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China Ocean Engineering 2020年第2期34卷 151-161页

作者： gu hong-lu guO Hai-yan LIU Zhen LI Fu-heng AN Wan-bo LI Peng College of Engineering Ocean University of ChinaQingdao 266100China College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China

In order to investigate the effect of internal friction of umbilical cable on its vortex-induced vibration(VIV)responses,the experimental study on VIV of bond umbilical cable(BUC)and un-bond umbilical cable(UBUC)was carried out in an experimental tank.A current generator in the laboratory simulated the uniform current,and the current velocities were observed in real time by using a Doppler *** addition,different sizes of top tension were applied to the umbilical cable *** VIV responses of the umbilical cable model were measured by using Fiber Bragg grating(FBG)strain *** displacement responses of umbilical cable model were reconstructed based on the experimental strain data processed by modal superposition *** this paper,the traveling wave characteristics,the spatial-temporal distribution characteristics of frequency and fatigue damage of the BUC and UBUC under VIV are *** experimental results show that there are obvious differences between BUC and UBUC in the response characteristics of *** UBUC appears the traveling wave sooner than BUC,but its standing wave characteristics are more obvious than those of BUC at high *** with BUC,the spatial-temporal distribution of UBUC frequencies appears wide-band distribution sooner,but has narrower bandwidth in the"lock-in"*** level of fatigue damage of BUC was approximately the same as that of UBUC.

关键词： internal friction umbilical cable vortex-induced vibration traveling wave fatigue damage

Effect of Weaning Ages on Pancreatic and Intestinal Chymotrypsin Activity in Piglet

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Agricultural Sciences in China 2002年第3期1卷 338-341页

作者： ZHANG hong-fu, LI Chang-zhong, gu Xian-hong, FANG lu MA Yong-xi, GONG Li-ming and FENG guang-ming(Institute of Animal Science, Chinese Academy of Agricultural Sciences China Agricultural University, Beijing 100094 Demonstrative Pig Farm , Beijing Huadu Group, Beijing 101407) Institute of Animal Science Chinese Academy of Agricultural Sciences China Agricultural University Beijing 100094 Demonstrative Pig Farm Beijing Huadu Group Beijing 101407

Twelve litters of new born piglets were divided randomly into groups I , I , M and F , and weaned at 17, 21, 28 and 35 days of age, respectively, to determine the effect of weaning age on pancreatic and intestinal chymotrypsin activity in piglets. The results showed that the relative and specific activity of pancreatic chymotrypsin increased significantly 12h after weaning compared with that of sucking piglets at the same age and then decreased and remained low for 2 - 3 weeks after weaning. Total pancreatic chymotrypsin activity had no change with the increase of pancreas weight during day 18 - 50 regardless of weaning (P > 0.05). Chymotrypsin activity of jejunum had the same change as that of pancreas during sulking stage. Jejunum chymotrypin activity decreased in the first week post-weaning in the piglets weaned before day 28, but had no change in groups weaned at 28 or 35 days. The earlier the weaning age, the longer the restoring time. Chymotrypsin activity in jejunum is more sensitive to the effects of weaning age than in duodenum and ileum.

关键词： Weaning age Chymotrypsin Pancreas Small intestine Piglet

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陡波形立管涡激振动疲劳损伤参数敏感性分析

中国海洋大学学报（自然科学版） 2021年第5期51卷 113-121页

作者：顾洪禄郭海燕刘震中国海洋大学工程学院山东青岛266100

基于柔性杆理论和尾流振子模型计算陡波形立管的涡激振动响应;综合使用S-N曲线法、雨流计数法、Palmgren-Miner线性累积疲劳理论对立管涡激振动导致的疲劳损伤进行计算分析。并以MATLAB为平台编写相应计算程序,将本文计算得到的静力分... 详细信息

基于柔性杆理论和尾流振子模型计算陡波形立管的涡激振动响应;综合使用S-N曲线法、雨流计数法、Palmgren-Miner线性累积疲劳理论对立管涡激振动导致的疲劳损伤进行计算分析。并以MATLAB为平台编写相应计算程序,将本文计算得到的静力分析结果、固有频率和疲劳损伤分别与专业海工计算软件OrcaFlex和已发表文献进行对比验证。进一步对陡波形立管在涡激振动下的疲劳损伤进行参数敏感性分析,结果表明:浮子段长度、浮力因子、弹性模量、海流速度、波浪高度对陡波形立管疲劳损伤均有较大影响,有望为陡波形立管的实际工程设计提供参考。

