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Chinese Journal of Natural Medicines 2019年第4期17卷 264-274页

作者： gong wen-xia ZHOU Yu-Zhi QIN Xue-Mei DU Guan-Hua Modern Research Center for Traditional Chinese Medicine Shanxi University Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

Atractylenolide Ⅲ(ATL-Ⅲ), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-Ⅲ on corticosterone injured rat phaeochromocytoma(PC12) cells. Our results demonstrate that ATL-Ⅲ increases cell viability and reduces the release of lactate dehydrogenase(LDH). The results suggest that ATL-Ⅲ protects PC12 cells from corticosterone-induced injury by inhibiting the intracellular Ca^(2+) overloading, inhibiting the mitochondrial apoptotic pathway and modulating the MAPK/NF-κB inflammatory pathways. These findings provide a novel insight into the molecular mechanism by which ATL-Ⅲ protected the PC12 cells against corticosterone-induced injury for the first time. Our results provide the evidence that ATL-Ⅲ may serve as a therapeutic agent in the treatment of depression.

关键词： Depression Atractylenolide Ⅲ Corticosterone Apoptosis MAPKs NF-κB

Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model

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World Journal of Gastroenterology 2012年第35期18卷 4934-4943页

作者： Wei-Hong gong wen-xia Zheng Jun Wang Shi-Hui Chen Bo Pang xia-Min Hu xiao-Lu Cao Department of Pharma-cology College of Medicine Wuhan University of Science andTechnology Wuhan 430065 Hubei Province China

AIM:To investigate the correlation of hyperlipemia(HL) and acute cerebral ischemia/reperfusion(I/R) injury on liver damage and its ***:Rats were divided into 4 groups:control,HL,I/R and HL+I/*** the induction of HL via a high-fat diet for 18 wk,middle cerebral artery occlusion was followed by 24 h of reperfusion to capture I/*** alanine transaminase(ALT) and aspartate aminotransferase(AST) were analyzed as part of liver function tests and liver damage was further assessed by histological *** apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling(TUNEL) *** expression of genes related to apoptosis(caspase-3,bcl-2) was assayed by immunohistochemistry and Western *** tumor necrosis factor-(TNF-),interleukin-1(IL-1) and liver mitochondrial superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA) and Ca 2+ levels were measured to determine inflammatory and oxidative/antioxidative status *** hydroxylase activity of the cytochrome P450 2E1(CYP2E1)-containing enzyme was measured with aniline as the substrate,and CYP2E1 expression in the liver tissue and microsome was determined by immunohistochemistry and Western blotting ***:HL alone induced by high-fat diet for 18 wk resulted in liver damage,indicated by histopathological analysis,and a considerable increase in serum ALT(25.13 ± 16.90 vs 9.56 ± 1.99,P < 0.01) and AST levels(18.01 ± 10.00 vs 11.33 ± 4.17,P < 0.05) compared with ***,HL alone induced hepatocyte apoptosis,which was determined by increased TUNEL-positive cells(4.47 ± 0.45 vs 1.5 ± 0.22,P < 0.01),higher caspase-3 and lower bcl-2 ***,compared with those in control,HL or I/R groups,massive increases of serum ALT(93.62 ± 24.00 vs 9.56 ± 1.99,25.13 ± 16.90 or 12.93 ± 6.14,P < 0.01) and AST(82.32 ± 26.92 vs 11.33 ± 4.17,18.01 ± 10.00 or 14.00 ± 6.19,P < 0.01) levels in HL+I/R group were

关键词： Hyperlipidemia High-fat diet Cerebral isch-emia/reperfusion Liver damage Hepatocyte apoptosis Cytochrome P450 2E1

Methyl Groups Pendant on Triphenylmethane Toward Modulating Thermal Stability and Dielectric Properties of the Crosslinkable Fluorinated Polyimide Films with High Transparency

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Chinese Journal of Polymer Science 2025年第2期43卷 316-327页

