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Comparative Proteomic Analysis in Left Ventricular Remodeling following Myocardial Infarction in Rats

Biomedical and Environmental Sciences 2012年第1期25卷 117-123页

作者： gu hong juan GAO Chang Bin GONG Jun Li LI Xiang Jun SUN Bo LI Xi Ning China-Japan Union Hospital of Jilin University Changchun 130021 Jilin China Changchun Municipal Central Hospital Changehun 130051 Jilin China Jilin University College of Pharmacy Changchun 130021 Jilin China

Objective Left ventricular remodeling （LVR） following myocardial infarction （MI） is a key pathophysiological process in which MI develops into heart failure. The exact mechanism of LVR remains unclear. We performed differential proteomic analysis on the myocardia of rats with LVR after MI, to explore the mechanism of ventricular remodeling after MI. Methods In the LVR group （n=12）, after the anterior descending coronary artery was ligated, the rats were fed for four weeks before the LVR models were established. Rats in the sham-operated group （n=11） underwent thread-drawing without ligation. The hemodynamic parameters, pathological findings, and proteomics were compared between the two groups. Results In the LVR group, the left ventricular end-diastolic pressure increased, the maximal left ventricular pressure increase/decrease ratio decreased significantly, and the left ventricular systolic pressure decreased. H-E staining and Masson staining of cardiac muscle tissues of the LVR group showed myocytolysis, disarray, and collagen proliferation. Twenty-one differentially expressed proteins were detected by proteomic analysis. We validated two proteins using western blot analysis. The differentially expressed proteins could be divided into six categories： energy metabolism-related proteins, cytoskeletal proteins, protein synthesis-related proteins, channel proteins, anti-oxidation- related proteins, and immune-related proteins. Conclusion These differentially expressed proteins might play key roles in LVR following M

关键词： Comparative proteomics Liquid chromatography-mass spectrometry Left ventricular remodeling Myocardial infarction Western blot

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Qualitative exploration of home life experiences and care needs among elderly patients with temporary intestinal stomas

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World Journal of Gastroenterology 2024年第22期30卷 2893-2901页

作者： Si-Meng Wang Jian-Ling Jiang Rui Li juan-juan Wang Chun-hong gu Jia Zeng Xiao-Hui Wei Mei Chen Wuxi Medical College of Jiangnan University Jiangnan UniversityWuxi 214122Jiangsu ProvinceChina Department of Gastrointestinal Surgery Tongren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China Department of Nursing Tong Ren Hospital Shanghai Jiao Tong University School of MedicineShanghai 200335China

BACKGROUND This study employed a phenomenological research approach within qualitative research to explore the challenges encountered by elderly individuals with temporary colostomies in managing their daily lives and care *** the anus surgery combined with temporary colostomy has emerged as a prevalent treatment modality for low rectal ***,the ileostomy is susceptible to peri-stoma skin complications,as well as fluid,electrolyte,and nutritional imbalances,posing challenges to effective *** successful selfmanagement of patients is intricately linked to their adjustment to temporary colostomy;nonetheless,there remains a dearth of research examining the factors influencing self-care among temporary colostomy patients and the obstacles they *** To investigate the lived experiences,perceptions,and care requirements of temporary colostomy patients within their home environment,with the ultimate goal of formulating a standardized management *** Over the period of June to August 2023,a purposive sampling technique was utilized to select 12 patients with temporary intestinal stomas from a tertiary hospital in Shanghai,*** a phenomenological research approach,a semi-structured interview guide was developed,and qualitative interviews were conducted using in-depth interview *** acquired data underwent coding,analysis,organization,and summarization following Colaizzi’s seven-step *** The findings of this study revealed that the experiences and needs of patients with temporary intestinal stomas can be delineated into four principal themes:Firstly,Temporary colostomy patients bear various burdens and concerns about the uncertainty of disease progression;secondly,patients exhibit limited self-care capabilities and face information deficits,resulting in heightened reliance on healthcare professionals;thirdly,patients demonstrate the potential for internal motivation through proactive self-adj

关键词： Elderly Temporary intestinal stomas Life experiences Intestinal ostomy complications Qualitative study

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Compressed Data Separation via ℓ_(q)-Split Analysis with ℓ_(∞)-Constraint

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1655-1673页

作者： Ming Yang gu Song Li Jun hong Lin School of Mathematical Science Zhejiang UniversityHangzhou310027P.R.China Center for Data Science Zhejiang UniversityHangzhou310027P.R.China

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0 详细信息

In this paper,we study compressed data separation(CDS)problem,i.e.,sparse data separation from a few linear random *** propose the nonconvex ℓ_(q)-split analysis with ℓ_(∞)-constraint and 0

关键词： Data separation ℓ_(q)-split analysis Dantzig selector frames restricted isometry property compressed sensing

