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In vivo percutaneous reflectance spectroscopy of fatty liver development in rats suggests that the elevation of the scattering power is an early indicator of hepatic steatosis

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 53-71页

作者： Daqing Piao Jerry W.ritchey greed holyoak.corey r.wall Nigar Sultana Jill K.Murray Kenneth E.Bartels School of Electrical and Computer Engineering Oklahoma State University 202 Engineering South StillwaterOK 74078USA Department of Veterinary Clinical Sciences Center for Veterinary Health Sciences 002 VTH Oklahoma State University StillwaterOK 74078USA Department of Veterinary Pathobiology Center for Veterinary Health Sciences Oklahoma State University 250 McElroy Hall StillwaterOK 74078USA Graduate Program on Interdisciplinary Sciences Oklahoma State University StillwaterOK 74078USA

This study assessed whether there was a scat tering spectral mar ker quantifiable by reflectance measurements that could indicate early development of hepatic steatosis in rats for potential applications to pre procurement organ *** rats were fed a methionine choline-deficient(MCD)diet and eight rats were fed a normal *** assessment of the liver parenchyma of rats in vivo was performed by percut aneous reflect ance spectroscopy using a single fiber probe at the beginning of diet-intake and arbitrary post-diet-intake times up to 11 weeks to render longitudinal *** sampling of the liver over the duration of diet adm inistration was performed on two MCD diet treated rats and one control rat eutha-nized after reflectance spectroscopy *** images of hematoxylin/eosin-stained liver specimens were analyzed morphometrically to evahuate the lipid size changes associated with the level of *** MCD-diet-treated group(n=16)had mild steatosis in seven rats,moderate in three rats,severe in six rats,and no other significant *** control rats(n=8)developed hepatic *** the parameters retrieved from per-SfS,only the scat tering power(can be either positive or negative)appeared to be statist ically diferent between MCD-treated and control *** scattering power for the 16 MCD-diet-treated livers at the time of euthanasia and presenting various levels of steatosis was 033±0.21,in comparison to 0.036±0.25 of the eight control livers(p=0.0189).When evaluated at days 12 and 13 combined,the scattering power of the 16 MCD-diet-treated livers was 032±0.17,in comparison to 0.10±0.11 of the eight control livers(p=0.0017).All of four MCD-treated livers harvested at days 12 and 13 presented mild steatosis with sub-micron size lipid droplets,even though none of the MCD-treated livers were sonogr aphically remarkable for fatty *** elevation of the scattering power may be a valuable marker indicating ear

关键词： Hepatic steatosis difuse reflect ance spectroscopy liver transplant

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