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nNOS-mediated protein-protein interactions:promising targets for treating neurological and neuropsychiatric disorders

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The Journal of Biomedical Research 2021年第1期35卷 1-10页

作者： yuanyuan gu Dongya Zhu Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Institution of Stem Cell and Neuroregeneration School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China

Neurological and neuropsychiatric disorders are one of the leading causes of disability worldwide and affect the health of billions of *** oxide(NO),a free gas with multitudinous bioactivities,is mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase(nNOS)in the *** nNOS benefits a variety of neurological and neuropsychiatric disorders,including stroke,depression and anxiety disorders,posttraumatic stress disorder,Parkinson’s disease,Alzheimer’s disease,chronic pain,and drug *** to critical roles of nNOS in learning and memory and synaptic plasticity,direct inhibition of nNOS may cause severe side ***,interactions of several proteins,including post-synaptic density 95(PSD-95),carboxyterminal PDZ ligand of nNOS(CAPON)and serotonin transporter(SERT),with the PSD/Disc-large/ZO-1 homologous(PDZ)domain of nNOS have been demonstrated to influence the subcellular distribution and activity of the enzyme in the ***,it will be a preferable means to interfere with nNOS-mediated proteinprotein interactions(PPIs),which do not lead to undesirable ***,we summarize the current literatures on nNOS-mediated PPIs involved in neurological and neuropsychiatric disorders,and the discovery of drugs targeting the PPIs,which is expected to provide potential targets for developing novel drugs and new strategy for the treatment of neurological and neuropsychiatric disorders.

关键词： nNOS PSD-95 CAPON SERT protein-protein interaction neurological and neuropsychiatric disorder

A MODEL-ORIENTED ROAD DETECTION APPROACH USING FUZZY SVM

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Journal of Electronics(China) 2010年第6期27卷 795-800页

作者： Zhang Yuying gu Xiaodong Wang yuanyuan Department of Electronic Engineering Fudan University Shanghai 200433 China

This paper presents an approach of model-oriented road detection based on trapezoidal model proposed by H. Jeong, et al and fuzzy Support Vector Machine (SVM). Firstly, the frames ex-tracted from the video are preprocessed by Pulse Coupled Neural Network (PCNN), and then handled by Kalman filter and Expectation Maximization (EM) algorithms. Next, according to the road's dif-ferent feathers, using fuzzy algorithm chooses a corresponding SVM for further lane detection, and then using morphological filters obtains the final detecting result. For different types of roads, this method uses fuzzy algorithm to choose different SVMs. Furthermore, in preprocessing using PCNN removes the shadow in the road to reduce the effect of illumination variations. Experimental results show that our method can receive better lane detecting results than the trapezoidal model and BP proposed by H. Jeong, et al..

关键词： Fuzzy Support Vector Machine (SVM) Kalman filter Model-oriented Lane detection Unstructured-road

Differentiation characteristics and influencing factors of ecological land rent among provinces in China

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Journal of Geographical Sciences 2013年第3期23卷 387-403页

作者： LONG Kaisheng ZHAO Yali ZHANG Honghui CHEN Ligen LU Fangfang gu yuanyuan College of Public Administration Nanjing Agricultural University Nanjing 210095 China School of Geographic and Oceanographic Sciences Nanjing University Nanjing 210093 China

Ecological land rent is the excess profit produced by resource scarcity, and is also an important indicator for measuring the social and economic effects of resource scarcity. This paper, by calculating the respective ecological land rents of all the provinces in China for the years 2002 and 2007, and with the assistance of the software programs ArcGIS and GeoDA, analyzes the spatial differentiation characteristics of ecological land rent; then, the influencing factors of ecological land rent differentiation among the provinces are examined using the methods of traditional regression and spatial correlation analysis. The following results were obtained： First, ecological land rent per unit of output in China shows stable dis- tribution characteristics of being low in the southwestern and northeastern provinces, and high in Hebei and Henan provinces. There is also an increasing tendency in the central and western provinces, and a decreasing one in the eastern provinces. In general, the spatial distribution of ecological land rent per unit of output in China is quite scattered. Second, the total ecological land rent shows significant spatial aggregation characteristics, in particular the provinces in China possessing high total amounts of ecological land rent tend to be adjacent to one another, as do those with low total amounts, and the spatial difference characteristics of the eastern, central and western provinces are distinguished. The Bohai Rim, Yangtze River Delta and Pearl River Delta are shown to be highly clustering regions of total ecological land rent, while the western provinces have very low ecological land rent in terms of total amount. Third, population distribution, economic level and industrial structure were all im- portant influencing factors influencing ecological land rent differentiation among provinces in China. Furthermore, population density, urbanization level, economic density, per capita consumption level and GDP per capita were all shown t

