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Chinese Physics Letters 1985年第1期2卷 13-14页

作者： FAN Hai-fu gu yuan-xin HAN Fu-son Institute of Physics Academia SinicaBeijing

The method proposed by Fan et *** been applied to the discrimination of the doublets arising from the experimental OAS(one-wave-length anomalous scattering)data of the Hg-derivative of *** result was obtained which sh... 详细信息

关键词： derivative method wave

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

直接法应用于蛋白质二维晶体的电子晶体学图像处理

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物理学报 2000年第10期49卷 1982-1987页

作者：阳世新李方华刘玉东古元新范海福中国科学院物理研究所和凝聚态物理中心北京100080

试把直接法应用于抗生蛋白链菌素 (streptavidin)沿 [0 0 1]方向投影的模拟像和相应的理论结构因子作图像处理 .先用两张高分辨电子显微像作直接法解卷 ,以互补因衬度传递函数的作用而损失的结构信息 ,求得的欠焦值比用单张像解卷的结... 详细信息

试把直接法应用于抗生蛋白链菌素 (streptavidin)沿 [0 0 1]方向投影的模拟像和相应的理论结构因子作图像处理 .先用两张高分辨电子显微像作直接法解卷 ,以互补因衬度传递函数的作用而损失的结构信息 ,求得的欠焦值比用单张像解卷的结果更接近真实值 .把从结构模型计算出的 0 30nm以内的相位 ,以及 0 2 5nm以内的振幅作为起始数据 ,进行直接法相位外推 ,并借助团簇分析方法得到 0 30nm至 0 2 5nm之间的相位 .所得分辨率为 0 30nm的解卷像和分辨率为 0 2 5nm的晶体结构投影均与理论结构模型的相应投影电势图一致 .

关键词：直接法图像处理蛋白质电子晶体学生物大分子

Antitumor Effect of a Novel Adeno-associated Virus Vector Targeting to Telomerase Activity in Tumor Cells

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Acta Biochimica et Biophysica Sinica 2004年第7期36卷 492-500页

作者： Yi-Gang WANG1,2#, Jin-Hui WANG1#, Yan-Hong ZHANG1, Qing gu2*, and xin-yuan LIU1* 1Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China School of Life Science, Nanchang University, Nanchang 330047, China Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of SciencesShanghai 200031 China School of Life Science Nanchang UniversityNanchang 330047 China

Telomerase activity is a wide tumor marker. Human telomerase reverse transcriptase (hTERT), the catalytic subunit of the telomerase, is transcriptionally upregulated exclusively in about 90% of cancer cells. In this study, we constructed a novel adeno-associated virus (AAV) vector containing the human interferon-β (hIFN-β) gene under the control of hTERT promoter (AAV-hTERT-hIFN-β) and investigated its antitumor effect against various human cancer cells in vitro. AAV-hTERT-hIFN-β displayed cancer-specific hIFN-β expression and cytotoxicity. The cytotoxic ratio was positively correlated with the time length of infection. AAV-hTERT-hIFN-β-mediated apoptotic morphology was observed by transmission electron microscopy. Flow cytometry assay also revealed that the cytotoxicity of AAV-hTERT-hIFN-β was mainly an apoptotic process. These data indicate that AAV in combination with hTERT-mediated therapeutic gene expression may open new possibilities for long-lasting and targeting gene therapy of varieties of cancers.

关键词： adeno-associated virus (AAV) telomerase hTERT promoter human interferon-β cancer

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起始套中特殊反射的作用

物理学报 1982年第12期 1690-1695页

作者：古元新中国科学院物理研究所

MULTAN法推引相角是以起始套反射开始逐轮进行迭代、扩大。由于起始套中的特殊反射包括确定原点的一般反射取值有限,所以一旦由它们组合的新反射的相角值有较大偏差时,就无法利用MULTAN的多解值特性从自身来缩小它,而只能依靠正切式中... 详细信息

MULTAN法推引相角是以起始套反射开始逐轮进行迭代、扩大。由于起始套中的特殊反射包括确定原点的一般反射取值有限,所以一旦由它们组合的新反射的相角值有较大偏差时,就无法利用MULTAN的多解值特性从自身来缩小它,而只能依靠正切式中的其它项给以弥补。然而,当这种情况发生在相角推引的最初几步时,由于此时往往仅有很少几项参与运算,加之它们的|E|值较大,权也高,势必会左右全过程的成败。处置这类失败的可行办法应该是从分析收敛图入手,改换那些可疑的反射。本文在一个MULTAN-80失败的例子上进行了7项试验,其结果充分证实了这一切。

