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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： Paz Cartas-Cejudo Adriana cortés Mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

New approaches in angiogenic targeting for colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5857-5866页

作者： Aleix Prat Esther Casado Javier cortés Department of Medical Oncology Vall d'Hebron University Hospital Barcelona Spain Department of Medical Oncology Vall d'Hebron University Hospital Barcelona Spain Department of Medical Oncology Hospital General de Manresa Barcelona Spain

Colorectal carcinoma （CRC） is one of the leading causes of cancer death worldwide. In the last decade, the addition of irinotecan and oxaliplatin to standard fluorouracil-based chemotherapy regimens have set the new benchmark of survival for patients with metastatic CRC at approximately 20 too. Despite these advances in the management of CRC, there is a strong medical need for more effective and well-tolerated therapies. The dependence of tumor growth and metastasis on blood vessels makes angiogenesis a rational target for therapy. One of the major pathways involved in this process is the vascular endothelial growth factor （VEGF） and its receptors （VEGFR）. In 2004, the first agent targeting angiogenesis, bevacizumab （BV）, was approved as an adjunct to first-line cytotoxic treatment of metastatic CRC. The role of BV as part of adjuvant treatment and in combination with other targeted therapies is the subject of ongoing trials. However, BV is associated with an increase in the risk of arterial thromboembolic events, hypertension and gastrointestinal perforations and its use must be cautious. Novel VEGFR TK inhibitors with different ranges of nanomolar potencies, selectivities, and pharmacokinetic properties are entering phase 111 trials for the treatment of cancer. Conversely, one of these novel agents, vatalanib, has been shown not to confer survival benefit in first and second-line treatment of advanced CRC. The basis of these findings is being extensively evaluated. Ongoing and new well-designed trials will define the optimal clinical application of the actual antiangiogenic agents, and, on the other hand, intensive efforts in basic research will identify new agents with different antiangiogenic approaches for the treatment of CRC. In this review we discuss and highlight current and future approaches in angiogenic targeting for CRC.

关键词： Angiogenesis inhibitors Vascular endothelial growth factor VEGF receptors Bevacizumab Vatalanib Colorectal carcinoma

Elastic smart Contracts in Blockchains

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IEEE/CAA Journal of Automatica sinica 2021年第12期8卷 1901-1912页

作者： schahram Dustdar Pablo Fernández JoséMaría García Antonio Ruiz-cortés Distributed systems Group Vienna University of TechnologyWien 1040Austria smart Computer systems Research and Engineering Lab Research Institute of Computer EngineeringUniversity of SevillaSevilla 41012Spain

In this paper,we deal with questions related to blockchains in complex Internet of Things(IoT)-based *** ecosystems are typically composed of IoT devices,edge devices,cloud computing software services,as well as people,who are decision makers in scenarios such as smart *** decisions related to analytics can be based on data coming from IoT sensors,software services,and ***,they are typically based on different levels of abstraction and *** poses a number of challenges when multiple blockchains are used together with smart *** work proposes to apply our concept of elasticity to smart contracts and thereby enabling analytics in and between multiple blockchains in the context of *** propose a reference architecture for Elastic smart Contracts and evaluate the approach in a smart city scenario,discussing the benefits in terms of performance and self-adaptability of our solution.

关键词： Blockchain elasticity Internet of Things(IoT) smart cities smart contracts virtual chains

Data-driven disturbance observer-based control: an active disturbance rejection approach

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Control Theory and Technology 2021年第1期19卷 80-93页

作者： Harvey Rojas-Cubides John cortés-Romero Jaime Arcos-Legarda Deparameno de Ingeniera Elétricay Electrónica Universidad Nacional de ColombiaAv.K30 No.45-03 Edif.453 Of.222BogoiáColombia Department of Mechatromies Engineering Universidad de San BuenaventuraBogotá.Colombia

