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Communications in Theoretical Physics 2008年第3期49卷 743-746页

作者： ZHONG Zhi-rong gong Yan-fang SU Wan-Jun Department of Electronic Science and Applied Physics Fuzhou University Fuzhou 350002 China

An alternative scheme is presented to generate arbitrary anticorrelated states of a two-mode field. In the scheme, a sequence of A-type three-level atoms are orderly sent across the cavity to interact with the cavity field initially in the two-mode vacuum state. The detection of all the atoms in the ground state collapses the two-mode field to the desired state. In this way, we can prepare the anticorrelated states of a two-mode field.

关键词： anticorrelated state resonant interaction A-type atom

Quantitative Evaluation of Bioluminescence Imaging Based on Radiative Transfer Equation

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Chinese Journal of Biomedical Engineering(English Edition) 2016年第1期25卷 39-46页

作者： KAN Xing-xing CHEN Chun-xiao gong rong-fang Department of Biomedical Engineering Nanjing University of Aeronautics & Astronautics Department of Mathematics Nanjing University of Aeronautics & Astronautics

B iolum inescence in aghg is a khd ofem erghg detection technology at cellular, m olecu lar and genetic level. The most popular b io lum m inescence in aghg model is diffusion approxin ation （DA）. However, because of the ill-posedness of the D A -based hverse problem and the instability of reconstruction algorithm s, the location accuracy of the reconstucted sources is low. Radiative transfer equation （RTE）, which considers the direction of the photon m igration and the effect of absorption and scattering in tissues, can accurately express the transmission ofbiolum hescent photns through the tissues. In this paper, we studied the biolum hescence inaging based on the RTE. 2D sinuiations were performed, and quantitative evaluation was given by the absolute source position error, the relative source area error and the m h in um bound hg box. The resu Its of the experin ent showed that the in aging quality based on R TE was beer than thatone based on D A.

关键词： biolum inescence in aghg radiative transfer equation disconthuous Galerkinmethod forward problem inverse problem

Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-rong Wu Xiao-Hong He Yong-fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

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Science China Life Sciences 2025年第01期 176-188页

作者： Zhiyi Wang Mengxue gong Yuanyuan fang Huijuan Yuan Chenhong Zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong University Department of Endocrinology Henan Provincial People's HospitalPeople's Hospital of Zhengzhou University

The human microbiota-associated(HMA) mice model, especially the germ-free(GF)-humanized mice, has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D). However, most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic reproducibility. In this study, we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice, and microbiota from each donor were transplanted into 10 mice. Mice with similar microbiota structure to the donor exhibited better phenotypic reproducibility. The characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice, and individuals with a higher proportion of stochastic processes showed more severe disorders. Microbes enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism, and microbiota functional features related to T1D were better reproduced in these mice. This indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized mice. Our findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

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A Non-Marker Mutagenesis Strategy to Generate Poly-hrp Gene Mutants in the Rice Pathogen Xanthomonas oryzae pv. oryzicola

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Agricultural Sciences in China 2011年第8期10卷 1139-1150页

作者： ZOU Li-fang LI Yu-rong CHEN gong-you School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240P.R.China Key Laboratory of Monitoring and Management for Plant Diseases and Insects Ministry of Agriculture/Department of Plant PathologyNanjing Agricultural UniversityNanjing 210095P.R.China

Xanthomonas oryzae *** （Xoc）,the critical pathogen causing bacterial leaf streak in rice,possesses a hrp cluster that is responsible for triggering hypersensitive response （HR） in non-host tobacco and pathogenicity in host rice,and is considered to be one of the model pathogens in the rice model ***,we developed a high-throughput mutagenesis system using a two-step integration mediated by a novel suicide vector *** was used to generate single or poly-gene mutants of hpa1,hpa2,hrcV,hrpE,hpaB,and hrpF gene for functional *** total,five single,four double,and two triple hrp gene mutants were *** double and triple hrp gene deletion mutants triggered novel phenotypes in *** data suggest that pKMS1 is a useful tool for non-marker mutagenesis of multiple genes in Xoc.

关键词： Xanthomonas oryzae pv. oryzicola suicide vector knockout mutagenesis hrp gene

Impact of ventilation design on the precooling effectiveness of horticultural produce-a review

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Food Quality and Safety 2020年第1期4卷 29-40页

作者： Yuhui Cao Ya-fang gong Xin-rong Zhang College of Engineering Sciences University of Chinese Academy of SciencesBeijingChina Department of Energy and Resource Engineering College of EngineeringPeking UniversityBeijingChina

Optimizing the ventilation design of packaging system is of crucial importance for improving the efficiency of the forced-air precooling process to maintain the quality of horticultural produce and extend the shelf life in food cold *** efforts had been devoted to the study about the impact of ventilation design on airflow and temperature distribution inside ventilated *** paper reviews relevant research methods,commonly used quantities for the measurement of precooling effectiveness,attractive design parameters,and their impact on precooling *** allow us to know exactly the characteristic and deficiency of each research method,identify dominant design parameters,and seek a promising way for the future improvement of the ventilated packaging system.

