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Extracts of the seaweed Bifurcaria bifurcata display antifungal activity against human dermatophyte fungi

journal of Oceanology and Limnology 2019年第3期37卷 848-854页

作者： CARVALHO G.Loic SILVA Raquel goncalves j.maria BATISTA T.maria PEREIRA Leonel Environmental and Biochemical Sciences Group the James Hutton InstituteDundee DD2 5DAScotlandUK Institute of Mechanical Process and Energy EngineeringSchool of Engineering and Physical SciencesHeriot Watt UniversityEdinburgh EH14 4ASScotlandUK MARE (Marine and Environmental Sciences Centre) Department of Life SciencesFaculty of Sciences and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal CIEPQPF Department of Chemical EngineeringFaculty of Science and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal

Bifurcaria bifurcata is a seaweed of the Order Fucales(Ochrophyta,Phaeophyceae)that can be found all year round along the Portuguese Atlantic *** it is considered edible in some countries,its biotechnological potential has not yet been assessed in detail and here we report its antimicrobial potential against human dermatophyte *** samples were harvested from Baleal Island(Peniche,Portugal)harvested in winter(BbPe);from Aguda Beach(Arcozelo,Vila Nova de Gaia,Portugal),harvested in autumn(BbAg)and a sample obtained by culturing the Aguda sample under laboratory conditions(BbLC).A broth macrodilution assay was applied to determine the MIC(minimum inhibitory concentration)and MLC(minimum lethal concentration)of the *** *** show that the BbPe MeOH extracts were the most effective and had higher antifungal activity against all the tested dermatophyte strains than the BbLC and BaAg extracts[Epidermophyton floccosum FF9(100–200μg/mL MIC;200μg/mL MLC),Microsporum canis FF1(400μg/mL MIC;≥400μg/mL MLC),Trichophyton mentagrophytes FF7(100μg/mL MIC;>800μg/mL MLC),*** CECT 2908(800μg/mL MIC;≥800μg/mL MLC),*** *** CECT 2958(800μg/mL MIC;≥800μg/mL MLC),*** CECT 2794(200μg/mL MIC;≥400μg/mL MLC)].In fact,only *** FF9 was sensitive to BbAg and BbLC MeOH *** our knowledge,this is the first report of antifungal activity of *** against human dermatophyte fungi.

关键词： seaweed Bifurcaria bifurcata bioactivity antifungal dermatophytes minimum inhibitory concentration minimum lethal concentration

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具有非线性刚度边界的杆梁结构的动态特性分析

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振动与冲击 2022年第14期41卷 158-163,232页

作者：许文峰唐斌 BRENNAN Michael j. MANCONI Elisabetta goncalves Paulo j.Paupitz 大连理工大学能源与动力学院辽宁大连116024 圣保罗州立大学工程学院伊利亚索泰拉15385-000 帕尔马大学工程和建筑系帕尔马43100 圣保罗州立大学工程学院巴鲁17033-360

许多工程结构中存在着非线性边界,而非线性边界会对结构振动产生一定的影响。对非线性刚度弹簧固定的杆梁结构进行了动力学特性研究。对于杆结构,分别采用了行波法和分离变量法进行分析,并通过比较得到了两种方法之间的联系。对于梁结构... 详细信息

许多工程结构中存在着非线性边界,而非线性边界会对结构振动产生一定的影响。对非线性刚度弹簧固定的杆梁结构进行了动力学特性研究。对于杆结构,分别采用了行波法和分离变量法进行分析,并通过比较得到了两种方法之间的联系。对于梁结构,分别考虑了入射传递波和入射近场波,应用谐波平衡法得到了无量纲频率、位移、反射系数及相位等参数之间的关系。最后,应用相位闭合原理与分离变量法得到了杆和梁的骨架与频响曲线。为了验证理论计算的准确性与有效性,对杆梁模型进行了有限元数值仿真。结果表明,理论解与仿真解基本吻合。

