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人工膝关节置换术围手术期相关因素评估及康复管理的意义

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中国临床康复 2006年第4期10卷 134-138页

作者：程千谷贵山孙希光吉林大学第一医院骨科吉林省长春市130021

目的:人工膝关节置换术治疗膝关节疾病日益增多,为获得良好的术后效果,对人工膝关节置换术适应症、危险评估因素、手术方法等围手术期相关因素和围手术期康复管理及术后康复干预等方面的进展进行归纳总结。资料来源:应用计算机检索Pubme... 详细信息

目的:人工膝关节置换术治疗膝关节疾病日益增多,为获得良好的术后效果,对人工膝关节置换术适应症、危险评估因素、手术方法等围手术期相关因素和围手术期康复管理及术后康复干预等方面的进展进行归纳总结。资料来源:应用计算机检索Pubmed数据库1993-01/2004-12的相关文章,检索词“totalkneearthroplasty,totalkneereplacement,rehabilitation”,限定文章语言种类为English,研究对象为人类。同时计算机检索中国期刊全文数据库、万方数据2000-01/2004-12期间的相关文章,检索词″人工膝关节置换术、康复″,限定文章语言种类为中文。资料选择:纳入标准:①关于膝关节置换发展史的研究。②关于人工膝关节假体设计的研究。③关于人工膝关节置换术围手术期的护理与康复的研究。排除标准:较陈旧的文献,重复研究。资料提炼:共收集到589篇与人工膝关节置换术相关的文献,其中20篇符合纳入标准。资料综合:①人工膝关节置换术病例数在逐年上升,其治疗效果已得到充分肯定,但由于手术技术和围手术期管理方法的不同,术后效果也有很大差异,良好的术后效果一定要有良好的围手术期管理和护理与之相适应。②术前要对膝关节进行功能评估,通过录像记录其步行状态,或者应用电子测角仪对膝关节的功能进行定量评估;并收集和评估患者家族情况,居住环境,以利于出院时的综合评定。③术后的康复管理主要是针对防止并发症和功能训练两个方面。术后早期主要的并发症是感染和深静脉血栓;假体松动在术后10～15年假体的松动率为11%～41%。进行实际的高效率的功能训练对预防并发症很重要。结论:成功的手术和高水准的围手术期管理是获得良好的术后效果的关键,进行适当的患者教育、生活指导和实际的高效率的功能训练,对术后患者功能恢复和预防并发症有重要意义。

关键词：关节成形术围手术期医护康复人工膝关节置换术康复管理

Chiari截骨加盖螺钉固定术治疗髋臼发育不良(附56例临床分析)

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中国矫形外科杂志 2008年第3期16卷 169-171页

作者：车明学谷贵山张新吉林大学第一医院骨科吉林大学第一医院骨科长春130021

[目的]介绍一种Chiari截骨、植骨加盖螺钉固定术治疗各种原因引起的髋臼发育不良。[方法]从1982年10月~2001年10月在吉林大学第一医院骨科共有63髋(56例患者)因髋臼发育不良而行Chiari截骨、植骨加盖螺钉固定术。患者年龄为8~42岁,平均2... 详细信息

[目的]介绍一种Chiari截骨、植骨加盖螺钉固定术治疗各种原因引起的髋臼发育不良。[方法]从1982年10月~2001年10月在吉林大学第一医院骨科共有63髋(56例患者)因髋臼发育不良而行Chiari截骨、植骨加盖螺钉固定术。患者年龄为8~42岁,平均20.7岁。术前X线片显示Wiberg CE角平均4°,髋臼覆盖率平均60%,Sharp角平均51°,髋臼角平均为27°,除2例外均有不同程度的半脱位(Shenton线不连续)。[结果]37髋(32例患者)有6个月~8年的随访结果,平均45个月,其中30髋疼痛明显改善,术后X线片显示Wiberg CE角平均44°,Sharp角平均37°,髋臼角平均12°。Harris评分从术前平均76.3分,提高到术后平均89分。术后并发症包括2髋骨块被吸收。[结论]Chiari截骨、植骨加盖螺钉固定术较适合治疗各种原因引起的髋臼发育不良。

关键词： Chiari截骨术髋臼发育不良治疗

A novel complex-high-order graph convolutional network paradigm:ChyGCN

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Chinese Physics B 2024年第5期33卷 665-672页

作者：郑和翔苗书宇顾长贵 Business School University of Shanghai for Science and TechnologyShanghai 200093China Ant Group Shanghai 200000China

