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Patient-Reported Outcomes of Postoperative NSCLC Patients with or without Staged Chinese Herb Medicine Therapy during Adjuvant Chemotherapy (NALLC 2): A Randomized, Double-Blind, Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第11期30卷 963-973页

作者： ZHANG Yi-lu JIAO Li-jing gong ya-bin XU Jian-fang NI Jian SHEN Xiao-yong ZHANG Jie ZHOU Di QIAN Cheng-xin WANG Qin yaO Jia-lin yaNG Wen-xiao SU Ling-zi WANG Li-yu LI Jia-qi yaO Yi-qin ZHANG Yuan-hui WANG Yi-chao CHEN Zhi-wei XU Ling Oncology Department Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Institute of Traditional Chinese Medicine Oncology Shanghai University of Traditional Chinese MedicineShanghai 201203China Oncology Department Shanghai Pulmonary HospitalShanghai Tongji UniversityShanghai 200433China Thoracic Surgery Department Huadong HospitalShanghai Fudan UniversityShanghai 200040China Thoracic Surgery Department Shanghai Cancer HospitalShanghai Fudan UniversityShanghai 200032China Oncology Department Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China

Objective:To investigate whether the combination of chemotherapy with staged Chinese herbal medicine(CHM) therapy could enhance health-related quality of life(QoL) in non-small-cell lung cancer(NSCLC)patients and prolong the time before deterioration of lung cancer symptoms,in comparison to chemotherapy ***:A prospective,double-blind,randomized,controlled trial was conducted from December 14,2017 to August 28,2020.A total of 180 patients with stage ⅠB-ⅢA NSCLC from 5 hospitals in Shanghai were randomly divided into chemotherapy combined with CHM(chemo+CHM) group(120 cases) or chemotherapy combined with placebo(chemo+placebo) group(60 cases) using stratified blocking *** European Organization for Research and Treatment of Cancer(EORTC) Quality-of-Life-Core 30 Scale(QLQ-C30) was used to evaluate the patient-reported outcomes(PROs) during postoperative adjuvant chemotherapy in patients with early-stage *** events(AEs) were assessed in the safety ***:Out of the total 180 patients,173 patients(116in the chemo+CHM group and 57 in the chemo+placebo group) were included in the PRO *** initial mean QLQ-C30 Global Health Status(GHS)/QoL scores at baseline were 57.16±1.64 and 57.67±2.25 for the two respective groups(P>0.05).Compared with baseline,the chemo+CHM group had an improvement in QLQ-C30GHS/QoL score at week 18 [least squares mean(LSM) change 17.83,95% confidence interval(CI) 14.29 to 21.38].Conversely,the chemo+placebo group had a decrease in the score(LSM change-13.67,95% CI-22.70 to-4.63).A significant between-group difference in the LSM GHS/QoL score was observed,amounting to 31.63 points(95% CI25.61 to 37.64,P<0.001).The similar trends were observed in physical functioning,fatigue and appetite *** week 18,patients in the chemo+CHM group had a higher proportion of improvement or stabilization in GHS/QoL functional and symptom scores compared to chemo+placebo group(P<0.001).The median time to deterioration

关键词： non-small-cell lung cancer adjuvant chemotherapy patient-reported outcome health-related quality of life Chinese herbal medicine

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中医药防治肝癌复发转移的研究进展

中国中医基础医学杂志 2021年第5期27卷 871-875页

作者：姚依勍龚亚斌上海中医药大学附属岳阳中西医结合医院上海200437

原发性肝癌是消化系统常见的恶性肿瘤,伴随着多种相关基因的异常表达。中国作为肝癌发病率最高的国家之一,每年新发病例约占全世界的50%,60岁以下男性人口的发病率和死亡率位居世界第一。本文从作用机制入手,述评了中药防治肝癌复发转... 详细信息

原发性肝癌是消化系统常见的恶性肿瘤,伴随着多种相关基因的异常表达。中国作为肝癌发病率最高的国家之一,每年新发病例约占全世界的50%,60岁以下男性人口的发病率和死亡率位居世界第一。本文从作用机制入手,述评了中药防治肝癌复发转移的最新研究进展。中药防治肝癌复发转移的作用机制主要包括直接细胞毒作用、抑制肝癌细胞的黏附侵袭能力、调控肝癌转移的相关信号通路,以及减毒增效、抗耐药和改善相关症状等其他作用机制,影响癌细胞关键基因的细胞信号通路表达,发挥抑制增殖、诱导凋亡和直接杀伤作用,同时缓解放疗、化疗等其他常用治疗的副作用,增强癌细胞对治疗药物的敏感性,降低耐药发生率,缓解疼痛等与生活质量密切相关的临床症状,从多靶点、多途径、多系统研究作用机制将成为今后中医药防治肝癌复发转移的研究重点。

