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Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： Qi-Hui Jiang Wei-dong gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

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Quantile-based optimization under uncertainties for complex engineering structures using an active learning basis-adaptive PC-Kriging model

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Chinese Journal of Aeronautics 2025年第1期38卷 340-352页

作者： Yulian gong Jianguo ZHANG Dan XU Ying HUANG School of Reliability and Systems Engineering Beihang UniversityBeijing 100191China

The Reliability-Based Design Optimization(RBDO)of complex engineering structures considering uncertainties has problems of being high-dimensional,highly nonlinear,and timeconsuming,which requires a significant amount of sampling simulation *** this paper,a basis-adaptive Polynomial Chaos(PC)-Kriging surrogate model is proposed,in order to relieve the computational burden and enhance the predictive accuracy of a *** active learning basis-adaptive PC-Kriging model is combined with a quantile-based RBDO ***,five engineering cases have been implemented,including a benchmark RBDO problem,three high-dimensional explicit problems,and a high-dimensional implicit *** with Support Vector Regression(SVR),Kriging,and polynomial chaos expansion models,results show that the proposed basis-adaptive PC-Kriging model is more accurate and efficient for RBDO problems of complex engineering structures.

关键词： Reliability-based design optimization Quantile-based Basis-adaptive PC-Kriging Complex engineering structures Active learning Uncertainty

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Why do CuAl catalysts outperform in CO_(2) electro-reduction to C_(2)H_(4)?

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Science China Chemistry 2025年第2期68卷 763-771页

作者： dongfang Cheng gong Zhang Lulu Li Xiangcheng Shi Wenjin Zhu Xintong Yuan Lyudmila Moskaleva Peng Zhang Zhi-Jian Zhao Jinlong gong Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin University Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Tianjin 300072China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207China Department of Chemistry University of the Free StateBloemfontein 9301South Africa Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China National Industry-Education Platform of Energy Storage Tianjin UniversityTianjin 300350China International Joint Laboratory of Low-carbon Chemical Engineering Tianjin 300192China Tianjin Normal University Tianjin 300387China

Highly efficient CO_(2) electroreduction(CO_(2)RR)holds the promise of closing the carbon ***,the strategies for enhancing activity and selectivity for single C2+ products are still *** paper describes the oxophilicity of doped metals on copper(Cu)as a key descriptor for predicting the selectivity in the production of ethylene and ethanol in CO_(2)*** findings reveal a volcano-like relationship between the*O binding energy and catalytic activity,with aluminum(Al)-doped Cu alloys situated at the *** strong Al–O bond facilitates C–O bond cleavage,thereby promoting C_(2)H_(4) *** grand canonical density functional theory(GCDFT)calculations,we elucidate the significance of strong oxygen affinity in enhancing*CO_(2) adsorption,leading to its activation into a bidentate-adsorbed ***,our results demonstrate that Al doping promotes C–C coupling by altering the adsorption mode of the key intermediate *OCCO,shifting it from a less favorable boattype to a more stable chair-type *** modification significantly contributes to the improved catalytic activity for C2+products on CuAl *** research provides a detailed mechanistic insight into the high activity and selectivity observed in CO_(2)RR to ethylene on CuAl catalysts,underscoring the critical role of metal oxophilicity in enhancing CO_(2)RR performance.

关键词： CO_(2)RR dilute alloy descriptor surface oxophilicity

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Dynamic Variation of Vegetation NPP and Its Driving Forces in the Yellow River Basin, China

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Chinese Geographical Science 2025年第1期35卷 24-37页

作者： WANG Shimei MA Yutao gong Jie JIN Tiantian Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Center for Remote Sensing of Ecological Environments in Cold and Arid Regions Lanzhou UniversityLanzhou 730000China

The productivity of vegetation is influenced by both climate change and human *** the specific contributions of these influencing factors is crucial for ecological conservation and regional *** study utilized a combination of multi-source data to examine the spatiotemporal patterns of Net Primary Productivity(NPP)in the Yellow River Basin(YRB),China from 1982 to ***,a scenario-based approach was employed to compare Potential NPP(PNPP)with Actual NPP(ANPP)to determine the relative roles of climatic and human factors in NPP *** PNPP was estimated using the Lund-Potsdam-Jena General Ecosystem Simulator(LPJ-GUESS)model,while ANPP was evaluated by the Carnegie-Ames-Stanford Approach(CASA)model using different NDVI data *** model simulations revealed that significant greening occurring in the YRB,with a gradual decrease observed from southeast to *** to the LPJ_GUESS model simulations,areas experiencing an increasing trend in NPP accounted for 86.82% of the *** using GIMMS and MODIS NDVI data with CASA model simulations,areas showing an increasing trend in NPP accounted for 71.42% and 97.02%,***,both climatic conditions and human factors had positive effects on vegetation restoration;approximated 41.15% of restored vegetation areas were influenced by both climate variation and human activities,while around 31.93% were solely affected by climate ***,it was found that human activities served as the principal driving force of vegetation degradation within the YRB,impacting 26.35% of degraded areas solely due to human ***,effective management strategies encompassing both human activities and climate change adaptation are imperative for facilitating vegetation restoration within this *** findings will valuable for enhancing our understanding in NPP changes and its underlying factors,thereby contributing to improved ecological man

