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Science China Mathematics 2006年第11期49卷 1539-1552页

作者： graham ian KOHR Gabriela Department of Mathematics University of Toronto TorontoOntario M5S 2E4Canada Faculty of Mathematics and Computer Science Babes-Bolyai University 1 M. Kogǎlniceanu Str. 400084 Cluj-NapocaRomania

In this paper we give a survey about the Roper-Suffridge extension operator and the developments in the theory of univalent mappings in several variables to which it has led. We begin with the basic geometric properties (most of which now have a number of different proofs)and discuss relations with the theory of Loewner chains and generalizations and modifications of the operator, some of which are very recent.

关键词： convex mapping, starlike mapping, Roper-Suffridge operator, growth theorem, distortion theorem, covering theorem, Loewner chain, parametric representation,extreme points, linear invariant family.

Extreme points, support points and the Loewner variation in several complex variables

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Science China Mathematics 2012年第7期55卷 1353-1366页

作者： graham ian HAMADA Hidetaka KOHR Gabriela KOHR Mirela Department of Mathematics University of Toronto Toronto Ontario M5S 2E4 Canada Faculty of Engineering Kyushu Sangyo University 3-1 Matsukadai 2-Chome Higashi-ku Fukuoka 8138503 Japan Faculty of Mathematics and Computer Science Babe s-Bolyai University 1 M. Koga lniceanu Str. Cluj-Napoca 400084 Romania Faculty of Mathematics and Computer Science Babes-Bolyai University 1 M. Kogǎlniceanu Str. Cluj-Napoca 400084 Romania

In this paper we consider extreme points and support points for compact subclasses of normalized biholomorphic mappings of the Euclidean unit ball Bn in Cn. We consider the class So（Bn） of biholomorphic mappings on Bn which have parametric representation, i.e., they are the initial elements f（-, O） of a Loewner chain f（x,t） = etz ＋ ... such that {e-tf（.,t）}t≥o is a normal family on Bn. We show that if f（.,O） is an extreme point （respectively a support point） of So（Bn）, then e-t f（., t） is an extreme point of So（Bn） for t≥0 （respectively a support point of So（Bn） for t C [O, t0] and some to〉 0）. This is a generalization to the n-dimensional case of work due to Pell. Also, we prove analogous results for mappings which belong to So（Bn） and which are bounded in the norm by a fixed constant. We relate the study of this class to reachable sets in control theory generalizing work of Roth. Finally we consider extreme points and support points for biholomorphic mappings of Bn generated by using extension operators that preserve Loewner chains.

关键词： biholomorphic mapping Loewner chain parametric representation reachable set starlike map-ping

The Effect of Wood Condition on Sound Wave Propagation

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Open Journal of Acoustics 2018年第3期8卷 37-51页

作者： Ahmed El-Hadad graham ian Brodie Berhan Shiday Ahmed Department of Forest and Ecosystem Faculty of Science The University of Melbourne Melbourne Australia Department of Agriculture and Food Science Faculty of Veterinary and Agricultural Sciences The University of Melbourne Melbourne Australia

This experiment aims to study the effects and modifications that occurred on acoustic signal harmonics when travelling through wood. The experiment measured the output amplitudes and frequencies of the travelling signals and compared them with the original input signal. The factors under investigation in this experiment included: wood type, wood moisture content (MC), input signal frequencies, signal travelling distance and wood condition (wood with/without cracks). The experiment findings demonstrated that higher input signal frequencies results in higher attenuation of acoustic emissions (AE) travelling through the wood. The results also indicate that: wood type, MC, the signal’s travelling distance, and the orientation of the travelling signal, compared to the wood’s grain direction, affected the signal propagation.

关键词： Acoustic Emission Sound Wood Interaction Moisture Content Sound Wave Propagation Wood Condition

Risk factors in cardiovascular patients:Challenges and opportunities to improve secondary prevention

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World Journal of Cardiology 2023年第7期15卷 342-353页

作者： Rahima Gabulova Anna Marzà-Florensa Uzeyir Rahimov Mahluga Isayeva Shahana Alasgarli Afag Musayeva Sona Gahramanova Firdovsi Ibrahimov Farid Aliyev Galib Imanov Rahmana Rasulova Ilonca Vaartjes Kerstin Klipstein-Grobusch ian graham Diederick E Grobbee Teaching-Therapeutical Hospital Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht 3508 GANetherlands Department of Cardiology Baku Medical PlazaBaku AZ1014Azerbaijan Department of CHD and Arrhythmias Scientific-Research Institute of CardiologyBaku AZ1072Azerbaijan Department of Cardiology Central Clinic HospitalBaku AZ1006Azerbaijan Heart Center Baku Health CenterBaku AZ1072Azerbaijan Teaching-Surgical Hospital Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Department of Public Health Azerbaijan Medical UniversityBaku AZ1022Azerbaijan Department of Cardiology Trinity College DublinDublin Dublin-2Ireland

