenerated carriers,thereby increasing photocatalytic ***,we report the fabrication of Ti_(3)C_(2)-Bi_(2)WO_(6)(TC-BW)heterojunctions hinged by Bi_(2)Ti_(2)O_(7)joints via an in situ hydrothermal reaction of Ti_(3)C_(2)in the presence of Na_(2)WO_(4)and Bi(NO_(3))_(3).The TC-BW was characterized using X-ray diffraction(XRD),scanning transmission electron microscopy(STEM),and Raman ***-BW showed superior photocatalytic activity(productivity over 15TC-WB reaches up to 5.0 mmolreacted BA·gcat.^(−1)·h^(−1))in the oxidation of benzyl alcohol using light-emitting diode(LED)light,arising from the surface defects and intimate heterojunction interface between the Ti_(3)C_(2)MXene and Bi_(2)WO_(6)***-BW heterojunctions provide an enhanced separation efficiency of photogenerated charges,which in turn yields superior photocatalytic ***,it is well substantiated by density functional theory(DFT)*** summary,this study elucidates the preparation of heterojunction composites with intimate interfaces for highly efficient photooxidation.

关键词： MXene-Bi_(2)WO_(6) heterojunction LED-light-driven photocatalysis Bi_(2)Ti_(2)O_(7) photooxidation

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Knockdown of the nucleoporin Nup50 protects cells against ionizing radiation through enhancing DNA-PKcs-mediated DNA damage repair

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Radiation Medicine and Protection 2024年第3期5卷 194-200页

作者： Zhijie Wan Jingwen gu Songyun zhao Hang Jia Tingting Liu Yuanyuan Chen Yanyong Yang Department of Radiation Medicine Faculty of Naval MedicineNaval Medical UniversityShanghai200433China Department of Respiratory and Critical Care Medicine the Second Naval Hospital of Southern Theater CommandSanyaHainan572000China Department of Colorectal Surgery Changhai HospitalNaval Medical UniversityShanghai200433China

Objective:To investigate the effect and mechanism of Nup50 on radiation-induced DNA damage repair to radiation and explore the potential role of Nup50 as radioprotective ***:The Nup50 gene was knocked down in HUVEC cells using *** formation,CCK-8,and flow cytometry were performed to determine the viability,proliferation and apoptosis of HUVEC cells treated withγ-rays,*** extent of DNA damage was evaluated by using comet assay and immu-nofluorescence staining againstγ-*** addition,we explored the role of Nup50 in DNA damage response(DDR)pathways through western blotting ***,nuclear and chromatin fractionation were performed to determine the potential molecular mechanism underlying the radiation protection function of Nup50 ***:Nup50 knockdown increased the cellular resistance to ionizing *** CCK-8 data showed that cell viability was significantly increased in the Nup50 knockdown group after radiation(t=4.23,Pgulating DNA-PKcs pathway,suggesting Nup50 as a potential target for radiation protection.

关键词： damage protective p50

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Modern pollen-vegetation relationships along altitudinal vegetation belts in the Leigong Mountain of southwestern China

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Journal of Mountain Science 2024年第7期21卷 2249-2262页

作者： LI Shuming zhao Wenwei WEI Lisi REN Weihe gu Qinran WU Siqi JI Yang YANG Ziteng ZHUANG Rui CHEN Chunzhu College of Geography and Tourism Hengyang Normal UniversityHengyang 421002China School of Geographical Science Nantong UniversityNantong 226019China State Key Laboratory of Modern Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of Sciences Nanjing 210008China 4 University of Chinese Academy of SciencesBeijing 100049China

Understanding the distribution,dispersal,and correlation of modern pollen with vegetation in mountainous regions is essential for establishing accurate modern analogs for fossil pollen *** study,conducted in Leigong Mountain on the Yunnanguizhou Plateau of southwestern China,involved the collection of 35 surface soil samples from diverse vegetation communities along an elevational gradient ranging from 1210 to 1875 *** results reveal a close correspondence between modern pollen assemblages and vegetation *** Component Analysis(PCA)results indicate that pollen assemblages can effectively distinguish between subtropical montane evergreen broad-leaved forest(SEBF)and subtropical montane deciduous broadleaved forest(SDBF).However,both SEBF and SDBF show significant overlap with subtropical montane evergreen-deciduous broad-leaved mixed forest(SEMF).Detrended Correspondence Analysis(DCA)results clearly distinguish the three vegetation zones,and the first axis of DCA shows a significant positive correlation with elevation(pguishing this vegetation zone from *** and Alnus display overrepresentation in the Leigong Mountain region,while Quercus(D,deciduous-type)and Poaceae exhibit high representation in the SEBF *** the SEBF zone,both pollen diversity and richness are the *** study reveals the complex relationship between the richness and diversity of pollen and *** diversity and richness of tree and shrub pollen are found to be lower than those of the corresponding *** pollen-vegetation relationship elucidated in this study serves as a critical reference for reconstructing ancient environments from fossil pollen retrieved in this region.

