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C3G contributes to platelet activation and aggregation by regulating major signaling pathways

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2103-2117页

作者： Sara Gutiérrez-Herrero Cristina Fernández-Infante Luis Hernández-Cano Sara Ortiz-Rivero Carlos Guijas Víctor Martín-Granado Joséramón gonzález-Porras Jesús Balsinde Almudena Porras Carmen Guerrero Instituto de Biología Molecular y Celular del Cáncer(IMBCC) University of Salamanca-CSICSalamancaSpain Instituto de Investigación Biomédica de Salamanca(IBSAL) SalamancaSpain Instituto de Biología y Genética Molecular(IBGM) Consejo Superior de Investigaciones Científicas(CSIC)University of ValladolidValladolidSpain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) MadridSpain Departamento de Hematologiá Hospital Universitario de Salamanca(HUS)SalamancaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaComplutense University of Madrid.Instituto de Investigación Sanitaria del Hospital Clínico San Carlos(IdISSC)MadridSpain Departamento de Medicina University of SalamancaSalamancaSpain

C3G is a GEF(guanine nucleotide exchange factor)for Rap GTPases,among which the isoform Rap1b is an essential protein in platelet *** transgenic mouse models with platelet-specific overexpression of C3G or mutant C3GΔCat,we have unveiled a new function of C3G in regulating the hemostatic function of platelets through its participation in the thrombin-PKCRap1b pathway.C3G also plays important roles in angiogenesis,tumor growth,and metastasis through its regulation of the platelet *** addition,C3G contributes to megakaryopoiesis and ***,we used a platelet-specific C3G-KO mouse model to further support the role of C3G in hemostasis.C3G-KO platelets showed a significant delay in platelet activation and aggregation as a consequence of the defective activation of Rap1,which resulted in decreased thrombus formation in ***,we explored the contribution of C3G-Rap1b to platelet signaling pathways triggered by thrombin,PMA or ADP,in the referenced transgenic mouse model,through the use of a battery of specific *** found that platelet C3G is phosphorylated at Tyr504 by a mechanism involving *** phosphorylation was shown to be positively regulated by ERKs through their inhibition of the tyrosine phosphatase ***,C3G participates in the ADP-P2Y12-PI3K-Rap1b pathway and is a mediator of thrombin-TXA2 ***,it inhibits the synthesis of TXA2 through cPLA2 *** together,our data reveal the critical role of C3G in the main pathways leading to platelet activation and aggregation through the regulation of Rap1b.

关键词： C3G platelet activation

Evolution of the Socio-cognitive Structure of Knowledge Management(1986–2015): An Author Co-citation Analysis

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Journal of Data and Information Science 2019年第2期4卷 36-55页

作者： Carlos Luis gonzález-Valiente Magda León Santos Ricardo Arencibia-Jorge Biblioteca nacional de Cuba "José Martí" ave.Independencia Facultad de Comunicación Universidad de la Habana San Pedro entre Ermita y Avenida Independencia Empresa de Tecnologías de la Información

Purpose: The evolution of the socio-cognitive structure of the field of knowledge management(KM) during the period 1986–2015 is described. Design/methodology/approach: Records retrieved from Web of Science were submitted to author co-citation analysis(ACA) following a longitudinal perspective as of the following time slices: 1986–1996, 1997–2006, and 2007–2015. The top 10% of most cited first authors by sub-periods were mapped in bibliometric networks in order to interpret the communities formed and their ***: KM is a homogeneous field as indicated by networks results. nine classical authors are identified since they are highly co-cited in each sub-period, highlighting Ikujiro nonaka as the most influential authors in the field. The most significant communities in KM are devoted to strategic management, KM foundations, organisational learning and behaviour, and organisational theories. Major trends in the evolution of the intellectual structure of KM evidence a technological influence in 1986–1996, a strategic influence in 1997–2006, and finally a sociological influence in 2007–*** limitations: Describing a field from a single database can offer biases in terms of output coverage. Likewise, the conference proceedings and books were not used and the analysis was only based on first authors. However, the results obtained can be very useful to understand the evolution of KM *** implications: These results might be useful for managers and academicians to understand the evolution of KM field and to(re)define research activities and organisational ***/value: The novelty of this paper lies in considering ACA as a bibliometric technique to study KM research. In addition, our investigation has a wider time coverage than earlier articles.