关键词： ecological land rent spatial differentiation influencing factors Global Moran's 1 China

Some recent advances in remote sensing-based monitoring of changes in the Greenland Ice Sheet

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Advances in Polar Science 2024年第2期35卷 275-280页

作者： FENG Tiantian JIA Jinyu WANG Wei YU Zeran LIU Xingchen LI guojun gu yuanyuan LI Rongxing The Center for Spatial Information Science and Sustainable Development Applications Tongji UniversityShanghai 200092China College of Surveying and Geo-Informatics Tongji UniversityShanghai 200092China College of Electronic Science and Technology National University of Defense TechnologyChangsha 410073China

The mass balance of the Greenland Ice Sheet(GrIS)plays a crucial role in global sea level *** the 1960s,remote sensing missions have been providing extensive and continuous observation data for change monitoring of the *** this paper,we present our recent research results from remote sensing-based GrIS change ***,historical satellite data are processed and used to fill data gaps and are combined with existing partial maps,completing an ice velocity map of the GrIS from the 1960s to *** map provides valuable data for estimating the historical mass balance of ***,the monthly gravimetry-based mass balance of the GrIS from 2002 to 2020 is estimated by combining Gravity Recovery and Climate Experiment(GRACE)and GRACE Follow On(GRACE-FO)*** is found that the GrIS has lost a total mass of approximately 4443±75 Gt during this ***,based on Global Land Ice Measurements from Space(GLIMS),an updated Greenland glacier inventory is achieved utilizing data collected between 2006 and *** inventory provides more detailed and up-to-data glacier boundaries of ***,these advances provide essential data support for estimating the mass balance of the GrIS,contributing to the advancement of research on global sea level change.

关键词： Greenland Ice Sheet remote sensing change monitoring ice velocity satellite gravimetry glacier inventory

Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer

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Protein & Cell 2017年第6期8卷 455-466页

作者： yuanyuan gu Shuoxin Liu Xiaodan Zhang guimin Chen Hongwei Liang Mengchao Yu Zhicong Liao Yong Zhou Chen-Yu Zhang Tao Wang Chen Wang Junfeng Zhang Xi Chen State Key Laboratory of Pharmaceutical Biotechnology Jiangsu Engineering Research Center for Micro-RNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University Nanjing 210046 China The Second Department of Medical Oncology Linyi Tumor Hospital Linyi 276000 China Department of Cardio-Thoracic Surgery Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing Universityand Nanjing Multi-Center Biobank Nanjing 210008 China

MTUS1 （microtubule-associated tumor suppressor 1） has been identified that can function as a tumor sup- pressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b （miR-19a/b） promote prolifer- ation and migration of lung cancer cells by targeting MTUS1. First, MTUS1 was proved to function as a tumor suppressor in lung cancer and was linked to cell prolif- eration and migration promotion. Second, an inverse correlation between miR-19a/b expression and MTUS1 mRNA/protein expression was noted in human lung cancer tissues. Third, MTUS1 was appraised as a direct target of miR-19a/b by bioinformatics analysis. Fourth, direct MTUS1 regulation by miR-19a/b in lung cancer cells was experimentally affirmed by cell transfection assay and luciferase reporter assay. Finally, miR-19a/b were shown to cooperatively repress MTUS1 expression and synergistically regulate MTUS1 expression to pro- mote lung cancer cell proliferation and migration. In conclusion, our findings have provided the first cluesregarding the roles of miR-19a/b, which appear to func- tion as oncomirs in lung cancer by downregulating MTUSI.

