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Chinese Journal of Integrative Medicine 2018年第4期24卷 304-307页

作者： ZHANG Wei-bo JIA De-xian LI Hong-yan WEI Yu-long YAN Huang ZHAO Peng-na gu fei-fei WANG guang-jun WANG Yan-ping ENNOVA Health Research Institute Langfang Hebei 065001 China Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Beijing 100700 China School of Acupuncture Moxibustion and Tuina Beijing University of Chinese Medicine Beijing 100029 China

Qi, blood and the meridians are fundamental concepts in Chinese medicine（CM）, which are components of the human body and maintain physiological function. Pathological changes of qi, blood and meridians may lead to discomfort and disease. Treatment with acupuncture or herbal medicine aims to regulate qi and blood so as to recover normal function of the meridians. This paper explores the nature of qi as well as compares and correlates them with the structures of the human body. We propose a conceptualization of qi as being similar to the interstitial fluid, and the meridians as being similar to interstitial space of low hydraulic resistance in the body. Hence, qi running in the meridians can be understood as interstitial fluid flowing via interstitial space of low hydraulic resistance.

关键词： qi interstitial fluid meridian interstitial space low hydraulic resistance

Molecular Epidemiology of Staphylococcus aureus among Patients with Skin and Soft Tissue Infections in Two Chinese Hospitals

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Chinese Medical Journal 2016年第19期129卷 2319-2324页

作者： fei-fei gu Ye Chen De-Ping Dong Zhen Song Xiao-Kui guo Yu-Xing Ni Li-Zhong Han Department of Clinical Microbiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Laboratory Haian Hospital Nantong University Nantong Jiangsu 226600 China Faculty of Laboratory Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Microbiology and Parasitology Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Background：Staphylococcus aureus is one of the predominant causes of skin and soft tissue infections （SSTIs）,but limited data were available regarding the characterization of *** from SSTIs patients in Jiangsu Province in *** aimed to investigate the molecular epidemiology *** among SSTIs patients in two hospitals of Jiangsu ***：Sixty-two patients with SSTIs from two Chinese hospitals in Jiangsu Province were enrolled in this study,and 62 *** isolates were collected from February 2014 to January *** isolates were characterized by antimicrobial susceptibility testing,toxin gene detection,and molecular typing with sequence type,Staphylococcus protein A gene type,accessorygeneregulator（agr）group,and Staphylococcal cassette chromosome mec ***：Sixteen （25.8%） methicillin-resistant *** （MRSA） isolates were detected,and there was no isolate found resistant to vancomycin,teicoplanin,sulfamethoxazole-trimethoprim,and *** sei was the toxin gene most frequently found,and no lukS/F-PV-positive isolates were detected among the SSTIs＆#39; *** analysis revealed that ST398 （10/62,16.1%;2 MRSA and 8 methicillin-susceptible ***） to be the dominant clone,followed by ST5 （8/62,12.9%） and ST7 （8/62,12.9%）.Conclusions：The livestock ST398 was the most common clone among patients with *** SSTIs in Jiangsu Province,*** and further studies on the important livestock ST398 clone in human infections are necessarily requested.

关键词： Livestock Molecular Epidemiology Skin and Soft Tissue Infections ST398 Staphylococcus aureus

Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions： an in vivo study using intravascular ultrasound

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Chinese Medical Journal 2009年第23期122卷 2820-2826页

作者： gu fei-fei LV Shu-zheng CHEN Yun-dai ZHOU Yu-jie SONG Xian-tao JIN Ze-ning LIU Hong Department of Cardiology Beijing Anzhen Hospital CapitalMedical University Beijing 100029 China Heart Center China Meitan General Hospital Beijing 100028China Department of Cardiology Chinese People's Liberation ArmyGeneral Hospital Beijing 100853 Cbina

Background Cathepsin S and its endogenous inhibitor cystatin C are implicated in the pathogenesis of atherosclerosis, especially in the plaque destabilization and rupture leading to acute coronary syndrome. However, whether circulating cathepsin S and cystatin C also change in association with coronary plaque morphology is unknown yet. Methods We recruited 98 patients with unstable angina （UA, n=56） or stable angina （SA, n=-42） who had a segmental stenosis resulting in 〉20% and 〈70% diameter reduction in one major coronary artery on coronary angiography. Thirty-one healthy subjects served as controls. Intravascular ultrasound （IVUS） was used to evaluate plaque morphology. Plasma cathepsin S and cystatin C were measured as well. Results At the culprit lesion site, plaque area （（7.85±2.83） mm^2 vs （6.53±2.92） mm^2, P=0.027）, plaque burden （（60.92±11.04）% vs （53.87±17.52）%, P=0.025）, remodeling index （0.93±0.16 vs 0.86±0.10, P=0.004） and eccentricity index （0.74±0.17 vs 0.66±0.21, P=0.038） were bigger in UA group than in SA group. Plasma cathepsin S and cystatin C were significantly higher in patients than in controls （P〈0.01）. Plasma cathepsin S was higher in UA group （（0.411±0.121） nmol/L） than in SA group （（0.355±0.099） nmol/L, P=0.007）, so did the plasma cystatin C （（0.95±0.23） mg/L in UA group, （0.84±0.22） mg/L in SA group; P=0.009）. Plasma cathepsin S positively correlated with remodeling index （r=0.402, P=0.002） and eccentricity index （r=0.441, P=0.001）, and plasma cystatin C positively correlated with plaque area （r=0.467, P 〈0.001） and plaque burden （r=0.395, P=0.003） in UA group but not in SA group. Conclusions Plasma cathepsin S and cystatin C increased significantly in UA patients. In angina patients, higher plasma cathepsin S may suggest the presence of vulnerable plaque, and higher plasma cystatin C may be a clue for larger atherosclerotic coronary plaque.