关键词：柔性杆理论尾流振子模型陡波形立管涡激振动疲劳损伤敏感性分析

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振荡流下悬链线式立管涡激振动特性研究

船舶力学 2022年第8期26卷 1227-1236页

作者：陈殿鹏顾洪禄李福恒李效民郭海燕中国海洋大学工程学院山东青岛266100

本文应用改进的尾流振子模型对振荡流下悬链线式立管的涡激振动特性进行了研究。首先基于向量式有限元建立了悬链线式立管振动控制方程,利用独立性原理和改进的尾流振子模型模拟时变的涡激升力,然后采用中央差分法求解立管的涡激振动响... 详细信息

本文应用改进的尾流振子模型对振荡流下悬链线式立管的涡激振动特性进行了研究。首先基于向量式有限元建立了悬链线式立管振动控制方程,利用独立性原理和改进的尾流振子模型模拟时变的涡激升力,然后采用中央差分法求解立管的涡激振动响应。利用相应的试验结果验证了本文模型的有效性。最后,对振荡流下悬链线式立管涡激振动响应特性进行了分析。研究结果表明:振荡流下悬链线式立管响应幅值出现“振幅调制”现象,大KC(Keulegan-Carpenter)数下,进一步出现典型的“间歇涡激振动”现象;KC数对质点振动相图形状以及流固能量传递有显著影响;振荡流下立管响应峰值随流速呈“多峰”现象,KC=20时多峰现象更为明显;在小KC数范围内,较小的KC数会激励立管产生较大的涡激振动位移。

关键词：悬链线式立管振荡流涡激振动尾流振子模型向量式有限元

基于柔性杆理论的脐带缆涡激振动数值模拟系统

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船舶力学 2021年第2期25卷 220-227页

作者：顾洪禄郭海燕李效民刘震李朋王宣淇中国海洋大学工程学院山东青岛266100 山东科技大学土木工程与建筑学院山东青岛266590

针对目前海洋脐带缆分析软件缺乏的状况,本文基于MATLAB开发了脐带缆涡激振动数值模拟系统UCVIV-1.0。由于脐带缆的大变形和大转角会产生显著的几何非线性,脐带缆的静态平衡位形和整体力学响应计算采用了细长柔性杆模型,采用尾流振子模... 详细信息

针对目前海洋脐带缆分析软件缺乏的状况,本文基于MATLAB开发了脐带缆涡激振动数值模拟系统UCVIV-1.0。由于脐带缆的大变形和大转角会产生显著的几何非线性,脐带缆的静态平衡位形和整体力学响应计算采用了细长柔性杆模型,采用尾流振子模型模拟海流作用下的涡激力。该系统界面清晰友好,操作简单,适用于悬链线型脐带缆。选取了一组脐带缆参数,使用该系统进行了静力计算以及涡激振动计算;并将静力结果与采用国外商业软件OrcaFlex计算的结果进行了比对,发现结果吻合程度较高,在一定程度上验证了系统的可行性和准确性。本系统有望为脐带缆设计软件的开发提供借鉴。

关键词：柔性杆理论图形用户界面脐带缆涡激振动数值模拟

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预张力对两种脐带缆涡激振动影响的试验研究

船舶力学 2021年第4期25卷 471-478页

作者：安万博郭海燕刘震李福恒顾洪禄王宣淇李朋中国海洋大学工程学院山东青岛266100 山东科技大学土木工程与建筑学院山东青岛266590

本文应用模型试验的方法,研究了预张力对粘结和非粘结两种脐带缆涡激振动响应特性的影响规律。基于模态叠加法,将测得的应变数据转变为结构的位移响应;对比分析了各级预张力下两种脐带缆模型的位移响应、结构振动频率、锁振影响区域、... 详细信息

本文应用模型试验的方法,研究了预张力对粘结和非粘结两种脐带缆涡激振动响应特性的影响规律。基于模态叠加法,将测得的应变数据转变为结构的位移响应;对比分析了各级预张力下两种脐带缆模型的位移响应、结构振动频率、锁振影响区域、模态占比等参数。结果表明:两种脐带缆模型锁振频率随着预张力的增加逐渐变大,非粘结锁振比粘结工况提前;远离锁振区域时,外流速变化对振幅的影响占主导地位,锁振区域附近,预张力变化对振幅的影响逐渐变大;随着流速增加,预张力变化对脐带缆横向振动模态占比影响逐渐变大;预张力较小时,粘结脐带缆振动模态随外流速转换相比于非粘结脐带缆滞后较多,预张力变大后,滞后程度减小。