关键词： horticultural produce precooling effectiveness ventilation design forced-air precooling technique packaging system

Design,synthesis and antiproliferative activities of novel 5H-pyridazino[4,5-b]indoles

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Chinese Chemical Letters 2007年第10期18卷 1191-1194页

作者： rong Dong Li Xin Zhai Yan fang Zhao Ping gong School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China School of Pharmacy Hunan University of Traditional Chinese Medicine Changsha 410208 China

A novel series of 5H-pyridazino[4,5-b]indoles were designed and synthesized in order to find novel potent anticancer compounds. The structures were confirmed by ^1H NMR and MS. Their antiproliferative activities against two cancer cell lines were tested by the MTT method in vitro. Three of compounds （1e, 1g, and 1h） exhibited potent antiproliferative activities, especially compound lh （with IC50 values of 5.2 μmol/L and 1.9 μmol/L against Bel-7402 and HT-1080, respectively）. The preliminary structure-activity relationships of 5H-pyridazino[4,5-b]indole derivatives were discussed.

关键词： 5H-pyridazino[4,5-b]indole derivatives Synthesis Antiproliferative activities

Extend ethylene aromatization single-event kinetic modeling with physical and chemical descriptor based on ZSM-5 catalyst

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Petroleum Science 2023年第6期20卷 3841-3853页

作者： Jia-rong Xie fang Jin School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan430205HubeiChina Key Laboratory for Green Chemical Process of Ministry of Education Wuhan Institute of TechnologyWuhan430205HubeiChina Novel Reactor&Green Chemical Technology Key Laboratory Wuhan Institute of TechnologyWuhan430205HubeiChina

The ethylene aromatization is critical for the methanol to aromatics and light alkane dehydroaromatization *** single-event microkinetic(SEMK)model combining the linear free energy theory and solid acid distribution concept were established and extend for the ethylene aromatization process,which can reduce the kinetic parameters and simplify the reaction network by comparison with the SEMK model including subtype elementary steps based on the type of carbenium *** introducing deactivation parametersφinto the model and applying the linear free energy model to the deactivation experimental data,the obtained deactivation parametersφindicate that the carbon deposition precursors have the greatest impact on reducing the reaction rate of single-molecular reactions and the smallest impact on the hydrogen transfer ***,according to the change of reaction enthalpy,effect of carbenium ion structure on methylation,ethylation,cyclization and endo-βscission was investigated by introducing linear free energy concept into the SEMK *** effect of different acid strengths on elementary steps was investigated based on the acid strength distribution model,it was found that the methylation and oligomerization reactions,the ali-βscission reaction,endo-βscission reaction and the cyclization reaction were more sensitive to strong acidity *** physisorption and chemisorption heat are separated from the protonation heat in the linear free energy kinetic model and the acid strength distribution kinetic model,and the absolute values of the obtained physisorption and chemisorption heat increase with the carbon number of carbenium ***,the parameters of the acid strength distribution kinetic model were applied to propane dehydroaromatization on H-ZSM-5 and the ethane dehydroaromatization on Zn/ZSM-5 to confirm the independence of parameters in the SEMK model with the similar reaction network.

关键词： Kinetic model Ethylene aromatization Acid strength distribution Linear free energy theory

Laser-Induced Distortions and Disturbance Propagation of Delocalized Electronic States in Monatomic Carbon Chains

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Chinese Physics Letters 2012年第6期29卷 219-222页

作者： YANG gong-Xian gong Xiu-fang School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048 Dongfang Turbine Co. LtdDeyang 618000

Tight-binding electron-ion dynamics of carbon chains pumped by intense laser pulses are performed to study the interactions between monatomic carbon chains and ***-induced distortions of carbon chains,which are enhanced by a long wavelength laser,are *** carbon chains with a strong laser beam focused on one terminal are simulated to study the disturbance of electronic *** the superposition of delocalized π band states,the disturbance propagates from the illuminated area to the non-illuminated area in a velocity ofabout 106 m/s at 0 K,and this velocity is weakened at room temperature due to the localization effect of thermal fluctuation.

关键词： pumped chains atomic