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World Journal of Gastroenterology 2005年第40期11卷 6243-6248页

作者： Anton Oertl Jens Castein Tobias Engl Wolf-Dietrich Beecken Dietger jonas Richard Melamed Roman A. Blaheta Zentrum der Chirurgie

AIM To study adhesion capacity and CD44 expression of human gastric adenocarcinoma MKN45 cells at different stages of a first cell cycle. METHODS MKN45 cells were synchronized by aphidicolin and assayed for adhesion to an endothelial cell （HUVEC） monolayer. Surface expression of CD44 and CD44 splice variants on MKN45 cells was evaluated by flow cytometry. Functional relevance of CD44 adhesion receptors was investigated by blocldng studies using anti CD44 monodonal antibodies or by hyaluronan digestion. RESULTS： Adhesion of MKN45 to HUVEC was increased during G2/M transit, after which adhesion returned to baseline levels with cell cycle completion. In parallel, CD44 splice vadants CD44v4, CD44v5, and CD44v7 were all upregulated on MKN45 during cell cycle progression with a maximum effect in G2/M. The function of CD44 surface receptors was assessed with specific receptor blocking monoclonal antibodies or removal of hyaluronan by digestion with hyaluronidase. Both strategies inhibited tumor cell adhesion to HUVEC by nearly 50%, which indicates that MKN45-HUVEC-interaction is CD44 dependent. CONCLUSION CD44 expression level is linked to the cell cycle in gastrointestinal tumor cells, which in turn leads to cell cycle dependent alterations of their adhesion behaviour to endothelium.

关键词： Cell cycle CD44 Adhesion Gastrointestinal tumors

A Novel Full-Euler Low Mach Number IMEX Splitting

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Communications in Computational Physics 2020年第1期27卷 292-320页

作者： jonas Zeifang Jochen Schutz Klaus Kaiser Andrea Beck Maria Lukacova-Medvid’ova Sebastian Noelle IAG Universiẗat StuttgartPfaffenwaldring 21DE-70569 StuttgartGermany Faculty of Sciences Hasselt UniversityAgoralaan Gebouw DBE-3590 DiepenbeekBelgium IGPM RWTH Aachen UniversityTemplergraben 55DE-52062 AachenGermany Institut f̈ur Mathematik Johannes Gutenberg-Universiẗat MainzStaudingerweg 9DE-55128 MainzGermany

In this paper,we introduce an extension of a splitting method for singularly perturbed equations,the socalled RS-IMEX splitting[Kaiser et al.,Journal of Scientific Computing,70(3),1390–1407],to deal with the fully compressible Euler *** straightforward application of the splitting yields sub-equations that are,due to the occurrence of complex eigenvalues,not hyperbolic.A modification,slightly changing the convective flux,is introduced that overcomes this *** is shown that the splitting gives rise to a discretization that respects the low-Mach number limit of the Euler equations;numerical results using finite volume and discontinuous Galerkin schemes show the potential of the discretization.

关键词： Euler equations low-Mach IMEX Runge-Kutta RS-IMEX

Management of Flood syndrome:What can we do better?

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World Journal of Gastroenterology 2021年第32期27卷 5297-5305页

作者： Sandra Strainiene Milda Peciulyte Tomas Strainys Ieva Stundiene Ilona Savlan Valentina Liakina jonas Valantinas Clinic of Gastroenterology Nephrourology and SurgeryCentre of HepatologyGastroenterology and DieteticsInstitute of Clinical MedicineVilnius UniversityVilnius 03104Lithuania Clinic of Anesthesiology and Reanimatology Centre of AnesthesiologyIntensive Care and Pain ManagementInstitute of Clinical MedicineVilnius UniversityVilnius 03104Lithuania Department of Chemistry and Bioengineering Faculty of Fundamental ScienceVilnius Gediminas Technical UniversityVilnius 10223Lithuania

Approximately 20%of cirrhotic patients with ascites develop umbilical *** patients usually suffer from multisystemic complications of cirrhosis,have a significantly higher risk of infection,and require accurate surveillance–especially in the context of the coronavirus disease 2019 *** rupture of an umbilical hernia,is an uncommon,life-threatening complication of largevolume ascites and end-stage liver disease resulting in spontaneous paracentesis,also known as Flood *** syndrome remains a challenging condition for clinicians,as recommendations for its management are lacking,and the available evidence for the best treatment approach remains *** this paper,four key questions are addressed regarding the management and prevention of Flood syndrome:(1)Which is the best treatment approach–conservative treatment or urgent surgery?(2)How can we establish the individual risk for herniation and possible hernia rupture in cirrhotic patients?(3)How can we prevent umbilical hernia ruptures?And(4)How can we manage these patients in the conditions created by the coronavirus disease 2019 pandemic?