In recent years,there has been a growing interest in graph convolutional networks(GCN).However,existing GCN and variants are predominantly based on simple graph or hypergraph structures,which restricts their ability to handle complex data correlations in practical *** limitations stem from the difficulty in establishing multiple hierarchies and acquiring adaptive weights for each of *** address this issue,this paper introduces the latest concept of complex hypergraphs and constructs a versatile high-order multi-level data correlation *** model is realized by establishing a three-tier structure of ***,we start by establishing hyperedge clusters on a foundational network,utilizing a second-order hypergraph structure to depict potential *** this second-order structure,truncation methods are used to assess and generate a three-layer composite *** the construction of the composite structure,an adaptive learning strategy is implemented to merge correlations across different *** evaluate this model on several popular datasets and compare it with recent state-of-the-art *** comprehensive assessment results demonstrate that the proposed model surpasses the existing methods,particularly in modeling implicit data correlations(the classification accuracy of nodes on five public datasets Cora,Citeseer,Pubmed,Github Web ML,and Facebook are 86.1±0.33,79.2±0.35,83.1±0.46,83.8±0.23,and 80.1±0.37,respectively).This indicates that our approach possesses advantages in handling datasets with implicit multi-level structures.

关键词： raph convolutional network complex modeling complex hypergraph

Flexible, Transparent and Conductive Metal Mesh Films with Ultra‑High FoM for Stretchable Heating and Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第5期16卷 201-213页

作者： Zibo Chen Shaodian Yang Junhua Huang Yifan gu Weibo Huang Shaoyong Liu Zhiqiang Lin Zhiping Zeng Yougen Hu Zimin Chen Boru Yang Xuchun gui State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China guangdong Provincial Key Laboratory of Materials for High Density Electronic Packing Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongPeople’s Republic of China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China

Despite the growing demand for transparent conductive films in smart and wearable electronics for electromagnetic interference(EMI)shielding,achieving a flexible EMI shielding film,while maintaining a high transmittance remains a significant ***,a flexible,transparent,and conductive copper(Cu)metal mesh film for EMI shielding is fabricated by self-forming crackle template method and electroplating *** Cu mesh film shows an ultra-low sheet resistance(0.18Ω□^(-1)),high transmittance(85.8%@550 nm),and ultra-high figure of merit(>13,000).It also has satisfactory stretchability and mechanical stability,with a resistance increases of only 1.3%after 1,000 bending *** a stretchable heater(ε>30%),the saturation temperature of the film can reach over 110°C within 60 s at 1.00 V applied ***,the metal mesh film exhibits outstanding average EMI shielding effectiveness of 40.4 dB in the X-band at the thickness of 2.5μ*** a demonstration,it is used as a transparent window for shielding the wireless communication electromagnetic ***,the flexible and transparent conductive Cu mesh film proposed in this work provides a promising candidate for the next-generation EMI shielding applications.

关键词： Metal mesh Transparent conductive film Stretchable heater Electromagnetic interference shielding

差异凝胶电泳筛选人骨肉瘤细胞多药耐药相关蛋白

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中国肿瘤生物治疗杂志 2008年第5期15卷 440-443,450页

作者：孙大辉张德宝谷贵山吉林大学第一医院骨关节一科长春130021

目的:应用差异凝胶电泳分析骨肉瘤多药耐药细胞株与亲本细胞株蛋白质表达的差别,筛查骨肉瘤细胞多药耐药相关蛋白。方法:以小剂量多柔比星(doxorubicin,DXR)诱导人骨肉瘤细胞株MG-63,建立骨肉瘤多药耐药细胞株MG-63/DXR100。以差异凝胶... 详细信息

目的:应用差异凝胶电泳分析骨肉瘤多药耐药细胞株与亲本细胞株蛋白质表达的差别,筛查骨肉瘤细胞多药耐药相关蛋白。方法:以小剂量多柔比星(doxorubicin,DXR)诱导人骨肉瘤细胞株MG-63,建立骨肉瘤多药耐药细胞株MG-63/DXR100。以差异凝胶电泳分离两组细胞中的全部蛋白质,应用图像扫描和DeCyder软件分析差异(表达增加或减少>30%)表达的蛋白质点,对其进行质谱鉴定,并在Mascot数据库中检索。结果:共检测到明显差异表达的蛋白质点30个,选择其中18个点进行质谱鉴定,有5个蛋白质点鉴定成功,它们分别是与肿瘤细胞转移相关的基质金属蛋白酶1(matrix metalloprotein-ases1,MMP1)、具有解毒功能的乙醇脱氢酶6(alcohol dehydrogenase6,ADH6)、属于抑癌基因的FERM域结合蛋白3(FERM domain containing protein3,FRMD3),以及两个分别由128和300个氨基酸残基构成的未知蛋白。MMP1、ADH6和2种未知蛋白在耐药细胞表达显著高于非耐药细胞组,而FRMD3表达显著显著低于非耐药细胞。结论:通过差异凝胶电泳筛查到,MMP1、ADH6、FRMD3及2种未知蛋白质在骨肉瘤细胞的多药耐药细胞和非耐药细胞中差异表达,它们可能参与骨肉瘤细胞的多药耐药机制。