关键词： Net Primary Productivity(NPP) vegetation greening Carnegie-Ames-Stanford Approach(CASA) Lund-Potsdam-Jena General Ecosystem Simulator(LPJ_GUESS) Yellow River Basin(YRB),China

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Gas-Solid Flow,Combustion Characteristics,and Gas Emissions in a 75 t/h CFB Boiler Based on the CPFD Method

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Journal of Thermal Science 2025年第1期34卷 323-336页

作者： HUANG Xiankun BAI Zhang ZHU Xiaoli WANG Shuoshuo MU Lin gong Liang College of New Energy China University of Petroleum(East China)Qingdao 266580China Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education School of Energy and Power EngineeringDalian University of TechnologyDalian 116024China

A 3D simulation using Computational Particle Fluid Dynamics(CPFD)methods was used to calculate coal combustion in a 75 t/h industrial-scale circulating fluidized bed(CFB)*** characteristics,gas-solid flow characteristics,and gaseous pollutant emissions of CFB boilers from combustion ignition to stable operation were systematically evaluated in this *** show that the temperature distribution is relatively uniform throughout the *** the combustion process unfolds within the boiler,the gas composition curve strikingly portrays the inverse correlation between CO_(2)and O_(2)*** the combustion reaction progresses,it becomes evident that the concentration of CO_(2)progressively increases,while the concentration of O_(2)concurrently *** inverse relationship underscores the fundamental combustion reaction,where carbon-based fuels react with oxygen to produce carbon dioxide and release ***,a comprehensive analysis has revealed that,from ignition to stable combustion,both nitric oxide(NO)and sulfur dioxide(SO_(2))emissions exhibit a declining *** reduction in pollutant generation is attributed to the improvement in combustion *** complete combustion leads to lower levels of unburned hydrocarbons,which are prone to NO ***,the sulfur content in the fuel is more efficiently oxidized to sulfur trioxide(SO_(3))or bound in sulfates,reducing SO_(2)*** steady state in the simulation,the SO_(2)mass flow rate varies significantly with the furnace height,gradually increasing from 0.07 kg·s^(-1)at 4 m at the bottom of the furnace to a peak of 0.078 kg·s^(-1)at 8 m in the center,and then decreasing to 0.06 kg·s^(-1)at 20m at the top of the furnace.

关键词： circulating fluidized bed particle flow combustion CPFD modeling

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Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

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Science China(Life Sciences) 2025年第1期68卷 176-188页

作者： Zhiyi Wang Mengxue gong Yuanyuan Fang Huijuan Yuan Chenhong Zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China Department of Endocrinology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003China

The human microbiota-associated(HMA)mice model,especially the germ-free(GF)-humanized mice,has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D).However,most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic *** this study,we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice,and microbiota from each donor were transplanted into 10 *** with similar microbiota structure to the donor exhibited better phenotypic *** characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice,and individuals with a higher proportion of stochastic processes showed more severe *** enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism,and microbiota functional features related to T1D were better reproduced in these *** indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized *** findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

关键词： gut microbiome human microbiota-associated animal model type 1 diabetes

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Metabolomic Changes in Mice Induced by Copper Exposure:Systematic Analysis and Exploration of Toxicity Mechanisms

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Biomedical and Environmental Sciences 2025年第1期38卷 106-118页

作者： Shuai Xiao Linqiang gong Shiyuan Zhao Xue Chu Fengfeng Li Yazhou Zhang Fangqiang Song Pei Jiang Gang ding Shuai Tang Department of Intensive Care Medicine Tengzhou Central People’s HospitalJining Medical UniversityTengzhou 277500ShandongChina Department of Gastroenterology Tengzhou Central People’s HospitalJining Medical UniversityTengzhou 277500ShandongChina Institute of Translational Pharmacy Jining Medical Research AcademyJining 272000ShandongChina Translational Pharmaceutical Laboratory Jining First People’s HospitalShandong First Medical UniversityJining 272000ShandongChina Department of Neurosurgery Tengzhou Central People’s HospitalJining Medical UniversityTengzhou 277500ShandongChina Department of Foot and Ankle Surgery Tengzhou Central People’s HospitalJining Medical UniversityTengzhou 277500ShandongChina 不详

Copper is one of the essential trace elements for living beings,influencing several critical processes like cellular energy production,antioxidant defense,communication within cells,and the functioning of enzymes[1].The daily intake of copper is 0.7−3.0 mg/d,and copper homeostasis is strictly regulated by physiological processes,including duodenal and small intestinal uptake,blood transport,liver storage and release,and bile excretion,thereby maintaining copper homeostasis in the body[2],and many studies have confirmed that copper disorders in the body are associated with neurodegenerative,metabolic,and genetic diseases[3].