关键词： Umbilical hernia rupture Ascites Cirrhosis Flood syndrome COVID-19 Literature review

The potential use of extended criteria donors and eligible recipients in liver transplantation for unresectable colorectal liver metastases in Central Sweden

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 476-485,I0001页

作者： Christina Villard Joakim Westman jonas Frank Oystein Jynge Ernesto Sparrelid Carl Jorns Department of Cancer Division of Upper GIKarolinska University HospitalStockholmSweden Karolinska Institutet StockholmSweden Department of Transplantation Surgery Karolinska University HospitalStockholmSweden Department of Clinical Science Intervention and TechnologyKarolinska InstitutetStockholmSweden

Background:Unresectable colorectal liver metastases(CRLM)is a condition with poor prognosis.A recent treatment alternative improving survival in patients with unresectable CRLM,has emerged with the introduction of liver transplantation(LT),yet not uncontroversial with the current organ *** study aimed to retrospectively investigate the potential of declined donors with acceptable risk as liver graft donors and patients with unresectable CRLM as potential ***:All declined donors in central Sweden and all patients with CRLM discussed at multidisciplinary team conference at Karolinska University Hospital,January 2013-October 2018,were *** were classified according to the European Committee Guide to the quality and safety of organs for transplantation and potential recipients were evaluated by selection criteria,based on studies on the Norwegian Secondary Cancer study ***:Out of 1,462 evaluated potential donors,62(2.7 pmp)donors were identified,corresponding to 6-18%of the utilized donor *** of 1,008 included patients with CRLM,25(2.1 pmp)potential recipients were *** for LT and left-sided colon cancer were favorable prognostic ***:Today’s donor pool could increase with the use of extended criteria donors,which is sufficient and display an acceptable risk-benefit ratio for patients with unresectable *** current selection criteria a small subset of patients with unresectable CRLM are eligible *** subset of patients has a better survival compared to patients ineligible for LT.

关键词： Colorectal cancer(CRC) extended criteria donor unresectable colorectal liver metastases(unresectable CRLM) liver transplantation(LT)

Benefits of conservation-driven mowing for the EU policy species Gladiolus palustris Gaudin in mountain fen meadows:a case-study in the European Alps

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Journal of Mountain Science 2020年第9期17卷 2097-2107页

作者： Marco CANELLA Gianni POLONIATO Cesare LASEN Simone ORSENIGO Graziano ROSSI jonas V.MüLLER Thomas ABELI Department of Earth and Environmental Sciences University of PaviaVia S.Epifanio1427100 PaviaItaly Dolomiti Bellunesi National Park Piazzale Zancanaro1-32032 FeltreItaly Millennium Seed Bank Conservation ScienceRoyal Botanic Gardens KewArdingly RH176TNWest SussexUK Department of Science University of Roma 3Viale Guglielmo Marconi 44600146RomaItaly

The sword lily Gladiolus palustris Gaudin is protected on European level and listed in Annexes II and IV of the EC Habitat Directive 92/43/*** grows in nutrient-poor,calcareous meadows in central and eastern *** encroachment in montane meadows of the European Alps as a result of recent land use changes and the abandonment of traditional farming practices threaten the survival of this ***-driven mowing is considered a feasible conservation measure for maintaining high species diversity in abandoned semi-natural *** assess the effects of tenyears of biennial mowing on a grassland community in the Dolomiti Bellunesi National Park,Italy(Site of Community Importance,Natura 2000 network),ten25 m2 plots were established whereby four plots were placed in the mowed area,four in the non-mowed area and two in a small non-mowed patch of grassland inside the mowed *** each plot the following variables were recorded,total percentage of plant cover,percentage cover of woody species,percentage cover of herbaceous species,percentage cover and number of flowering ramets of *** and a complete list of species and their percentage *** plots showed a higher species richness than non-mowed *** number of *** flowering ramets and percentage cover increased manifold in mowed plots compared to nonmowed *** resumption of mowing forconservation purposes undertaken by the managing authority halted the process of tree encroachment and avoided a drastic change in plant *** mowing(every second or third year)was demonstrated to be a cost-effective conservation measure in non-productive grasslands to keep grasses at bay in favour of forbs of high conversation value.