关键词： Knowledge management Bibliometrics Author co-citation analysis Knowledge domain visualization Social network analysis Intellectual structure

Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RICA registry

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Journal of Geriatric Cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel Manuel Méndez-Bailón JoséPérez-Silvestre JoséMaría Fernández-rodríguez Beatriz Cuesta García Adrián Argüelles-Curto Álvaro gonzález-Franco Alicia Conde-Martel Sara Carrascosa-García Marta Sánchez-Marteles JoséManuel Cerqueiro-gonzález noel Lorenzo-Villalba Manuel Montero-Pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain Servicio de Medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain Servicio de Medicina Interna Consorcio Hospital General Universitario de ValenciaSpain Servicio de Medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain Servicio de Medicina Interna Hospital Universitario Central de AsturiasOviedoSpain Servicio de Medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain Servicio de Medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de Médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance Servicio de Medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BACKGROUnD Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection *** PIOnEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced nT-proBnP levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and ***-life studies in the elderly population are *** aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(ACEI)in elderly patients who initiate this treatment during hospitalization for acute *** We conducted a retrospective cohort study using the Spanish acute heart failure registry(RICA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with *** One hundred and ninety-nine patients hospitalized between October 2016 and november 2020 were included,with a median age of 82 years and high rate of *** these,107 were treated with sacubitril-valsartan and 92 with *** adjusted OR for readmission for HF at 3 months was 0.906(95%CI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%CI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%CI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%CI:0.325-1.612).COnCLUSIOn Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with ACEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission

Effect of light on seed germination and seedling shape of succulent species from mexico

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Journal of Plant Ecology 2016年第2期9卷 174-179页

作者： Joel Flores Claudia gonzález-Salvatierra Enrique Jurado División de Ciencias Ambientales Instituto Potosino de Investigación Científica y TecnológicaA.C.Camino a la Presa de San José2055Col.Lomas4SecciónSan Luis PotosíSan Luis Potosí78216México Facultad de Ciencias Forestales Universidad Autónoma de Nuevo LeónCarretera Nacionalkm 145LinaresN.L.67700México

Aims Light requirements for cactus seed germination have been considered to be associated with their adult plant height and seed mass,but this has not been thoroughly studied for other succulent *** order to understand seed photosensitivity from desert species belonging to Asparagaceae(subfamily Agavoideae)and Cactaceae,we performed a germination experiment with and without light for 12 species and 2 varieties from 1 species from the Southern Chihuahuan *** also determined if adult growth is totally determined by seedling‘growth form’in *** We performed a germination experiment using light and darkness for 13 species from Southern Chihuahuan Desert:10 rosette species(Asparagaceae),as well as 1 globose,1 columnar and 2 varieties from 1 depressed-globose species(Cactaceae).The response variables were seed germination percentage and relative light germination(RLG).In addition,in order to determine if adult-globose cacti could have cylindrical seedlings,we calculated the shape index(height/width ratio)for Coryphanta clavata and Mammillaria *** Findings All species were considered neutral *** species had similar seed germination in both light and dark conditions,and three taxa(*** and the two varieties of Ferocactus latispinus)showed higher germination with light than without *** salmiana,*** and the two varieties of *** had higher RLG than the other *** mass was an important factor because with higher seed mass there was lower dependence to *** findings support the hypothesis that small seed mass and light requirements have coevolved as an adaptation to ensure *** adult-globose cactus species,***,and one adult-columnar species,***,had small seeds and neutral *** from these two species exposed to light were cylindrical and those under darkness conditions were *** seeds from this species are able to germinate in

关键词： Asparagaceae Cactaceae Chihuahuan Desert photoblasticism seed germination succulent plants

Automated Synthesis of Wideband Bandpass Filters Based on Slow-Wave EBG Structures

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Computers, Materials & Continua 2016年第6期52卷 159-174页

