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透明细胞乳头状肾细胞癌的研究进展

南京医科大学学报（自然科学版） 2018年第1期38卷 130-137页

作者：王亦秋顾民东南大学医学院附属徐州医院肿瘤外科东南大学(徐州)肿瘤研究所江苏徐州221009 南京医科大学第一附属医院泌尿外科江苏南京210029

2016年WHO正式将透明细胞乳头状肾细胞癌作为一种肾细胞癌新类型。该肿瘤可以为散发性也可以发生于终末期肾病或Von Hippel-Lindau综合征(VHL综合征),具有相对特征性的病理组织学形态、免疫表型和分子遗传学特点,诊断时应与透明细胞肾... 详细信息

2016年WHO正式将透明细胞乳头状肾细胞癌作为一种肾细胞癌新类型。该肿瘤可以为散发性也可以发生于终末期肾病或Von Hippel-Lindau综合征(VHL综合征),具有相对特征性的病理组织学形态、免疫表型和分子遗传学特点,诊断时应与透明细胞肾细胞癌、乳头状肾细胞癌以及Xp11.2易位/TFE3基因融合相关性肾癌相鉴别。鉴于透明细胞乳头状肾细胞癌生物学行为相对惰性或低度恶性,因此准确诊断对指导临床治疗和判断预后具有十分重要的意义。

关键词：透明细胞乳头状肾细胞癌鉴别诊断

Preparation and Characterization of BAS Reinforced with SiC Platelets

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Journal of Materials Science & Technology 2000年第5期16卷 481-485页

作者： Jiancun RAO+, Jiancheng gu, Yu ZHOU, feng YE and Tingquan LEI (Harbin Institute of Technology, Harbin 150001, China) Harbin Institute of Technology Harbin 150001 China

BAS glass-ceramic powders were prepared by sol-gel processing. SiC platelets reinforced BAS glass-ceramic matrix composites with high density and uniform microstructure could be made using hot-pressing method. The related processing parameters were studied in this work, including effects of additional seed on transformation from H to M of barium aluminosilicate. DTA method was used to determine exact time to press mixture powders during hot-pressing for the purpose of effective densification. Microstructure and mechanical properties of the composites were investigated by mean of SEM, XRD and TEM techniques as well as three points bending test and single edge notched beam measurement. The results showed that the flexural strength and fracture toughness value of the BAS glass-ceramic matrix composites could be effectively improved by the addition of the SiC platelets. But the relative densities of composites were slightly decreased. The main toughening mechanism is crack deflection, platelets' pull-out and bridging. The increased value of flexural strength is contributed to the load transition effect from matrix to SiC platelets.

关键词： BAS Preparation and Characterization of BAS Reinforced with SiC Platelets SiC

Effect of indirect non-thermal plasma on particle size distribution and composition of diesel engine particles

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Plasma Science and Technology 2017年第11期19卷 59-66页

作者： Linbo gu Yixi CAI Yunxi SHI Jing WANG Xiaoyu PU Jing TIAN Runlin FAN School of Automotive and Traffic Engineering Jiangsu University Zhenjiang 212013 People＇s Republic of China

To explore the effect of the gas source flow rate on the actual diesel exhaust particulate matter（PM）, a test bench for diesel engine exhaust purification was constructed, using indirect nonthermal plasma technology. The effects of different gas source flow rates on the quantity concentration, composition, and apparent activation energy of PM were investigated, using an engine exhaust particle sizer and a thermo-gravimetric analyzer. The results show that when the gas source flow rate was large, not only the maximum peak quantity concentrations of particles had a large drop, but also the peak quantity concentrations shifted to smaller particle sizes from 100 nm to 80 nm. When the gas source flow rate was 10L min^-1, the total quantity concentration greatly decreased where the removal rate of particles was 79.2%, and the variation of the different mode particle proportion was obvious. Non-thermal plasma（NTP） improved the oxidation ability of volatile matter as well as that of solid carbon. However, the NTP gas source rate had little effects on oxidation activity of volatile matter, while it strongly influenced the oxidation activity of solid carbon. Considering the quantity concentration and oxidation activity of particles, a gas source flow rate of 10L min^-1 was more appropriate for the purification of particles.