关键词： Conservation management Seminatural habitats Habitat directive Montane grassland Natura 2000 network Dolomiti Bellunesi National Park

Liver cirrhosis and left ventricle diastolic dysfunction: Systematic review

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World Journal of Gastroenterology 2019年第32期25卷 4779-4795页

作者： Ieva Stundiene Julija Sarnelyte Ausma Norkute Sigita Aidietiene Valentina Liakina Laura Masalaite jonas Valantinas Vilnius University Institute of Clinical MedicineClinic of GastroenterologyNephrourology and SurgeryVilnius UniversityVilnius LT-03101Lithuania Vilnius University Institute of Clinical MedicineClinic of Internal diseasesFamily medicine and OncologyVilnius UniversityVilnius LT-03101Lithuania Vilnius University Institute of Clinical MedicineClinic of Cardiology and AngiologyVilnius UniversityVilnius LT-03101Lithuania Vilnius Gediminas Technical University Faculty of Fundamental SciencesDepartment of Chemistry and BioengineeringVilnius LT-10223Lithuania

BACKGROUND Liver cirrhosis is a chronic hepatic disease which is associated with cardiovascular *** circulation in liver cirrhosis causes functional and structural cardiac *** prevalence of left ventricle diastolic dysfunction(LVDD)in cirrhotic patients ranges from 25.7%to as high as 81.4%as reported in different *** several studies the severity of diastolic dysfunction(DD)correlated with a degree of liver failure and the rate of dysfunction was higher in patients with decompensated cirrhosis compared with *** directions of comprehensive assessment of cardiac function in cirrhotic patients might provide a better prognosis for these *** To clarify the correlation between the severity of liver cirrhosis and left ventricle diastolic dysfunction in the existing *** Through January and February of 2019 at Vilnius University we conducted a systematic review of the global existing literature on the prevalence of left ventricle diastolic dysfunction in patients with liver *** searched for articles in PubMed,Medline and Web of science *** were selected by using adequate inclusion and exclusion *** interest was the outcome of likely correlation between the severity of cirrhosis[evaluated by Child-Pugh classes,Model For End-Stage Liver Disease(MELD)scores]and left ventricle diastolic dysfunction[classified according to American Society of Echocardiography(ASE)guidelines(2009,2016)],as well as relative risk of dysfunction in cirrhotic *** analyses were performed to evaluate the ratio and grades of left ventricle diastolic dysfunction with respect to cirrhosis *** A total of 1149 articles and abstracts met the initial search *** articles which met the predefined eligibility criteria were included in the final ***,1067 patients(out of them 723 men)with liver cirrhosis were evaluated for left ventricle diastolic dysf

关键词： Liver cirrhosis Left ventricle Diastolic dysfunction Correlation Echocardiography Systematic review

Aorto-oesophageal fistula after corrosive ingestion:A case report

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World Journal of Gastrointestinal Surgery 2022年第5期14卷 506-513页

作者： Matthias Frank Scriba Urda Kotze Nadraj Naidoo Eduard jonas Galya Eileen Chinnery Surgical Gastroenterology Unit Department of SurgeryGroote Schuur HospitalUniversity of Cape TownCape Town 7925Western CapeSouth Africa Surgical Gastroenterology Unit Department of SurgeryUniversity of Cape TownFaculty of Health SciencesCape Town 7925Western CapeSouth Africa Vascular and Endovascular Surgery Unit Department of SurgeryGroote Schuur HospitalUniversity of Cape TownCape Town 7925Western CapeSouth Africa

BACKGROUND Aorto-oesophageal fistula(AOF)are uncommon and exceedingly rare after corrosive *** authors report a case of AOF after corrosive ingestion that survived.A comprehensive literature review was performed to identify all cases of AOF after corrosive ingestion to determine the incidence of this condition,how it is best managed and what the outcomes *** SUMMARY A previously healthy 30-year-old male,presented with a corrosive oesophageal injury after drain cleaner *** did not require acute surgical resection,but developed long-segment oesophageal stricturing,which was initially managed with cautious dilatation and later *** AOF was suspected at endoscopy performed two months after the ingestion,when the patient represented with massive upper gastrointestinal *** fistula was confirmed on computerised tomographic *** initial bleeding at endoscopy was temporised by oesophageal stenting;a second stent was placed when bleeding recurred later the same *** stenting successfully achieved temporary bleeding control,but resulted in sudden respiratory distress,which was found to be due to left main bronchus compression caused by the overlapping oesophageal *** bleeding control was achieved by endovascular aortic stent-grafting.A retrosternal gastroplasty was subsequently performed to achieve gastrointestinal diversion to reduce the risk of stent-graft *** was subsequently successfully discharged and remains well one year post *** AOF after corrosive ingestion is exceedingly rare,with a very high *** occur weeks to months after the initial corrosive *** management is ill-advised.