关键词：非线性边界相位闭合原理谐波平衡法骨架曲线

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Benfotiamine supplementation prevents oxidative stress in anterior tibialis muscle and heart

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journal of Integrative Medicine 2019年第6期17卷 423-429页

作者： Alisson de Carvalho goncalves Einy jéssika Siqueira Moreira Guilherme Vannucchi Portari Laboratory of Experimental Nutrition Health Sciences InstituteFederal University of Triangulo MineiroUberabaMG 38025-440Brazil Department of Nutrition Health Sciences InstituteFederal University of Triangulo MineiroUberabaMG 38025-440Brazil

Objective: This study aimed to evaluate the influence of oral supplementation with benfotiamine on oxidative stress in the liver, heart and muscles of endurance-trained ***: Twenty-five male BALB/c mice were allocated to the following treatment groups: standard diet and sedentary activity(Sta–Sed), benfotiamine–supplemented diet and sedentary activity(Ben–Sed),standard diet and training activity(Sta–Tr) and benfotiamine–supplemented diet and training activity(Ben–Tr). The training comprised 6 weeks of endurance swimming training. The concentration of thiobarbituric acid reactive substances(TBARS), carbonylated proteins, total thiols and non-protein thiols was analyzed in the liver, heart and tibialis anterior ***: In the muscle, TBARS concentration in the Sta–Sed group was higher than that in other groups;in the heart, TBARS concentration in the Sta–Sed and Ben–Tr groups was higher than that in the Ben–Sed group. The carbonyl content of the muscle tissues was higher in the Sta–Sed group than in both supplemented groups. In liver, the carbonyl content was lower in the Ben–Sed group than in the Sta–Sed *** level of total thiols was lower in the Ben–Sed group than in the Sta–Tr group. In the heart, the level of total thiols was higher in the Ben–Sed group than in the Ben–Tr group. The concentration of non-protein thiols in the muscle was higher in the Ben–Sed group than in the Ben–Tr group, whereas in the heart, concentration of non-protein thiols of Sta–Tr group was lower than that of Sta–Sed ***: The results show that benfotiamine is an efficient antioxidant for the anterior tibialis muscle and heart;however, swimming training did not alter redox status.

关键词： Benfotiamine Thiamine Endurance exercise Oxidative stress Vitamins

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Two-Dimensional Metal-Organic Frameworks with Unique Oriented Layers for Oxygen Reduction Reaction:Tailoring the Activity through Exposed Crystal Facets

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CCS Chemistry 2022年第5期4卷 1633-1642页

作者： Yanzhi Wang Tu Sun Amir H.B.Mostaghimi Tiago j.goncalves Zuozhong Liang Yuye Zhou Wei Zhang Zhehao Huang Yanhang Ma Rui Cao Samira Siahrostami Haoquan Zheng Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’an 710119 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210 Department of Chemistry University of CalgaryCalgaryAB T2N 1N4 School of Engineering Sciences in Chemistry Biotechnologyand HealthDepartment of ChemistryDivision of Applied Physical ChemistryAnalytical ChemistryKTH Royal Institute of TechnologySE-10691 Stockholm Department of Materials and Environmental Chemistry Stockholm UniversitySE-10691 Stockholm

As one of the most important families of porous materials,metal–organic frameworks(MOFs)have well-defined atomic *** provides ideal models for investigating and understanding the relationships between structures and catalytic activities at the molecular ***,the active sites on the edges of two-dimensional(2D)MOFs have rarely been studied,as they are less exposed to the ***,for the first time,we synthesized and observed that the 2D layers could align perpendicular to the surface of a 2D zeolitic imidazolate framework L(ZIF-L)with a leaf-like *** to this unique orientation,the active sites on the edges of the 2D crystal structure could mostly be exposed to the ***,when another layer of ZIF-L-Co was grown heteroepitaxially onto ZIF-L-Zn(ZIF-L-Zn@ZIF-L-Co),the two layers shared a common b axis but rotated by 90°in the ac *** demonstrated that we could control exposed facets of the 2D *** ZIF-L-Co with more exposed edge active sites exhibited high electrocatalytic activity for oxygen reduction *** work provides a new concept of designing unique oriented layers in 2D MOFs to expose more edge-active sites for efficient electrocatalysis.