作者： Marco Orellana Jordi Selga Paris Vélez Marc Sans Ana rodríguez Vicente Boria Ferran Martín GEMMA/CIMITEC Departament d’Enginyeria ElectrònicaUniversitat Autònoma de Barcelona08193 Bellaterra(Barcelona)Spain Departamento de Comunicaciones-iTEAM Universitat Politècnica de València46022 ValenciaSpain

This paper is focused on the automated synthesis of wideband bandpass filters operating at microwave frequencies and based on electromagnetic bandgap(EBG)*** classical counterpart of such filter consists of a combination of transmission line sections and shunt-connected grounded stubs placed at equidistant *** replacing the transmission line sections with capacitively-loaded lines(a kind of EBG-based lines)exhibiting the same phase shift at the lower cutoff frequency and the same characteristic(actually Bloch)impedance,filter size is reduced and the spurious pass bands can be efficiently *** practice,the loading capacitances are implemented by means of patches,in order to achieve a fully planar filter *** presence of the patches reduces the effective phase velocity of the capacitively-loaded lines,thus providing a slow-wave effect useful for filter ***,due to periodicity,such EBG-based lines exhibit wide stop bands,which are used for spurious *** though such EBGbased filters were previously reported by some of the authors,a systematic synthesis method was not applied for filter *** this paper,the main aim is to demonstrate the potential of aggressive space mapping(ASM)for that purpose,and it will be shown that such filters can be automatically synthesized.

关键词： Electromagnetic bandgaps(EBG) microwave filters slow-wave transmission lines space mapping.

Fe-dependent cellular alterations of oxidative balance in aquatic *** be ferroptosis involved?

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BIOCELL 2023年第5期47卷 1177-1189页

作者： PAULA MARIELA gonzÁlez JOAQUIn CABRERA SUSAnA PUnTARULO Fisicoquímica Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresC1113 AADArgentina Instituto de Bioquímica y Medicina Molecular(IBIMOL) CONICET-Universidad de Buenos AiresBuenos AiresC1113 AADArgentina

The purpose of this review is to briefly summarize the central role of iron(Fe)in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic *** ferroptotic cells or tissues,the intracellular Fe level increases;meanwhile the treatment with Fe chelators limits *** algae can assimilate Fe from the environment through several mechanisms,and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic *** central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high Fe concentrations could induce oxidative stress and programmed cell *** animals have high levels of polyunsaturated fatty acids and numerous studies have analyzed Fe effects on the lipidic fraction which could be related to *** ferroptosis reaction can be regulated through the antioxidant defense system,in combination with the protein degradation structure,metabolism,and gene *** depletion of nonenzymatic antioxidants like reduced glutathione(GSH)in animals,and the reduction of both GSH and ascorbate in photosynthetic organisms,are characteristic features of ***,ferroptosis can be prevented if Fe chelators,certain antioxidants,and specifically regulating genes are ***,the global scenario for the Fe role as a toxic component in biological systems seems to be even more complicated than it was previously *** more research on this subject is needed to improve the life span and survival of aquatic organisms after exposure to natural and anthropogenic adverse conditions.

关键词： Glutathione Labile Fe pool Lipid peroxidation Oxidative stress

Evaluation of a crop rotation with biological inhibition potential to avoid n_(2)O emissions in comparison with synthetic nitrification inhibition

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Journal of Environmental Sciences 2023年第5期127卷 222-233页

作者： Adrián Bozal-Leorri Mario Corrochano-Monsalve Luis M.Arregui Pedro M.Aparicio-Tejo Carmen gonzález-Murua Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Apdo.644E-48080Bilbao 48940Spain Institute for Innovation and Sustainable Development in Food Chain(ISFOOD) Public University of NavarrePamplona 31006Spain Institute for Multidisciplinary Research in Applied Biology(IMAB) Public University of NavarrePamplona 31006Spain