作者： wen Yang Liang Yuan Kai gong Ruo-Han Zhang Lan Lei Hui Li School of Chemistry and Chemical Engineering Shandong Key Laboratory of Fluorine Chemistry and Chemical Engineering MaterialsUniversity of JinanJinan250022China School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin300350China

It is urgent to develop high-performance polyimide(PI)films that simultaneously exhibit high transparency,exceptional thermal stability,mechanical robustness,and low dielectric to fulfil the requirements of flexible display ***,a series of fluorinated polyimide films(FPIs)were fabricated by the condensation of 5,5′-(perfluoropropane-2,2-diyl)bis(isobenzofuran-1,3-dione)(6FDA)and the fluorinated triphenylmethane diamine monomer(EDA,MEDA and DMEDA)with heat-crosslinkable tetrafluorostyrene side groups,which was incorporated by different numbers of methyl groups pendant in the ortho position of amino ***,the FPI films underwent heating to produce crosslinking FPIs(C-FPIs)through the self-crosslinking of double bonds in the *** transparency,solvent resistance,thermal stability,mechanical robustness and dielectric properties of FPI and C-FPI films can be tuned by the number of methyl groups and crosslinking,which were deeply investigated by virtue of molecular dynamics(MD)simulations and density functional theory(DFT).As a result,all the films exhibited exceptional optically colorless and transparent,with transmittance in the visible region of 450-700 nm exceeding 79.9%,and the cut-off wavelengths(λ_(off))were nearly 350 *** thermal decomposition temperatures at 5% weight loss(T_(d5%))for all samples exceeded 504℃.These films exhibited a wide range of tunable tensile strength(46.5-75.1 MPa).Significantly,they showed exceptional dielectric properties with the dielectric constant of 2.3-2.5 at full frequency(10^(7)-20 Hz).This study not only highlights the relationship between the polymer molecular structure and properties,but offer insights for balancing optical transparency,heat resistance and low dielectric constant in PI films.

关键词： Crosslinkable fluorinated polyimide Methyl group Triphenylmethane Transparency Thermal stability Low dielectric constant

Autophagy serves as a protective effect against inflammatory injury of oxidative stress in ARPE-19 cell

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 28-38页

作者： Na-Na Meng Lei-Zhou xia Yi-Qing gong Pei-Rong Lu Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Ophthalmology Affiliated People’s HospitalJiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Zhenjiang Kangfu Eye Hospital Zhenjiang 212002Jiangsu ProvinceChina Department of General Surgery Affiliated People’s HospitalJiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina

AIM:To test the effect of autophagy on inflammatory damage resulting from oxidative stress in adult retinal pigment epithelial cell line(ARPE-19).METHODS:ARPE-19 cells were pretreated with 200 and 600μmol/L hydrogen peroxide(H_(2)O_(2))at various time *** changes of cell morphology,cell viability,reactive oxygen species(ROS)level,autophagic activity,and the inflammatory cytokines(TNFα,IL-6,and TGFβ)were measured at baseline and after treatment with autophagy inducer rapamycin(Rapa)and suppressor wortmannin(Wort)or ***:The levels of ROS,cytokines(TNFα,IL-6,and TGFβ),and autophagic activity were significantly increased in ARPE-19 cells after pretreated with H2O2(all P<0.05)and IL-10 was significantly decreased(P<0.05).By upregulating autophagy,Rapa significantly reduced oxidative stress-induced secretion of pro-inflammatory factors(TNFα and IL-6)and ROS(all P<0.05),yet elevated the production of TGFβ(P<0.05).In contrast,suppression of autophagy through Wort or ATG5 knockdown reduced cell viability,increased cell apoptotic rate,and exacerbated the generation of ROS and inflammatory cytokines(TNFα,IL-6,and TGFβ;all P<0.05).CONCLUSION:Autophagy demonstrates a protective effect on ARPE-19 cell through mitigating oxidative damage and oxidative stress-induced inflammatory *** of autophagy may be a potential way for agerelated macular degeneration.

