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How antithymocyte globulin,a polyclonal soup of the past century,when carefully dosed,has become crucial for hematopoietic stem cell transplantation with haplo-identical donors in the 21st century

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Science Bulletin 2021年第24期66卷 2445-2447页

作者： norbert claude gorin Department of Hematology and Cell Therapy Hopital Saint Antoine and Paris Sorbonne UniversityParis 75012France

Hematopoeitic stem cell transplantation(HSCT)using a haploidentical family donor(HAPLO)was long thought to be non-feasible,essentially because of HLA incompatibility leading to graft rejection,severe acute(aGVH)and chronic(cGVH)graft versus host disease(GVH),severe infections and unacceptable nonrelapse mortality(NRM).The group in Perugia in the last decade of the past century[1],was the first to be successful by initiating a positive selection of CD34+cells from peripheral blood stem cell(PBSC)collections,providing T cell depleted grafts with very high doses of CD34+cells to be *** combined with intensive conditioning regimen and profound immunosuppression,the Perugia group obtained the first demonstration of feasibility and *** later improved their results in acute myeloid leukemia(AML)by showing that a mismatch for natural killer(NK)cells in the killer-cell immunoglobulin-like receptor(KIR)-human leukocyte-antigen class I(HLA1)donor to recipient direction[2]decreased considerably the relapse incidence(RI).Unfortunately this approach was associated with severe infections,a high NRM and in addition was cumbersome and difficult to reproduce in other non-expert centers.

关键词：造血干细胞移植 acute doses

A vision for the future of allogeneic hematopoietic stem cell transplantation in the next decade

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Science Bulletin 2022年第19期67卷 1921-1924页

作者： Meng Lv norbert claude gorin Xiao-Jun Huang Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Department of Hematology and Cell Therapy European Society for Blood and Marrow Transplantation Global CommitteeHôpital Saint-Antoine AP-HPParis Sorbonne UniversityParis 75012France Peking-Tsinghua Center for Life Sciences Beijing 100871China

The whole field of hematological malignancies has experienced a huge breakthrough during the past 40 *** methodological progress in cytogenetics(e.g.,fluorescence in situ hybridization,FISH),immunophenotyping(e.g.,multicolor flow cytometers),and molecular biology(with the discovery of numerous tumor molecular markers by polymerase chain reaction and,more recently,next-generation sequencing)has paved the way for the new concept of detecting and monitoring undetectable minimal residual disease(uMRD)and the engineering of multiple new targeted therapies,such as tyrosine kinase inhibitors and various immunotherapies,including monoclonal antibodies combined or not with antitumor agents,bispecific T-cell-engaging(BiTE)antibodies and chimeric antigen receptor T(CAR-T)cells(Supplementary Text 1 online).

关键词： antibodies monoclonal breakthrough

A new species of Crocodile Newt, genus Tylototriton(Amphibia, Caudata, Salamandridae) from the mountains of Kachin State, northern Myanmar

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Zoological Research 2019年第3期40卷 151-174页

作者： Than Zaw Paw Lay Parinya Pawangkhanant Vladislav A.gorin Nikolay A.Poyarkov,Jr Zoology Department Mohnyin Degree CollegeMohnyinKachin StateMyanmar Flora and Fauna International Lon Ton VillageIndawgyiKachin StateMyanmar Bansomdejchaopraya Rajabhat University Hiran RuchiThon BuriBangkok 10600Thailand Department of Vertebrate Zoology Biological FacultyLomonosov Moscow State UniversityMoscow 119234Russia Joint Russian-Vietnamese Tropical Research and Technological Center Nghia DoCau GiayHanoiVietnam

We describe a new species of the genus Tylototriton from Ingyin Taung Mt.,Mohnyin Township,Kachin State,Myanmar,based on morphological and molecular *** new species is assigned to the subgenus Tylototriton *** is clearly distinct from all known congeners by the following characters:medium body size;thin,long tail,lacking lateral grooves;rough skin;truncate snout;wide,protruding supratemporal bony ridges on head,beginning at anterior corner of orbit;weak,almost indistinct sagittal ridge;long,thin limbs,broadly overlapping when adpressed along body;distinct,wide,non-segmented vertebral ridge;13 or 14 rib nodules;brown to darkbrown background coloration with dull orange-brown to yellowish-brown markings on labial regions,parotoids,rib nodules,whole limbs,vent,and ventral tail *** also briefly discuss biogeography and species diversity of the genus Tylototriton in Myanmar.

