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A vibration isolator with a controllable quasi-zero stiffness region based on nonlinear force design

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1279-1294页

作者： Xinyu LIAN bing LIU Huaxia DENG Xinglong gong CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern MechanicsUniversity of Science and Technology of ChinaHefei 230027China state Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China state Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

To achieve stability optimization in low-frequency vibration control for precision instruments,this paper presents a quasi-zero stiffness(QZS)vibration isolator with adjustable nonlinear ***,the stress-magnetism coupling model is established through meticulous theoretical *** controllable QZS interval is constructed via parameter design and magnetic control,effectively segregating the high static stiffness bearing section from the QZS vibration isolation ***,a displacement control scheme utilizing a magnetic force is proposed to regulate entry into the QZS working range for the vibration isolation *** results demonstrate that the operation within this QZS region reduces the peak-to-peak acceleration signal by approximately 66.7%compared with the operation outside this region,thereby significantly improving the low frequency performance of the QZS vibration isolator.

关键词： low frequency nonlinear vibration isolator quasi-zero stiffness(QzS)

Remote sensing and geographic information systems in the spatial temporal dynamics modeling of infectious diseases

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Science China(Life Sciences) 2006年第6期49卷 573-582页

作者： gong Peng 1,XU bing 2 & LIANG Song 1、3.1. state Key Laboratory of Remote Sensing Science,Jointly Sponsored by the Institute of Remote Sensing Applications,Chi-nese Academy of Sciences and Beijing Normal {3.,Box 9718,Beijing 100101,China 2. department of Geography,{3. of Utah,Salt Lake City,UT 84112,usa 3. School of Public Health,{3. of California,Berkeley,CA 94720,usa 1. state Key Laboratory of Remote Sensing Science Jointly Sponsored by the Institute of Remote Sensing Applications Chinese Academy of Sciences and Beijing Normal University Box 9718 Beijing 100101 China 2. department of Geography University of Utah Salt Lake City UT 84112 USA 3. School of Public Health University of California Berkeley CA 94720 USA

Similar to species immigration or exotic species invasion,infectious disease transmis-sion is strengthened due to the globalization of human activities. Using schistosomiasis as an exam-ple,we propose a conceptual model simulating the spatio-temporal dynamics of infectious diseases. We base the model on the knowledge of the interrelationship among the source,media,and the hosts of the disease. With the endemics data of schistosomiasis in Xichang,China,we demonstrate that the conceptual model is feasible; we introduce how remote sensing and geographic information systems techniques can be used in support of spatio-temporal modeling; we compare the different effects caused to the entire population when selecting different groups of people for schistosomiasis control. Our work illustrates the importance of such a modeling tool in supporting spatial decisions. Our mod-eling method can be directly applied to such infectious diseases as the plague,lyme disease,and hemorrhagic fever with renal syndrome. The application of remote sensing and geographic informa-tion systems can shed light on the modeling of other infectious disease and invasive species studies.

关键词： spatio-temporal modeling, spatial connectivity, prevention and control of infectious diseases, biological invasion.

Spatial Memory Deficit and Tau Hyperphosphorylation Induced by Inhibiting PP2A in Rat Brain

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Wuhan university Journal of Natural Sciences 2005年第6期 89-93页

作者： TIAN Qing~1,2, ZHENG Hong-yun~1, CHEN Juan~1,LI Hong-lian~1, gong Cheng-xin~3.WANG Jian-zhi~11. Pathophysiology department, Tongji Medical College, Huazhong university of Science and Technology, Wuhan 43.03., Hubei, China 2. Medical College, Huangshi College of Technology, Huangshi 43.003. Hubei,China 3. The New {3. state Institute for Basic Research in Developmental Disabilities, staten Island, New {3. 103.4, usa

Hyperphosphorylation of Tau in Alzheimer’s disease (AD) brain appears to be caused by a down-regulation of protein phosphatase 2A (PP2A). In this study, we selectively inhibited PP2A by injection of okadaic acid (OA) into the Meynert nucleus basalis of rats and found that 0.4 pmol of OA injection induced approximately 60% inhibition of PP2A 24 h after injection, 13. inhibition 48 h after injection and no obvious inhibition 72 h after injection. Hyperphosphorylation of Tau at Ser-198/Ser-199/Ser-202 and Ser-3.6/Ser-404 and spatial memory deficit of rats were induced 24 h after 0.4 pmol of OA injection. This study suggests that a down-regulation of PP2A may underlie abnormal hyperphosphorylation of cytoskeletal proteins leading to neurofibrillary degeneration in AD.