BACKGROUND Effective management of major cardiovascular risk factors is of great importance to reduce mortality from cardiovascular disease(CVD).The Survey of Risk Factors in Coronary Heart Disease(SURF CHD)II study is a clinical audit of the recording and management of CHD risk *** was developed in collaboration with the European Association of Preventive Cardiology and the European Society of Cardiology(ESC).Previous studies have shown that control of major cardiovascular risk factors in patients with established atherosclerotic CVD is generally *** is a country in the South Caucasus,a region at a very high risk for *** To assess adherence to ESC recommendations for secondary prevention of CVD based on the measurement of both modifiable major risk factors and their therapeutic management in patients with confirmed CHD at different hospitals in Baku(Azerbaijan).METHODS Six tertiary health care centers participated in the SURF CHD II study between 2019 and *** on demographics,risk factors,physical and laboratory data,and medications was collected using a standard questionnaire in consecutive patients aged≥18 years with established CHD during outpatient *** from 687 patients(mean age 59.6±9.58 years;24.9%female)were included in the *** Only 15.1%of participants were involved in cardiac rehabilitation *** rate of uncontrolled risk factors was high:Systolic blood pressure(BP)(SBP)(54.6%),low-density lipoprotein cholesterol(LDL-C)(86.8%),diabetes mellitus(DM)(60.6%),as well as overweight(66.6%)and obesity(25%).In addition,significant differences in the prevalence and control of some risk factors[smoking,body mass index(BMI),waist circumference,blood glucose(BG),and SBP]between female and male participants were *** cardiovascular health index score(CHIS)was calculated from the six risk factors:Non-or ex-smoker,BMI<25 kg/m2,moderate/vigorous physical activity,controlled BP(<140/90 mmHg;140/80 mmHg

关键词： Coronary heart disease Cardiovascular risk factors Secondary prevention Clinical practice guidelines Clinical audit Survey of risk factors

Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield

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Molecular Plant 2022年第8期15卷 1310-1328页

作者： Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan graham Jiang Xu Boli Zhang Shilin Chen Instituteof ChineseMateria Medica China Academyof ChineseMedical SciencesBeijing 100700China Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration the Second Clinical CollegeGuangzhou Universityof ChineseMedicineGuangzhou510006China Institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China Artemisinin Research.Center China Academy of Chinese Medical SciencesBeijing 100700China Pharmacy College Chengdu University of Traditional Chinese MedicineChengdu 611137China Centre for Novel Agricultural Products Department of BiologyUniversity of YorkYorkUK Wellcome Sanger Institute Wellcome Trust Genome CampusHinxton CB101RQUK Kentucky Tobacco Research and Development Center University of KentuckyLexingtonKY 40546USA Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement&Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChineseAcademyof SciencesGuangzhou 510520China School of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 300193China Chengdu University of Traditional Chinese Medicine Chengdu 611137China

Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used ***,we present chromosome-level haploid maps for two *** strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin ***-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of *** 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this *** analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes *** correlation was further confirmed by resequencing of *** samples with varied artemisinin *** consensus sequencing of transcripts facilitated the detection of paralog ***,our study provides chromosome-level allele-aware genome assemblies for two *** strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide.

关键词： Artemisia annua artemisinin haplotype chromosome amorpha-4 11-diene synthase copy number variation

The Cretaceous Turn of Geological Evolution: Key Evidence from East Asia

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 1991-2003页

作者： Victor P.NECHAEV DAI Shifeng F.Lin SUTHERLAND ian T.graham Eugenia V.NECHAEVA Far East Geological Institute Far Eastern Branch Russian Academy of Sciences Engineering School Far Eastern Federal University State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology School of Resources and Geosciences China University of Mining and Technology Geoscience Australian Museum PANGEA Research Centre School of Biological Earth and Environmental Sciences University of New South Wales

this work focuses on one of the critical points of Earth＇s history when the Solar System passed through the most distant point of its galactic orbit. During this event, Earth may have suffered from maximum extension, associated with its relative proximity to the Sun at that time, followed by long-term contraction related to its later distancing. This paper is based on generalized data on the Cretaceous evolution of the Earth as a whole and of East Asia in particular. The evidence suggests that major geological processes at this time may be interpreted as transitional changes in the state of Earth. A liquid nature of its core may have reacted to the gravitational and electromagnetic transformations. When the cosmic changes took place at 135-120 Ma, more turbulent flows in the outer core would have favoured the rise of voluminous magmatic plumes and associated fluid flows. These would substantially transform the mantle, crust, hydrosphere, biosphere and atmosphere. In particular, plume-related melting of overlying subducting slabs and lower continental crust could have initiated numerous adakitic melts that formed the East Asian Adakitic Province. These and associated juvenile events produced numerous metallic ore, coal, gas and oil deposits. The Cretaceous is one of the most significant resource-producing periods.

关键词： Cretaceous geological evolution galactic orbit super plume adakitic rocks coal ore and petroleum resources

WHAT ARE THE DIFFERENCES OF POLYMER SURFACE RELAXATION FROM THE BULK?