关键词： diesel engine particulate matter non-thermal plasma gas source flow rate

Stability analysis of gravity anchor foundation of layered argillaceous sandstone under dry-wet cycles

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Journal of Mountain Science 2023年第4期20卷 1118-1130页

作者： ZHENG Jing-cheng CHEN Wei ZHENG Ke-ren gu Yu-peng WANG Fei HUANG Zhen LI Yun School of Civil Engineering Central South UniversityChangsha410075China The 8th Engineering Co. LTDChina Railway Major Bridge Engineering Group Co.LTD.Chongqing400026China Key Laboratory of ministry of Education on Safe mining of Deep Metal mines Northeastern UniversityShenyang110819China College of Civil Engineering and Architecture Key Laboratory of Disaster Prevention and Structural SafetyGuangxi UniversityNanning530004China

To investigate the stability of gravity anchors of suspension bridges,in-situ tests of the vertical bearing capacity of the bedrock,shear resistance of the anchor-rock interface,shear resistance of the bedrock were conducted in a suspension bridge *** dry-wet cycles,the deterioration law of the mechanical properties of argillaceous sandstone was identified in laboratory tests:the elastic modulus,cohesion and friction of the argillaceous sandstone deteriorated significantly at first few dry-wet cycles and then declined slowly after 10 cycles,ultimately these three mechanical parameters were reduced to about 1/3,1/3,2/3 of the initial value ***,numerical simulation was used to restore in-situ shear tests and a good agreement was *** on the results of in-situ and laboratory tests,the stability of the gravity anchor foundation under natural conditions and drywet cycles was calculated and its failure modes were *** results demonstrated that the dry-wet cycles caused uneven settlement of the anchor foundation,resulting in more serious stress concentration in the *** dry-wet cycles remarkably reduced the stability coefficient of the anchor foundation,whose failure mode shifted from overturning failure under natural conditions to sliding *** there was weak interlayer in the rock layer,the anti-sliding stability of the anchor foundation was affected drastically.

关键词： Gravity anchor foundation Stability In-situ tests Dry-wet cycles Numerical simulation

Defective Kernel 39 encodes a PPR protein required for seed development in maize

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Journal of Integrative Plant Biology 2018年第1期60卷 45-64页

作者： Xiaojie Li Wei gu Silong Sun Zongliang Chen Jing Chen Weibin Song Haiming Zhao Jinsheng Lai State Key Laboratory of Agrobiotechnology and National Maize Improvement Center Department of Plant Genetics and Breeding China Agricultural University

RNA editing is a posttranscriptional process that is important in mitochondria and plastids of higher plants. All RNA editing-specific trans-factors reported so far belong to PLS-class of pentatricopeptide repeat(PPR)proteins. Here, we report the map-based cloning and molecular characterization of a defective kernel mutant dek39 in maize. Loss of Dek39 function leads to delayed embryogenesis and endosperm development, reduced kernel size, and seedling lethality. Dek39 encodes an E subclass PPR protein that targets to both mitochondria and chloroplasts, and is involved in RNA editing in mitochondrial NADH dehydrogenase3(nad3) at nad3-247 and nad3-275. C-to-U editing of nad3-275 is not conserved and even lost in Arabidopsis, consistent with the idea that no close DEK39 homologs are present in Arabidopsis. However, the amino acids generated by editing nad3-247 and nad3-275 are highly conserved in many other plant species, and the reductions of editing at these two sites decrease the activity of mitochondria NADH dehydrogenase complex I,indicating that the alteration of amino acid sequence is necessary for Nad3 function. Our results indicate that Dek39 encodes an E sub-class PPR protein that is involved in RNA editing of multiple sites and is necessary for seed development of maize.

关键词： PPR Defective Kernel 39 encodes a PPR protein required for seed development in maize

Highly Efficient Co-removal of Heavy Metals in Wastewater from Chemical Oxygen Demand Testing Instrument by Cysteine-functionalized Magnetic Nanoparticles

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Chemical Research in Chinese Universities 2014年第3期30卷 472-479页

作者： CAI Botai gu Pei ZENG Lixi ZHOU Ying LIU Qingju LI Xun YUAN Longfei HE Yujian College of Chemistry and Chemical Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China Stake Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 P R. China Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of Sciences Urumqi 830011 P. R. China

Wastewater discharged from chemical oxygen demand（COD） testing instrument was generally difficult to treat due to its high content of heavy metals and very low pH. In this study, a kind of cysteine-functionalized magnetic nanoparticles（MNPs-Cys） was synthesized and used to treat the wastewater. The synthesized MNPs-Cys as the adsorbent for heavy metal removal from aqueous solutions were systematically investigated. The adsorption dynamic process fit the Langmuir isotherms well with a maximum adsorption capacity of 76.92 mg/g for Cu（Ⅱ）. The adsorbent could be easily regenerated by 0.1 mol/L HNO3, which exhibited a high adsorption performance within 10 cycles. This adsorbent, combined with a developed pretreatment approach, could make Cr（Ⅲ）, Hg（Ⅱ） and Ag（Ⅰ） in the wastewater discharged from COD testing instrument effectively removed and the removal efficiency is more than 99%. This work gave a new insight into the design and synthesis of high-performance materials for treating wastewater with heavy metals.