关键词： retinal pigment epithelium autophagy reactive oxygen species inflammation

A cross-sectional study of the association between dietary inflammatory index and glaucoma prevalence in a US population

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 139-145页

作者： wen-Li Chen Li-xia Zhang Department of Ophthalmology Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000Zhejiang ProvinceChina Eye Hospital China Academy of Chinese Medical SciencesBeijing 100040China

AIM:To assess the relationship between dietary inflammatory index(DII)and prevalence of glaucoma among individuals aged 40y and above in the United ***:Participants were drawn from 2 cycles of the National Health and Nutrition Examination Survey(NHANES,2005-2008)for a cross-sectional *** was calculated from 24-hour dietary recall questionnaire conducted by experienced researchers and data analyzed in R according to the NHANES user guide,“Stratified Multi-stage Probability Sampling”.The relationship between DII and glaucoma was evaluated by multi-factor logistic regression analysis and the existence of a non-linear association examined by restricted cubic spline(RCS)***:A total of 5359 subjects were included and the cross-sectional analysis weighted to represent the US population of 109 *** was elevated in glaucoma patients(P<0.001)and smoking and alcohol use contributed to significant differences(P<0.001).DII correlated negatively with Healthy Eating Index(HEI)-2015(Spearman rank correlation coefficient,r=-0.49).RCS analysis showed a linear relationship between DII and glaucoma risk(P of non-linear relationship=0.575).CONCLUSION:An increased DII is strongly associated with high risk of glaucoma and diet-induced inflammation should be controlled to delay glaucoma progression.

关键词： glaucoma risk factors dietar y inflammatory index National Health and Nutrition Examination Survey restricted cubic spline regression cross-sectional study

Achieving further refinement of grain structure and improvement of mechanical properties in Al-12Si-4Cu-2Ni-1Mg alloy by Al-Ti-C-B master alloy addition and deep cryogenic treatment

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China Foundry 2025年第1期22卷 75-82页

作者： Lin-fei xia wen-bo Li Zuo-shan Wei Yu-ying Wu xiang-fa Liu China Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China Shandong Key Laboratory of Advanced Aluminum Materials and Technology Binzhou Institute of TechnologyBinzhou 256600ShandongChina

Near-eutectic Al-Si alloys are widely used in automotive manufacturing due to their superior wear resistance and high temperature *** of high Si content,the grain refinement of near-eutectic Al-Si alloy has been a problem for many *** this study,the effect of deep cryogenic treatment(DCT)on the microstructure and mechanical properties of Al-12Si-4Cu-2Ni-Mg alloy with addition of Al-Ti-C-B master alloy was fully *** show that the average grain size of the alloy is greatly reduced from 0.92 mm to 0.50 mm,and the eutectic Si and Al7Cu4Ni precipitates are spheroidized and refined in Al-12Si-4Cu-2Ni-Mg after DCT for 24 h and aging *** these changes of microstructures result in a significant increment of about 22.5%in elongation and a slight enhancement of about 6.8%in tensile ***,the refinement of microstructure also significantly improves the fatigue life of the alloy.

关键词： deep cryogenic treatment near-eutectic Al-Si master alloy microstructure mechanical properties

Neuroprotective effect of isoliquriitin on corticosterone-induced apoptosis in PC12 cells

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中国药理学与毒理学杂志 2017年第5期31卷 467-467页

作者： LI xiao gong wen-xia ZHOU Yu-zhi QIN Xue-mei Modern Research Center for Traditional Chinese Medicine Shanxi University College of Chemistry and Chemical Engineering Shanxi University

