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COMPARATIvE TREATMENT OF ACNE vULGARIS USING PALOMAR LUX APPLIQU´E TECHNIQUE AND DIRECT INTRALESIONAL INJECTION

Journal of Innovative Optical Health Sciences 2009年第3期2卷 279-287页

作者： ELINA A.GENINA ALEXEY N.BASHKATOv vALERY v.TUCHIN georgy v.simonenko vERA N.SHERSTNEvA ILYA v.YAROSLAvSKY GREGORY B.ALTSHULER Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya str. Saratov 410012Russia Saratov State Medical University 112 B.Kazachya str. Saratov 410012Russia Palomar Medical Technologies Inc. 82 Cambridge St.Burlington 01803MAUSA

Intralesional injection of triamcinolone(TMC)preparations is an effective therapy for cystic acne ***,invasive delivery techniques limit the use of this modality to a relatively narrow class of *** permeability can be enhanced through creating a lattice of microzones(islets)of light-induced limited thermal damage in the upper layers of *** this paper,we directly compared safety and efficacy of delivering TMC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions.A combination of an intense pulsed light system and a specially designed appliqu´e with a pattern of absorbing centers has been used to create the lattice of islets of damage(LID).Quantitative analysis has included estimation of the following parameters:redness,diameter,and height of acne *** photography has been used to document dynamics of lesion development at successive visits(two hours,24 hours and one week post-treatment).Seven subjects have participated in the *** difference in lesion dynamics between the treatment and control groups was observed at two-hours *** 24-hours/one-week follow-ups,TMC-injected and TMC-LID-delivered groups have demonstrated 82%/93%and 80%/89%improvement in height of lesions in comparison to control(60%/68%).Delivery of TMC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne *** of skin permeability using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin.

关键词： Acne vulgaris drug delivery skin permeability enhancement.

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PHOTOTHERAPY OF GINGIvITIS:PILOT CLINICAL STUDY

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 437-446页

作者： ELINA A.GENINA vLADIMIR A.TITORENKO vALERY v.TUCHIN georgy v.simonenko ALEXEY N.BASHKATOv GENNADY M.SHUB ALEXANDER v.LEPILIN ILYA v.YAROSLAvSKY GREGORY B.ALTSHULER Saratov State University Saratov410012Russia Saratov State Medical University Saratov410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia Palomar Medical Technology Inc.Burlington MA 01803USA

The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush(R-LETB)emitting at wavelength of 663 nm with power density of 3.3mW/cm2 in combination with 0.1%-methylene blue(MB)solution for the reduction of plaque and treatment of gingivitis.A microbiological in vitro study and a pilot clinical study were *** microbiological study has shown total suppression of pathogenicflora after a 3-min exposure to the dye solution followed by a 20-sec treatment with the *** the clinical study,37 subjects of both sexes with gingivitis were enrolled and randomly assigned to one of two *** in thefirst(treatment)group were instructed to rinse their mouth with MB solution provided for 1 min and then brush the teeth with the R-LETB and standardized *** second(control)group used only the toothpaste and a regular *** in both groups followed their respective procedures 2 times a day(morning and evening)for 30 *** of plaque,gingival bleeding,and inflammation were evaluated at 14-day and 30-day *** the both groups,all indices improved in comparison with ***,the treatment group demonstrated more pronounced improvement of the studied indices that was attributed to additional anti-microbial action of red light and MB on gum ***,the use of R-LETB with MB appears to have a multifactor therapeutic action on oral pathological microflora:mechanical removal of the bacteria and suppressing action on microorganisms due to photodynamic reaction.

关键词： Tooth brushing methylene blue photodynamic therapy pathogenic bacteria

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Exploring van der Waals materials with high anisotropy:geometrical and optical approaches

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Light(Science & Applications) 2024年第4期13卷 645-653页

