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送风方式对辐射供冷系统防结露效果的模拟研究

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制冷与空调（四川） 2022年第2期36卷 203-208,219页

作者：赵英博章文杰贡桐丹周建伟南京理工大学能源与动力工程学院南京210094

辐射供冷空调系统作为一种新型空调技术,相比传统空调系统具有热舒适性好、换热效率高和能耗低等优点,同时也存在辐射表面易结露,供冷能力有限以及初投资过大等问题。针对辐射供冷结露的问题,通过有限元计算软件对贴附射流送风的辐射供... 详细信息

辐射供冷空调系统作为一种新型空调技术,相比传统空调系统具有热舒适性好、换热效率高和能耗低等优点,同时也存在辐射表面易结露,供冷能力有限以及初投资过大等问题。针对辐射供冷结露的问题,通过有限元计算软件对贴附射流送风的辐射供冷系统和普通送风方式下的辐射供冷系统的传热过程进行模拟计算,探究贴附射流对辐射供冷系统的防结露效果。结果表明,在辐射板温度和相关送风参数选择合理且一致的条件下,贴附射流的加入会使贴壁处空气温度整体提高2℃,在出现室内湿负荷突然增大的情况下,贴附射流送风的辐射供冷系统防结露效果比普通送风方式的辐射供冷系统更优。

关键词：辐射供冷贴附射流结露数值模拟能耗分析

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ERRATUM TO:Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival

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Science China(Life Sciences) 2024年第7期67卷 1548-1548页

作者： Jialiang Yang Yuhong Chen tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Ophthalmology and Visual Science Eye and Ear Nose Throat(ENT)HospitalFudan UniversityShanghai 200032China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Chengdu Biology Sichuan Translational Medicine HospitalChinese Academy of SciencesChengdu 610093China Department of Ophthalmology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China

Erratum to:SCIENCE CHINA Life Sciences,Volume 66,Issue 2:211-225(2022),https://***/10.1007/s11427-021-2126-2 This paper contains an error in Figure 4C,where the representative images of filipin staining of retinal sections from 6-month-old mice were misused.We provide the correct picture for Figure 4C as follows.The statistical result in Figure 4D was corrected as well.This new Figure 4 does not affect the conclusion of this article.

关键词： Figure critical conclusion

ERRATUM TO: Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival

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Science China Life Sciences 2024年

作者： Jialiang Yang Yuhong Chen tongdan Zou Bai Xue Fang Yang Xiangzhou Wang Yibo Huo Boyun Yan Yuxia Xu Shiyu He Yi Yin Jing Wang Xiong Zhu Lin Zhang Yu Zhou Zhengfu Tai Ping Shuai Man Yu Qian Luo Yilian Cheng Bo gong Xianjun Zhu Jing Zhang Xinghuai Sun Ying Lin Houbin Zhang Zhenglin Yang Key Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Department of Ophthalmology and Visual Science Eye and Ear Nose Throat (ENT) Hospital Fudan University Institute of Chengdu Biology Sichuan Translational Medicine Hospital Chinese Academy of Sciences School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Erratum to:SCIENCE CHINA Life Sciences, Volume 66, Issue 2:211-225 (2022), https://***/10.1007/s11427-021-2126-2This paper contains an error in Figure 4C, where the representative images of filipin staining of retinal sections from 6-month-old mice were misused.We provide the correct picture for Figure 4C as follows. The statistical result in Figure 4D was corrected as well. This new Figure 4does not affect the conclusion of this article.

关键词：

Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival

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Science China(Life Sciences) 2023年第2期66卷 211-225页

Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1.ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein(HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells(RGCs) by using an artificial intelligence(AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing(scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1-/-retina, as well as activation of the mTORC1 signaling pathway and suppression of autophagy. Treatment of Abca1-/-mice using atorvastatin reduced the cholesterol level in the retina,thereby improving metabolism and protecting RGCs from death. Collectively, we show that lower ABCA1 expression and lower HDL are risk factors for POAG. Accumulated cholesterol in the Abca1-/-retina causes profound aberrant metabolism, leading to a POAG-like phenotype that can be prevented by atorvastatin. Our findings establish statin use as a preventive treatment for POAG associated with lower ABCA1 expression.

关键词： ABCA1 glaucoma retinal ganglion cell HDL cholesterol atorvastatin

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