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Original article Relationship between perinatal characteristics and later activities of daily living in Chinese elderly people

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Chinese Medical Journal 2009年第9期122卷 1015-1019页

作者： XU Tao ZHANG Zhen-xin HAN Shao-mei xiao Xin-hua gong xiao-ming CHEN Xia HU Hong-tao WANG Zi-shi LIU Ai-min Department of Epidemiology and Statistics Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College Beijing 100005 China Department of Neurology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Obstetrics Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Case Registry Office Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Cardiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China

Background There are no reports on the association between perinatal characteristics and comprehensive physical function in Chinese elderly people. In this study, we traced 875 subjects who were born at the Peking Union Medical College Hospital （PUMCH） of China from 1921 to 1941. The purpose of this study was to determine the effects of perinatal characteristics on activities of daily living （ADL） function in the geriatric period.Methods Birth data of 875 subjects were obtained from obstetric birth records of PUMCH. Adulthood data collection was conducted in the outpatient clinics of PUMCH. During the clinic visits, trained research staff administered physical examinations, activities of daily living scale and a demographic questionnaire. ADLs of all subjects were assessed with the activities of daily living scale.Results There were 101 subjects whose ADL function was limited and the rate of ADL limitation was 11.5%. Binary logistic regression analyses results showed that the main influencing factors of ADL were age, maternal age at birth, occupation, daily exercise and chronic disease. Subjects whose maternal age at their birth exceeded 35 years were at 2.202 times （1.188-4.083） greater risk of ADL limitation when we applied multivariate logistic rearession models.Conclusions This study validated the relationship between perinatal characteristics and ADL in the geriatric period. An older maternal age at birth could predict a higher ADL limitation rate in the geriatric period.

关键词： perinatal epidemiology geriatrics activities of daily living physical activity maternal age

Defect detection of light guide plate based on improved YOLOv5 networks

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Optoelectronics Letters 2024年第9期20卷 560-567页

作者： xiao ming gong Yefei WANG Hongding LU mingli GAO Hua School of Electrical Engineering Yancheng Institute of TechnologyYancheng 224007China School of Electrical and Automation Engineering Changshu Institute of TechnologyChangshu 215500China School of Physics and Electronic Engineering Northeast Petroleum UniversityDaqing 163318China Wuxi Novo Automation Technology Corporation Wuxi 214000China

Light guide plate(LGP)is a kind of material used in the backlight *** to improve the quality control of LGP has become the focus of research in the *** address issues such as low gray contrast and a high proportion of small target defects in LGP images,an improved you only look once version 5(YOLOv5)neural network based on multi-scale dilation convolution and a novel loss function is proposed.

关键词： network plate light

Even Search in a Promising Region for Constrained Multi-Objective Optimization

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 474-486页

作者： Fei ming Wenyin gong Yaochu Jin School of Computer Science China University of GeosciencesWuhan 430074China IEEE Faculty of Technology Bielefeld UniversityNorth Rhine-Westphalia 33619Germany School of Engineering Westlake UniversityHangzhou 310030China

In recent years, a large number of approaches to constrained multi-objective optimization problems(CMOPs) have been proposed, focusing on developing tweaked strategies and techniques for handling constraints. However, an overly finetuned strategy or technique might overfit some problem types,resulting in a lack of versatility. In this article, we propose a generic search strategy that performs an even search in a promising region. The promising region, determined by obtained feasible non-dominated solutions, possesses two general ***, the constrained Pareto front(CPF) is included in the promising region. Second, as the number of feasible solutions increases or the convergence performance(i.e., approximation to the CPF) of these solutions improves, the promising region shrinks. Then we develop a new strategy named even search,which utilizes the non-dominated solutions to accelerate convergence and escape from local optima, and the feasible solutions under a constraint relaxation condition to exploit and detect feasible regions. Finally, a diversity measure is adopted to make sure that the individuals in the population evenly cover the valuable areas in the promising region. Experimental results on 45 instances from four benchmark test suites and 14 real-world CMOPs have demonstrated that searching evenly in the promising region can achieve competitive performance and excellent versatility compared to 11 most state-of-the-art methods tailored for CMOPs.