关键词： unique oriented layer two-dimensional material metal-organic framework electrocatalyst oxygen reduction reaction

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Species diversity,population structure and regeneration of woody species in fallows and mature stands of tropical woodlands of southeast Angola

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journal of Forestry Research 2018年第6期29卷 1569-1579页

作者： Francisco M.P.goncalves Rasmus Revermann Manuel j.Cachissapa Amandio L.Gomes Marcos P.M.Aidar Herbarium of Lubango ISCED HuilaSarmento Rodrigues Str.230 LubangoAngola Biocentre Klein Flottbek University of HamburgOhnhorststr.1822609 HamburgGermany Department of Biology Faculty of SciencesAgostinho Neto UniversityAv.4 de Fevereiro 714th FloorLuandaAngola Plant Physiology and Biochemistry Institute of BotanyCP 3005Sao PauloSP CEP:01061-970Brazil

This study in the dry tropical woodlands of SE Angola in Cuando-Cubango Province assessed the diversity and composition of woody species in fallows compared to those in mature woodlands. We assessed the population structure of the most harvested woody species by calculating size class distribution and evaluated their regeneration potential based on the density of saplings. The vegetation was surveyed in 20 plots of 20 × 50 m(1000 m2). In each plot, we measured the diameter at breast height(DBH) of all woody species with DBH ≥ 5 cm. The saplings were counted, identified and recorded; 718 individuals, corresponding to 34 species in 32 genera and 15 families were recorded. The size class distribution of target woody species showed three different patterns in fallows and mature woodlands. In general,most of the smaller diameter classes had more individuals than the larger ones did, showing that the regeneration may take place. However, in some diameter classes, the absence of larger stems indicated selective logging of larger trees. Few saplings were recorded in the fallows or mature woodlands; fire frequency and intensity is probably the main obstacle for seed germination and seedling survival rates in the studied area.

关键词： Baikiaea woodlands Fallows Mature woodlands Regeneration Woody species

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j-F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS jET QUARK GLUON TAGGING

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SC Hemoglobinopathy(HbSC) with Osteoarticular Complications:Case Report

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Health 2017年第7期9卷 1075-1080页

作者： Filipe Bezerra Macedo jucier goncalves júnior Fabiana Gouveia Guimaraes Raphael Cisne Tomaz Débora Valentim Monte Alto Paula Pessoa Pinheiro jácia maria Neves Coelho Department of Pediatric Hospital Maternidade Sao Vicente de Paulo(HMSVP)BarbalhaBrazil School of Medicine Federal University of Cariri(UFCA)BarbalhaBrazil Residence in Pediatrics Federal University of Cariri(UFCA)BarbalhaBrazil

Background: Among hemoglobinopathies, the most prevalent in our population are hemoglobins S and C, which are capable of producing disease when homozygous. In cases of double heterozygotes with sickle hemoglobin C (SC), the disease is less expressive in its clinical condition and rarer. Case report: Patient has a previous hospitalization with pain in the joints in knee and hip and several febrile peaks. Upon physical examination, the patient had difficulty in walking, without edema, pedal and tibial posterior pulses present, with no signs of compartment syndrome. Complementary exams revealed anemia, leukocytosis and lymphopenia. The hemoglobin electrophoresis showed the SC Hemoglobinopathy. The treatment with antibiotic therapy according to the protocol (Oxacillin and Ceftriaxone) was restarted and submitted to joint drainage in affected limb. Conclusion: Osteomyelitis and septic arthritis in patients in the pediatric age group should be considered as serious infections that deserve hospitalization and more expressive treatment.