关键词： cathepsin S cystatin C, intravascular ultrasound atherosclerosis vulnerable plaque

A novel frameshift mutation in the BCOR gene is associated with oculo-facio-cardio-dental syndrome:a case report

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 370-374页

作者： Qiu-Mei gu Xue-fei He Wen-Zhe Xiao Chao Qu Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Biobank West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Respiratory and Critical Care Medicine Center for High Altitude MedicineInstitutes for Systems GeneticsNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Ophthalmology Sichuan Academy of Medical Sciences and Sichuan People’s HospitalChengdu 610072Sichuan ProvinceChina

Dear Editor,Oculo-facio-cardio-dental(OFCD)syndrome is a rare X chromosome-linked dominant genetic disease with multiple system and site *** typical traits shown in this disease are:1)eye abnormalities,notably congenital cataracts,microphthalmia,and secondary glaucoma;2)facial deformities,in particular long and narrow face,high nasal bridge,nasal tip cartilage division,and cleft palate.

关键词： nasal cataract congenital

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不同桩核材料抗折强度的比较研究

上海第二医科大学学报 2005年第4期25卷 362-364页

作者：顾飞飞张保卫上海第二医科大学口腔医学院第九人民医院口腔修复科上海200011

目的比较根管螺纹桩、parapost桩两种成品桩和复合树脂、银汞合金、银粉加强的玻璃离子三种核心材料的抗折强度。方法将60颗上颌前磨牙随机分成六组,截冠后进行桩核制备,比较桩—核复合体抗折强度。将10颗上颌前磨牙随机分成两组,进行... 详细信息

目的比较根管螺纹桩、parapost桩两种成品桩和复合树脂、银汞合金、银粉加强的玻璃离子三种核心材料的抗折强度。方法将60颗上颌前磨牙随机分成六组,截冠后进行桩核制备,比较桩—核复合体抗折强度。将10颗上颌前磨牙随机分成两组,进行桩核冠制备,比较桩抗折强度。结果复合树脂和银汞合金组的抗折强度无明显差异,但均大于银粉加强的玻璃离子组。parapost桩的抗折强度大于根管螺纹桩。结论两种成品桩和三种核心材料中以复合树脂+parapost桩具有较好的修复效果。

关键词：桩-核复合体抗折强度成品桩核心材料

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基于分层规则的市级调度操作票自动生成系统

继电器 2006年第4期34卷 61-65页

作者：李秋燕郭伟顾飞飞东南大学电气工程系江苏南京210096 东大金智电气自动化公司江苏南京210036

电网调度操作涉及到的厂站之间、设备之间的配合协调具有复杂的逻辑关系,在开发智能操作票自动生成系统时,描述这种关系的操作规则表示是开发的难点和重点。针对电网拓扑结构具有层次性和调度操作具有严格操作顺序等特点,采用分层结构... 详细信息

电网调度操作涉及到的厂站之间、设备之间的配合协调具有复杂的逻辑关系,在开发智能操作票自动生成系统时,描述这种关系的操作规则表示是开发的难点和重点。针对电网拓扑结构具有层次性和调度操作具有严格操作顺序等特点,采用分层结构的思想对操作规则进行描述,并研究了在此基础上的推理机制,能够适应电网结构的复杂性、操作任务的多样性和电力系统运行方式的灵活性,显示出较好的智能性和良好的自适应性,以此思想开发的操作票自动生成系统已成功应用于某市级调度管理中。

关键词：操作票专家系统分层规则

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海洋石油钻井作业风险管理与安全评价

石油矿场机械 2014年第5期43卷 81-84页

作者：顾菲菲胜利油田检测评价研究有限公司山东东营257062

海洋石油钻井作业具有高风险性且投入巨大,风险管理工作至关重要。风险管理就是在风险分析与评估的基础上,采取有针对性的措施,将各项作业的风险降到可接受的水平。应用风险分析评估方法分析了海洋石油钻井作业各阶段的主要风险,并对海... 详细信息