关键词： Constrained multi-objective optimization even search evolutionary algorithms promising region real-world problems

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling xiao Yue gong Ying-Jia Qi Zhi-ming Shao Yi-Zhou Jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

Plasma-assisted ammonia synthesis under mild conditions for hydrogen and electricity storage:Mechanisms,pathways,and application prospects

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Frontiers in Energy 2024年第4期18卷 418-435页

作者： Feng gong Yuhang JING Rui xiao Key Laboratory of Energy Thermal Conversion and Process Measurement and Control of the Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Ammonia,with its high hydrogen storage density of 17.7 wt.%(mass fraction),cleanliness,efficiency,and renewability,presents itself as a promising zero-carbon ***,the traditional Haber−Bosch(H−B)process for ammonia synthesis necessitates high temperature and pressure,resulting in over 420 million tons of carbon dioxide emissions annually,and relies on fossil fuel *** contrast,dielectric barrier discharge(DBD)plasma-assisted ammonia synthesis operates at low temperatures and atmospheric pressures,utilizing nitrogen and hydrogen radicals excited by energetic electrons,offering a potential alternative to the H−B *** method can be effectively coupled with renewable energy sources(such as solar and wind)for environmentally friendly,distributed,and efficient ammonia *** review delves into a comprehensive analysis of the low-temperature DBD plasma-assisted ammonia synthesis technology at atmospheric pressure,covering the reaction pathway,mechanism,and catalyst system involved in plasma nitrogen *** from current research,it evaluates the economic feasibility of the DBD plasmaassisted ammonia synthesis technology,analyzes existing dilemmas and challenges,and provides insights and recommendations for the future of nonthermal plasma ammonia processes.

关键词： plasma catalysis nitrogen fixation ammonia synthesis hydrogen storage catalyst carbon neutralization

Applications of mercury stable isotopes for tracing volcanism in the geologic record

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Science China Earth Sciences 2024年第5期67卷 1436-1458页

作者： Qing gong ming-Xing LING Wang ZHENG State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China School of Earth System Science Institute of Surface-Earth System ScienceTianjin UniversityTianjin 300072China

Mercury(Hg)enrichments in ancient sediments have been used as a proxy of volcanism,especially large igneous province(LIP)***,considering the existence of other potential Hg sources besides volcanoes and the diverse factors(e.g.,organic matters,clay minerals,sulfide minerals and Fe oxides)that can affect Hg sequestration,there are considerable uncertainties to simply regard sedimentary Hg anomalies as signatures of volcanic *** stable isotopes,a promising tool for tracing the origins and transformations of Hg,have been increasingly used for determining the causes of Hg spikes and understanding the geochemical behavior of Hg in the geologic *** date,lots of researches have applied Hg concentrations and Hg isotopes to identify LIP volcanisms linking with significant geological events such as mass extinctions,ocean anoxic events and other environmental perturbations that mainly occurred in the ***,the results in previous studies clearly show that not all Hg enrichments are derived from volcanic inputs,which emphasize the need for more caution in using Hg as a fingerprint of *** a better understanding of Hg isotopes in the future,there will be important implications for Hg isotopes to reconstruct volcanic activities in the rock records and their impacts on biological evolution.

关键词： Mercury stable isotopes Large igneous province Mass extinction event Ocean anoxic event

Constrained Multi-Objective Optimization With Deep Reinforcement Learning Assisted Operator Selection

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 919-931页

作者： Fei ming Wenyin gong Ling Wang Yaochu Jin the School of Computer Science China University of GeosciencesWuhan 430074China the Department of Automation Tsinghua UniversityBeijing 100084China the Faculty of Technology Bielefeld UniversityNorth Rhine-Westphalia33619 BielefeldGermany