作者： Aleksandr S.Slavich georgy A.Ermolaev Mikhail K.Tatmyshevskiy Adilet N.Toksumakov Olga G.Matveeva Dmitriy v.Grudinin Kirill v.voronin Arslan Mazitov Konstantin v.Kravtsov Alexander v.Syuy Dmitry M.Tsymbarenko Mikhail S.Mironov Sergey M.Novikov Ivan Kruglov Davit A.Ghazaryan Andrey A.vyshnevyy Aleksey v.Arsenin valentyn S.volkov Kostya S.Novoselov Moscow Center for Advanced Studies Kulakova str.20Moscow 123592Russia. Emerging Technologies Research Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. Donostia International Physics Center(DIPC) Donostia/San-Sebastián 20018Spain. Institute of Materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Advanced Functional Materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Institute(NGI) University of ManchesterManchester M139PLUK. Department of Materials Science and Engineering National University of SingaporeSingapore 03-09 EASingapore. Institute for Functional Intelligent Materials National University of Singapore117544 SingaporeSingapore

The emergence of van der Waals(vdW)materials resulted in the discovery of their high optical,mechanical,and electronic anisotropic properties,immediately enabling countless novel phenomena and *** success inspired an intensive search for the highest possible anisotropic properties among vdW ***,the identification of the most promising among the huge family of vdW materials is a challenging quest requiring innovative ***,we suggest an easy-to-use method for such a survey based on the crystallographic geometrical perspective of vdW materials followed by their optical *** our approach,we found As2S3 as a highly anisotropic vdW *** demonstrates high in-plane optical anisotropy that is~20%larger than for rutile and over two times as large as calcite,high refractive index,and transparency in the visible range,overcoming the century-long record set by *** these benefits,As2S3 opens a pathway towards nextgeneration nanophotonics as demonstrated by an ultrathin true zero-order quarter-wave plate that combines classical and the Fabry–Pérot optical phase ***,our approach provides an effective and easy-to-use method to find vdW materials with the utmost anisotropic properties.

关键词： anisotropy anisotropic high

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3,6-Bis-β-Dicarbonylsubstituted Carbazoles Bearing N-Spacers and Their Eu(III) Complexes as Immunofluorescent Labelling Agents

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International Journal of Organic Chemistry 2024年第1期14卷 20-31页

作者： Dmitry E. Pugachev georgy v. Zatonsky Tatyana S. Kostryukova Anna G. Shubina Nikolay v. vasiliev Department of Biological Microanalysis FGUP State Research Institute of Biological Engineering Moscow Russia Department of Theoretical and Applied Chemistry State University of Education Mytishchi Russia

New reagents for immunofluorescence analysis of carbazole series containing fluorinated β-dicarbonyl fragments and carboxylic substituent groups separated by spacers of different lengths from the light-gathering carbazole scaffold have been developed. The markers in complex with Eu3+ ions possess stability in the aqueous phase, intense and prolonged luminescence (τ 550 - 570 μs) with characteristic emission maxima in the region of 615 nm and excitation wavelengths in the region of 380 - 390 nm, which distinguishes them from most of the analogs used. In the study of marker conjugation with streptavidin, a reagent containing 4 - 5 europium labeling complexes based on spacer-containing carbazole tetraketone was obtained. The marker-doped silicate nanoparticles exhibit intense and long-lived luminescence in the characteristic region.

关键词： Fluorescence Immunoassay Fluorinated β-Diketones Carbazole Europium Complexes Streptavidin Nanodispersions

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Pulsed THz radiation under ultrafast optical discharge of vacuum photodiode

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Frontiers of Optoelectronics 2024年第2期 100-113页

作者： Aleksandr A.Ushakov Kseniia A.Mamaeva Leonid v.Seleznev georgy E.Rizaev vladimir Bukin Timophey v.Dolmatov Pavel A.Chizhov vladimir Bagdasarov Sergey v.Garnov Prokhorov General Physics Institute of the Russian Academy of Sciences Physical Institute Russian Academy of Sciences Moscow Institute of Physics and Technology Russian Institute for Scientific and Technical Information

In this paper, we first present an experimental demonstration of terahertz radiation pulse generation with energy up to 5 pJ under the electron emission during ultrafast optical discharge of a vacuum photodiode. We use a femtosecond optical excitation of metallic copper photocathode for the generation of ultrashort electron bunch and up to 45 kv/cm external electric field for the photo-emitted electron acceleration. Measurements of terahertz pulses energy as a function of emitted charge density, incidence angle of optical radiation and applied electric field have been provided. Spectral and polarization characteristics of generated terahertz pulses have also been studied. The proposed semi-analytical model and simulations in COMSOL Multiphysics prove the experimental data and allow for the optimization of experimental conditions aimed at flexible control of radiation parameters.

