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Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing gu hong-Xin Long Dan-Dan Zhang mei-Feng Ruan guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

Compressed Data Separation via ℓ_(q)-Split Analysis with ℓ_(∞)-Constraint

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1655-1673页

作者： Ming Yang gu Song Li Jun hong Lin School of Mathematical Science Zhejiang UniversityHangzhou310027P.R.China Center for Data Science Zhejiang UniversityHangzhou310027P.R.China

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0 详细信息

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0

关键词： Data separation ℓ_(q)-split analysis Dantzig selector frames restricted isometry property compressed sensing

Microvesicles derived from mesenchymal stem cells inhibit acute respiratory distress syndrome-related pulmonary fibrosis in mouse partly through hepatocyte growth factor

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World Journal of Stem Cells 2024年第8期16卷 811-823页

作者： Qi-hong Chen Ying Zhang Xue gu Peng-Lei Yang Jun Yuan Li-Na Yu Jian-mei Chen Department of Critical Care Medicine Jiangdu People’s Hospital of YangzhouJiangdu People’s Hospital Affiliated to Yangzhou UniversityYangzhou 225200Jiangsu ProvinceChina Department of Critical Care Medicine Jiangdu People’s Hospital of YangzhouYangzhou 225200Jiangsu ProvinceChina Institute of Translational Medicine Medical CollegeYangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND Pulmonary fibrosis is one of the main reasons for the high mortality rate among acute respiratory distress syndrome(ARDS)*** stromal cell-derived microvesicles(MSC-MVs)have been shown to exert antifibrotic effects in lung *** To investigate the effects and mechanisms of MSC-MVs on pulmonary fibrosis in ARDS mouse *** MSC-MVs with low hepatocyte growth factor(HGF)expression(siHGF-MSC-MVs)were obtained via lentivirus transfection and used to establish the ARDS pulmonary fibrosis mouse *** intubation,respiratory mechanics-related indicators were measured via an experimental small animal lung function *** of MSC-MVs in lung tissues was investigated by near-infrared live ***,western blotting,ELISA and other methods were used to detect expression of pulmonary fibrosis-related proteins and to compare effects on pulmonary fibrosis and fibrosis-related *** The MSC-MVs gradually migrated and homed to damaged lung tissues in the ARDS model *** with MSC-MVs significantly reduced lung injury and pulmonary fibrosis ***,low expression of HGF(siHGF-MSC-MVs)significantly inhibited the effects of MSC-MVs(P<0.05).Compared with the ARDS pulmonary fibrosis group,the MSC-MVs group exhibited suppressed expression of type I collagen antigen,type III collagen antigen,and the proteins transforming growth factor-βandα-smooth muscle actin,whereas the siHGF-MVs group exhibited significantly increased expression of these *** addition,pulmonary compliance and the pressure of oxygen/oxygen inhalation ratio were significantly lower in the MSC-MVs group,and the effects of the MSC-MVs were significantly inhibited by low HGF expression(all P<0.05).CONCLUSION MSC-MVs improved lung ventilation functions and inhibited pulmonary fibrosis in ARDS mice partly via HGF mRNA transfer.

关键词： Microvesicles derived from mesenchymal stem cells Acute respiratory distress syndrome Pulmonary fibrosis Hepatocyte growth factor Mesenchymal stromal cells

都市型观光农业发展趋势与对策研究——以北京海淀区观光农业发展为例

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旅游学刊 2005年第5期20卷 30-33页

作者：古红梅北京市海淀区旅游局北京100089

本文总结了都市型观光农业研究现状与我国的发展历程,分析了都市型观光农业的主要特征、功能及其发展趋势,并根据北京海淀区观光农业的管理经验,提出了加快发展都市型观光农业的具体对策。

关键词：都市型观光农业都市农业发展趋势

Design and Maintenance of Valves on a H_2 Reciprocating Compressor

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International Journal of Plant Engineering and Management 2010年第2期15卷 103-106页

作者： gu hong-mei WANG Qi ZHANG Xiao-hua Enzo Giacomelli Daqing Refining & Chemical Company China National Petroleum Company(CNPC) Daqing 163411 P.R. China Dott. Ing. Mario Cozzani Srl Italy 10921

Cylinder valves are the most important parts of a reciprocating compressor; their working condition affects the safety and operation of the reciprocating compressor directly. In initial design, it is dedicated to simulate the behaviour of a reciprocating compressor and peorformance of cylinder valves. For hydrogen application, it is considering carefully the real operating conditions both from the dynamic point of view and taking care of the effective condi- tions of the gas purity. The dynamic aspects of the design are related to the mechanical behaviour and to the conse- quent fatigue. The mathematical models are able to determine the ring displacement and the flow and pressure drop of the gas. Instruments are available for on-line monitoring of the reciprocating compressor. The various parts have to be repaired in time in case they have abrupt problems during the operating period. By detail design and maintenance, saving the quantities of spare parts, the reciprocating compressor of the plant can be running smoothly. Actually, the cylinder valves can be used nearly three years.