关键词：肝癌复发转移中药作用机制

The Simulation of Grinding Wheels and Ground Surface Roughness Based on Virtual Reality Technology

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厦门大学学报（自然科学版） 2002年第S1期41卷 29-页

作者： gong ya-dong, WANG bin, WANG Wan-Shan (School of Mechanical Engineering & Automation, Northeastern University, Shenyang 110004, China)

The paper describes the feasibility and method of the application of virtual reality technology to grinding process, and introduces the modeling method of object entity in the environment of virtual reality. The simulation process of grinding wheels and ground surface roughness is discussed, and the computation program system of numerical simulation is compiled with Visual C++ programming language. At the same time, the three-dimensional simulation models of grinding wheels and ground surface roughness are made with OpenGL tool. The choice of grinding wheels, the forecast of ground surface quality and some simulation results can be realized by interactively inputting grinding parameters. The paper applies virtual reality technology to grinding process,makes the model of virtual grinding wheel and simulates the grinding process. The roughness of ground surface is showed in three-dimensional images, and therefore the grinding technology is studied. Computer simulation can not only be used as a shortcut to analyze and research the grinding process, but also increase the research scope and content. The virtual reality technology used in the paper is an advanced visualized simulation with interaction. The surface roughness Ra on simulated ground workpiece can be calculated by the arithmetic average of contour warp absolute value in sampling length of simulated ground workpiece. The parameters of virtual wheel and simulated grinding process can be changed by interaction input, so the simulated results in the desired grinding condition are gained. The effect of each parameter to ground surface can be analyzed by comparing the grinding results in different condition.

关键词： virtual reality simulation ground surface roughness

厌氧发酵+A/O大循环处理生猪养殖粪污工程实例

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中国给水排水 2023年第22期39卷 121-125页

作者：马骏涛于建海宫亚斌杭州能源环境工程有限公司浙江杭州310020 浙江省生物燃料利用技术研究重点实验室浙江杭州310014

中粮家佳康(赤峰)有限公司四期900 m^(3)/d生猪养殖废弃物资源化利用项目,采用“减负还田”的工艺路线,养殖粪污经浓稀分流后,浓液进行厌氧发酵产沼利用,沼液用于灌溉;稀液经UASB+A/O大循环为主的生化处理后,可达到《农田灌溉水质标准》... 详细信息

中粮家佳康(赤峰)有限公司四期900 m^(3)/d生猪养殖废弃物资源化利用项目,采用“减负还田”的工艺路线,养殖粪污经浓稀分流后,浓液进行厌氧发酵产沼利用,沼液用于灌溉;稀液经UASB+A/O大循环为主的生化处理后,可达到《农田灌溉水质标准》(GB 5084—2021)的旱作标准和《畜禽养殖业污染物排放标准》(GB 18596—2001),处理成本约9.25元/m^(3)。该生化工艺具有占地面积小、二次提升能耗低、脱氮除磷效率高的特点,出水水质稳定,可为类似猪粪水处理项目提供参考。

关键词：养殖废水沼气工程 A/O大循环浓稀分流

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30位名中医辨证治疗肺癌经验述要

中医药导报 2018年第10期24卷 49-51页

作者：扈冰龚亚斌上海市闵行区中医医院上海201103 上海中医药大学附属岳阳中西结合医院上海200437

总结30位名中医辨证治疗肺癌的经验,他们注重扶正祛邪、从化痰清热、祛瘀解毒、益气养阴、健脾补肾、疏肝理气等方面治疗,同时注重病理类型阶段、肺肝同调、顾护脾肾;并列举用药特点。

关键词：肺癌名中医经验总结

Cowl Shock-Boundary Layer Interaction in Three Dimensional Compression Scramjet Inlet

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Cowl Shock-Boundary Layer Interaction in Three Dimensional C...

The 4th Across-strait Workshop on Shock Wave/Vortex Interaction

作者： Lian-Jie Yue~*,Peng gong,ya-bin Xiao,Li-Hong Chen,Xin-Yu Chang LHD,Institute of Mechanics,Chinese Academy of Sciences,Beijing,100190,China

The shock-boundary layer interaction and boundary layer separation are frequently encountered phenomena in hypersonic inlet and play a major role in its ***, the flow is more complicate in three-dimensional compression scramjet inlet by there-dimensional shock-shock and shock-boundary layer *** of researches had basically emphasized on the glancing-shock-induced separation and two-dimensional shock separation,which are included in three-dimensional compression ***,the flow in the isolator has not been adequately studied,especially in which the shocks interact with the turbulent boundary layers in a constrained flow.

