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Aberrant FoxM1 expression increases ASPM transcription and promotes progression of gliomas

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中国药理学与毒理学杂志 2019年第10期 892-892页

作者： ZENG Wen-jing WEN zhi-peng gong zhi-cheng CHEN Xiao-ping Department of Clinical Pharmacology Xiangya HospitalCentral South University Institute of Clinical Pharmacology Central South UniversityHunan Key Laboratory of Pharmacogenetics Department of Pharmacy Xiangya HospitalCentral South University

OBJECTIVE Gliomas is the most common form ofmalignant tumorincentral nervous system. However,the molecular mechanism of the tumorigenesis and progression of gliomas remains unclear. METHODS In this study, we used GEO database to identify genes differentially expressed in gliomas and predict the prognosis of glioma. Then we investigated the effects of ASPM on the biological functions of glioma cells, as well as the role of FoxM1 in up-regulating ASPM expression in *** ASPM mRNA was increased obviously in glioma tissue, and higher ASPM mRNA expressionpredicted worse disease prognosis. ASPM was highly expressed in gliomacell lines U87-MG and U251,and knockdown of ASPM expression in these cells significantly repressed the proliferation, migration and invasion ability,and induced G;/G;phase arrest. In addition, downregulation of ASPM suppressed the growth of glioma in nude mice. Five potential binding sites for transcription factor FoxM1 are predicted in the ASPM promoter. FoxM1 overexpression significantly increased the expression of ASPM and promoted the proliferation and migration of glioma cells, which was abolished by ASPM ablation. ChIP and dual luciferase reporter analysis confirmed that FoxM1 bound to the ASPM promoter at-236～-230 bp and-1354～-1348 bp and activated the transcription of ASPM directly. CONCLUSION Our results demonstrated for the first time that FoxM1 can directly activate the expression of ASPM at transcription level, and thereby regulating malignant properties of glioma cells.

关键词： glioma FoxM1 ASPM biomarker

Thickness and sp3 bond modulation of（Ti/tetrahedral amorphous carbon）_n multilayer coatings

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Tungsten 2025年第1期7卷 152-160页

作者： zhi-Jun Xie Jia-Lin Li Ling gong Xiang-Li Zhong Hong-Jia Song Jin-Bin Wang National-Provincial Laboratory of Special Function Thin Film Materials School of Materials Science and Engineering Xiangtan University

The durability of wear-resistant tetrahedral amorphous carbon（ta-C） coatings is intimately linked to their thickness and the concentration of *** enhance the lifespan of the coatings,we have prepared a multilayer coating consisting of alternating layers of Ti and ta-C,denoted as（Ti/ta-C）_n,using arc ion plating.A multi-layer structure in conjunction with stage cooling is employed to enhance the thickness and promote *** results indicate that the ID/IGvalue,representing the ratio of the intensity of the D peak to that of the G peak in Raman spectroscopy,decreases from 0.85 when no stage cooling is applied to 0.35 when stage cooling is employed,suggesting an enhancement in the fraction of sp3bonds within the *** obtained（Ti/ta-C）_n multilayer coating without peeling off has a maximum thickness of 1.14 μm,which is almost double that of the ta-C coating single layer *** the same time,the coating has a low coefficient of friction,down to 0.069,and maintains excellent friction properties with a wear rate of 3.4×10-6mm3·N-1·*** results conclusively show that the preparation technology can enhance both thickness and sp3bonding in ta-C coatings,significantly expanding their utility across tools,molds,and precision engineering components.