Solving constrained multi-objective optimization problems with evolutionary algorithms has attracted considerable *** constrained multi-objective optimization evolutionary algorithms(CMOEAs)have been developed with the use of different algorithmic strategies,evolutionary operators,and constraint-handling *** performance of CMOEAs may be heavily dependent on the operators used,however,it is usually difficult to select suitable operators for the problem at ***,improving operator selection is promising and necessary for *** work proposes an online operator selection framework assisted by Deep Reinforcement *** dynamics of the population,including convergence,diversity,and feasibility,are regarded as the state;the candidate operators are considered as actions;and the improvement of the population state is treated as the *** using a Q-network to learn a policy to estimate the Q-values of all actions,the proposed approach can adaptively select an operator that maximizes the improvement of the population according to the current state and thereby improve the algorithmic *** framework is embedded into four popular CMOEAs and assessed on 42 benchmark *** experimental results reveal that the proposed Deep Reinforcement Learning-assisted operator selection significantly improves the performance of these CMOEAs and the resulting algorithm obtains better versatility compared to nine state-of-the-art CMOEAs.

关键词： Constrained multi-objective optimization deep Qlearning deep reinforcement learning(DRL) evolutionary algorithms evolutionary operator selection

Reactor field reconstruction from sparse and movable sensors using Voronoi tessellation-assisted convolutional neural networks

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Nuclear Science and Techniques 2024年第5期35卷 173-185页

作者： He-Lin gong Han Li Dunhui xiao Sibo Cheng Paris Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai 200240China School of Mathematical Sciences Tongji UniversityShanghai 200092China Department of Computing Data Science InstituteImperial College LondonLondon SW72AZUK

The aging of operational reactors leads to increased mechanical vibrations in the reactor *** vibration of the incore sensors near their nominal locations is a new problem for neutronic field *** field-reconstruction methods fail to handle spatially moving *** this study,we propose a Voronoi tessellation technique in combination with convolutional neural networks to handle this *** from movable in-core sensors were projected onto the same global field structure using Voronoi tessellation,holding the magnitude and location information of the *** convolutional neural networks were used to learn maps from observations to the global *** proposed method reconstructed multi-physics fields(including fast flux,thermal flux,and power rate)using observations from a single field(such as thermal flux).Numerical tests based on the IAEA benchmark demonstrated the potential of the proposed method in practical engineering applications,particularly within an amplitude of 5 cm around the nominal locations,which led to average relative errors below 5% and 10% in the L_(2) and L_(∞)norms,respectively.

关键词： Voronoi tessellation Field reconstruction Nuclear reactors Reactor physics On-line monitoring

Long-lived lunar volcanism sustained by precession-driven core-mantle friction

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National Science Review 2024年第2期11卷 114-123页

作者： Shuoran Yu xiao xiao Shengxia gong Nicola Tosi Jun Huang Doris Breuer Long xiao Dongdong Ni State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology Planetary Science Institute State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences CAS Key Laboratory of Planetary Sciences Shanghai Astronomical Observatory Institute of Planetary Research German Aerospace Centre(DLR)

Core-mantle friction induced by the precession of the Moon's spin axis is a strong heat source in the deep lunar mantle during the early phase of a satellite's evolution, but its influence on the long-term thermal evolution still remains poorly explored. Using a one-dimensional thermal evolution model, we show that core-mantle friction can sustain global-scale partial melting in the upper lunar mantle until ～3.1 Ga, thus accounting for the intense volcanic activity on the Moon before ～3.0 Ga. Besides, core-mantle friction tends to suppress the secular cooling of the lunar core and is unlikely to be an energy source for the long-lived lunar core dynamo. Our model also favours the transition of the Cassini state before the end of the lunar magma ocean phase(～4.2 Ga), which implies a decreasing lunar obliquity over time after the solidification of the lunar magma ocean. Such a trend of lunar obliquity evolution may allow volcanically released water to be buried in the lunar regolith of the polar regions. As a consequence, local water ice could be more abundant than previously thought when considering only its accumulation caused by solar wind and comet spreading.

关键词： Moon precession orbit volcanism