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Journal of Iron and Steel Research(International) 2024年第2期31卷 442-451页

作者： Guang-hu Liu Mao-xiang Chu Rong-fen gong ze-hao Zheng School of Electronic and Information Engineering University of Science and Technology LiaoningAnshan114051LiaoningChina

Surface defects can affect the quality of steel plate.Many methods based on computer vision are currently applied to surface defect detection of steel plate.However,their real-time performance and object detection of small defect are still unsatisfactory.An improved object detection network based on You Only Look One-level Feature(YOLOF)is proposed to show excellent performance in surface defect detection of steel plate,called DLF-YOLOF.First,the anchor-free detector is used to reduce the network hyperparameters.Secondly,deformable convolution network and local spatial attention module are introduced into the feature extraction network to increase the contextual information in the feature maps.Also,the soft non-maximum suppression is used to improve detection accuracy significantly.Finally,data augmentation is performed for small defect objects during training to improve detection accuracy.Experiments show the average precision and average precision for small objects are 42.7%and 33.5%at a detection speed of 62 frames per second on a single GPU,respectively.This shows that DLF-YOLOF has excellent performance to meet the needs of industrial real-time detection.

关键词： Steel surface defects detection YOLOF Anchor-free detector Small object detection Real-time detection

Fundamentals and application in phytoremediation of an efficient arsenate reducing bacterium Pseudomonas putida ARS1

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Journal of Environmental Sciences 2024年第3期137卷 237-244页

作者： ze-Wen Wang Guang Yang Jian Chen Yaoyu Zhou Avelino Nunez Delgado hui-Ling Cui Gui-Lan Duan Barry P.Rosen Yong-Guan Zhu Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China department of Cellular Biology and pharmacology Florida International UniversityHerbert Wertheim College of MedicineMiamiFL33199USA University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China College of Resources and Environment Hunan Agricultural UniversityChangsha 410128China department of Soil Science and Agricultura Chemistry Engineering Polytechnic SchoolUniversity of Santiago de CompostelaCampus Univ.s/n27002LugoSpain

Arsenic is a ubiquitous environmental pollutant.Microbe-mediated arsenic biotransformations significantly infuence arsenic mobility and toxicity.Arsenic transformations by soil and aquatic organisms have been well documented,while little is known regarding effects due to endophytic bacteria.An endophyte Pseudomonas putida ARS1 was isolated from rice grown in arsenic contaminated soil.P.putida ARS1 shows high tolerance to arsenite(As(Ⅲ))and arsenate(As(V)),and exhibits efficient As(V)reduction and As(Ⅲ)effux activities.When exposed to 0.6 mg/L As(V),As(V)in the medium was completely converted to As(Ⅲ)by P.putida ARS1 within 4 hr.Genome sequencing showed that P.putida ARS1 has two chromosomal arsenic resistance gene clusters(arsRCBH)that contribute to efficient As(V)reduction and As(Ⅲ)effux,and result in high resistance to arsenicals.Wolffia globosa is a strong arsenic accumulator with high potential for arsenic phytoremediation,which takes up As(Ⅲ)more efficiently than As(V).Co-culture of P.putida ARS1 and W.globosa enhanced arsenic accumulation in W.globosa by 69%,and resulted in 91%removal of arsenic(at initial concentration of 0.6 mg/L As(V))from water within 3 days.This study provides a promising strategy for in situ arsenic phytoremediation through the cooperation of plant and endophytic bacterium.

关键词： Arsenic Pseudomonas putida Arsenate reduction Endophyte Wolffia globosa Phytoremediation

Single-atom Rh catalysts for efficiently degrading Rhodamine B with high concentration

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Rare Metals 2024年第5期43卷 2331-2338页

作者： Shou-Yao Hu Jian-Ping Guan Run-ze Ma Yu Tao Dong-Hao Liu Jia-Xin gong Yu Xiong department of Chemistry and Chemical Engineering Central South University

Highly concentrated dye wastewater has a serious effect on the quality of natural waters; thus, developing novel catalysts to degrade dyes rapidly and efficiently is of great significance. For the first time, this study reports an Rh single atom loaded on a nitrogen-doped carbon(SA-Rh/CN) catalyst. This catalyst exhibits an excellent processing capacity for high concentrations of Rhodamine B(Rh B),high catalytic activity(95.7% degradation of Rh B in60 min) and excellent stability(93.5% degradation efficiency after 10 stable runs),

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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng gong Haiying Liang Tingting Chen department of pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be used to treat these disorders. We concluded that

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

苯丁酸氮芥联合伊布替尼对套细胞淋巴瘤Jeko-1细胞株的作用及相关机制

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中国实验血液学杂志 2024年第1期32卷 132-137页

作者：蔡妮娜刘婉艺刘志强龚佳惠林艺玲王泽川黄月琴郭健欣福建医科大学附属第二医院血液科福建泉州362000

目的:探讨苯丁酸氮芥联合伊布替尼对套细胞淋巴瘤Jeko-1细胞株的抑制作用及相关机制。方法:分别将不同浓度的苯丁酸氮芥、伊布替尼单药及两药联合作用于Jeko-1细胞株,采用CCK-8检测细胞增殖情况,同时采用Western blot检测细胞中BCL-2、c... 详细信息