关键词： Copper homeostasis thereby

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正则线性凸区域上可微分函数的积分表示

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牡丹江师范学院学报（自然科学版） 2008年第4期34卷 5-6页

作者：龚定东杨邦明浙江理工大学理学院

利用一种改进的方法建立线性凸区域上的无穷次可微分函数的积分表达式.

关键词：线性凸区域函数C^∞ 积分表示

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Methyl Groups Pendant on Triphenylmethane Toward Modulating Thermal Stability and Dielectric Properties of the Crosslinkable Fluorinated Polyimide Films with High Transparency

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Chinese Journal of Polymer Science 2025年第2期43卷 316-327页

作者： Wen Yang Liang Yuan Kai gong Ruo-Han Zhang Lan Lei Hui Li School of Chemistry and Chemical Engineering Shandong Key Laboratory of Fluorine Chemistry and Chemical Engineering MaterialsUniversity of JinanJinan250022China School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China

It is urgent to develop high-performance polyimide(PI)films that simultaneously exhibit high transparency,exceptional thermal stability,mechanical robustness,and low dielectric to fulfil the requirements of flexible display ***,a series of fluorinated polyimide films(FPIs)were fabricated by the condensation of 5,5′-(perfluoropropane-2,2-diyl)bis(isobenzofuran-1,3-dione)(6FDA)and the fluorinated triphenylmethane diamine monomer(EDA,MEDA and DMEDA)with heat-crosslinkable tetrafluorostyrene side groups,which was incorporated by different numbers of methyl groups pendant in the ortho position of amino ***,the FPI films underwent heating to produce crosslinking FPIs(C-FPIs)through the self-crosslinking of double bonds in the *** transparency,solvent resistance,thermal stability,mechanical robustness and dielectric properties of FPI and C-FPI films can be tuned by the number of methyl groups and crosslinking,which were deeply investigated by virtue of molecular dynamics(MD)simulations and density functional theory(DFT).As a result,all the films exhibited exceptional optically colorless and transparent,with transmittance in the visible region of 450-700 nm exceeding 79.9%,and the cut-off wavelengths(λ_(off))were nearly 350 *** thermal decomposition temperatures at 5% weight loss(T_(d5%))for all samples exceeded 504℃.These films exhibited a wide range of tunable tensile strength(46.5-75.1 MPa).Significantly,they showed exceptional dielectric properties with the dielectric constant of 2.3-2.5 at full frequency(10^(7)-20 Hz).This study not only highlights the relationship between the polymer molecular structure and properties,but offer insights for balancing optical transparency,heat resistance and low dielectric constant in PI films.

关键词： Crosslinkable fluorinated polyimide Methyl group Triphenylmethane Transparency Thermal stability Low dielectric constant

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Identifying Three Shapes of Potential Vorticity Streamers Using Mask R-CNN

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Advances in Atmospheric Sciences 2025年第1期42卷 190-203页

作者： Luqiang HAO Zuowei XIE Yuanfa gong Jinfang YIN College of Atmospheric Science Chengdu University of Information TechnologyChengdu 610225China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

Potential vorticity(PV)streamers are elongated filaments of high PV intrusions that generally exhibit three distinct shapes:ordinarily southwestward,hook,and treble-clef,each with significant influences on *** PV streamers are most frequent over arid and semi-arid Central Asia in the mid–high *** study applied the Mask Region-based Convolutional Neural Network algorithm(Mask R-CNN)to PV streamers on the dynamical tropopause during the warm season(May to September)over the years 2000–04 to train a weighted variational model capable of identifying these different *** trained model demonstrated a strong ability to distinguish between the three shapes.A climatological analysis of PV streamers over Central Asia spanning 2000 to 2021 revealed an increasingly deep and pronounced reversal of circulation from ordinary to treble-clef *** treble-clef shape featured a PV tower and distinct cut-off low in the troposphere,but the associated upward motions and precipitation were confined within approximately 1200 km to the east of the PV *** the hook-shape PV streamers were linked to a weaker cut-off low,the extent of upward motion and precipitation was nearly double that of the treble-clef *** contrast,the ordinary PV streamer was primarily associated with tropopause Rossby wave breaking and exhibited relatively shallow characteristics,which resulted in moderate upward motion and precipitation to 500 km to its east.

关键词： Rossby wave breaking potential vorticity streamers Mask-RCNN Central Asia dynamical tropopause

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