关键词： SC Hemoglobinopathy Paediatrics Case Report

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Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats

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Animal Models and Experimental Medicine 2019年第1期2卷 51-57页

作者： Priscilla Hakime Scalize Luiz Gustavo de Sousa Lígia maria Napolitano goncalves Dimitrius Leonardo Pitol Marcelo Palinkas Antonio Augusto Coppi mariah Acioli Righeti Vitória Ricardo Karina Fittipaldi Bombonato-Prado Simone Cecílio Hallak Regalo Selma Siessere Department of Morphology Physiology and Basic PathologySchool of Dentistry of Ribeirao PretoUSP-University of Sao Paulo Faculty of Health and Medical Sciences School of Veterinary MedicineUniversity of Surrey

Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 j/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P j/cm^2)( P j/cm^2 given for six and 12 sessions.

关键词： bone low-level laser therapy osteocytes osteoporosis

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Acupuncture Effects on Heart Failure: How to Create Objective Study Designs

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journal of Acupuncture and Tuina Science 2008年第5期6卷 307-308页

作者： Hj Greten A Kick E Scholz j Fischer T Greten F Brazkiewicz F Schroder S Sertel Wendt M goncalves O Karrer A Remppis German Society of Traditional Chinese Medicine Heidelberg Germany Porto University ICBAS Portugal Dept. of Endocrinology and Metabolism University of Heidelberg Germany Dept. of Cardiology University of Heidelberg Germany Dept. of Otorhinolaryngology Head & Neck Surgery University of Heidelberg Germany

根据对针刺机制的现代理解,针刺可以引起植物神经反射,可能是影响与心力衰竭(其特征之一是6分钟步行实验得分较低)症状有关的系统植物神经调节异常。笔者进行了一个初步的前瞻性随机、单盲、交叉临床试验,比较符合海德尔堡中医模型诊断(... 详细信息

根据对针刺机制的现代理解,针刺可以引起植物神经反射,可能是影响与心力衰竭(其特征之一是6分钟步行实验得分较低)症状有关的系统植物神经调节异常。笔者进行了一个初步的前瞻性随机、单盲、交叉临床试验,比较符合海德尔堡中医模型诊断(i-ACU)和不符合这一模型(u-ACU)的两种针刺治疗。重复测量分析提示:与不符合海德尔堡中医模型的针灸治疗相比,符合这一模型的针灸治疗更有效(F=7.2,df=1.37,P=0.011)。这一研究结果表明针刺可延长6分钟行走距离这一心力衰竭的重要指标。

关键词：针刺疗法心力衰竭随机对照试验人类

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Cellulosic ethanol and its co-products from different substrates,pretreatments,microorganisms and bioprocesses:A review

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Natural Science 2013年第5期5卷 624-630页

作者： Fabiano Avelino goncalves Eliana j.Sanjinez-Argandona Gustavo Graciano Fonseca Laboratory of Bioengineering Faculty of EngineeringFederal University of Grande DouradosDouradosBrazil Laboratory of Food Technology Faculty of EngineeringFederal University of Grande DouradosDouradosBrazil

Cellulosic ethanol involves the following production steps: physical and/or chemical pretreatment, biological treatment, fermentation and distillation. First three steps are also the bottlenecks for the production of cellulosic ethanol and its co-products. Their production still pose some difficulties in terms of pretreatment, the high cost of enzymes for substrate hydrolysis, the formation of inhibitory compounds in the hydrolyzate, the lack of efficient and viable microorganisms for industrial fermentation of hexose and pentose among others. The solution or minimization of these difficulties may lead to numerous socio-environmental, political, and economic advantages for cellulosic ethanol production. This paper highlights the potential of different substrates, pretreatments, microorganisms and bioprocesses for cellulosic ethanol production.

关键词： Cellulosic Ethanol Pretreatments Fermentation

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