关键词： microRNA MTUS1 miR-19a/b,lung cancer proliferation migration

“高技术”的嬗变——试论现代书籍设计的新发展

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出版科学 2014年第6期22卷 33-37页

作者：顾媛媛南京师范大学美术学院南京210023

论述技术因素在书籍发展过程中的重要作用与意义,指出现代书籍设计呈现"高技术"化倾向,并指出"高技术"概念是一个包含多种语义、具有丰富内涵的特殊概念,由此从不同角度论述现代书籍设计的新发展,重点阐释现代书籍设计核心的思想问题,... 详细信息

论述技术因素在书籍发展过程中的重要作用与意义,指出现代书籍设计呈现"高技术"化倾向,并指出"高技术"概念是一个包含多种语义、具有丰富内涵的特殊概念,由此从不同角度论述现代书籍设计的新发展,重点阐释现代书籍设计核心的思想问题,目的是为现代书籍设计实践提供理论性的参考与指导。

关键词：高技术书籍书籍设计机械美学审美价值

互动课堂环境下“血液循环途径”一节的教学设计

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生物学教学 2020年第2期45卷 36-38页

作者：顾源媛西安交通大学苏州附属初级中学

以苏科版初中生物学教材“血液循环途径”一课为例,在互动课堂环境下开展活动,将信息技术融入教学环节,通过学情前测、分组实验、观察模型、小组讨论等手段,突破本课时的重要概念,提高教与学的有效性。

关键词：互动课堂血液循环途径教学设计初中生物学

中国留学教育能否减少生源国人口贫困——基于“一带一路”沿线国家的实证研究

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教育研究 2019年第11期40卷 124-142页

作者：谷媛媛邱斌东南大学经济管理学院

减贫是全球实现联合国2030年可持续发展目标面临的重要挑战。以"一带一路"沿线46个国家为样本,把"一带一路"来华留学人才培养与缓解生源国贫困相联系,分析中国留学教育影响生源国贫困的内在逻辑机制。研究发现,发展中国留学教育可以通... 详细信息

减贫是全球实现联合国2030年可持续发展目标面临的重要挑战。以"一带一路"沿线46个国家为样本,把"一带一路"来华留学人才培养与缓解生源国贫困相联系,分析中国留学教育影响生源国贫困的内在逻辑机制。研究发现,发展中国留学教育可以通过促进人力资本积累、吸引外商投资以及技术溢出等渠道对生源国产生显著的减贫效应,来华留学生规模每增加1%,贫困人口比例将降低0.02,贫困差距将降低0.005;而且这种减贫效应在中低收入国家和贫富差距较小国家更为显著。有鉴于此,中国政府在制定相关优惠政策时,应更好地发挥"中国政府奖学金"等留学生优惠政策的精准性,推动中国留学教育合作项目的多元化发展,进一步优化中国高等学校人才培养模式,同时制定合理的留学生教育质量评价标准。

关键词：中国留学教育生源国减贫一带一路

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我国区域高等教育发展水平评价与特征分析

高校教育管理 2023年第5期17卷 25-41页

作者：黄榕顾元媛江苏省教育科学研究院江苏南京210024 南京审计大学经济学院江苏南京210029

本研究聚焦要素、能力和功能3个维度,分析我国31个省份2003—2020年的区域高等教育发展水平,并把脉区域高等教育发展特征。研究发现,我国31个省份2003—2020年的高等教育发展水平总体表现为上升趋势,按走势可以分为阶梯式上升、波动式... 详细信息

本研究聚焦要素、能力和功能3个维度,分析我国31个省份2003—2020年的区域高等教育发展水平,并把脉区域高等教育发展特征。研究发现,我国31个省份2003—2020年的高等教育发展水平总体表现为上升趋势,按走势可以分为阶梯式上升、波动式上升和平缓式上升3类;在时间维度,四大区域高等教育呈现总体上升趋势,形成了全局式、跨越式发展,但在发展中扩大了差距,形成发散效应,呈现时序动态性;在空间维度,31个省份高等教育发展水平可分为卓越、中等和起步3类,每一类对应的省份基本保持相对稳定,但现阶段省域层面的高等教育集群化并不显著,呈现空间异质性;31个省份高等教育发展过程阶段性与内部结构梯次性的交织配置,共同形成了区域高等教育发展的双雁阵模式。鉴于此,未来我国区域高等教育应坚持差异化策略、集群化方向和多样化发展,以更好地促进中国式现代化的早日实现。

关键词：区域高等教育发展水平雁阵模式差异化发展集群化发展多样化发展

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