OBJECTIVE Isoliquiritin,a flavonoid glycosides compound,possess a broad spectrum of pharmacological activities including antioxidant,antiinflammatory. However,rare studies in the field of isoliquiritin antidepressant-like effects have been carried out,the molecular mechanism also remains unclear. In this study,the model of corticosterone-damaged rat adrenal pheochromocytoma(PC12)cells has been used to generate an in vitro experimental model of depression. The aim was to investigate thecytoprotective efficiency and potential mechanisms of isoliquiritin in corticosterone-damaged PC12 cells. METHODS The cells were treated with 400 μmol·L^(-1)corticosterone in the absence or presence of isoliquiritin for 24 h; cells viability and lactate dehydrogenase(LDH) leakage were then determined,Hoechst 33342/PI and Annexin V/PI double staining were performed to evaluate the cytoprotective efficiency of isoliquiritin. Next,intracellular calcium([Ca^(2+)]_i),mitochondrial membrane potential(MMP),reactive oxygen species(ROS),malondialdehyde(MDA),the activity of superoxide dismutase(SOD)and catalase(CAT),and Western blotting analysed for the expression of Bcl,Bax,caspase-3 and cytochrome C(Cyt-C) were investigated to explore the potential mechanisms. RESULTS The results of the present study showed that pretreatment of PC12 cells with isoliquiritinsignificantly prevented the corticosterone-induced cell apoptosis. In addition,isoliquiritin increased the activity of SOD and CAT,decreased the contents of ROS and MDA. These findings suggest that isoliquiritin provided a protective action against corticosterone-induced celldamage by reducing oxidative stress. Furthermore pretreatmented with isoliquiritin reduced corticosterone-induced mitochondrial dysfunction by preventing mitochondrial membrane potentials *** findings indicated that isoliquiritin might exert its therapeutic effects viaregulating mitochondrial dysfunction. Moreover isoliquiritin strongly attenuated [Ca^(2+)]_i

关键词： isoliquiritin neurotoxicity oxidative stress mitochondria apoptotic calcium

Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO_(2) photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang wen-Jie Shi Yu-Xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Dinuclear metal synergistic catalysis(DMSC)has been proved powerful in boosting CO_(2)reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework(MOF),obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center(M-In),three MOFs with dinuclear homometallic catalytic centers(MM-In),and three MOFs with dinuclear heterometallic catalytic centers(MM’-In,M/M’=Co(II),Ni(II),Zn(II)).It was found that all these MOFs can serve as catalysts for photochemical CO_(2)reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g^(-1)h^(-1),which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO_(2)reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO_(2)reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO_(2)reduction photocatalysis

A single-pixel elemental imaging method using neutron-induced gamma-ray activation

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Nuclear Science and Techniques 2025年第1期36卷 1-12页

作者： Can Cheng Yong-Ji Xie Xun-Rong xia Jia-Yu Gu Dong Zhao Yi-Ze Chen Ai-Yun Sun Xu-wen Liang wen-Bao Jia Da-Qian Hei Department of Ionizing Radiation and Medical Engineering Jiangsu Institute of MetrologyNanjing 210023China Institute of Nuclear Analytical Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China China Nuclear Power Engineering Co. LtdBeijing 100840China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

Neutron-induced gamma-ray imaging is a spectroscopic technique that uses characteristic gamma rays to infer the elemental distribution of an ***,this technique requires the use of large facilities to supply a high neutron flux and a time-consuming detection procedure involving direct collimating *** this study,a new method based on low neutron flux was proposed.A single-pixel gamma-ray detector combined with random pattern gamma-ray masks was used to measure the characteristic gamma rays emitted from the *** of the elemental distribution in the sample,comprising 30×30 pixels,were reconstructed using the maximum-likelihood expectation-maximization *** results demonstrate that the elemental imaging of the sample can be accurately determined using this *** proposed approach,which eliminates the need for high neutron flux and scanning measurements,can be used for in-field imaging applications.

关键词： Elemental imaging Neutron-induced gamma-ray activation Single-pixel imaging

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LR-C半群的半直积

纯粹数学与应用数学 2006年第2期22卷 279-283,288页

作者：宫文霞张玉芬民政部管理干部学院北京101601 山东师范大学数学科学院山东济南250014

给出了两个半群的半直积是LR-C半群的充要条件.

关键词： LR-C半群半直积