关键词： compressor valve design maintenance

Fabrication and properties of lightweight zirconia with fine closed porosity

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Journal of Iron and Steel Research International 2024年第6期31卷 1449-1458页

作者： Yi-bo Zhang Hua-zhi gu Lv-ping Fu Ao Huang mei-je Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

Lightweight refractory materials with thermal insulation properties and erosion resistance are advantageous for hightemperature *** zirconia refractories were prepared using starch as a pore-forming agent,basic magnesium carbonate as a stabilizer,and nano-zirconia as an *** effects of the nano-zirconia content on the pore and thermal insulation properties of the lightweight zirconia refractories were investigated based on the porosity,phase composition,microstructure,and thermal ***-zirconia was shown to have a high surface energy,and its addition effectively increased the driving force for sintering,reduced the sintering temperature,and promoted the sintering reaction,thereby reducing the apparent porosity and improving the density of the prepared *** to the superplasticity of nano-zirconia,the surface stress caused plastic deformation between particles,which increased the migration rate of grain boundaries and trapped more gas inside the material before it diffused to the surface,thereby enhancing the closed porosity of the *** presence of closed pores could extend the thermal conduction path,decrease the conduction rate,and hinder the conduction effect to effectively reduce the thermal conductivity of the *** a nano-zirconia content of 0.75 wt.%,the prepared lightweight zirconia had the highest closed porosity and the lowest thermal *** apparent porosity,closed porosity,and total porosity of the material were 2.8%,7.0%,and 9.8%,respectively,and the thermal conductivity at 800℃was 1.37 W m^(-1)k^(-1).

关键词： Sintering Nano-zirconia Closed pore:Thermal conductivity Refractory material

Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas

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World Journal of Gastroenterology 2024年第22期30卷 2893-2901页

作者： Si-Meng Wang Jian-Ling Jiang Rui Li Juan-Juan Wang Chun-hong gu Jia Zeng Xiao-Hui Wei mei Chen Wuxi Medical College of Jiangnan University Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gastrointestinal Surgery Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tong Ren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care *** the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal ***,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective *** successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they *** To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management *** Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,*** a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview *** acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step *** The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adj

关键词： Elderly Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study

乡村旅游发展与构建农村居民利益分享机制研究——以北京市海淀区西北部地区旅游业发展为例

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旅游学刊 2012年第1期27卷 26-30页

作者：古红梅北京联合大学北京100101

文章运用利益相关者理论,对北京市海淀区西北部地区旅游发展中利益相关者的利益关系进行分析,提出构建乡村旅游的利益分享机制,通过为旅游行业提供公共服务、对旅游市场实施行业管理、向当地社区提供财政支持和转移支付等措施,达到了以... 详细信息

文章运用利益相关者理论,对北京市海淀区西北部地区旅游发展中利益相关者的利益关系进行分析,提出构建乡村旅游的利益分享机制,通过为旅游行业提供公共服务、对旅游市场实施行业管理、向当地社区提供财政支持和转移支付等措施,达到了以旅游业发展促进农村居民等弱势群体增权的目的,进而实现区域旅游业的和谐发展。

关键词：利益相关者乡村旅游海淀区西北部地区

The story of a decade:Genomics,functional genomics,and molecular breeding in Brassica napus

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Plant Communications 2024年第4期5卷 94-111页

作者： Jianwei gu Zhilin guan Yushun Jiao Kede Liu Dengfeng hong National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Life Science and Technology Hubei Engineering UniversityXiaogan 432100 HubeiChina Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074 HubeiChina Yazhouwan National Laboratory Sanya 572024 HainanChina These authors contributed equally to this article.

Rapeseed(Brassica napus L.)is one of the major global sources of edible vegetable oil and is also used as a feed and pioneer crop and for sightseeing and industrial *** in genome sequencing and molecular marker technology have fueled a boom in functional genomic studies of major agronomic characters such as yield,quality,flowering time,and stress ***,introgression and pyra-miding of key functional genes have greatly accelerated the genetic improvement of important *** we summarize recent progress in rapeseed genomics and genetics,and we discuss effective molecular breeding strategies by exploring thesefindings in *** insights will extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture throughout the world.

关键词： Brassica napus functional genomics genomics molecular breeding agronomic traits