关键词：

来源： cnki会议评论

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中高温过渡区餐厨垃圾厌氧工程案例分析

中国给水排水 2021年第20期37卷 106-111页

作者：李月中谭婧宫亚斌寿亦丰维尔利环保科技集团股份有限公司江苏常州213125 杭州能源环境工程有限公司浙江杭州310020

厌氧发酵是餐厨垃圾无害化和资源化处理的重要技术手段,而温度是影响厌氧发酵的重要参数。西安市餐厨垃圾资源化利用和无害化处理项目(一期)的厌氧工段采用优化发酵条件,着重介绍了中温和高温过渡区发酵温度为43~45℃时的餐厨垃圾厌氧... 详细信息

厌氧发酵是餐厨垃圾无害化和资源化处理的重要技术手段,而温度是影响厌氧发酵的重要参数。西安市餐厨垃圾资源化利用和无害化处理项目(一期)的厌氧工段采用优化发酵条件,着重介绍了中温和高温过渡区发酵温度为43~45℃时的餐厨垃圾厌氧发酵技术,并对项目稳定运行期的生产数据进行分析总结。结果表明,采用中温和高温过渡区厌氧发酵技术,有机负荷率高,垃圾挥发性固体(VS)产气率达到1170 m^(3)/tVS,全混发酵CSTR发酵装置容积产气率达3.0 m^(3)/(m^(3)·d)以上,取得了良好运行效果。

关键词：餐厨垃圾温度厌氧发酵沼气

电针联合阿片类药物治疗癌性疼痛的临床疗效观察

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中医肿瘤学杂志 2021年第3期3卷 30-35页

作者：杨之泠龚亚斌同济大学附属第十人民医院中医科上海200072 上海中医药大学附属岳阳中西医结合医院肿瘤一科上海200437

目的评价电针联合阿片类药物治疗癌性疼痛的临床疗效。方法将60例患者随机分为对照组和治疗组,每组各30例。对照组单用阿片类药物,治疗组采用阿片类药物联合电针刺激四关、孔最、内关、足三里等穴。观察治疗7天后两组疼痛数字评分量表(N... 详细信息

目的评价电针联合阿片类药物治疗癌性疼痛的临床疗效。方法将60例患者随机分为对照组和治疗组,每组各30例。对照组单用阿片类药物,治疗组采用阿片类药物联合电针刺激四关、孔最、内关、足三里等穴。观察治疗7天后两组疼痛数字评分量表(Numeric Rating Scales,NRS)的评分变化、药物维持剂量变化、爆发痛次数和止痛药物不良反应发生情况。结果两组患者疼痛程度都较治疗前显著降低(P<0.05),治疗组疼痛程度更轻。比较两组治疗前后在NRS评分、爆发痛次数和止痛药物维持剂量的变化,治疗组效果更好,差异有统计学意义。治疗组阿片类药物相关性便秘发生率更低。结论电针联合阿片类药物更能缓解癌性疼痛,并可减少药物相关便秘反应的发生率。

关键词：癌性疼痛阿片电针临床疗效

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肺癌证候研究现状

医学综述 2010年第23期16卷 3580-3582页

作者：龚亚斌徐振晔上海中医药大学附属龙华医院肿瘤科上海200032 青岛市黄岛中医院肿瘤科山东青岛266500

原发性支气管肺癌是全球常见的恶性肿瘤之一,居我国恶性肿瘤死因之首,非小细胞肺癌占全部肺癌的75%～80%。通过对1998～2009年肺癌证候相关研究文献分析、总结可知,目前肺癌中医证候研究主要是中医证候与TNM分期相关性研究、预后相关性... 详细信息

原发性支气管肺癌是全球常见的恶性肿瘤之一,居我国恶性肿瘤死因之首,非小细胞肺癌占全部肺癌的75%～80%。通过对1998～2009年肺癌证候相关研究文献分析、总结可知,目前肺癌中医证候研究主要是中医证候与TNM分期相关性研究、预后相关性研究、病理分型相关性研究、病因病机研究及中医证候规范化研究等。并提出开展肺癌证候的动态变化与预后相关性研究,特别要重视舌象变化在肺癌辨证及预后中的重要性,进一步将现代医学诊疗手段整合到肺癌中医证候的客观化研究。

关键词：肺癌恶性肿瘤中医证候