关键词： Tylototriton kachinorum sp.nov. mtDNA genealogy ND2 16S rRNA Shan Biogeography Endemism Taxonomy

Flexible surface-enhanced Raman scattering-active substrates based on nanofibrous membranes

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Nano Research 2018年第9期11卷 4468-4488页

作者： Ekaterina S. Prikhozhdenko Daniil N. Bratashov Dmitry A. gorin Alexey M. Yashchenok Remote Controlled Theranostic Systems Lab Education and Research Institute of Nanostructures and Biosystems Saratov State University 83 As trakhanskaya Str. Saratov 410012 Russia Skoltech Center for Photonics and Quantum Materials Skolkovo Institute of Science and Technology Skolkovo Innovation Center 3 Nobel Str. Moscow 143026 Russia

Surface-enhanced Raman scattering （SERS） has emerged as an excellent analytical tool for the effective detection and fingerprint identification of various chemicals. Recently, significant progress has been made in the fabrication of SERS-active substrates using simple, inexpensive, and affordable methods. The full potential of universal SERS diagnostics will likely be realized with the development of approaches and devices capable of effectively detecting analytes on various surfaces as well as in multicomponent media. In addition, the combination of implantable or wearable SERS-active substrates and remote portable devices enables real-time diagnostics that ideally fit the concept of personalized medicine. In this paper, we summarize recent achievements in fabricating flexible SERS substrates made of cellulose paper, polymer membranes, and textile fibrous films. Emphasis is placed on the in-situ extraction and detection of various chemicals in real-world surfaces and complex media using flexible nanofibrous SERS platforms. The potential SERS applications and future perspectives in on-site diagnostics are also discussed.

关键词： paper electrospun membrane fabric surface-enhanced Ramanspectroscopy on-site diagnostics swabbing

A new species of Micryletta (Amphibia: Microhylidae) from southern Thailand

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Zoological Research 2020年第5期41卷 581-588页

作者： Chatmongkon Suwannapoom Tan Van Nguyen Parinya Pawangkhanant Vladislav A.gorin Siriwadee Chomdej Jing Che Nikolay A.Poyarkov Division of Fishery School of Agriculture and Natural ResourcesUniversity of PhayaoPhayao 56000Thailand Department of Species Conservation Save Vietnam's Wildlife CenterNinh BinhVietnam Faculty of Biology Department of Vertebrate ZoologyMoscow State UniversityMoscow 119234Russia Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Research Center in Bioresources for Agriculture Industry and MedicineChiang Mai UniversityChiang Mai 50200Thailand State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezin Nay Pyi Taw 05282Myanmar Laboratory of Tropical Ecology Joint Russian-Vietnamese Tropical Research and Technological CenterHanoiVietnam

DEAR EDITOR,We report on a new species,Micryletta dissimulans ***.,from the lowland forests of southern Thailand,which is described based on molecular and morphological *** new species is characterized by a combinatio... 详细信息

关键词： sp.nov. Amphibia new

Counting stripes:revision of the Lipinia vittigera complex(Reptilia, Squamata, Scincidae) with description of two new species from Indochina

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Zoological Research 2019年第5期40卷 358-393页

作者： Nikolay A. Poyarkov Jr. Peter Geissler Vladislav A. gorin Evgeniy A. Dunayev Timo Hartmann Chatmongkon Suwannapoom Department of Vertebrate Zoology Biological Faculty Lomonosov Moscow State University Moscow 119991 Russia Joint Russian-Vietnamese Tropical Research and Technological Center Nghia Do Cau Giay Hanoi Vietnam Museum Natur und Mensch Freiburg 79098 Germany Zoological Museum Moscow State University Moscow 125009 Russia Zoological Research Museum Alexander Koenig Bonn 53113 Germany School of Agriculture and Natural Resources University of Phayao Phayao 56000 Thailand

We provide an integrative taxonomic analysis of the Lipinia vittigera species complex from mainland Southeast Asia. Based on examination of external morphology, color pattern, and 681 base pairs of the cytochrome oxidase subunit I (COI) mitochondrial gene, we demonstrate the presence of four morphologically distinct lineages of Lipinia in Vietnam, Cambodia, Thailand, and Malaysia, showing a sequence divergence ranging 15.5%–20.4%. All discovered lineages are discretely diagnosable from one another by a combination of scalation traits and color patterns. A review of the published distribution data and a re-examination of available type material revealed the following results:(1) distribution of L. vittigera (Boulenger, 1894) sensu stricto is restricted to Sundaland and the Thai-Malay Peninsula south of the Isthmus of Kra;(2) L. microcercus (Boettger, 1901) stat. nov. is elevated to full species rank;the species has a wide distribution from central and southern Vietnam across Cambodia to eastern Thailand;we regard Lygosoma vittigerum kronfanum Smith, 1922 and Leiolopisma pranensis Cochran, 1930 as its junior synonyms;(3) Lipinia trivittata sp. nov. occurs in hilly areas of southern Vietnam, Cambodia, and eastern Thailand;and (4) Lipinia vassilievi sp. nov. is currently known only from a narrow area along the Vietnamese-Cambodian border in the foothills of the central Annamite Mountain Range. We further provide an identification key for Lipinia occurring in mainland Southeast Asia.