关键词： Aorto-oesophageal fistula Corrosive/caustic injury Corrosive ingestion Case report

A Comparative Study of the Effect of Gold Seed Particle Preparation Method on Nanowire Growth

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Nano Research 2010年第7期3卷 506-519页

作者： Maria E.Messing Karla Hillerich Jessica Bolinsson Kristian Storm jonas Johansson Kimberly A.Dick Knut Deppert Solid State Physics Lund UniversityBox 118S-22100 LundSweden Polymer&Materials Chemistry Lund UniversityBox 124S-22100 LundSweden

Highly controlled particle-assisted growth of semiconductor nanowires has been performed for many years,and a number of novel nanowire-based devices have been *** control of the epitaxial growth is required to optimize the performance of devices,and gold seed particles are known to provide the most controlled *** nanowire growth from gold particles generated and deposited by various different methods has been reported,but no investigation has yet been performed to compare the effects of gold particle generation and deposition methods on nanowire *** this article we present a direct comparative study of the effect of the gold particle creation and deposition methods on nanowire growth characteristics and nanowire crystal structure,and investigate the limitations of the different generation and deposition methods used.

关键词： Nanowire growth nanoparticles gold epitaxy electron microscopy

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一种自动驾驶电动汽车线束布局优化方法

同济大学学报（自然科学版） 2022年第S1期50卷 186-191页

作者： jonas MAIER Benjamin KRüGER Hans-Christian REUSS 斯图加特大学汽车工程学院(IFS) 德国斯图加特70569

近年来,随着汽车自动驾驶、数字化、电动化技术的不断发展,汽车的功能不断增加,车辆内部线束也随之增加。由于过多的线束导致车辆自重增加的问题日益突出。为了实现能源的高效利用和出行方式的可持续性,开发人员需要通过优化线束布置来... 详细信息

近年来,随着汽车自动驾驶、数字化、电动化技术的不断发展,汽车的功能不断增加,车辆内部线束也随之增加。由于过多的线束导致车辆自重增加的问题日益突出。为了实现能源的高效利用和出行方式的可持续性,开发人员需要通过优化线束布置来尽可能多的减轻车辆自重,同时降低成本。由于与线束相连的车辆零件位置固定,因此需要一个算法在车辆零件位置为限制条件下,优化车辆线束布局。之前的研究方法通常只考虑线束设计的部分限制因素,且没有考虑线束三维结构。在本文研究中,开发了一种新型的优化线束布局的方法,该方法考虑了与包装,温度负载以及装配难易相关的各种限制因素。该方法可以根据设计需求来控制线束布置方法,如在沿着车辆纵轴方向布置更多线束,以避免在车辆外围布置线束。通过该方法,可以高效地计算出线束长度、直径,以及精确的布线路径。

关键词：电动汽车汽车线束布线优化 Dijkstra算法

The role of shaded cocoa plantations in the maintenance of epiphytic orchids and their interactions with phorophytes

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Journal of Plant Ecology 2020年第1期13卷 27-35页

作者： jonas Morales-Linares JoséGGarcía-Franco Alejandro Flores-Palacios Thorsten Krömer Tarin Toledo-Aceves Red de Ecología Funcional Instituto de EcologíaA.C.Carretera Antigua a Coatepec 351El HayaXalapa 91070VeracruzMexico Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCuernavaca 62209MorelosMexico Present address:Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaCuernavaca 62209MorelosMéxico Centro de Investigaciones Tropicales Universidad VeracruzanaJoséMaría Morelos 44-46Zona CentroXalapa 91000VeracruzMexico

Aims Habitat loss and fragmentation are the main threats to biodiversity in tropical *** such as shaded cocoa plantations(SCP)provide refuge for tropical forest ***,it is poorly known whether the interspecific ecological interactions are also maintained in these transformed *** evaluated the diversity,reproductive status and photosynthetic metabolism(CAM or C3)of the epiphytic orchid community,and their interactions with host trees(phorophytes)in SCP compared to tropical rainforest(TRF).Methods In southeastern Mexico,three sites each in TRF and SCP were studied,with four 400 m2 plots established at each site to record all orchids and their *** determined the reproductive(adult)or non-reproductive(juvenile)status of each orchid individual in relation to the presence or absence,respectively,of flowers/fruits(or remnants),and assigned the photosynthetic pathway of each orchid species based in *** used true diversity and ecological networks approaches to analyze orchid diversity and orchid–phorophyte interactions,*** Findings In total,607 individuals belonging to 47 orchid species were *** diversity was higher in TRF(19 effective species)than in SCP(11 effective species)and only seven species were shared between the two *** orchid species were more frequent in SCP(53%)than in TRF(14%).At the community level the proportion of non-reproductive and reproductive orchid species and the nested structure and specialization level of the TRF orchid–phorophyte network were maintained in ***,only a subset of TRF epiphytic orchids remains in SCP,highlighting the importance of protecting *** this difference,shaded agroecosystems such as SCP can maintain some of the diversity and functions of natural forests,since the SCP epiphytic orchid community,mainly composed of CAM species,and its phorophytes constitute a nested interaction network,which would confer robustness to d

关键词： agroecosystem ecological networks Mexico photosynthetic pathway tropical rainforest