关键词：差异凝胶电泳骨肉瘤细胞多药耐药基质金属蛋白酶1 乙醇脱氢酶6 FERM域结合蛋白3

Insight into Lithium–sulfur batteries performance enhancement: from metal nanoparticles to metal nanoclusters to single metal atoms

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Tungsten 2024年第3期6卷 504-521页

作者： Shuang Ma Qing-Ling Ruan Xue-Cheng Liu gui-Jun Zhu Die Yuan Ling-Qiao Hu Yu-Mei Huang Xing-Xing gu Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and Resources Chongqing Technology and Business University National Research Base of Intelligent Manufacturing Service Chongqing Technology and Business University

Lithium-sulfur(Li-S) batteries have attracted much attention and developed rapidly in recent years due to their high energy density,low cost,and ***,its commercialization process still encounters various *** them,the sulfur cathode is easy to dissolve and shuttle,resulting in the loss of active substances and the severe growth of lithium anode dendrites,which is one of the biggest *** the redox conversion kinetics of sulfur cathode is expected to fundamentally alleviate the shuttle phenomenon of poly ***,this paper reviews the effects of metal nanoparticles to metal nanoclusters to metal single-atom catalysts on improving the redox of Li-S batteries,to let researchers better understand the size effect on the kinetics of sulfur cathodes in Li-S batteries,which will provide important guidance for the future large-scale commercialization of Li-S batteries.

关键词： Lithium–sulfur batteries Metal nanoparticles Metal nanoclusters Metal single atoms Size effects

高龄股骨颈骨折患者行全髋关节置换与人工双极股骨头置换的比较

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中国组织工程研究与临床康复 2008年第9期12卷 1651-1654页

作者：张德宝王铁军谷贵山吉林大学第一医院骨关节一科吉林省长春市130021

目的:高龄股骨颈骨折患者在人工全髋假体和人工双极股骨头假体置换的选择上存在争议。回顾性分析全髋关节假体置换与人工双极股骨头假体置换治疗70岁以上股骨颈骨折远期生物相容性反应及关节功能恢复状况。方法:2002-01/2006-12吉林大... 详细信息

目的:高龄股骨颈骨折患者在人工全髋假体和人工双极股骨头假体置换的选择上存在争议。回顾性分析全髋关节假体置换与人工双极股骨头假体置换治疗70岁以上股骨颈骨折远期生物相容性反应及关节功能恢复状况。方法:2002-01/2006-12吉林大学第一医院骨关节一科收治的70岁以上股骨颈骨折实行髋关节置换的患者60例60髋。按照手术方式分为人工全髋置换组和人工双极股骨头置换组。全髋关节置换组21例,男8例,女13例,平均年龄(72.1±3.5)岁,合并内科疾病18例。人工双极股骨头置换组39例,男16例,女23例,平均年龄(75.1±6.4)岁,合并内科疾病35例。①人工假体选择:16例假体采用德国Link公司及美国Zimmer公司产品,44例为北京蒙太因公司提供的人工关节。②术者资质:手术均由本科从事人工关节专业工作≥10年高年资医师作为术者完成,术者资格符合岗位技术标准要求。③置入后评估:全部病例平均随访37个月,从材料与宿主的生物相容性、关节功能、Harris评分、住院时间、住院费用、不良反应、手术时间、术中出血量等方面进行比较和随访。结果:①材料与宿主生物相容性的比较:人工双极股骨头置换组2例患者在术后5年出现髋臼壁磨损而行翻修手术。其余患者无切口感染,无关节脱位,无假体松动。②两组不良反应比较:全髋关节置换组和人工双极股骨头置换组各有1例在术后出现患侧髋部红肿、疼痛,经证实无假体周围感染,对症治疗后痊愈。③关节功能随访比较:平均随访37个月,全髋关节置换组Harris评分平均为(89.8±8.6)分,人工双极股骨头置换组Harris评分平均为(72.7±9.5)分,两组比较差异有显著性意义(P0.05)。⑤手术时间与术中出血量的比较:全髋关节置换组平均手术时间(150.2±24.3)min,人工双极股骨头置换组平均手术时间(105.8±22.1)min,两组相比差异有显著性意义(P<0.05)。全髋关节置换组平均术中出血(990.1±184.6)mL,人工双极股骨头置换组平均术中出血量(680.5±154.7)mL,两组相比差异有显著性意义(P<0.05)。结论:高龄股骨颈骨折行人工全髋关节置换后关节功能恢复较好,远期出现髋关节疼痛及髋臼磨损等生物相容性反应的几率较低,是人工关节置换治疗的首选方法。