In this paper,a data-driven method for disturbance estimation and rejection is *** proposed approach is divided into two stages:an inner stabilization loop,to set the desired reference model,together with an outer loop for disturbance estimation and *** by the active disturbance rejection control framework,the exogenous and endogenous disturbances are lumped into a lotal disturbance *** signal is estimaed using an on-line algorithm based on a data-driven predictor scheme,whose parameters are chosen Io salisfy high robustnessperformance *** above process is presented as a novel enhancement lo design a disturbance observer,w hich constitutes the main contribution of the *** addition,the control strategy is completely presented in discrete time,avoiding the use of discretization methods for its digital *** a case study,the voltage control of a DC-DC synchronous buck converter aflected by disturbances in the input voltage and the load is ***,experimental results that validate the proposed stralegy and some comparisons with the classical disturbance observer-based control are presented.

关键词： Active disturbance rejection control Data-driven disturbance observer Disturbance observer-based control signal prediction

Temporal decay of the catalytic oxidation of methane over palladium supported on silica

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science China Chemistry 2013年第11期56卷 1601-1607页

作者： corts Joaquín VALENCIA Eliana PINEDA Marcelo ARAYA Paulo Departamento de Ingeniería Química y Biotecnología Universidad de Chile Departamento de Ciencia de Materiales Universidad de Chile

The temporal decay of the oxidation of methane(CH4-O2reaction)over palladium supported on silica is determined experimentally at different temperatures,comparing the results with those of various classical models which show the behavior of the adsorbed phase as the cause of the *** effect is visualized through Monte Carlo simulations of the CH4-O2reaction on a mixed lattice whose partial poisoning,due to the configuration of the OH groups on the surface of the adsorbate,is translated into a gradual decay of the reaction’s activity.

关键词： catalytic CH4-O2 reaction surface heterogeneity in superficial reaction Monte Carlo simulation superficial catalyticreaction CH4-O2 reaction over palladium

Robust Disturbance Rejection Based Control with Extended-state Resonant Observer for sway Reduction in Uncertain Tower-cranes

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International Journal of Automation and computing 2019年第6期16卷 812-827页

作者： Horacio Coral-Enriquez santiago Pulido-Guerrero John cortés-Romero Programa de Ingeniería Mecatrónica Facultad de IngenieríaUniversidad de San Buenaventura sede BogotáCra.8H No 172-20 Edif.DBBogotáOf204Colombia Departamento de Ingeniería Eléctrica y Electrónica Facultad de IngenieríaUniversidad Nacional de Colombia sede BogotáCra.30 No 45-03 Edif.453BogotáOf222Colombia

In this paper, the problem of load transportation and robust mitigation of payload oscillations in uncertain tower-cranes is addressed. This problem is tackled through a control scheme based on the philosophy of active-disturbance-rejection. Here, a general disturbance model built with two dominant components: polynomial and harmonic, is stated. Then, a disturbance observer is formulated through state-vector augmentation of the tower-crane model. Thus, better performance of estimations for system states and disturbances is achieved. The control law is then formulated to actively reject the disturbances but also to accommodate the closed-loop system dynamics even under system uncertainty. The proposed control schema is validated via experimentation using a small-scale tower-crane,and compared with other relevant active disturbance rejection control(ADRC)-based techniques. The experimental results show that the proposed control scheme is robust under parametric uncertainty of the system, and provides improved attenuation of payload oscillations even under system uncertainty.