海洋石油钻井作业具有高风险性且投入巨大,风险管理工作至关重要。风险管理就是在风险分析与评估的基础上,采取有针对性的措施,将各项作业的风险降到可接受的水平。应用风险分析评估方法分析了海洋石油钻井作业各阶段的主要风险,并对海洋石油钻井作业的风险管理方法与工作流程进行了研究,以期对海洋石油钻井风险管理有所帮助。

关键词：海洋石油钻井风险分析安全评价动态风险管理

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文体视域下的布宁短篇小说

浙江工商职业技术学院学报 2009年第1期8卷 32-35页

作者：顾飞飞浙江工商职业技术学院国际交流学院浙江宁波315012

俄国现实主义作家布宁把纯俄罗斯式的短篇小说发展到了高度完美的程度。他的作品不仅语言细腻,结构自由,容量异常大,不受情节的约束,而且源于现实生活,给读者审美享受的同时,又留下广阔的想象空间,在语言形态、结构形态和审美形态方面... 详细信息

俄国现实主义作家布宁把纯俄罗斯式的短篇小说发展到了高度完美的程度。他的作品不仅语言细腻,结构自由,容量异常大,不受情节的约束,而且源于现实生活,给读者审美享受的同时,又留下广阔的想象空间,在语言形态、结构形态和审美形态方面表现出其短篇小说的文体特色,对小说文体的发展产生重大影响。

关键词：布宁短篇小说文体语言结构审美

Genome-wide CRISPR screens identify CLC-2 as a drug target for anti-herpesvirus therapy:tackling herpesvirus drug resistance

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Science China(Life Sciences) 2025年第2期68卷 515-526页

作者： Fayu Yang Nan Wei Shuo Cai Jing Liu Qingping Lan Hao Zhang Lu Shang Bo Zheng Mi Wang Yingchun Liu Lifang Zhang Chenzhong fei Wu Tong Changlong Liu Ersheng Kuang guangzhi Tong Feng gu Shanghai Veterinary Research Institute Chinese Academy of Agricultural SciencesShanghai 200241China Key Laboratory of Veterinary Chemical Drugs and Pharmaceutics Ministry of Agriculture and Rural AffairsShanghai 200241China State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Institute of Human Virology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China School of Medicine Tsinghua UniversityBeijing 100084China

The emergence of drug resistance to virus(i.e.,acyclovir(ACV)to herpesviruses)has been termed one of the common clinical issues,emphasizing the discovery of new antiviral *** address it,a genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)screening was performed in mouse haploid embryonic stem cells infected with pseudorabies virus(PRV),anα-herpesvirus causing human and pig *** results demonstrated that type 2 voltage-gated chloride channels(CLC-2)encoded by one of the identified genes,CLCN2,is a potential drug target for anti-herpesvirus ***-2 inhibitors,omeprazole(OME)and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid(DIDS),can efficiently inhibit infection of multiple herpesviruses in cellulo(i.e.,PRV,HSV and EBV),and effectively treat murine herpes simplex encephalitis(HSE).Additionally,DIDS was found to inhibit HSV-1 replication by blocking the PI3K/Akt *** importantly,both DIDS and OME were able to inhibit ACV-resistant HSV-1 strain *** study's findings suggest that targeting host-cell factors such as CLC-2 may be a promising approach to tackling herpesvirus drug *** discovery of CLC-2 as a potential drug target for anti-herpesvirus therapy provides a new direction for the development of novel antiviral agents.

关键词： herpesviruses CRISPR host-directed therapy CLC-2 DIDS

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祁木香提取工艺优选

中国实验方剂学杂志 2012年第9期18卷 26-28页

作者：王刚侯志飞相会欣谷菲菲张雪荣河北化工医药职业技术学院石家庄050026

目的:确定祁木香的最佳提取工艺。方法:采用正交试验对祁木香提取工艺进行优选,以土木香内酯和异土木香内酯含量为指标,考察乙醇体积分数、溶剂用量、提取时间、提取次数4个因素的影响,采用HPLC进行含量测定。结果:最佳提取工艺为15倍量... 详细信息

目的:确定祁木香的最佳提取工艺。方法:采用正交试验对祁木香提取工艺进行优选,以土木香内酯和异土木香内酯含量为指标,考察乙醇体积分数、溶剂用量、提取时间、提取次数4个因素的影响,采用HPLC进行含量测定。结果:最佳提取工艺为15倍量85%乙醇提取3次,每次1 h。结论:该优选提取工艺稳定可行、提取率高,为祁木香的提取提供科学依据。

关键词：祁木香提取工艺正交试验土木香内酯异土木香内酯