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Ensembles vs. information theory: supporting science underuncertainty

1998年

作者：（美）（G.佩里）grey Perry 沈刚等译

来源：畅想之星图书光盘版（南... 评论

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Frontiers of Earth Science 2018年第4期12卷 653-660页

作者： grey S.NEARING Hoshin V.GUPTA University of Alabama Department of Geological SciencesTuscaloosaAL 35294-1152USA University of Arizona Department of Hydrology and Atmospheric SciencesTucsonAZ 85721-0158USA

Multi-model ensembles are one of the most common ways to deal with epistemic uncertainty in hydrology. This is a problem because there is no known way to sample models such that the resulting ensemble admits a measure that has any systematic (i.e., asymptotic, bounded, or consistent) relationship with uncertainty. Multi-model ensembles are effectively sensitivity analyses and cannot – even partially – quantify uncertainty. One consequence of this is that multi-model approaches cannot support a consistent scientific method – in particular, multi-model approaches yield unbounded errors in inference. In contrast, information theory supports a coherent hypothesis test that is robust to (i.e., bounded under) arbitrary epistemic uncertainty. This paper may be understood as advocating a procedure for hypothesis testing that does not require quantifying uncertainty, but is coherent and reliable (i.e., bounded) in the presence of arbitrary (unknown and unknowable) uncertainty. We conclude by offering some suggestions about how this proposed philosophy of science suggests new ways to conceptualize and construct simulation models of complex, dynamical systems.

关键词： information theory multi-model ensembles Bayesian methods uncertainty quantification hypothesis testing

Up-regulation of calmodulin involved in the stress response to cyantraniliprole in the whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae)

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Insect Science 2021年第6期28卷 1745-1755页

作者： Lei Guo Changyou Li grey Coupland Pei Liang Dong Chu Key Lab of Integrated Crop Pest Management of Shandong Province College of Plant Health and MedicineQingdao Agricultural UniversityQingdaoShangdong266109China Harry Butler Institute Murdoch UniversityMurdochWA6150Australia Department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing100193China

Cyantraniliprole is the first diamide insecticide to have cross-spectrum activity against a broad range of insect *** insecticide,like other diamides,selectively acts on ryanodine receptor,destroys Ca^(2+) homeostasis,and ultimately causes insect *** expression regulations of genes associated with calcium signaling pathways are known to be involved in the response to diamides,little is known regarding the function of calmodulin(CaM),a typical Ca^(2+)sensor central in regulating Ca^(2+) homeostasis,in the stress response of insects to the *** this study,we cloned and identified the full-length complementary DNA of CaM in the whitefly,Bemisia tabaci(Gennadius),named *** real-time reverse transcription polymerase chain reaction-based analyses showed that the messenger RNA level of BtCaM was rapidly induced from l.5l-to 2.43-fold by cyantraniliprole during 24 *** of BtCaM by RNA interference increased the toxicity of cyantraniliprole in whiteflies by 42.85%.In contrast,BtCaM expression in Sf9 cells significantly increased the cells,tolerance to cyantraniliprole as much as *** addition,the expression of BtCaM in Sf9 cells suppressed the rapid increase of intracellular Ca^(2+) after exposure to cyantraniliprole,and the maximum amplitude in the Sf9-BtCaM cells was only 34.9%of that in control cells(Sf9-PIZ/V5).These results demonstrate that overexpression of BtCaM is involved in the stress response of *** to cyantraniliprole through regulation of Ca^(2+)*** CaM is one of the most evolutionarily conserved Ca^(2+) sensors in insects,outcomes of this study may provide the first details of a universal insect response to diamide insecticides.

关键词： Bemisia tabaci Ca^(2+)homeostasis calmodulin cyantraniliprole insecticide stress overexpression

Current status and future of targeted peptide receptor radionuclide positron emission tomography imaging and therapy of gastroenteropancreatic-neuroendocrine tumors

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World Journal of Gastroenterology 2022年第17期28卷 1768-1780页

作者： Neil grey Michael Silosky Christopher H Lieu Bennett B Chin Radiology-Nuclear Medicine University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States Department of Radiology University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States Medical Oncology University of Colorado School of MedicineAnschutz Medical CampusAuroraCO 80045United States

Theranostics is the highly targeted molecular imaging and therapy of *** peptide receptor radionuclide therapy has taken the lead in demonstrating the safety and effectiveness of this molecular approach to treating ***,well-differentiated gastroenteropancreatic neuroendocrine tumors may be most effectively imaged and treated with DOTATATE *** review the current practice,safety,advantages,and limitations of DOTATATE based ***,we briefly describe the exciting new areas of development and future directions of gastroenteropancreatic neuroendocrine tumor theranostics.