目的:探讨苯丁酸氮芥联合伊布替尼对套细胞淋巴瘤Jeko-1细胞株的抑制作用及相关机制。方法:分别将不同浓度的苯丁酸氮芥、伊布替尼单药及两药联合作用于Jeko-1细胞株,采用CCK-8检测细胞增殖情况,同时采用Western blot检测细胞中BCL-2、caspase-3、PI3K、AKT、P-AKT蛋白表达的变化。结果:分别用苯丁酸氮芥(3.125、6.25、12.5、25、50μmol/L)及伊布替尼(3.125、6.25、12.5、25、50μmol/L)单药处理Jeko-1细胞株24、48和72 h后,细胞增殖均受到抑制,且抑制作用呈时间及剂量依赖性,两药联合时抑制作用更明显(均P<0.05)。与对照组相比,苯丁酸氮芥(3.125、6.25、12.5、25、50μmol/L)及伊布替尼(3.125、6.25、12.5、25、50μmol/L)单药组细胞凋亡率增加,呈剂量依赖性;与相应剂量(3.125、6.25、12.5μmol/L)单药组比较,两药联合应用组Jeko-1细胞株的凋亡率明显增加(均P<0.05)。与单药组相比,两药联合时可产生协同作用,Jeko-1细胞的caspase-3表达明显增强,BCL-2、PI3K、p-AKT/AKT表达明显减弱(均P<0.05)。结论:苯丁酸氮芥及伊布替尼能够促进套细胞淋巴瘤Jeko-1细胞株的凋亡,两药联合应用可以产生协同作用,其主要是通过AKT相关信号通路发挥作用。

关键词：套细胞淋巴瘤苯丁酸氮芥伊布替尼细胞凋亡

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航空发动机进口帽罩结/防冰特性试验研究

科学技术与工程 2024年第9期24卷 3876-3881页

作者：陈竹兵周澎录龚欢王泽宇宋思泽中国航发沈阳发动机研究所强度试验研究室沈阳110015

航空发动机进口帽罩作为发动机重要的进口部件,防冰能力关乎发动机性能甚至影响飞行安全。为了研究航空发动机进口帽罩防冰性能,通过冰风洞对进口帽罩进行结/防冰试验,得到了进口帽罩表面结冰状况随热气流量、来流温度、来流风速的影响... 详细信息

航空发动机进口帽罩作为发动机重要的进口部件,防冰能力关乎发动机性能甚至影响飞行安全。为了研究航空发动机进口帽罩防冰性能,通过冰风洞对进口帽罩进行结/防冰试验,得到了进口帽罩表面结冰状况随热气流量、来流温度、来流风速的影响规律。试验结果表明:进口帽罩防冰能力从尖锥头部到帽罩后端逐渐增强;帽罩防冰能力随热气流量增加而提升;帽罩表面冰型随来流温度、来流风速变化而发生改变;帽罩表面结冰区域随风速增加而扩大。研究成果可以为进口帽罩防冰系统设计和验证提供重要指导。

关键词：航空发动机进口帽罩冰风洞结冰防冰

Chronic pulmonary mucormycosis caused by rhizopus microsporus mimics lung carcinoma in an immunocompetent adult:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3295-3303页

作者： Xing-Zi Guo Liang-hui gong Wen-Xiang Wang De-Song Yang Bai-Hua Zhang ze-Tao Zhou Xiao-hui Yu department of Gynecologic Oncology Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410031Hunan ProvinceChina The Second department of Thoracic Surgery Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410031Hunan ProvinceChina GZMU-GIBH School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436Guangdong ProvinceChina department of Pathology Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410031Hunan ProvinceChina

BACKGROUND Pulmonary mucormycosis is a rare but life-threatening invasive fungal infection that mostly affects immunocompromised patients.This disease usually develops acutely and progresses rapidly,often leading to a poor clinical prognosis.Chronic pulmonary mucormycosis is highly unusual in immunocompetent patients.CASE SUMMARY A 43-year-old man,who was a house improvement worker with a long history of occupational dust exposure,presented with an irritating cough that had lasted for two months.The patient was previously in good health,without dysglycemia or any known immunodeficiencies.Chest computed tomography revealed a mass in the left lower lobe,measuring approximately 6 cm in diameter,which was suspected to be primary lung carcinoma complicated with obstructive pneumonia.Thoracoscopic-assisted left lower lobectomy was performed,and metagenomic next-generation sequencing detection,along with special pathological staining of surgical specimens,suggested Rhizopus microsporus infection.Postoperatively,the patient’s respiratory symptoms were relieved,and no signs of recurrence were found during the six-month follow-up.CONCLUSION This article reports a rare case of chronic pulmonary mucormycosis caused by Rhizopus microsporus in a middle-aged male without dysglycemia or immunodeficiency.The patient’s surgical outcome was excellent,reaffirming that surgery remains the cornerstone of pulmonary mucormycosis treatment.