关键词：收敛图迭代相角

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失碳倍半萜内酯晶体结构测定

物理学报 1982年第7期 963-968页

作者：古元新中国科学院物理研究所

失碳倍半萜内酯的分子式为C14H20O3,属正交晶系,空间群为D24-P212121。晶胞参数为α=7.526（3）A,b=24.642（10）A,c=6.887（2）A。晶胞内分子数z=4,计算密度Dx=1.23(g·cm-3。用RASA-IIS四圆衍射仪收集衍射强度数据。用直接法（MULTAN... 详细信息

失碳倍半萜内酯的分子式为C14H20O3,属正交晶系,空间群为D24-P212121。晶胞参数为α=7.526（3）A,b=24.642（10）A,c=6.887（2）A。晶胞内分子数z=4,计算密度Dx=1.23(g·cm-3。用RASA-IIS四圆衍射仪收集衍射强度数据。用直接法（MULTAN-80）测定晶体结构时曾遭遇失败,改善了起始套衍射点的指标分布后,才获得正确结构解。用准对角矩阵最小二乘法修正了结构参数,对全部独立可观察点,R=0.059。由差值Fouruer综合获得了全部氢原子坐标。最后就原起始套失败的原因和新选起始套的依据作了必要的分析。

关键词：倍半萜萜类化合物内酯晶体结构测定氢原子

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二维码在医疗设备管理和维护中的应用

中国医疗设备 2014年第10期29卷 66-68页

作者：顾昕元高磊青岛市妇女儿童医院器械科山东青岛266000

本文阐述了二维码的原理及优点,并介绍了其在医疗设备管理方面的应用以及使用过程中需注意的事项,指出二维码的应用可提高医护人员和工程技术人员的工作效率,具有一定的使用和推广价值。

关键词：二维码医疗设备管理和维护快速响应矩阵码

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

准噶尔盆地彩参2井侏罗纪孢粉化石及层序地层分析

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石油大学学报（自然科学版） 2001年第1期25卷 16-21页

作者：张满郎顾新元张琴詹家祯石油大学地球科学系北京昌平102200 新疆石油管理局勘探开发研究院克拉玛依834000

对准噶尔盆地彩参 2井侏罗纪孢粉化石研究表明 ,八道湾组具有deltoidospora cycadopites protoconiferus classopollis组合 ,三工河组具有cyathidites osmundacites pinuspollenites classopollis组合 ,西山窑组为cyathidites dic tyophyllidites cycadopites perinopollenites组合 ,石树沟群为cyathidites klukisporites classopollis concentrisporites组合 ,它们对地层时代有较好的指示意义。对孢粉古生态和沉积岩颜色、岩性及粘土矿物成分综合研究表明 ,研究区八道湾为暖温带潮湿气候 ;三工河早期为亚热带干旱、半干旱气候 ;三工河中晚期至西山窑期为亚热带潮湿气候 ;石树沟群早期为亚热带半干旱气候 ,但发生过两次时潮时旱的气候波动 ,石树沟群晚期气候干旱炎热 ,并促使湖盆急剧收缩、消亡。侏罗系可划分为 6个层序 ,层序界面附近的孢粉丰度及分异度最小。

关键词：准噶尔盆地侏罗纪孢粉化石古气候层序地层彩南油田

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准噶尔盆地南缘紫泥泉子组孢粉组合及其意义

新疆石油地质 2007年第1期28卷 67-71页

作者：师天明周春梅顾新元何卓生中国石油新疆油田分公司勘探开发研究院新疆克拉玛依834000 中国石化西北分公司乌鲁木齐830000

报道了新疆准噶尔盆地南缘紫泥泉子组中、下部孢粉组合Schizaeoisporites-Classopollis-Yenjiapollis.根据孢粉组合特征及其对比,将组合的时代划归晚白垩世中晚期(赛诺早期)。这一研究成果填补了新疆北部晚白垩世孢粉资料的空白,为准噶... 详细信息

报道了新疆准噶尔盆地南缘紫泥泉子组中、下部孢粉组合Schizaeoisporites-Classopollis-Yenjiapollis.根据孢粉组合特征及其对比,将组合的时代划归晚白垩世中晚期(赛诺早期)。这一研究成果填补了新疆北部晚白垩世孢粉资料的空白,为准噶尔盆地、乃至中国晚白垩世植物群的研究提供了重要的孢粉资料。依据孢粉的特殊性,新疆北部属于西北干旱孢粉植物区。

关键词：准噶尔盆地孢粉组合晚白垩世孢粉植物区