关键词：脐带缆涡激振动预张力模态占比

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马来酸氟吡汀缓释滴丸的制备

中国新药杂志 2017年第15期26卷 1832-1836页

作者：顾彩虹吕晓敏王冬东孙程张辉靠胡荣扬州大学医学院扬州225001

目的:制备马来酸氟吡汀缓释滴丸。方法:应用固体分散体技术,以聚乙二醇6000(PEG6000)和硬脂酸(stearic acid,SA)为药物载体,以缓释和速释两部分配比的方式制备马来酸氟吡汀缓释滴丸;采用相似因子法与现有缓释片剂进行体外溶出比较;将体... 详细信息

目的:制备马来酸氟吡汀缓释滴丸。方法:应用固体分散体技术,以聚乙二醇6000(PEG6000)和硬脂酸(stearic acid,SA)为药物载体,以缓释和速释两部分配比的方式制备马来酸氟吡汀缓释滴丸;采用相似因子法与现有缓释片剂进行体外溶出比较;将体外平均累积释放数据,分别按零级、一级和Higuichi方程进行拟合;通过加速试验和长期实验进行稳定性考察。结果:马来酸氟吡汀缓释滴丸由缓释和速释两部分以3∶1配比组成,速释体外释药90%时间12 min,缓释部分12 min释药30%;自制马来酸氟吡汀缓释滴丸与同等剂量的国外市售缓释片剂相比药物溶出时间短,溶出曲线出现平顶时间较长,对应的释药量较多,两制剂溶出度试验数据统计计算出相似因子f2为65,自制缓释滴丸中马来酸氟吡汀溶出符合一级释药模型;马来酸氟吡汀及其缓释滴丸在密封和40℃条件下稳定性良好,室温可以长时间贮存。结论:自制马来酸氟吡汀缓释滴丸具有良好的释药效果,可较迅速起效和较长时间持续释药,该滴丸新剂型具有进一步研发和临床应用的意义。

关键词：马来酸氟吡汀缓释滴丸体外溶出评价稳定性考察

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian gu Haoyu Li Mengyao Li Yude Wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen gu Hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

兔多杀性巴氏杆菌铁调节外膜蛋白(IROMPs)抗原交叉性试验

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微生物学报 2004年第5期44卷 667-671页

作者：顾宏伟陆承平南京农业大学农业部疾病诊断与免疫重点开放实验室南京210095

分别以含铁培养基和限铁培养基培养 4株兔多杀性巴氏杆菌JS、C5 1 2、C5 1 3及C5 1 17株 ,用刚果红结合试验初步分析铁调节外膜蛋白 (IROMPs)表达情况 ,同时破碎菌体 ,提取外膜蛋白 ,经SDS PAGE比较这 4株细菌在正常培养条件、富铁培养... 详细信息

分别以含铁培养基和限铁培养基培养 4株兔多杀性巴氏杆菌JS、C5 1 2、C5 1 3及C5 1 17株 ,用刚果红结合试验初步分析铁调节外膜蛋白 (IROMPs)表达情况 ,同时破碎菌体 ,提取外膜蛋白 ,经SDS PAGE比较这 4株细菌在正常培养条件、富铁培养条件及限铁培养条件时外膜蛋白的表达差异 ,结果表明 :限铁培养时 ,细菌表现出对刚果红染料较强结合性 ,且这 4株巴氏杆菌均表达数种高分子量的IROMPs,主要有 14 7kD、135kD、99kD、94kD、82kD及 72kD蛋白带 ,4株之间存在一定的差异 ,而正常或富铁条件培养时均不表达上述条带。免疫印迹结果显示 ,正常条件培养的全菌 (C5 1 17株 )抗血清中不含有针对IROMPs的抗体 ,限铁培养的C5 1 17株IROMPs可诱导机体产生相应抗体 ,并且能与JS、C5 1 2及C5 1 3株的IROMPs发生抗原交叉性反应。同时用间接ELISA检测C5 1 17株 3种IROMP(99kD、94kD和 87 6kD)的交叉抗体效价 ,结果这 3种抗血清均与其它 3株的产生较高的交叉抗体滴度。

关键词：兔多杀性巴氏杆菌铁调节外膜蛋白交叉抗原性