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Translating Pathological Brain Activity Primers in Parkinson’s Disease Research

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Research 2024年第1期2023卷 735-752页

作者： Daniela Mirzac Svenja L.Kreis Heiko J.Luhmann Gabriel gonzalez-escamilla Sergiu Groppa Movement Disorders and Neurostimulation Department of NeurologyFocus Program Translational NeuroscienceRhine Main Neuroscience NetworkUniversity Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany Institute of Physiology University Medical Center of the Johannes Gutenberg University Mainz55131 MainzGermany

Translational experimental approaches that help us better trace Parkinson’s disease(PD)pathophysiological mechanisms leading to new therapeutic targets are urgently *** this article,we review recent experimental and clinical studies addressing abnormal neuronal activity and pathological network oscillations,as well as their underlying mechanisms and *** aim is to enhance our knowledge about the progression of Parkinson's disease pathology and the timing of its symptom’s ***,we present mechanistic insights relevant for the generation of aberrant oscillatory activity within the cortico-basal ganglia *** summarize recent achievements extrapolated from available PD animal models,discuss their advantages and limitations,debate on their differential applicability,and suggest approaches for transferring knowledge on disease pathology into future research and clinical applications.

关键词： clinical knowledge insight

Laser-induced plasma formation in water with up to 400 mJ double-pulse LIBS

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Plasma Science and Technology 2024年第1期26卷 93-100页

作者： Marion HeNKeL Michelle SIeMeNS Ralf MeTHLING Benjamin eMDe Jörg HeRMSDORF Steffen FRANKe Diego gonzalez Leibniz Institute for Plasma Science and Technology(INP) Felix-Hausdorff-Straße 2Greifswald 17489Germany Laser Zentrum Hannover e.V.(LZH) Hollerithallee 8Hannover 30419Germany

Double-pulse LIBS is a promising technique for deep-sea *** measurements in shallow water with up to 400 mJ each pulse were done to select laser parameters which promote optimized spectral line emission from plasma even at elevated pressures,where line broadening until loss of most of the spectral information can *** emission spectroscopy,using a Czerny-Turner spectrometer,has been applied to investigate the dependence of the emitted radiation on laser parameters and hydrostatic *** has been found,that higher laser pulse energies,especially with short pulse delay as required in high water pressure,can also have an adverse effect on the measured spectrum.

关键词： double-pulse LIBS underwater plasma formation emission spectrosocpy

HVOF-sprayed HAp/S53P4 BG composite coatings on an AZ31 alloy for potential applications in temporary implants

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Journal of Magnesium and Alloys 2024年第1期12卷 345-360页

作者： Carlos A.Poblano-Salas John Henao Astrid L.Giraldo-Betancur Paola Forero-Sossa Diego german espinosa-Arbelaez Jorge A.González-Sánchez Luis R.Dzib-Pérez Susana T.estrada-Moo Idelfonso e.Pech-Pech CIATeQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-CIATeQ A.C. Av.Manantiales 23-AParque Industrial Bernardo QuintanaEl MarquésQuerétaro 76246Mexico CONAHCYT-Cinvestav Libramiento Norponiente#2000.Fraccionamiento Real de JuriquillaQuerétaro 76230Mexico Universidad Tecnológica de Querétaro Av.Pie de la Cuesta N°2501Querétaro 76148Mexico CIDeSI Av.Playa Pie de la Cuesta No 702Col.San PabloQuerétaro 76125Mexico Center for Corrosion Research Autonomous University of CampecheAv.Héroe de Nacozari No.480P.C.24070San Francisco de CampecheCam.Mexico

Bioactive thermal spray coatings produced via high-velocity oxygen fuel spray(HVOF)from hydroxyapatite(HAp)and bioactive glasses(BG)have the potential to be employed on temporary implants due to the ability of both HAp and BG to dissolve and promote osseointegration,considering that both phases have different reaction and dissolution rates under in-vitro *** the present work,75%***-25%wt.S53P4 bioactive glass powders were HVOF-sprayed to obtain HAp/S53P4 BG composite coatings on a bioresorbable AZ31 *** study is focused on exploring the effect of the stand-off distance and fuel/oxygen ratio variation as HVOF parameters to obtain stable structural coatings and to establish their effect on the phases and microstructure produced in those *** characterization techniques,such as scanning electron microscopy,X-ray diffraction,and Fourier transform infrared spectroscopy,were employed to characterize relevant structural and microstructural properties of the composite *** results showed that thermal gradients during coating deposition must be managed to avoid delamination due to the high temperature achieved(max 550℃)and the differences in coefficients of thermal *** was also found that both spraying distance and oxygen/fuel ratio allowed to keep the hydroxyapatite as the main phase in the *** addition,in-vitro electrochemical studies were performed on the obtained HAp/S53P4 BG composite coatings and compared against the uncoated AZ31 *** results showed a significant decrease in hydrogen evolution(at least 98%)when the bioactive coating was applied on the Mg alloy during evaluation in simulated body fluid(SBF).