关键词： Arc ion plating Multilayer structure sp3 bond Ta-C coating Wear resistance

Adaptive Backstepping Sliding Mode Trajectory Tracking Control for a Quad-rotor

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International Journal of Automation and computing 2012年第5期9卷 555-560页

作者： Xun gong 1 zhi-cheng Hou 1 Chang-Jun Zhao 2 Yue Bai 2 Yan-Tao Tian 1 1 School of Telecommunication Engineering,Jilin University,Changchun 130025,China 2 Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,Changchun 130080,China School of Telecommunication Engineering Jilin University Changchun China Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Changchun China

A quad-rotor aircraft is an under-actuated,strongly coupled nonlinear system with parameter uncertainty and un-modeled *** order to make the aircraft track the desired trajectory,a nested double-loops control system is adopted in this paper.A position error proportional-derivative(PD) controller is designed as the outer-loop controller based on the coupling action between rotational and translational movement,and an adaptive backstepping sliding mode control algorithm is used to stabilize the ***,both the numerical simulation and prototype experiment are utilized to demonstrate the effectiveness of the proposed control system.

关键词： Quad-rotor nested double-loops coupling action adaptive backstepping sliding mode

中国女性卵泡刺激素受体基因多态性与卵巢过度刺激综合征的研究

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中国现代医学杂志 2013年第18期23卷 36-40页

作者：颜元良龚志成中南大学药学院湖南长沙410013 中南大学湘雅医院药学部湖南长沙410008

目的探讨中国汉族人群中FSHR基因307位点和680位点多态性分布与使用卵泡刺激素治疗后产生OHSS反应的关系。方法采用PCR-RFLP,对471例中国汉族人群307位点和680位点的多态性进行分析。结果发生OHSS不良反应人群中307位点TT、TA和AA基因... 详细信息

目的探讨中国汉族人群中FSHR基因307位点和680位点多态性分布与使用卵泡刺激素治疗后产生OHSS反应的关系。方法采用PCR-RFLP,对471例中国汉族人群307位点和680位点的多态性进行分析。结果发生OHSS不良反应人群中307位点TT、TA和AA基因型频率分别为52.73%、40.00%和7.27%,680位点NN、NS和SS基因型频率分别为58.18%、36.36%和5.46%。汉族人群中307位点和680位点基因多态性分布与OHSS发生无统计学意义。结论 FSHR基因307和680位点基因多态性的分布与使用卵泡刺激素后产生OHSS不良反应的关系呈现一定趋势,AA、SS基因型患者OHSS发生率分别相对于其他两组均较低,但无统计学意义。

关键词：卵泡刺激素卵泡刺激素受体基因多态性卵巢过度刺激综合症

Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang gong Hong-Jie Zhang Yan cheng Jianxun Liu Yuhan Ai Yaqin Li zhihui Feng Qiong Zhang Shaolong gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu Liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

选择性激光熔覆钴铬钼合金可摘局部义齿支架的加工精度分析

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上海口腔医学 2020年第6期29卷 596-600页

作者：徐红珍龚志成钟群上海市口腔病防治院永嘉路门诊部上海200031 上海市口腔病防治院修复工艺科上海200031

目的:采用选择性激光熔覆(selective laser melting,SLM)技术制作钴铬钼合金可摘局部义齿(removable partial denture,RPD)支架,评估其加工精度。方法:采用3Shape三维光学扫描仪口外扫描上颌肯氏Ⅰ类牙列缺损石膏模型,将获取的三维形貌... 详细信息

目的:采用选择性激光熔覆(selective laser melting,SLM)技术制作钴铬钼合金可摘局部义齿(removable partial denture,RPD)支架,评估其加工精度。方法:采用3Shape三维光学扫描仪口外扫描上颌肯氏Ⅰ类牙列缺损石膏模型,将获取的三维形貌数据重建为数字化模型。利用3shape设计软件在其上进行RPD支架的计算机辅助(computer aided design,CAD)设计。SLM制作5个钴铬钼RPD支架,扫描各支架,获取三维数据,与原CAD数据进行逆向比对,评估其加工精度。结果:SLM钴铬钼支架在石膏模型上就位顺利,组织面与模型贴合,无翘动。与原模型之间的总体3D偏差值为(0.088±0.021)mm。结论:采用SLM技术打印的钴铬钼合金RPD支架偏差较小,精度较高。