关键词：人工全髋关节置换人工双极股骨头置换股骨颈骨折老年人工假体生物相容性

Eccrine porocarcinoma in the tempus of an elderly woman:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1523-1529页

作者： Zhi-Wei Wu Wen-Jie Zhu shan Huang Qi Tan Cong You Dian-gui Hu Long-Nian Li Department of Dermatology First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000Jiangxi ProvinceChina Department of Laser and Cosmetic Dermatology Ganzhou Dermatology HospitalGanzhou 341000Jiangxi ProvinceChina Department of Dermatology Tongxiang Dermatology HospitalJiaxing 314000Zhejiang ProvinceChina Department of Infectious Diseases The Fifth people’s Hospital of GanzhouGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Eccrine porocarcinoma(EPC)is a rare skin tumor that mainly affects the elderly *** often present with slow growth and a good *** are usually distinguished from other skin tumors using histopathology and ***,surgical management alone may be inadequate if the tumor has ***,currently,surgical resection is the most commonly used treatment *** SUMMARY A seventy-four-year-old woman presented with a slow-growing nodule in her left temporal area,with no obvious itching or pain,for more than four *** examination showed small columnar and short spindle-shaped cells;thus,basal cell carcinoma was ***,immunohistochemical analysis revealed the expression of cytokeratin 5/6,p63 protein,p16 protein,and Ki-67 antigen(40%),and EPC was taken into *** skin biopsy was repeated,and hematoxylin and eosin staining revealed ductal differentiation in some ***,the patient was diagnosed with EPC,and Mohs micrographic surgery was *** adapted follow-up visits in a year and not found any recurrence of *** This case report emphasizes the diagnosis and differentiation of EPC.

关键词： Eccrine porocarcinoma Sweat gland carcinoma Histopathology Immunohistochemistry Prognosis Case report

Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1564-1577页

作者： Sai-Nan Li shan Yang Hao-Qi Wang Tian-Li Hui Meng Cheng Xi Zhang Bao-Kun Li gui-Ying Wang The First Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Second Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina Department of General Surgery The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and a significant cause of cancer-related mortality *** to chemotherapy,especially during CRC treatment,leads to reduced effectiveness of drugs and poor patient *** noncoding RNAs(lncRNAs)have been implicated in various pathophysiological processes of tumor cells,including chemotherapy resistance,yet the roles of many lncRNAs in CRC remain *** To identify and analyze the lncRNAs involved in oxaliplatin resistance in CRC and to understand the underlying molecular mechanisms influencing this *** Gene Expression Omnibus datasets GSE42387 and GSE30011 were reanalyzed to identify lncRNAs and mRNAs associated with oxaliplatin *** bioinformatics tools were employed to elucidate molecular *** expression levels of lncRNAs and mRNAs were assessed via quantitative reverse transcription-polymerase chain *** assays,including MTT,wound healing,and Transwell,were conducted to investigate the functional implications of lncRNA *** between lncRNAs and trans-cription factors were examined using RIP and luciferase reporter assays,while Western blotting was used to confirm downstream ***,a xenograft mouse model was utilized to study the in vivo effects of lncRNAs on chemotherapy *** LncRNA prion protein testis specific(PRNT)was found to be upregulated in oxaliplatin-resistant CRC cell lines and negatively correlated with homeodomain interacting protein kinase 2(HIPK2)*** was demonstrated to sponge transcription factor zinc finger protein 184(ZNF184),which in turn could regulate HIPK2 *** expression of PRNT influenced CRC cell sensitivity to oxaliplatin,with overexpression leading to decreased sensitivity and decreased expression reducing *** RIP and luciferase reporter assays indicated that ZNF184 and HIPK2 are targets of *** PRNT/ZNF184

关键词： Colorectal cancer Oxaliplatin resistance Prion protein testis specific Zinc finger protein 184 Homeodomain interacting protein kinase 2