关键词： DOTATATE Theranostics Gastroenteropancreatic neuroendocrine tumors 68Ga DOTATATE 177Lu DOTATATE Review

The Human Side of Poverty Alleviation

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Beijing Review 2021年第23期64卷 30-31页

作者： Jerry grey 不详

Poverty shouldn’t be a controversial subject, but it is. The World Bank, the World Health Organization, the U.S. State Department and pretty much every government in the world has a different definition of what poverty means. In China, absolute poverty is defined as 11 yuan a day;this is about $1.7. The World Bank disagrees and sets a higher number. In 2011 the U.S. considered people to be in poverty if their consumption was less than $21.7 a day. If that were the case, given inflation, almost all Chinese people outside of a few large cities would be in poverty. But living in China is different.

关键词： outside Poverty poverty

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Let the Facts Speak

Beijing Review 2021年第12期64卷 28-29页

作者： Jerry grey 不详

Inconclusive conclusions lead to inadmissible evidence on Xinjiang The U.S. State Department lawyers have concluded there’s no evidence to prove "genocide" in *** UK Parliament has decided it’s a job for the lawyers... 详细信息

关键词： has admissible lawyer

Cardio- and hepato-protective potential of methanolic extract of Syzygium cumini(L.) Skeels seeds:A diabetic rat model study

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Asian Pacific Journal of Tropical Biomedicine 2017年第2期7卷 126-133页

作者： Sumaiya Nahid Kishor Mazumder Zillur Rahman Saiful Islam Md. Humayun Rashid Philip grey Kerr Department of Pharmacy University of Science and Technology ChittagongFoy's LakePahartaliChittagong 4202Bangladesh School of Biomedical Sciences Charles Sturt UniversityBoorooma StreetWaggaWaggaNew South Wales 2678Australia Department of Pathology Chittagong Medical College HospitalChittagong 4202Bangladesh

Objective: To evaluate the effect of methanolic extract of Syzygium cumini(L.) Skeels(S. cumini) seeds on the major organs in an animal model of diabetes through biochemical and histopathological ***: The methanolic extracts of S. cumini seeds(100 and 200 mg/kg body weight) were administered to alloxan-induced diabetic rats daily, with fasting blood glucose levels being measured by glucometry at one-day interval for a duration of two weeks. Biochemical assays to evaluate changes in the functions of the heart, liver,pancreas and kidney were carried out. Histopathological changes in the diabetic rat organs(pancreas, liver, heart, kidney and spleen) were also observed after the 14 days of treatment with the ***: Oral administration of methanolic extracts of S. cumini seeds(100 and 200 mg/kg body weight), with gliclazide as a positive control(25 mg/kg), showed beneficial effects including lowering blood glucose levels(P < 0.001), improved heart and liver functions, and hyperlipidemia due to diabetes. At 200 mg/kg, the extracts reversed cardiac and liver damage caused by ***: In addition to the anti-hyperglycemic activity of methanolic extracts of S. cumini seeds, the extracts demonstrates potential to minimize cardiac and hepatic complications.

关键词： Syzygium cumini seeds Diabetes Cardioprotection Hepatoprotection

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灰色参数线性规划解法论

聊城大学学报（自然科学版） 1996年第1期14卷 21-25页

作者：李孝忠

叙述了灰色参数线性规划的基本思想和模型，总结了近十多年来求解的主要研究成果，并对该领域的进一步研究提出了一些想法和展望．

关键词：灰色参数线性规划满意解信度解

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一类灰随机事件的概率及灰度

聊城大学学报（自然科学版） 1994年第4期12卷 23-27页

作者：李孝忠灰色系统理论研究所

从实际问题中抽象出了灰色随机事件的定义，讨论了一类灰色随机事件的关系和运算，给出了它的概率Ｐ与灰度Ｇ的定义及具体计算公式，阐述了灰色概率的公理化体系，得到了Ｐ和Ｇ的若干结果．

关键词：灰色随机事件灰色概率灰色概率的公理化体系灰度

SENS-a Damage-Repair Strategy for Postponing Aging

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SENS-a Damage-Repair Strategy for Postponing Aging