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Chinese Journal of Polymer Science 2011年第1期29卷 81-86页

作者： ian Mann Ryan M.Van Horn Jason J.Ge Matthew J.graham Frank W.Harris Stephen Z.D.Cheng College of Polymer Science and Polymer Engineering Department of Polymer Sciencethe University of Akron

The polymer surface relaxation in thin films has been a long debating issue. We report a new method on studying surface relaxation behaviors of polymer thin films on a solid substrate. This method involved utilizing a rubbed polyimide surface with a pretilting angle in a liquid crystalline cell. Due to the surface alignment, the liquid crystals were aligned along the rubbing direction. During heating the liquid crystalline cell, we continuously monitored the change of orientation of the liquid crystals. It is understood that at a temperature where the orientation of liquid crystal is lost, the surface relaxation on the glass substrate takes place to lose the polyimide surface orientation. It was found that the relaxation temperature at which the liquid crystals lose their orientation depends on the film thickness of the polyimide. A quantitative linear relationship between the relaxation temperature and reciprocal of the film thickness can be observed. Furthermore, different topologies of the rubbed and relaxed thin films were amplified using the polyethylene decoration method and observed using atomic force microscopy.

关键词： Surface relaxation Liquid crystal orientation Polyethylene decoration.

Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy

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World Journal of Gastroenterology 2016年第41期22卷 9104-9116页

作者： Angela C Baird Dominic Mallon graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott ian C Lawrance Meri K Tulic Faculty of Medicine and Dentistry School of Medicine and Pharmacology University of Western Australia Perth WA 6009 Australia Department of Immunology Fremantle Hospital Royal Brisbane and Women’s Hospital Perth WA 6160 Australia Royal Brisbane Queensland 4006 Australia University of Nice Sophia-Antipolis EA6302 06202 Nice France Department of Gastroenterology and Nutrition l’Archet Hospital 2 06202 Nice France School of Paediatrics and Child Health University of Western Australia Subiaco WA 6008 Australia International Inflammation network (in-FLAME) of the World Universities Network University of Western Australia Subiaco WA 6008 Australia Centre for Inflammatory Bowel Diseases St John of God Subiaco Hospital Perth WA 6009 Australia Mediterranean Center for Molecular Medicine (C3M)-INSERM U1065 Team 12 06204 Nice France

AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) *** Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC "responders"(n = 12) and "non-responders"(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with *** Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy

关键词： Ulcerative colitis Innate immunity Antitumor necrosis factor therapy Toll-like receptor IRAK4 Inflammatory bowel disease

Developing Wheat for Improved Yield and Adaptation Under a Changing Climate： Optimization of a Few Key Genes

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Engineering 2018年第4期4卷 514-522页

作者： M.A.N. Nazim Ud Dowl ian Edwards graham O'Hara Shahidul Islam Wujun Ma School of Veterinary and Life Sciences Murdoch University Perth WA 6150 Australia Edstar Genetics Pry. Ltd. Perth WA 6150 Australia

Wheat grown under rain-fed conditions is often affected by drought worldwide. Future projections from a climate simulation model predict that the combined effects of increasing temperature and changing rainfall patterns will aggravate this drought scenario and may significantly reduce wheat yields unless appropriate varieties are adopted. Wheat is adapted to a wide range of environments due to the diversity in its phenology genes. Wheat phenology offers the opportunity to fight against drought by modifying crop developmental phases according to water availability in target environments. This review summa- rizes recent advances in wheat phenology research, including vernalization （Vrn）, photoperiod （Ppd）, and also dwarfing （Rht） genes. The alleles, haplotypes, and copy number variation identified for Vrn and Ppd genes respond differently in different climatic conditions, and thus could alter not only the development phases but also the yield. Compared with the model plant Arabidopsis, more phenology genes have not yet been identified in wheat; quantifying their effects in target environments would benefit the breeding of wheat for improved drought tolerance. Hence, there is scope to maximize yields in water-limited envi-ronments by deploying appropriate phenology gene combinations along with Rht genes and other important physiological traits that are associated with drought resistance.

关键词： Phenology Wheat Vernalization Photoperiod Drought Climate change

Sensing Properties of Femtosecond Laser-Inscribed Long Period Gratings in Photonic Crystal Fiber

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Photonic Sensors 2011年第3期1卷 228-233页

作者： Kyriacos KALLI Tom ALLSOP Kaimin ZHOU graham SMITH Michael KOMODROMOS David WEBB ian BENNION Nanophotonics Research Laboratory Department of Electrical Engineering and Information Technology CyprusUniversity of Technology Limassol 3036 Cyprus photonics Research Group Aston University Birmingham B4 7ET United Kingdom Department of Electrical Engineering Frederick University Filokyprou 7 Nicosia Cyprus

The use of near infrared, high intensity femtosecond laser pulses for the inscription of long period fiber gratings in photonic crystal fiber is reported. The formation of grating structures in photonic crystal fiber is complicated by the fiber structure that allows wave-guidance but that impairs and scatters the femtosecond inscription beam. The effects of symmetric and asymmetric femtosecond laser inscriptions are compared and the polarization characteristics of long period gratings and their responses to external perturbations are reported.

关键词： Fiber gratings femtosecond laser inscription photonic crystal fiber