关键词：可摘局部义齿支架选择性激光熔覆钴铬钼合金精度

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对构建服务型政府的思考

天水行政学院学报（哲学社会科学版） 2006年第6期7卷 53-56页

作者：巩志成中共天水市委党校甘肃天水741018

服务型政府的重点在服务,建设服务型政府就要围绕服务做文章,从创新服务理念、建立高效运转的服务机制、完善服务体系等方面入手,构建具有中国特色的服务型政府。

关键词：服务型政府职能转变服务体系

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多光谱遥感卫星图像的精确配准方法研究

信号处理 2013年第10期29卷 1398-1406页

作者：龚志成裴继红谢维信深圳大学ATR国防科技重点实验室广东深圳518060

针对一组多光谱遥感图像中,各谱段图像之间配准不一致的问题,本文提出了一种基于特征点的快速自动配准方法。在图像信息熵的基础上,利用环形移动窗口,自动快速寻找感兴趣区域,并利用尺度不变特征转换(SIFT)算法提取特征。为提高精度,文... 详细信息

针对一组多光谱遥感图像中,各谱段图像之间配准不一致的问题,本文提出了一种基于特征点的快速自动配准方法。在图像信息熵的基础上,利用环形移动窗口,自动快速寻找感兴趣区域,并利用尺度不变特征转换(SIFT)算法提取特征。为提高精度,文中对特征初匹配方法作了改进,并用余弦定理和空间距离约束条件剔除误匹配点,之后提取最稳定的特征点对计算变换参数,完成配准。最后根据配准前后图像的互信息和特征点的均方根误差(RMSE)来衡量配准的程度。通过对大量中巴地球资源卫星拍摄的多光谱图像进行实验,该方法能达到亚像素级配准精度,并能快速对各谱段图像进行配准。

关键词：遥感图像环形移动窗口特征提取图像配准

国内调强放疗联合替莫唑胺化疗治疗恶性脑胶质瘤疗效的Meta分析

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中国临床药理学与治疗学 2015年第1期50卷 64-69页

作者：颜元良钱龙龚志成中南大学湘雅医院药学部

目的:系统评价调强放疗联合TMZ化疗治疗脑恶性胶质瘤的疗效及安全性,为临床治疗决策和临床研究提供参考依据。方法:检索CNKI、CBM、VIP和万方数字化期刊全文数据库,查找国内所有有关调强放疗联合TMZ化疗与单用调强放疗治疗脑恶性胶质瘤... 详细信息

目的:系统评价调强放疗联合TMZ化疗治疗脑恶性胶质瘤的疗效及安全性,为临床治疗决策和临床研究提供参考依据。方法:检索CNKI、CBM、VIP和万方数字化期刊全文数据库,查找国内所有有关调强放疗联合TMZ化疗与单用调强放疗治疗脑恶性胶质瘤的临床对照试验的文献,评价纳入研究质量并进行资料提取。采用RevMan 5.0.23统计软件进行Meta分析。结果:共纳入9篇临床对照试验文献,包括457例患者,220例患者纳入试验组,237患者纳入对照组。Meta分析结果显示:与单用调强放疗相比,调强放疗联合TMZ化疗的临床有效率[OR=3.63,95%CI(2.34,5.62)]、1年生存率[OR=2.39,95%CI(1.50,3.81)]、2年生存率[OR=2.20,95%CI(1.11,4.38)]、3年生存率[OR=2.00,95%CI(0.81,4.94)]差异有统计学意义,调强放疗联合TMZ化疗可明显提高脑恶性胶质瘤疗效。结论:应用调强放疗联合TMZ化疗治疗脑恶性胶质细胞瘤有效,优于单纯的放射治疗,但由于纳入的部分研究质量较低,尚需更多高质量、大样本的随机双盲对照试验进一步证实。

关键词：脑胶质瘤调强放疗替莫唑胺 Meta分析