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急性冠状动脉综合征患者血浆B型钠尿肽及超敏C反应蛋白水平的临床分析

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中国实验诊断学 2011年第10期15卷 1683-1684页

作者：顾红娟长春市中心医院心血管科吉林长春130051

目的探讨急性冠状动脉综合征患者血浆B型钠尿肽(BNP)和超敏CRP(hs-CRP)水平变化及临床意义。方法对32例不稳定型心绞痛(UAP组)、28例急性心肌梗死患者(AMI组)和30例健康人(对照组)进行血浆BNP和超敏CRP水平检测。结果急性心肌梗死患者血... 详细信息

目的探讨急性冠状动脉综合征患者血浆B型钠尿肽(BNP)和超敏CRP(hs-CRP)水平变化及临床意义。方法对32例不稳定型心绞痛(UAP组)、28例急性心肌梗死患者(AMI组)和30例健康人(对照组)进行血浆BNP和超敏CRP水平检测。结果急性心肌梗死患者血浆BNP水平高于不稳定心绞痛组(P<0.01)。急性心肌梗死患者血浆hs-CRP水平高于不稳定心绞痛组(P<0.05)。不稳定心绞痛组患者血浆BNP及hs-CRP水平高于对照组(P<0.01)。结论血浆BNP及hs-CRP水平可以作为急性冠状动脉综合征患者诊断及危险分层的重要参考。

关键词：急性冠状动脉综合征 B型钠尿肽超敏C反应蛋白

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The story of a decade:Genomics,functional genomics,and molecular breeding in Brassica napus

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Plant Communications 2024年第4期5卷 94-111页

作者： Jianwei gu Zhilin guan Yushun Jiao Kede Liu Dengfeng hong National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Life Science and Technology Hubei Engineering UniversityXiaogan 432100 HubeiChina Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074 HubeiChina Yazhouwan National Laboratory Sanya 572024 HainanChina These authors contributed equally to this article.

Rapeseed(Brassica napus L.)is one of the major global sources of edible vegetable oil and is also used as a feed and pioneer crop and for sightseeing and industrial *** in genome sequencing and molecular marker technology have fueled a boom in functional genomic studies of major agronomic characters such as yield,quality,flowering time,and stress ***,introgression and pyra-miding of key functional genes have greatly accelerated the genetic improvement of important *** we summarize recent progress in rapeseed genomics and genetics,and we discuss effective molecular breeding strategies by exploring thesefindings in *** insights will extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture throughout the world.

关键词： Brassica napus functional genomics genomics molecular breeding agronomic traits

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Electronic regulation to achieve efficient anaerobic digestion of organic fraction of municipal solid waste(OFMSW):strategies,challenges and potential solutions

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 159-165页

作者： Yongdong Chen hong Wang Parisa Ghofrani-Isfahani Li gu Xiaoguang Liu Xiaohu Dai State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Tongji UniversityShanghai 200092China Department of Chemical and Biochemical Engineering Technical University of DenmarkKgs Lyngby DK-2800Denmark College of Environment and Ecology Chongqing UniversityChongqing 400045China

Anaerobic digestion(AD)of organic fraction of municipal solid waste(OFMSW)is prone to system breakdown under high organic loading rates(OLRs)condition,which subsequently reduces the efficiency of digestion process and results in substantial economic *** this perspective paper,the substances metabolisms,electrons flow,as well as microbial interaction mechanisms within AD process are comprehensively discussed,and the underlying bottleneck that causes inefficient methane production is identified,which is“electrons surplus”.Systems encountering severe electron surplus are at risk of process failure,making it crucial to proactively prevent this phenomenon through appropriate *** this basis,the present perspective proposes three potential electronic regulation strategies to prevent electrons surplus,namely,electron shunt,accelerating electron transfer and regulating methanogenic metabolism pathway,and presents specific methodologies for each ***,the potential solutions to challenges that may occur during the electronic regulation process are also presented in this *** perspective aims to provide innovative approaches to achieve the efficient and stable operation of OFMSW anaerobic digestion,especially under high OLRs condition.