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The Confirmed validity of the Thermohydrogravidynamic Theory Concerning the Forthcoming Intensification of the Global Natural Processes from December 7, 2019 to April 18, 2020 AD

The Confirmed Validity of the Thermohydrogravidynamic Theory...

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作者： Sergey v.simonenko v.I. Il’ichev Pacific Oceanological Institute Far Eastern Branch of Russian Academy of Sciences

We present the confirmed validity of the prediction（made in unpublished article（simonenko, 2019 b） presented on December 9, 2019 to the journal Energy Research） of the thermohydrogravidynamic theory（simonenko, 2014） concerning the evaluated probabilities of the forthcoming intensification of the global seismotectonic, volcanic, climatic and magnetic processes of the Earth during the evaluated beginning（from December 7, 2019 to April 18, 2020） of the established in 2012 AD（simonenko, 2012 a） and finally confirmed in 2019 AD（simonenko, 2019 a） "first forthcoming subrange 2020 ÷ 2026 AD of the increased intensification of the Earth" determined by the combined non-stationary cosmic energy gravitational influences on the Earth of the planets（Mercury, venus, Mars and Jupiter） and the Sun（owing to the gravitational interaction of the Sun with Jupiter, Saturn, Uranus and Neptune）.

关键词： Thermohydrogravidynamic Theory Non-Stationary Cosmic Gravitation Cosmic Geophysics Cosmic Seismology Cosmic Geology Generalized First Law of Thermodynamics Global Seismotectonic volcanic Climatic and Magnetic Processes

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The Confirmed validity of the Explanatory Aspect of the Thermohydrogravidynamic Theory Concerning the Evaluated Maximal Magnitude of the Strongest Earthquake during the Considered Intensification of the Global Natural Processes from December 7, 2019 to Apr

The Confirmed Validity of the Explanatory Aspect of the Ther...

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作者： Sergey v.simonenko v.I.Il’ichev Pacific Oceanological Institute Far Eastern Branch of Russian Academy of Sciences

We present the confirmed validity of the significant explanatory aspect of the thermohydrogravidynamic theory（simonenko, 2007, 2009, 2012-2020） concerning the evaluated（on April 7, 2021, especially for the presentation on the 11 th International Conference on Geology and Geophysics） maximal magnitude 7.725 of the possible most strongest earthquake during the considered（simonenko, 2020） intensification of the global natural processes of the Earth from December 7, 2019 to April 18, 2020 AD. To obtain the satisfactory explanation of the maximal magnitude M = 7.7（according to the U.S. Geological Survey） of the strongest earthquake occurred on January 28, 2020 AD（123 km NNW of Lucea, Jamaica） near the calculated（simonenko, 2020） mean date（February 5, 2020 AD） of the probable most strongest earthquake during the considered（simonenko, 2020） range from December 7, 2019 to April 18, 2020 AD, we have analyzed the strongest earthquakes of the Earth occurred near the calculated local maximal combined（planetary and solar） integral energy gravitational influences on the internal rigid core of the Earth.

关键词： Thermohydrogravidynamic Theory Non-Stationary Cosmic Gravitation Generalized First Law of Thermodynamics Cosmic Geology Cosmic Geophysics Cosmic Seismology Global Seismotectonic volcanic Climatic and Magnetic Processes

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The Confirmed validity of the Explanatory Aspect of the Thermohydrogravidynamic Theory Concerning the Evaluated Maximal Magnitude of the Strongest Earthquake of the Earth near the Predicted Date 2021.1 AD during the Range from October 27, 2020 to May 17, 2

The Confirmed Validity of the Explanatory Aspect of the Ther...

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作者： Sergey v.simonenko v.I.Il’ichev Pacific Oceanological Institute Far Eastern Branch of Russian Academy of Sciences

We present the explanation(in the frame of the established thermohydrogravidynamic technology) of the maximal magnitude M = 8.1(according to the U.S. Geological Survey) of the strongest earthquake of the Earth occurred in Kermadec Islands, New Zealand on March 4, 2021 AD(during the considered range from October 27, 2020 to May 17, 2021 AD). This strongest earthquake occurred near the calculated date 2021.1 AD corresponding(in the frame of the thermohydrogravidynamic theory) to the local maximal combined planetary and solar integral energy gravitational influence on the internal rigid core of the Earth. To obtain this explanation, we have analyzed the strongest earthquakes of the Earth(according to the U.S. Geological Survey) occurred near the dates of the local maximal combined planetary and solar integral energy gravitational influences on the internal rigid core of the Earth.