关键词： protein phosphatase 2A Tau Alzheimer’s disease

蛋白磷酸酯酶2A调节微管相关蛋白1b的磷酸化

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生物化学与生物物理进展 2004年第11期31卷 986-990页

作者：王丽岳刁路明田青王建枝龚成新湖北省武汉市第三人民医院武汉大学医学院病理教研室华中科技大学同济医学院病理生理系 department of Neurochemistry New York State Institute for Basic research Staten Island New York 10314 USA

微管相关蛋白MAP1b的生物学活性受其磷酸化修饰的调节 ,后者则受相应的蛋白激酶和蛋白磷酸酯酶(PP)调控 .为研究蛋白磷酸酯酶在脑内对MAP1b磷酸化的调控作用 ,采用有代谢活性的大鼠脑片作为模型 ,分别应用冈田酸 (okadaicacid)和cyclosp... 详细信息

微管相关蛋白MAP1b的生物学活性受其磷酸化修饰的调节 ,后者则受相应的蛋白激酶和蛋白磷酸酯酶(PP)调控 .为研究蛋白磷酸酯酶在脑内对MAP1b磷酸化的调控作用 ,采用有代谢活性的大鼠脑片作为模型 ,分别应用冈田酸 (okadaicacid)和cyclosporinA选择性地抑制PP2A和PP2B活性 ,来研究其对脑内蛋白磷酸酯酶MAP1b磷酸化的调控 .采用特异性的MAP1bⅠ型磷酸化依赖性抗体 5 2 2和免疫印迹技术检测MAP1bⅠ型磷酸化 .结果表明 ,当PP2A被okadaicacid选择性抑制后 ,MAP1bⅠ型磷酸化明显增加 .而PP2B被选择性地抑制后 ,MAP1b磷酸化的变化不大 .免疫组化染色显示 ,MAP1b广泛分布于鼠大脑神经元和突起中 ,与对照组相比 ,在PP2A抑制的脑片中抗体 5 2 2的免疫活性在神经元中明显升高 .上述结果表明 ,PP2A是脑中调控MAP1bⅠ型磷酸化的主要蛋白磷酸酯酶 .

关键词：蛋白磷酸酯酶2A 微管相关蛋白1b 蛋白磷酸化大鼠脑片冈田酸

Ru-Ni alloy nanosheets as tandem catalysts for electrochemical reduction of nitrate to ammonia

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Nano Research 2024年第6期17卷 4815-4824页

作者： Xingchao You Jiawei Xu Zechao Zhuang Junkai Xia Suwen Wang Haiyan Wei Yongfu Li Yanjiang Cai Hai Xiang bing Yu state Key Laboratory of Subtropical Silviculture Zhejiang A&F UniversityHangzhou 311300China Ecological-Environment&Health College(EEHC) Zhejiang A&F UniversityHangzhou 311300China Jiangsu Key Laboratory of Numerical Simulation of Large Scale Complex Systems and School of chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China department of chemistry Tsinghua UniversityBeijing 100084China department of Chemical Engineering Columbia UniversityNew YorkNY 10027USA

Developing electrocatalysts that exhibit both high activity and ammonia selectivity for nitrate reduction is a significant and demanding challenge,primarily due to the complex nature of the multiple-electron reduction process *** encouraging approach involves coupling highly active precious metals with transition metals to enhance catalytic performance through ***,we report a ruthenium-nickel alloy catalyst with nanosheets(Ru-Ni NSs)structure that achieves a remarkable ammonia Faradaic efficiency of approximately 95.93.,alongside a yield rate of up to 6.11 g·h^(−1)·cm^(−2).Moreover,the prepared Ru-Ni NSs exhibit exceptional stability during continuous nitrate reduction in a flow reactor for 100 h,maintaining a Faradaic efficiency of approximately 90%and an ammonia yield of 3..4 mg·L^(−1)·h^(−1)using 0.05 M nitrate alkaline *** studies reveal that the catalytic process follows a two-step pathway,in which HONO serves as a migration *** presence of a partially oxidized Ru(002)surface enhances the adsorption of nitrate and facilitates the release of the migration intermediate by adjusting the strength of the electrostatic and covalent interactions between the adsorbate and the surface,*** the other hand,the Ni(111)surface promotes the utilization of the migration intermediate and requires less energy for NH_(3.*** tandem process contributes to a high catalytic activity of Ru-Ni NSs towards nitrate reduction.