关键词： Modern pollen assemblages Pollenvegetation relationship Pollen diversity and richness Leigong Mountain Southwestern China

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Wettability-driven synergistic resistance of scale and oil on robust superamphiphobic coating

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Chinese Chemical Letters 2024年第7期35卷 433-438页

作者： Yixuan Wang Jiexin Li Zhihao Shang Chengcheng Feng Jianmin gu Maosheng Ye Ran zhao Danna Liu Jingxin Meng Shutao Wang CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences(UCAS) Beijing 100049China State Key Laboratory of Metastable Materials Science and Technology(MMST) Yanshan UniversityQinhuangdao 066004China

Disgusting deposits(e.g.,scale and crude oil)in daily life and industrial production are always serious problems,posing great threats to the safety and economic ***,most of developed coatings can only conquer one part of these deposits such as superhydrophobic coatings possess antiscaling capacity but would adhere crude *** integrate scale resistance with oil repellence,we herein report a robust superamphiphobic(SAB)coating simultaneously reducing pollution of scale and oil for extended period of time(two weeks with over 98%reduction).Compared with single role of superhydrophobic and amphiphilic surfaces,the SAB coating can not only inhibit interfacial nucleation of scale but also reduce the adhesion of formed scale and polluted *** durability of the SAB coating is evaluated via mechanical tests(sandpaper abrasion,tape stripping and sand falling)and chemical corrosion(corrosive liquid immersing),revealed by sustainable high contact angles and low contact angle hysteresis of water and *** universality of this strategy can be further confirmed by adding different particles like kaolin,Al_(2)O_(3),and SiO_(2),resisting multiple types of scale(i.e.,CaSO_(4),BaSO_(4)and MgCO_(3))and oil(i.e.,glycerol,glycol,and mineral oil).Therefore,this study provides an ideal avenue for resisting scale and oil,which may be used for conquering the complexity of application environments(e.g.,oil production and transportation).

关键词： Superamphiphobic Durability Wettability Anti-scaling Oil repellence

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Ultralow charge-discharge voltage gap of 0.05 V in sunlight-responsive neutral aqueous Zn-air battery

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Carbon Energy 2024年第9期6卷 172-183页

作者： Zhimin Niu Yan Gao Tianhui Wu Fei Zhang Ran zhao Zijia Chen Yiming Yuan Tifeng Jiao Jianmin gu Li Lu Desong Wang State Key Laboratory of Metastable Materials Science and Technology(MMST) Hebei Key Laboratory of Applied ChemistryYanshan UniversityQinhuangdaoChina Department of Mechanical Engineering National University of SingaporeSingaporeSingapore School of Sciences Hebei University of Science and TechnologyShijiazhuangChina

Rechargeable neutral aqueous zinc-air batteries(ZABs)are a promising type of energy storage device with longer operating life and less corrosiveness compared with conventional alkaline ***,the neutral ZABs normally possess poor oxygen evolution reactions(OERs)and oxygen reduction reactions performance,resulting in a large charge–discharge voltage gap and low round-trip ***,we demonstrate a sunlight-assisted strategy for achieving an ultralow voltage gap of 0.05 V in neutral ZABs by using the FeOOH-decorated BiVO4(Fe-BiVO4)as an oxygen *** sunlight,the electrons move from the valence band(VB)of Fe-BiVO_(4) to the conduction band producing holes in VB to promote the OER process and hence reduce the ***,the photopotential generated by the Fe-BiVO_(4) compensates a part of the charging potential of neutral ***,the energy loss of the battery could be compensated via solar energy,leading to a record-low gap of 0.05 V between the charge and discharge voltage with a high round-trip efficiency of 94%.This work offers a simple but efficient pathway for solar-energy utilization in storage devices,further guiding the design of high energy efficiency of neutral aqueous ZABs.

关键词： neutral ZABs oxygen catalytic reactions photocatalysis round-trip efficiency solar energy

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Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges

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Genes & Diseases 2024年第1期11卷 283-293页

作者： Liyuan zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun gu Gang Liu Feng Miao Yan Chang Fanghua Huang Naping Tang Anhui University of Traditional Chinese Medicine HefeiAnhui 230000China Yangtze Delta Drug Advanced Research Institute Yangtze Delta Pharmaceutical CollegeNantongJiangsu226133China Shanghai Innostar Bio-Technology Co. LtdChina State Institute of Pharmaceutical IndustryShanghai 201203China Innostar Bio-tech Nantong Co. Ltd.NantongJiangsu 226133China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China

In recent years,significant breakthroughs have been made in the field of gene ***-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of *** the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific ***,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases.