关键词： Coatings Composites Thermal spray Temporary implants Hydrogen evolution

Notes on the family Brassicaceae in China

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Journal of Systematics and evolution 2009年第3期47卷 202-219页

作者： Dmitry A german Altai State University

A critical revision of the collections of Brassicaceae in some Chinese (Pe, XJA, XJBI, XJFA, XJNM, XJU) and foreign (Le, P) herbaria is made. One genus, Neurotropis (DC.) F. K. Mey., and 11 species, Alyssum szarabiacum Nyár., Barbarea stricta Andrz., erysimum czernjajevii N. Busch, erysimum kotuchovii D. german, erysimum mongolicum D. german, Lepidium karelinianum Al-Shehbaz, Matthiola superba Conti, Neurotropis platycarpa (Fisch. & Mey.) F. K. Mey., Ptilotrichum dahuricum Peschkova, Sisymbrium subspinescens Bunge, and Smelowskia micrantha (Botsch. & Vved.) Al-Shehbaz & S. I. Warwick, are reported from China for the first time. Six species, Aphragmus involucratus (Bunge) O. e. Schulz, Dontostemon perennis C. A. Mey., Goldbachia torulosa DC., Lepidium amplexicaule Willd., Neotorularia brevipes (Kar. & Kir.) Hedge & J. Léonard, and Parrya stenocarpa Kar. & Kir., are confirmed to occurr in China. Five species, Dontostemon integrifolius (L.) C. A. Mey., Draba zangbeiensis L. L. Lou, Lepidium alashanicum H. L. Yang, Sinapis arvensis L., and Strigosella brevipes (Bunge) Botsch., are reported as novelties for some provinces in China, and Strigosella hispida (Litv.) Botsch. occurs in Xinjiang, China. However, the occurrence of one genus, Pseudoarabidopsis Al-Shehbaz, O’Kane & Price, and four species, Draba huetii Boiss., eutrema halophilum (C. A. Mey.) Al-Shehbaz & S. I. Warwick, Galitzkya spathulata (Steph. ex Willd.) V. Bocz., and Pseudoarabidopsis toxophylla (Bieb.) Al-Shehbaz, O’Kane & Price, could not be confirmed in China. The occurrence of six species, Aphragmus bouffordii Al-Shehbaz, Barbarea orthoceras Ledeb., Lepidium latifolium L., Ptilotrichum canescens (DC.) C. A. Mey., Strigosella hispida (Litv.) Botsch., and Strigosella scorpioides (Bunge) Botsch., is not confirmed in certain provinces of China. All names follow the latest taxonomic treatment for relevant groups; detailed morphological descriptions of the newly recorded taxa are provided; and distinguishing c

关键词： Brassicaceae China Cruciferae distribution new record.

Artificial intelligence meets body sense: task-driven neural networks reveal computational principles of the proprioceptive pathway

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3147-3149页

作者： Leonard e.van Dyck Frank Bremmer Katharina Dobs Department of Psychology Justus Liebig University GiessenGiessenGermany Max Planck Institute for Human Cognitive and Brain Sciences LeipzigGermany Center for Mind Brain and BehaviorUniversities of MarburgGiessenand DarmstadtMarburgGermany Department of Neurophysics Philipps-Universitat MarburgMarburgGermany

In a recent study published in Cell,Marin Vargas and Bisi et al.1 present an innovative approach to unravel the computational principles underlying proprioceptive processing in non-human *** findings showcase the utility of task-driven modeling in advancing neuroscience and offer translational potential by providing seminal insights into the goals and mechanisms by which the brain encodes body position and movements.

关键词： networks neural principles

A transition from a large open pit into a novel “macroblock variant” block caving geometry at Chuquicamata mine, Codelco Chile

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Journal of Rock Mechanics and Geotechnical engineering 2019年第3期11卷 549-561页

作者： german Flores Alex Catalan Newcrest Mining Ltd. Melbourne3004Australia Codelco Chile Santiago8320000Chile