关键词： Rhizopus microsporus Pulmonary mucormycosis Immunocompetent patient Surgical resection Case report

Combining network pharmacology， molecular docking， and experimental verification to investigate the anti-rheumatoid arthritis effect and mechanism of Baeckea frutescens leaves

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Food Science and Human Wellness 2024年

作者： Xueyang Guo Mengyao Zhang Haixia Cai Xinyue Jiang Siyuan Zhou Wen gong Zijiao Wei Weili Qiao Beixi Jia department of Pharmacognosy School of Pharmaceutical Science Zhengzhou University department of Pharmacy Henan Provincial People's Hospital

The aromatic Baeckea frutescens leaves (BFL) known as “Gang-Song-Cha” is a popular drink (Tea) in South China. To explore the healthcare value， a systematic and in-depth study on BFL alleviating rheumatoid arthritis (RA) was carried out by integrating network pharmacology， molecular docking， and experimental verification. The efficacy was first evaluated， and the BFL extract could ameliorate RA by inhibiting articular swelling， lowering immune organ index， improving the ankle pathologies， and regulating serum levels of TNF-α， IL-6， and IL-10 in CIA rats. Then the anti-RA mechanism of BFL was investigated by leveraging the high-content and active component 5-hydroxy-7-methoxy-2-isopropylchromone (Chro.)， and the potential signaling pathway and related target proteins for Chro. acting on RA were analyzed by KEGG enrichment and docking simulation. Finally， the experimental validations were conducted on RA-FLS cells， and compound Chro. could inhibit cell invasion and migration， block cell cycle at G2/M phase and induce apoptosis， and reduce the secretion of inflammatory cytokines by suppressing the PI3K-Akt pathway. These results provided pharmacological basis for the folk usage of “Gang-Song-Cha (Tea)” for intervening RA.

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不同运动方式对衰老大鼠神经肌肉接头和骨骼肌相关蛋白代谢的影响

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生理学报 2024年第3期76卷 376-384页

作者：苏艳红程翌李婷婷张熠晨杜泽宇陈娟王福清刘忠浩龚文翰辽宁师范大学体育学院大连116029 齐鲁医药学院淄博255300 辽宁师范大学生命科学学院大连116029 大连市大连湾中学大连116033 闽南理工学院体育学院泉州362799

本研究通过对衰老大鼠进行运动训练,探究不同运动方式对神经肌肉接头(neuromuscular junction,NMJ)和骨骼肌相关蛋白代谢的影响及机制。从38只3月龄SPF级Sprague-Dawley(SD)雄性大鼠中随机选出10只作为青年对照组(Y组),其余养至21月龄... 详细信息

本研究通过对衰老大鼠进行运动训练,探究不同运动方式对神经肌肉接头(neuromuscular junction,NMJ)和骨骼肌相关蛋白代谢的影响及机制。从38只3月龄SPF级Sprague-Dawley(SD)雄性大鼠中随机选出10只作为青年对照组(Y组),其余养至21月龄后随机分为老年对照组(O组、8只)、耐力运动组(EN组、10只)、抗阻运动组(R组、10只)。经过相对应的8周训练后,取大鼠腓肠肌,用免疫荧光染色法检测S100B在施旺细胞上的表达水平。用Western blot检测凝集蛋白(Agrin)、低密度脂蛋白受体相关蛋白4(low-density lipoprotein receptor-related protein 4,Lrp4)、肌肉特异性激酶(muscle-specific kinase protein,MuSK)、酪氨酸激酶下游分子7(downstream of tyrosine kinase 7,Dok7)与磷酸化蛋白激酶B(phosphorylated protein kinase B,p-Akt)、磷酸化哺乳动物雷帕霉素靶蛋白(phosphorylated mammalian target of rapamycin,p-mTOR)、磷酸化叉头转录因子1(phosphorylated forkhead box O1,p-FoxO1)蛋白表达水平。结果显示,耐力和抗阻运动均提高衰老大鼠腓肠肌湿重比。R组S100B蛋白表达显著高于O组和EN组;与Y组比较,O组大鼠腓肠肌NMJ功能相关蛋白Agrin、Lrp4、MuSK、Dok7蛋白表达水平显著下调;衰老大鼠经过抗阻运动后,腓肠肌Agrin、Lrp4、MuSK、Dok7蛋白表达水平均显著上调,而衰老大鼠经耐力运动后仅Agrin蛋白表达水平显著上调,而Lrp4、MuSK、Dok7蛋白表达未得到改善。在骨骼肌相关蛋白代谢相关通路中,与Y组比较,O组大鼠腓肠肌p-Akt、p-mTOR蛋白表达水平下调,p-FoxO1蛋白表达水平上升;抗阻和耐力运动可逆转衰老大鼠p-mTOR和p-FoxO1蛋白表达的变化。以上结果表明,两种运动方式均可改善衰老大鼠NMJ功能,并增加骨骼肌蛋白质合成,降低骨骼肌蛋白质分解代谢,且抗阻运动效果更加显著。

关键词：骨骼肌肌肉萎缩神经肌肉接头运动