关键词： alloy catalyst nitrate reduction ammonia synthesis Faradaic efficiency

Improving iconic memory through contrast detection training with HOA-corrected vision

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Fundamental Research 2024年第1期4卷 95-102页

作者： Ling gong Junlei Zhao Yun Dai Zili Wang Fang Hou Yudong Zhang Zhong-Lin Lu Jiawei Zhou state Key Laboratory of Ophthalmology Optometry and Vision ScienceEye HospitalSchool of Ophthalmology and OptometryWenzhou Medical UniversityWenzhou 325027China Institute of Optics and Electronics Chinese Academy of SciencesChengdu 610209China The Key Laboratory of Adaptive Optics Chinese Academy of SciencesChengdu 610209China Chengdu university of Traditional Chinese Medicine Chengdu 610075China Division of Arts and Sciences New York University ShanghaiShanghai 200126China Center for Neural Science Department of PsychologyNew York UniversityNew York 10003United States NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai Shanghai 200062China

Iconic memory and short-term memory are not only crucial for perception and cognition,but also of great importance to mental ***,we first showed that both types of memory could be improved by improving limiting processes in visual processing through perceptual *** adults were trained in a contrast detection task for ten days,with their higher-order aberrations(HOA)corrected in *** found that the training improved not only their contrast sensitivity function(CSF),but also their iconic memory and baseline information maintenance for short-term memory,and the relationship between memory and CSF improvements could be well-predicted by an observer *** results suggest that training the limiting component of a cognitive task with visual perceptual learning could improve visual *** may also provide an empirical foundation for new therapies to treat people with poor sensory memory.

关键词： Perceptual learning Iconic memory Higher-order aberrations Contrast sensitivity Short-term memory

Phosphorylation of SC3. regulates the alternative splicing of tau exon 10

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Phosphorylation of SC35 regulates the alternative splicing o...

缺血性脑血管病变组织中葡萄糖转运蛋白1的改变

“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Wei Qian~2,Weihua Wang~1,Xiaomin Yin~2,Cheng-Xin gong~3.Fei Liu~(1,2,3. 1.Jiangsu Key Laboratory of Neuroregeneration 2.department of Biochemistry,Medical School,Nantong {3.,Jiangsu 226001,P.R.China 3.department of Neurochemistry,New york state Institute for Basic Research in Developmental Disabilities,staten Island,NY 103.4, usa.

Background:Abnormal alternative splicing of tau exon 10 results in imbalance of 3.-tau and 4R-tau expression,which is sufficient to cause neurofibrillary *** factor SC3.,a member of the superfamily of the serine/arginine-rich(SR) proteins,promotes tau exon 10 *** function of SC3. is tightly regulated by *** of DyrklA(dual-specificity tyrosine-phosphorylated and regulated kinase 1A) due to trisome in Down syndrome brain may contribute to the dysregulation of tau exon 10 ***1(protein phosphatase 1) dysregulated in Alzheimer’s desease brain is an abundant neuronal serine/threoning ***:By mutation of mini-tau gene,pCI/SI9-SI10 which consists of exons 9,10,11,a part of intron 9 and intron 10 and RNA co-immunoprecipitation(RNA-IP),we elucidated the molecular mechanism by which SC3. works on tau exon 10 splicing and whether and how Dyrk1A or PP1 regulates SC3.-promoted tau exon 10 inclusion in vitro and in cultured ***:We observed that tau pre-mRNA could be precipitated by anti-SC3. *** of the SC3.-like exonic splicing enhancer located at exon 10 of tau affected both the binding of SC3. to tau pre-mRNA and promotion of tau exon 10 inclusion,suggesting that SC3. acts on the SC3.-like exonic splicing enhancer to promote tau exon 10 ***1A interacted with and phosphorylated *** affected the interaction between SC3. and tau pre-mRNA and suppressed SC3.-promoted tau exon 10 ***1 also interacted with SC3. and downregulated the tau exon 10 ***:The phosphorylation of SC3. is regulated by DyrklA or PP1,which may cause dysregulation of tau exon 10 splicing,leading to the imbalance in 3.-tau and 4R-tau expression,which may initiate or accelerate tau pathology.

