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Quantitative assessment of the impact of a triage physician on the Accreditation Council for Graduate Medical Education resident milestones in the emergency department

2000年

作者： Donald S. Baim William grossman

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World Journal of Emergency Medicine 2024年第3期15卷 220-222页

作者： Julie Cueva Duncan grossman Vishnu Muppala Arlene Chung Mahlaqa Butt Jefferson Drapkin Antonios Likourezos Errel Khordipour Department of Emergency Medicine Maimonides Medical CenterNew York 11219USA

The “door-to-doctor” time for patients to be seen by a physician is an increasingly studied *** may shorten this time by implementing a triage physician (TP).The exact role of a TP may vary across *** put in preliminary orders for lab work,imaging,and treatment,and decide treatment location for further *** the prevalence of TPs grows,its effect on resident education in academic emergency departments (EDs) remains *** implemented a TP in the spring of 2016 and assessed resident physicians before and after implementation.

关键词： physician doctor treatment

Topology-enhanced mechanical stability of swelling nanoporous electrodes

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npj Computational Materials 2023年第1期9卷 1161-1175页

作者： Benjamin E.grossman-Ponemon Ataollah Mesgarnejad Alain Karma Center for Interdisciplinary Research on Complex Systems Department of PhysicsNortheastern UniversityBostonMA 02115USA School of Engineering Brown UniversityProvidenceRI 02912USA

Materials like silicon and germanium offer a 10-fold improvement in charge capacity over conventional graphite anodes in lithium-ion batteries but experience a roughly threefold volume increase during lithiation,which challenges ensuring battery *** silicon,created by liquid-metal-dealloying,is a potentially attractive anode design to mitigate this challenge,exhibiting both higher capacity and extended cycle ***,how nanoporous structures accommodate the large volume change is ***,we address this question by using phase-field modeling to produce nanoporous particles and to investigate their elastoplastic swelling behavior and *** simulations show that enhanced mechanical stability results from the network topology consisting of ligaments connected by bulbous,sphere-like *** ligaments forcefully resist elongation while the nodes,behaving like isolated spherical particles,experience large stresses driving ***,being smaller compared to a sphere of the same volume as the entire nanoporous particle,the nodes are more protected against fracture.

关键词： swelling stability attractive

The association between orthostatic hypertension and all-cause mortality in hospitalized elderly persons

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Journal of Geriatric Cardiology 2016年第3期13卷 239-243页

作者： Avraham Weiss Yichayaou Beloosesky Alon grossman Agata Shlesinge Nira Koren-Morag Ehud grossman Department of Geriatrics Rabin Medical Center Beilinson Hospital Petach Tikvah lsrael Sackler Faculty of Medicine Tel Aviv University Israel Department of Internal Medicine E Rabin Medical Center Beilinson Hospital Petach Tikvah lsrael Department of Epidemiology and Preventive Medicine Tel Aviv University Israel Internal Medicine Department and Hypertension Unit Chaim Sheba Medical Center Tel Hashomer lsrael

Background Little is known about the prevalence oforthostatic hypertension （OHT） and its effect on long-term mortality in the eld- erly. We evaluated the prevalence of OHT and its effect on mortality in hospitalized elderly patients. Methods Out of 1852 patients admit- ted between 31/12/1999 and 31/12/2000 to an acute geriatric ward, 474 patients （48% males） with a mean age of 81.5 ±6.8 years were en- rolled in this study. Blood pressure （BP） was measured three times during the day in a supine and standing position. Patients with at least one increase in systolic or diastolic BP levels upon standing were diagnosed with OHT. Medical history, physical examination and laboratory parameters were retrieved from the medical records. Mortality data until 18th June 2014 were retrieved from the computerized system of the Ministry of the Interior. Results Four hundred and seven patients （86%） were diagnosed with OHT. Those without OHT had a lowerbody mass index and were more likely males, smokers, had a higher rate of Parkinson＇s disease and less congestive heart failure compared with those with OHT. Patients with OHT had a better survival rate than those without OHT （P = 0.024）. Hazard ratios （HRs） for mortality in those with OHT adjusted to age and multiple risk factors were： 0.67 [95% confidence interval （CI）： 0.51-0.87] and 0.73 （95% CI： 0.55-0.97）, respectively; a similar tendency was noticed in a sensitivity analysis by gender. Conclusion Hospitalized elderly patients with OHT had a better survival rate than those without OHT.

关键词： Hypertension Mortality Orthostatic The elderly

A Novel Two Domain-Fusion Protein in Cyanobacteria with Similarity to the CAB/ELIP/HLIP Superfamily： Evolutionary Implications and Regulation

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Molecular Plant 2008年第1期1卷 155-166页

作者： Oliver Kilian Anne Soisig Steunou Arthur R. grossman Devaki Bhaya Department of Plant Biology The Carnegie Institution Stanford CA 94305 USA