With a history of more than 100 years, Chuquicamata has become one of the largest open pits in the world. Its current depth of 1100 m, length of 4500 m and width of 3000 m, resulting in haulage distances of over 11,000 m from pit bottom to the processing plant or waste dumps, with waste/ore ratio greater than 4 and much lower grades, are effectively determining its profitable limit by the end of this decade. Currently, there are over 4300 Mt of geological resources containing 0.7% of copper and 340 ppm (1 ppm = 1 g/t) of molybdenum below the final pit shell. The corresponding orebody geometry is 3000 m northsouth, 300-800 m eastwest and the drilling campaign suggested the existence of more than 900 m of mineable ore from the final pit bottom. This is in spite of the fact that the Chuquicamata orebody is still open at depth. The business case to continue with the mining of the Chuquicamata orebody is to change from the current large open pit to a novel macroblock variant block caving geometry. This requires a production rate of 140,000 t/d (50 Mt per annum), with a continuous material handling system to achieve the 7-year ramp-up to full production. The resolution of a number of known technical, operational and logistical challenges outside current industry practises which Chuquicamata will face over its projected 40-year mine life is therefore essential. These challenges include simultaneous operations of open pit and underground macroblocks and from the initial lift to the second lift, rapid ramp-up and optimum sequencing of the planned macroblocks, early dilution from the west fault and late dilution from potential slope failures, and the potential for major operational hazards. An equally important issue to be addressed is cultural given that the mining history in the northern region of Chile, which includes Chuquicamata, is predominantly open pit. This paper presents a synopsis of the main challenges that the Chuquicamata underground project will face in order t

关键词： Macroblock variant Block caving Cave propagation early and late dilutions Intensive preconditioning Rib pillar West fault Ore buffer

Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget Julian Breidenbach Tobias Claff Alexandra Hingst Katharina Sylvester Christian Steinebach Lan Phuong Vu Renato H.Weiße Ulrike Bartz Norbert Sträter Christa e.Müller Michael Gütschow Pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of Bioanalytical Chemistry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Department of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 main protease(M^(pro))was developed that enables,for the first time,the exact determination of the concentration of the enzymatically active M^(pro) by active-site *** covalent binding mode of the tetrapeptidic titrant was elucidated by the determination of the crystal structure of the enzyme–titrant *** fluorogenic substrates of M^(pro),including a prototypical,internally quenched Dabcyl-eDANS peptide,were compared in terms of solubility under typical assay *** exploiting the new titrant,key kinetic parameters for the M^(pro)-catalyzed cleavage of these substrates were determined.

关键词： COVID-19 SARS-CoV-2 Main protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

Interaction between xylanase and a proton pump inhibitor on broiler chicken performance and gut function

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Animal Nutrition 2022年第1期8卷 277-288页

作者： Gemma gonzalez-Ortiz Sophie A.Lee Kirsi Vienola Kari Raatikainen german Jurgens Juha Apajalahti Michael R.Bedford AB Vista MarlboroughWiltshireSN84ANUnited Kingdom Alimetrics Ltd. Koskelontie 19 BEspooFinland

Three hundred thirty-six Ross 308 male broiler chicks were used in a 21-d study to explore performance and gut function when treated with a proton pump inhibitor(PPI;0 or 89 mg/kg)in a 2×2 factorial arrangement with a xylanase(Xyl;0 or 0.1 g/kg)to determine if the beneficial activity of arabinoxylan(AX)depolymerisation,through arabinoxylo-oligosaccharides(AXOS)production,starts in the upper gastrointestinal *** with the PPI started from d 14,and by d 21 animal performance had deteriorated(Peraction was observed between PPI and Xyl for feed conversion ratio(FCR)(Pereby the combination reduced the negative effect of PPI on *** of PPI raised digesta pH in the gizzard and caecum(Peased protein concentrations in the lower gut(Peduced intake of digestible nutrients(Pecal concentrations of indole,p-cresol,ammonia and the ratio of total volatile fatty acid(VFA)to butyric acid were increased with PPI(Penhanced protein *** activity in the digesta were greatest in the caeca,especially when Xyl was supplemented(Pe concentration of total soluble AX was greater in the gizzard and ileal digesta with Xyl supplementation(Pe depolymerisation action of xylanase even under acidic *** data suggest xylanase may function in the gizzard even though pH is not optimal for activity and emphasises the importance of chlorohydric acid secretions in ensuring overall optimum gut *** depolymerisation benefits animal performance although it is still unknown how the AXOS produced with xylanase supplementation in the upper gastrointestinal tract influence the microbial populations and overall gut functionality.

关键词： Xylanase Proton pump inhibitor Arabinoxylan degradation Protein fermentation Broiler chicken

Pursuit of CP violation in hyperon decays at e^(+)e^(-) colliders

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Science Bulletin 2022年第18期67卷 1840-1843页

作者： Xiao-Gang He Jusak Tandean german Valencia Tsung-Dao Lee Institute KLPAC and SKLPPC laboratoriesSchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Gayungsari III/20 Surabaya 60235Indonesia School of Physics and Astronomy Monash UniversityMelbourne VIC-3800Australia

The phenomenon of CP violation——the breaking of the combination of charge-conjugation symmetry(C) and parity symmetry(P)——is one of the least understood aspects of high-energy *** frst evidence for CP violation wa... 详细信息

关键词： symmetry 超子衰变 neutral