关键词： tau SC3. alternative splicing

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生物化学与生物物理进展 2010年第4期37卷 397-401页

作者：刘颖江洪白静龚成新武汉大学人民医院心血管内科武汉430060 New york state Institute for Basic Research in Developmental Disabilities NY 10314 USA

葡萄糖通过血脑屏障从血液中进入脑组织必须依赖葡萄糖转运蛋白(glucose transporter,GLUT)的帮助.GLUT1是血脑屏障上最主要的GLUT,也是脑毛细血管壁内皮细胞的分子标记.动物研究显示在急性脑缺血后脑内的GLUT1表达增加.检测了7例慢性... 详细信息

葡萄糖通过血脑屏障从血液中进入脑组织必须依赖葡萄糖转运蛋白(glucose transporter,GLUT)的帮助.GLUT1是血脑屏障上最主要的GLUT,也是脑毛细血管壁内皮细胞的分子标记.动物研究显示在急性脑缺血后脑内的GLUT1表达增加.检测了7例慢性微血管缺血性脑血管病变(ischemic cerebrovascular diseases,ICVD)的尸检脑组织中的GLUT1水平,并与11例同龄对照组比较.结果发现GLUT1水平在ICVD组中降低.其降低可能是由于低氧诱导因子-1α(hypoxia-induciblefactor-1α,HIF-1α)的下调所致.但是,在ICVD脑组织中的GLUT1水平降低不伴随有蛋白质O-GlcNAc糖基化水平的下降.上述结果为探讨脑缺血病变的机理提供了新线索.

关键词：缺血性脑血管病变葡萄糖转运蛋白低氧诱导因子-1α O-GlcNAc糖基化

微小残留病灶在非转移性结直肠癌中的应用研究进展

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中华胃肠外科杂志 2024年第7期27卷 749-755页

作者：曹玓王芳张荣欣魏冰何明彦彭俊杰陈功中山大学肿瘤防治中心结直肠科华南肿瘤学国家重点实验室肿瘤医学省部共建协同创新中心广州510060 中山大学肿瘤防治中心分子诊断科华南肿瘤学国家重点实验室肿瘤医学省部共建协同创新中心广州510060 郑州大学附属肿瘤医院分子病理科郑州450003 中山大学附属肿瘤医院甘肃医院甘肃省肿瘤医院结直肠外科兰州730050 复旦大学附属肿瘤医院大肠外科复旦大学上海医学院肿瘤学系上海200032

近年来,微小残留病灶(MRD)在实体瘤中的应用受到广泛关注,一般是指在接受根治性治疗,如手术切除等手段后影像学无法发现的残留癌灶,术后MRD阳性状态与肿瘤复发风险升高明显相关。在结直肠癌中,循环肿瘤DNA(ctDNA)是评估MRD的有效标志物... 详细信息

近年来,微小残留病灶(MRD)在实体瘤中的应用受到广泛关注,一般是指在接受根治性治疗,如手术切除等手段后影像学无法发现的残留癌灶,术后MRD阳性状态与肿瘤复发风险升高明显相关。在结直肠癌中,循环肿瘤DNA(ctDNA)是评估MRD的有效标志物,其在非转移性(Ⅰ~Ⅲ期)结直肠癌中的应用尤为重要,作为一种实时、准确和便捷的生物标志物,能够有效预警肿瘤复发,指导术后辅助化疗决策,并为复发监测提供重要信息。ctDNA检测技术的应用前景广阔,有望为结直肠癌患者带来更为精准的个体化治疗方案。本文综合分析了ctDNA在检测非转移性结直肠癌患者MRD中的应用进展,详细探讨并梳理了其在临床治疗决策中的指导作用,同时展望了该领域的未来发展方向。

关键词：结直肠肿瘤,非转移性循环肿瘤DNA 微小残留病灶精准医疗