Agriculture has increased the release of reactive nitrogen to the environment due to crops’low nitrogen-use efficiency(nUE)after the application of *** like the use of stabilized-fertilisers with nitrification inhibitors such as DMPP(3,4-dimethylpyrazole phosphate)have been adopted to reduce nitrogen ***,cover crops can be used in crop-rotation-strategies to reduce soil nitrogen pollution and benefit the following ***(Sorghum bicolor)could be a good candidate as it is drought tolerant and its culture can reduce nitrogen losses derived from nitrification because it exudates biological nitrification inhibitors(BnIs).This work aimed to evaluate the effect of fallow-wheat and sorghum cover crop-wheat rotations on n_(2)O emissions and the grain yield of winter wheat *** addition,the suitability of DMPP addition was also *** use of sorghum as a cover crop might not be a suitable option to mitigate nitrogen losses in the subsequent *** sorghum–wheat rotation was able to reduce 22%the abundance of amoA,it presented an increment of 77%in cumulative n_(2)O emissions compared to fallow–wheat rotation,which was probably related to a greater abundance of heterotrophic-denitrification *** the other hand,the application of DMPP avoided the growth of ammonia-oxidizing bacteria and maintained the n_(2)O emissions at the levels of unfertilized-soils in both *** a conclusion,the use of DMPP would be recommendable regardless of the rotation since it maintains nH_(4)^(+)in the soil for longer and mitigates the impact of the crop residues on nitrogen soil dynamics.

关键词： Fallow Sorghum Crop rotation nitrification inhibitor n-cycling genes Soil mineral nitrogen

High CO_(2)permeation using a new Ce_(0.85)Gd_(0.15)O_(2-δ)-LaniO_(3)composite ceramic–carbonate dual-phase membrane

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Journal of Environmental Sciences 2024年第6期140卷 219-229页

作者： Daniela gonzález-Varela JFrancisco Gómez-García Gustavo Tavizon Heriberto Pfeiffer Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico Departamento de Física y Química Teórica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaDel.CoyoacánCP 04510Ciudad de MéxicoMéxico 不详

This work shows the synthesis,characterization and evaluation of dense-ceramic membranes made of Ce_(0.85)Gd_(0.15)O_(2-δ)-LaniO_(3)(CG-Ln)composites,where the fluorite-perovskite ratio(CG:Ln)was varied as follows:75:25,80:20 and 85:15 wt.%.Supports were initially characterized by XRD,SEM and electrical conductivity(using vacuum and oxygen atmospheres),to determine the composition,microstructural and ionic-electronic conductivity ***,supports were infiltrated with an eutectic carbonates mixture,producing the corresponding dense dual-phase membranes,in which CO_(2)permeation tests were ***,CO_(2)permeation experiments were performed from 900 to 700℃,in the presence and absence of oxygen(flowed in the sweep membrane side).Results showed that these composites possess high CO_(2)permeation properties,where the O_(2)addition significantly improves the ionic conduction on the sweep membrane ***,the GC80-Ln20 composition presented the best results due to the following physicochemical characteristics:high electronic and ionic conductivity,appropriate porosity,interconnected porous channels,as well as thermal and chemical stabilities between the composite support and carbonate phases.

关键词： CO_(2)permeation Doped CeO_(2) LaniO_(3) Impedance Ceramic carbonate membrane

Frontal penetrating arrow injury:A case report

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World Journal of Clinical Cases 2023年第17期11卷 4117-4122页

作者： Alejandra rodríguez-ramos Carlos A Zapata-Castilleja José L Treviño-gonzález Gerardo C Palacios-Saucedo ramón G Sánchez-Cortés Leonor G Hinojosa-Amaya Adriana nieto-Sanjuanero Manuel de la O-Cavazos Department of Pediatrics Hospital Universitario“Dr.JoséEleuterio González”Universidad Autónoma de Nuevo LeónMonterrey 64460Nuevo LeónMexico

BACKGROUnD Penetrating arrow injuries of the head and neck are exceedingly rare in pediatric *** pathology has high morbidity and mortality because of the presence of vital organs,the airway,and large ***,the treatment and removal of an arrow is a challenge that requires multidisciplinary *** SUMMARY A 13-year-old boy was brought to the emergency room after an arrow injury to the frontal *** arrowhead was lodged in the *** studies showed a lesion of the paranasal sinuses without compromising vital *** arrow was successfully removed by retrograde nasoendoscopy without complications,and the patient was *** Although rare,maxillofacial arrow injuries have high morbidity and mortality and require multidisciplinary management to preserve function and aesthetics.

关键词： Arrow Penetrating trauma Maxillofacial injuries Pediatrics Pediatric emergency medicine Case report