关键词： Magnetic nanoparticle Heavy metal Adsorption Magnetic separation Wastewater

Neural Integration of Audiovisual Sensory Inputs in Macaque Amygdala and Adjacent Regions

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Neuroscience Bulletin 2023年第12期39卷 1749-1761页

作者： Liang Shan Liu Yuan Bo Zhang Jian Ma Xiao Xu Fei gu Yi Jiang Ji Dai CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of PsychologyChinese Academy of SciencesBeijing 100101China Chinese Institute for Brain Research Beijing 102206China Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen 518055China Key Laboratory of Brain Science Zunyi Medical UniversityZunyi563000China

Integrating multisensory inputs to generate accurate perception and guide behavior is among the most critical functions of the *** regions such as the amygdala are involved in sensory processing including vision and audition,yet their roles in multisensory integration remain *** this study,we systematically investigated the function of neurons in the amygdala and adjacent regions in integrating audiovisual sensory inputs using a semi-chronic multi-electrode array and multiple combinations of audiovisual *** a sample of 332 neurons,we showed the diverse response patterns to audiovisual stimuli and the neural characteristics of bimodal over unimodal modulation,which could be classified into four types with differentiated regional *** the hierarchical clustering method,neurons were further clustered into five groups and associated with different integrating functions and ***,regions distinguishing congruent and incongruent bimodal sensory inputs were ***,visual processing dominates audiovisual integration in the amygdala and adjacent *** findings shed new light on the neural mechanisms of multisensory integration in the primate brain.

关键词： Macaque Amygdala-Multisensory Audiovisual integration Neural activity Multichannel recording

Predictors of dysphagia screening and pneumonia among patients with acute ischaemic stroke in China:findings from the Chinese Stroke Center Alliance(CSCA)

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Stroke & Vascular Neurology 2022年第4期7卷 294-301,I0005-I0008页

作者： Jianshu Liang Zhike Yin Zixiao Li Hongqiu gu Kaixuan Yang Yunyun Xiong Yongjun Wang Chunjuan Wang Nursing Department Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Vascular NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Vascular NeurologyChina National Clinical Research Center for Neurological DiseasesBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose guidelines recommend dysphagia screening to identify those at high risk of ***,little is known about the prevalence and predictors of dysphagia screening and pneumonia among patients with acute ischaemic stroke in *** Using data from the Chinese Stroke Center Alliance,which is a multicentre,prospective,consecutive patient enrolment programme,univariate and multivariate analyses were conducted to identify patient and hospital characteristics associated with dysphagia screening and pneumonia during acute *** Of 790811 patients admitted to 1476 hospitals,622718(78.7%)underwent dysphagia screening,and 64398(8.1%)developed *** in stroke units were more likely to be screened for dysphagia than those not in stroke units(OR 1.50;95%CI 1.48 to 1.52),while patients with a past history of stroke were less likely to be screened(OR 0.87;95%CI 0.86 to 0.88).Dysphagia screening(OR 1.46;95%CI 1.30 to 1.65),dysphagia(OR 7.31;95%CI 7.15 to 7.46),and admission to stroke units(OR 1.17;95%CI 1.14 to 1.19)were significantly associated with a greater risk of *** Dysphagia was a critical factor in the development of *** one in five patients with acute ischaemic stroke in the Chinese Stroke Center Alliance were not screened for *** prevention during acute hospitalisation is dependent not only on dysphagia screening but also on the effectiveness of subsequent dysphagia management *** studies are needed to elucidate the relationship between dysphagia screening,stroke unit care and pneumonia in patients with acute ischaemic stroke.

关键词： pneumonia prevention likely

Structure Design and Properties of Three-Layer Particleboard Based on High Voltage Electrostatic Field(HVEF)

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Journal of Renewable Materials 2021年第8期9卷 1433-1445页

作者： Man Yuan Lu Hong Zehui Ju Wenli gu Biqing Shu Jianxin Cui Xiaoning Lu Zhiqiang Wang College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037China

In this study,the effects of three different particle sizes of wood wastes(A=–8+12 mesh;B=–12+20 mesh;C=–20+30 mesh)and factory shavings(D)on the properties of particleboard were *** to the test results,three-layer particleboard was *** face layers made with mixture of A,B,and *** core layer made with *** ratio of core layer to face layers is 50:***-layer particleboard were fabricated with 12%urea-formaldehyde(UF)resins and three different high voltage electrostatic field intensities(0 kv,30 kv,60 kv).The internal bond(IB)strength,modulus of rupture(MOR),modulus of elasticity(MOE),thickness swelling(TS),and water absorption(WA)of particleboard were *** density distribution of the three-layer particleboard were examined by vertical density profiles(VDP),and the bonding mechanism and functional groups changes in the particles were analyzed by FTIR *** results showed that HVEF treatment intensity play a remarkable role in properties of *** particleboard with higher electrostatic field intensities treatment has higher MOE,MOR,IB,and *** HVEF treatment(60 kv),the MOR,modulus of MOE,and IB of three-layer particleboard were 23.61 N/mm^(2),2787.09 N/mm^(2),and 0.86 N/mm^(2),*** indicated that the surface activity of wood particles was increased electric field treatment.

关键词： High voltage electric field three-layer particleboard physical property mechanical property