关键词： AAV8 Adeno-associated virus Gene therapy Primates

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Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation

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National Science Review 2024年第6期11卷 119-128页

作者： Chunyu zhao Jia Tu Chuchu Wang Wenbin Liu Jinge gu Yandong Yin Shengnan Zhang Dan Li Jiajie Diao Zheng-Jiang Zhu Cong Liu Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education Shanghai Jiao Tong University Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Department of Cancer Biology University of Cincinnati College of Medicine

Accumulation of aggregated α-synuclein(α-syn) in Lewy bodies is the pathological hallmark of Parkinson's disease(PD). Genetic mutations in lipid metabolism are causative for a subset of patients with Parkinsonism. The role of α-syn's lipid interactions in its function and aggregation is recognized, yet the specific lipids involved and how lipid metabolism issues trigger α-syn aggregation and neurodegeneration remain unclear. Here, we found that α-syn shows a preference for binding to lysophospholipids(LPLs),particularly targeting lysophosphatidylcholine(LPC) without relying on electrostatic interactions. LPC is capable of maintaining α-syn in a compact conformation, significantly reducing its propensity to aggregate both in vitro and within cellular environments. Conversely, a reduction in the production of cellular LPLs is associated with an increase in α-syn accumulation. Our work underscores the critical role of LPLs in preserving the natural conformation of α-syn to inhibit improper aggregation, and establishes a potential connection between lipid metabolic dysfunction and α-syn aggregation in PD.

关键词： α-synuclein Parkinson's disease lysophosphatidylcholine, aggregation

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Recent Progress in Space Science and Applications on Chinese Space Station in 2022–2024

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空间科学学报 2024年第4期44卷 607-621页

作者： gu Yidong GAO Ming zhao guangheng WANG Qiang LYU Congmin ZHONG Hongen LIU guoning Key Laboratory of Space Utilization Technology and Engineering Center for Space UtilizationChinese Academy of SciencesBeijing 100094

Chinese Space Station(CSS)has been fully deployed by the end of 2022,and the facility has entered into the application and development *** has conducted scientific research projects in various fields,such as space life science and biotechnology,space materials science,microgravity fundamental physics,fluid physics,combustion science,space new technologies,and *** this review,we introduce the progress of CSS development and provide an overview of the research conducted in Chinese Space Station and the recent scientific findings in several typical research *** compelling findings mainly concern the rapid solidification of ultra-high temperature alloy melts,dynamics of fluid transport in space,gravity scaling law of boiling heat transfer,vibration fluidization phenomenon of particulate matter,cold atom interferometer technology under high microgravity and related equivalence principle testing,the full life cycle of rice under microgravity and so ***,the planned scientific research and corresponding prospects of Chinese space station in the next few years are presented.

关键词： Chinese Space Station(CSS) Space material science Micro-gravity fluid physics Fundamental physics Space life sciences and biotechnology

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Fine mapping of two recessive genes TaFLA1 and TaSPL8 controlling flag leaf angle in bread wheat

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The Crop Journal 2024年第4期12卷 1159-1167页

作者： Qiushi Wang Jiaxing Bai Hongchun Xiong Yongdun Xie Chaojie Wang Jiayu gu Linshu zhao Huiyuan Li Jinfeng Zhang Shirong zhao Yuping Ding Zhengwu Fang Huijun guo Luxiang Liu College of Agriculture Yangtze University/MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River(Co-Construction by Ministry and Province)Jingzhou 434000HubeiChina State Key Laboratory of Crop Gene Resources and Breeding/National Engineering Laboratory of Crop Molecular Breeding/CAEA Research and Development Centre on Nuclear Technology Applications for Irradiation Mutation Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Flag leaf angle is one of the key target traits in high yield wheat breeding.A smaller flag leaf angle reduces shading and enables plants to grow at a higher density,which increases *** we identified a mutant,je0407,with an 84.34%-89.35%smaller flag leaf angle compared with the wild *** mutant also had an abnormal lamina joint and no ligule or *** analysis indicated that the ligule was controlled by two recessive genes,which were mapped to chromosomes 2AS and *** mutant allele on chromosome 2AS was named Tafla1b,and it was fine mapped to a 1 Mb physical *** mutant allele on chr.2DL was identified as Taspl8b,a novel allele of TaSPL8 with a missense mutation in the second exon,which was used to develop a cleaved amplified polymorphic sequence marker.F3 and F4 lines derived from crosses between Jing411 and je0407 were genotyped to investigate interactions between the Tafla1b and Taspl8b *** with the Tafla1b/Taspl8a genotype had 58.41%-82.76%smaller flag leaf angles,6.4%-24.9%shorter spikes,and a greater spikelet density(0.382 more spikelets per cm)compared with the wild *** with the Tafla1a/Taspl8b genotype had 52.62%-82.24%smaller flag leaf angles and no differences in plant height or spikelet density compared with the wild ***1b/Taspl8b plants produced erect leaves with an abnormal lamina *** two alleles had dosage effects on ligule formation and flag leaf angle,but no significant effect on thousand-grain *** mutant alleles provide novel resources for improvement of wheat plant architecture.

关键词： Wheat Ligule Flag leaf angle Fine mapping Tafla1 Taspl8

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