关键词： Lipinia microcercus stat. nov. Lipinia trivittata sp. nov. Lipinia vassilievi sp. nov. Vietnam, Thailand, Cambodia Biogeography mtDNA COI-barcoding

Uniqueness Theorem for the Non-Local Ionization Source in Glow Discharge and Hollow Cathode

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Journal of Modern Physics 2012年第10期3卷 1647-1662页

作者： Vladimir V. gorin Kyiv National Taras Shevchenko University Kiev UkraineMoscow Institute of Physics and Technology Moscow Russia

The paper is devoted to the proof of the uniqueness theorem for solution of the equation for the non-local ionization source in a glow discharge and a hollow cathode in general 3D geometry. The theorem is applied to wide class of electric field configurations, and to the walls of discharge volume, which have a property of incomplete absorption of the electrons. Cathode is regarded as interior singular source, which is placed arbitrarily close to the wall. The existence of solution is considered also. During the proof of the theorem many of useful structure formulae are obtained. Elements of the proof structure, which have arisen, are found to have physical sense. It makes clear physical construction of non-local electron avalanche, which builds a source of ionization in glow discharge at low pressures. Last has decisive significance to understand the hollow cathode discharge configuration and the hollow cathode effect.

关键词： Integro-Differential Operator The Fredholm 2-nd Kind Equation Existence and Uniqueness Theorem Nil-potency Glow Discharge Hollow Cathode Non-Local Ionization Non-Local Kinetics

A new species of Nanohyla(Anura:Microhylidae)from the lowland forests of southern Vietnam

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Zoological Research 2023年第4期44卷 732-736页

作者： Vladislav A.gorin Alexey V.Trofimets Svetlana S.Gogoleva Le Xuan Dac Nikolay A.Poyarkov Department of Vertebrate Zoology Lomonosov Moscow State UniversityMoscow 119991Russia Joint Vietnam-Russia Tropical Science and Technology Research Centre Cau GiayHanoi 122000Vietnam A.N.Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscow 119071Russia

DEAR EDITOR,We describe a new species of Nanohyla from the Song Hinh Protected Forest in Phu Yen Province,southern Vietnam,based on an integrative taxonomic *** new species represents a divergent lineage(16S rRNA gene uncorrected P-distance>5.3%),which clearly differs from any other Nanohyla species based on a series of morphological characters,most notably the presence of white spots on the top of its ***,Nanohyla albopunctata *** characterized by small body size(male snout-vent length(SVL)18.2-20.2 mm);moderately slender body habitus;rounded snout;distinct tympanum;rounded canthus rostralis;loreal region slightly concave;skin on dorsum tubercular,ventral surfaces smooth;mid-vertebral skin ridge and dorsomedial stripe absent;superciliary tubercles absent.

关键词： Morphological Vietnam slightly

On the road to Mandalay: contribution to the Microhyla Tschudi, 1838(Amphibia: Anura: Microhylidae) fauna of Myanmar with description of two new species

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Zoological Research 2019年第4期40卷 244-276页

作者： Nikolay A. Poyarkov, Jr Vladislav A. gorin Than Zaw Valentina D. Kretova Svetlana S. Gogoleva Parinya Pawangkhanant Jing Che Department of Vertebrate Zoology Biological FacultyLomonosov Moscow State UniversityMoscow 119234Russia Joint Russian-Vietnamese Tropical Research and Technological Center Nghia DoCau GiayHanoiVietnam Zoology Department Mohnyin Degree CollegeMohnyinKachin State 1111Myanmar A.N. Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscow 119071Russia Zoological Museum of the Lomonosov Moscow State University Moscow 125009Russia Bansomdejchaopraya Rajabhat University Thon BuriBangkok 10600Thailand State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezin Nay Pyi Taw 05282Myanmar

We prese nt a morphological and molecular assessment of the Microhyla fauna of Myanmar based on new collections from central (Magway Division) and northem (Kachin State) parts of the country. In total, six species of Microhyla are documented, including M. berdmorei, M. heymonsi, M. butleri, M. mukhlesuri and two new species described from the semi-arid savarma-like plains of the middle part of the Irrawaddy (Ayeyarwady) River Valley. We used a 2 481 bp long 12S rRNA- 16S rRNA fragment of mtDNA to hypothesize gen ealogical relati on ships within Microhyla. We applied an in teg rati ve taxonomic approach combining molecular, morphological, and acoustic lines of evidenee to evaluate the taxonomic status of Mya nmar Microhyla. We dem on strated that the newly discovered populations of Microhyla sp. from the Magway Division represent two yet undescribed species. These two new sympatric species are assigned to the M. achatina species group, with both adapted to the seas on ally dry environments of the Irrawaddy Valley. Microhyla fodiens sp. nov. is a stout-bodied species with a remarkably enlarged shovel-like outer metatarsal tubercle used for burrowing and is highly diverge nt from other know n congeners (P-distancea8.8%). Microhyla irrawaddy sp. nov. is a small-bodied slender frog reconstructed as a sister species to M. kodial from southern India (P-distance=5.3%);however, it clearly differs from the latter both in external morphology and advertisement call parameters. Microhyla mukhlesuri is reported from Myanmar for the first time. We further discuss the morphological diag no sties and biogeography of Microhyla species recorded in Myanmar.

关键词： Narrow-mouth frogs Burma Indochina Magway Kachin Biodiversity Taxonomy mtDNA Morphology Acoustics Advertisement call