Vascular plants contain abundant, light-harvesting complexes in the thylakoid membrane that are non-covalently associated with chlorophylls and carotenoids. These light-harvesting chlorophyll a/b binding （LHC） proteins are members of an extended CAB/ELIP/HLIP superfamily of distantly related polypeptides, which have between one and four transmembrane helices （TMH）. This superfamUy includes the single TMH, high-light-inducible proteins （Hlips）, found in cyanobacteria that are induced by various stress conditions, including high light, and are considered ancestral to the LHC proteins. The roles of, and evolutionary relationships between, these superfamily members are of particular interest, since they function in both light harvesting and photoprotection and may have evolved through tandem gene duplication and fusion events. We have investigated the Hlips （hli gene family） in the thermophilic unicellular cyanobacterium Synechococcus OS-B＇. The five hli genes present on the genome of Synechococcus OS-B＂ are relatively similar, but transcript analyses indicate that there are different patterns of transcript accumulation when the cells are exposed to various growth conditions, suggesting that different Hlips may have specific functions. Hlip5 has an additional TMH at the N-terminus as a result of a novel fusion event. This additional TMH is very similar to a conserved hypothetical, single membrane-spanning polypeptide present in most cyanobacteria. The evolutionary significance of these results is discussed.

关键词： light-harvesting chlorophyll a/b binding (LHC) transmembrane helices (TMH) high-light-inducible proteins (Hlips)

Optimization for performance-based design under seismic demands, including social costs

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Earthquake Engineering and Engineering Vibration 2015年第2期14卷 315-328页

作者： Oscar Moller Ricardo O.Foschi Juan P.Ascheri Marcelo Rubinstein Sergio grossman Instituto de Mecanica Aplicada y Estructuras (IMAE) Facultad Cs.Ex. Ingenieríay Agrimensura Universidad Nacional de Rosario Riobambay Berutti 2000 Rosario Argentina Civil Engineering Department University of British Columbia 6250 Applied Sciences Lane Vancouver B.C. Canada V6T1Z4

Performance-based design in earthquake engineering is a structural optimization problem that has, as the objective, the determination of design parameters for the minimization of total costs, while at the same time satisfying minimum reliability levels for the specifi ed performance criteria. Total costs include those for construction and structural damage repairs, those associated with non-structural components and the social costs of economic losses, injuries and fatalities. This paper presents a general framework to approach this problem, using a numerical optimization strategy and incorporating the use of neural networks for the evaluation of dynamic responses and the reliability levels achieved for a given set of design parameters. The strategy is applied to an example of a three-story offi ce building. The results show the importance of considering the social costs, and the optimum failure probabilities when minimum reliability constraints are not taken into account.

关键词： earthquake engineering performance-based design optimization reliabiliy social costs

Transcriptome and Metabolic Profiling Provides Insigh into Betalain Biosynthesis and Evolution in Mirabilis jalapa

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Molecular Plant 2018年第1期11卷 189-204页

作者： Guy Polturak Uwe Heinig Noam grossman Maor Battat Dena Leshkowitz Sergey Malitsky liana Rogachev~ and Asaph Aharoni Department of Plant and Environmental Sciences Weizmann Institute of Science 234 Herzl Street Rehovot 7610001 Israel Bioinformatics Unit Life Sciences Core Facilities Weizmann Institute of Science 234 Herzl Street Rehovot 7610001 Israel

Betalains are tyrosine-derived pigments that occur solely in one plant order, the Caryophyllales, where they largely replace the anthocyanins in a mutually exclusive manner. In this study, we conducted multi-species transcriptome and metabolic profiling in Mirabilisjalapa and additional betalain-producing species to identify candidate genes possibly involved in betalain biosynthesis. Among the candidates identified, betalainrelated ytochrome P450 and glucosyltransferase-type genes, which catalyze tyrosine hydroxylation or （hydroxy）cinnamoyl-glucose formation, respectively, were further functionally characterized. We detected the expression of genes in the flavonoid/anthocyanin biosynthetic pathways as well as their metabolite intermediates in betalain-accumulating M. jalapa flowers, and found that the anthocyanin-related gene ANTHOCYANIDIN SYNTHASE （MjANS） is highly expressed in the betalain-accumulating petals. However, it appears that MjANS contains a significant deletion in a region spanning the corresponding enzyme active site. These findings provide novel insights into betalain biosynthesis and a possible explanation for how anthocyanins have been lost in this plant species. Our study also implies a complex, non-uniform history for the loss of anthocyanin production across betalain producers, previously assumed to be strictly due to diminished expression of anthocyanin-related genes.

关键词： betalain anthocyanin caryophyllales plant pigment biosynthesis secondary metabolism

The World as Classroom

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China Today 2010年第1期59卷 70-72页

作者： SETH grossman

IT was 11 years ago when Chen Bei, then a high school student in Henan, stood at one of life＇s first crossroads. She, like several million other Chinese students, faced the annual ＂Gaokao,＂ China＇s college entrance exam. Although it is equivalent to the SAT in the U.S. or the ＂A＂ levels in the U.K., it is considerably longer and more intimidating.

关键词：课堂世界国家税务总局资讯科技十字路口入学考试中学生河南省

Kosher Made in China?

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China Today 2009年第11期58卷 65-67页

作者： SETH ADAM grossman

THERE is an old joke that hints at the understanding two cultures joined through food have for each other：＂If, accordingto the Jewish calendar, the year is 5770, and, according to the Chinese calendar, the year is ... 详细信息

关键词：食品制造食品市场中国犹太人食物

Ensuring that Systemically Administered Antineoplastic Therapies reach Glioblastoma Cells in Therapeutic Concentrations

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Ensuring that Systemically Administered Antineoplastic Thera...