关键词： Anaerobic digestion Electrons surplus Electronic regulation Electrons shunt Electron transfer Methanogenic metabolism pathway

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Two positive effects with one arrow:Modulating crystal and interfacial decoration towards high-potential cathode material

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Journal of Energy Chemistry 2024年第5期92卷 216-223页

作者： Xuexiu gu Xuan-Wen Gao Dongrun Yang Qinfen gu YSong hong Chen Tianzhen Ren Wen-Bin Luo Institute for Energy Electrochemistry and Urban Mines Metallurgy School of MetallurgyNortheastern UniversityShenyang 110819LiaoningChina Australian Synchrotron(ANSTO) 800 Blackburn RdClaytonVictoria 3168Australia School of Science and Engineering University of DundeeNethergateDundee DD14HNScotlandUK

As the primary suppliers of cyclable sodium ions,O3-type layer-structured manganese-based oxides are recognized as highly competitive cathode candidates for sodium-ion *** advance the development of high-energy sodium-ion batteries,it is crucial to explore cathode materials operating at high voltages while maintaining a stable cycling *** orbital and electronic structure of the octahedral center metal element plays a crucial role in maintaining the octahedra structural integrity and improving Na^(+)ion diffusion by introducing heterogeneous chemical *** by the abundant configuration of extra nuclear electrons and large ion radius,we employed trace amounts of tungsten in this *** obtained cathode material can promote the reversibility of oxygen redox reactions in the high-voltage region and inhibit the loss of lattice ***,the formation of a Na_(2)WO_(4) coating on the material surface can improve the interfacial stability and interface ions *** demonstrates an initial Coulombic efficiency(ICE)of 94.6%along with 168.5 mA h g^(-1 )discharge capacity within the voltage range of 1.9-4.35 *** findings contribute to the advancement of high-energy sodium-ion batteries by providing insights into the benefits of tungsten doping and Na_(2)WO_(4) coating on cathode materials.

关键词： Sodium ion battery Layer-structured manganese-based oxides Cathodematerial Surface modification Elements doping

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Source-Load Coordinated Optimal Scheduling Considering the High Energy Load of Electrofused Magnesium and Wind Power Uncertainty

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Energy Engineering 2024年第10期121卷 2777-2795页

作者： juan Li Tingting Xu Yi gu Chuang Liu guiping Zhou guoliang Bian School of Electrical Engineering Northeast Electric Power UniversityJilin132013China Ministry of Science and Technology Communication State Grid Liaoning Electric Power Co.Ltd.Shenyang110000China

In fossil energy pollution is serious and the“double carbon”goal is being promoted,as a symbol of fresh energy in the electrical system,solar and wind power have an increasing installed capacity,only conventional units obviously can not solve the new energy as the main body of the scheduling *** enhance the systemscheduling ability,based on the participation of thermal power units,incorporate the high energy-carrying load of electro-melting magnesiuminto the regulation object,and consider the effects on the wind unpredictability of the ***,the operating characteristics of high energy load and wind power are analyzed,and the principle of the participation of electrofusedmagnesiumhigh energy-carrying loads in the elimination of obstructedwind power is ***,a two-layer optimization model is suggested,with the objective function being the largest amount of wind power consumed and the lowest possible cost of system *** the upper model,the high energy-carrying load regulates the blocked wind power,and in the lower model,the second-order cone approximation algorithm is used to solve the optimizationmodelwithwind power uncertainty,so that a two-layer optimizationmodel that takes into account the regulation of the high energy-carrying load of the electrofused magnesium and the uncertainty of the wind power is ***,the model is solved using gurobi,and the results of the simulation demonstrate that the suggested model may successfully lower wind abandonment,lower system operation costs,increase the accuracy of day-ahead scheduling,and lower the final product error of the thermal electricity unit.

关键词： High energy load of electrofused magnesium wind energy consumption thermal power unit wind power uncertainty two-layer optimization

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Structural insights, synthesis, and electrocatalysis of high entropy nanoparticles for fuel cell, metal-air battery, and water-splitting applications

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Progress in Natural Science:Materials International 2024年第3期34卷 512-523页

作者： Xin Tong Hao Ye Yunrou Wu Xinxing Zhan Manqi gu Shixia Luo Jiangning Gong juan Tiana Yadian Xie School of Chemistry and Material Science Guizhou Normal University Center for the Physics of Low-Dimensional Materials School of Physics and Electronics School of Future Technology Henan University Key Laboratory of Low-Dimensional Materials and Big Data Guizhou Minzu University

High-entropy alloy nanoparticles(HEA-NPs) have recently sparked great interest in materials science. Their solidsolution states, derived from distinct HEA configurations, make them promising candidates for catalysts with exceptional activity, stability, and tunable performance. However, a comprehensive understanding of the underlying mechanisms governing their electrocatalytic behavior is still lacking, hindering the rational design of HEA electrocatalysts. This review summarizes the fundamental knowledge of HEA-NPs, including the structureactivity correlations of HEA-NPs, diverse synthesis strategies, and applications in electrochemical catalysis. The design strategies for guiding improvements in tunable performance were highlighted. The article concludes with insights, perspectives, and future directions, encapsulating the state-of-the-art knowledge and paving the way for further exploration in this dynamic field.

关键词： Electrochemical catalysis High-entropy alloy nanoparticles Structure-activity correlations Synthesis strategies

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Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing gu hong-Xin Long Dan-Dan Zhang Mei-Feng Ruan guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

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