关键词： Active disturbance rejection control(ADRC) extended state observer(EsO) tower-crane control resonant observer disturbance observer linear matrix inequality

Dimensionality reduction of hyperspectral images of vegetation and crops based on self-organized maps

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Information Processing in Agriculture 2021年第2期8卷 310-327页

作者： David Ruiz Hidalgo Bladimir Bacca cortés Eduardo Caicedo Bravo Perception and Intelligent systems Research Group School of Electrical and Electronic EngineeringUniversidad del ValleSantiago de Cali 76001Colombia

Hyperspectral images are multidimensional massive sets of information that have shown a great potential for different kind of applications as urban mapping,environmental management,vegetation and crops supervision and mineral ***,due to its high dimensional nature and the high variability of the spectral information,the dimensionality reduction process is one of the main challenges in processing hyperspectral *** aim of dimensionality reduction is to eliminate redundant information and simplify the subsequent processes of classification and the search of *** this context,several dimensionality reduction methods have been proposed,but most of them are not flexible enough to deal with the particular features of the hyperspectral *** this way,the use of intelligent methods as neural networks and specially an unsupervised approach as self-organized maps,may improve the dimensionality reduction stage and the final classification *** paper proposes an unsupervised method for the dimensionality reduction of hyperspectral images based on Kohonen self-organized maps,which,compared with other traditional methods such as principal component analysis(PCA)and wavelet decomposition,provides better classification *** results provided in this paper use an RBF(radial basis function)*** average,the proposed method provides a 64%dimensionality reduction and an 88.5%classification *** results suggest that the dimensionality reduction algorithm based on self-organized maps is an efficient approach compared with other popular *** is due to the ability of self-organized maps to automatically detect(self-organizing)relationships within the set of input patterns,which provides flexibility to deal with the special features of the hyperspectral images.

关键词： Dimensionality reduction Hyperspectral images Principal component analysis Radial basis function Remote sensing self-organized maps Wavelet transform

Methane Dry Reforming over Alumina supported Co Catalysts

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Chemical Research in Chinese Universities 2004年第4期20卷 457-461页

作者： sergio L. González cortés Malcolm L. H. Green Inorganic Chemistry Laboratory University of OxfordInorganic Chemistry Laboratory University of Oxford South Parks Road OX1 3QR UKSouth Parks Road OX1 3QR UK

A series of Co/γ-Al_2O_3 catalysts were prepared with the impregnation method and characterized by means of the BET specific surface area, X-ray diffraction(XRD), thermogravimetric analysis(TGA) and Laser Raman spectroscopy. The Co/γ-Al_2O_3 catalysts were activated by using H_2, 20%CH_4/H_2 or CH_4, respectively. There was no obvious difference between the activities of the Co/γ-Al_2O_3 catalyst activated by using the different activation methods for methane dry reforming. The catalytic properties of the Co/γ-Al_2O_3 catalysts with different Co loadings were also investigated. The optimized Co loading for the Co/γ-Al_2O_3 catalyst pretreated with 20% CH_4/H_2 is around 12%(mass fraction).

关键词： Methane dry reforming Alumina supported cobalt catalysts Catalytic deactivation

Don´t give up on mitochondria as a target for the treatment of diabetes and its complications

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World Journal of Diabetes 2024年第10期15卷 2015-2021页

作者： Christian cortés-Rojo Manuel Alejandro Vargas-Vargas Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico

In this editorial,we discuss an article by Wang et al,focusing on the role of mitochondria in peripheral insulin resistance and insulin *** numerous in vitro and pre-clinical studies supporting the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of diabetes and its complications,efforts to target mitochondria for glycemic control in diabetes using mitochondria-targeted antioxidants have produced inconsistent *** intricate functionality of mitochondria is summarized to underscore the challenges it poses as a therapeutic *** mitochondria-targeted antioxidants have demonstrated improvement in mitochondrial function and oxidative stress in pre-clinical diabetes models,the results regarding glycemic control have been mixed,and no studies have evaluated their hypoglycemic effects in diabetic ***,pre-clinical trials have shown promising outcomes in ameliorating diabetes-related ***,we review some reasons why mitochondria-targeted antioxidants may not function effectively in the context of mitochondrial *** also highlight several alternative approaches under development that may enhance the targeting of mitochondria for diabetes treatment.

关键词： Diabetes mellitus Insulin resistance Mitochondrion Mitochondrial dysfunction MitoQ MitoTEMPO skQ Elamipretide Mitochondria transplantation Glycemic control