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The Application of the Generalized Differential Formulation of the First Law of Thermodynamics for Evidence of the Tidal Mechanism of Maintenance of the Energy and viscous-Thermal Dissipative Turbulent Structure of the Mesoscale Oceanic Eddies

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Journal of Modern Physics 2018年第3期9卷 357-386页

作者： Sergey v.simonenko vyacheslav B.Lobanov v.I.Il'ichev Pacific Oceanological Institute Far Eastern Branch of Russian Academy of SciencesVladivostokRussia

The practical significance of the established generalized differential formula-tion of the first law of thermodynamics (formulated for the rotational coor-dinate system) is evaluated (for the first time and for the mesoscale oceanic eddies) by deriving the general (viscous-compressible-thermal) and partial (incompressible, viscous-thermal) local conditions of the tidal maintenance of the quasi-stationary energy and dissipative turbulent structure of the mesoscale eddy located inside of the individual fluid region of the ther-mally heterogeneous viscous (compressible and incompressible, respective-ly) heat-conducting stratified fluid over the two-dimensional bottom topog-raphy characterized by the horizontal coordinate x along a horizon-tal axis X. Based on the derived partial (incompressible) local condition (of the tidal maintenance of the quasi-stationary energy and viscous-thermal dis-sipative turbulent structure of the mesoscale eddy) and using the calculated vertical distributions of the mean viscous dissipation rate per unit mass and the mean thermal dissipation rate per unit mass in four regions near the observed mesoscale (periodically topographically trapped by nearly two-dimensional bottom topography h(x) eddy located near the northern region of the Yamato Rise in the Japan Sea, the combined analysis of the energy structure of the eddy and the viscous-thermal dissipative structure of turbulence is presented. The convincing evidence is presented of the tidal mechanism of maintenance of the eddy energy and viscous-thermal dissipa-tive structure of turbulence (produced by the breaking internal gravity waves generated by the eddy) in three regions near the Yamato Rise subjected to the observed mesoscale eddy near the northern region of the Yamato Rise of the Japan Sea.

关键词： Generalized Formulation of the First Law of Thermodynamics Cosmic Gravitation Small-Scale Dissipative Turbulence viscous and Thermal Dissipation Rates Mesoscale Oceanic Eddies Internal Tide

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Geochemistry of Thermal Waters of Continental Margin of Far East of Russia

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Acta Geologica Sinica(English Edition) 2016年第1期90卷 276-284页

作者： Ivan v. BRAGIN georgy A. CHELNOKOv Oleg v. CHUDAEv Natalia A. KHARITONOvA Sergey v. vYSOTSKIY Far East Geological Institute Russian Academy of SciencesVladivostok690022 Russia Moscow State University Moscow119991 Russia Far East Federal University Vladivostok690922 Russia

Studied waters belong to warm （T=30-50℃）, alkaline （pH=8.9-9.3）, low mineralized （TDS〈235 mg/l） Na-HCO3 or Na-SO4-HCO3 thermal waters with high content of SiO2 （up to 81 mg/1） and F （up to 3.9 mg/l）, occur on modern volcano-tectonic rejuvenated areas of Eastern Sikhote-Alin orogenic belt. Low 3He concentration as well as N2/O2 and N2/Ar ratios exclude influence of deep mantle fluid. New rare earth element data constrain our understanding of water-rock interaction occurring in the water source region. Meteoric origin of waters is proved by stable isotope values varying from -71%o to -136.1‰ and from -10.8‰ to -18.8%o for δ^2H and δ^18O respectively. REE patterns reflect high pH, resultfing from water-rock interaction and oxidative conditions. Calculations of deep aquifer temperature using Na-K and quartz geothermometers show 116.8-131.1℃ and 82.2-125.8℃ respectively. Presence of deep faults both with abnormal thermal gradient （-45- 50 K/km） define unique geochemical shape of thermal waters of Sikhote-Alin, area, where no present volcanic activity is registered.

关键词： thermal waters water-rock interaction stable water isotopes rare earth elements in thermal waters

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