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Community analysis of ammonia-oxidizing bacteria in activated sludge of eight wastewater treatment systems

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Journal of Environmental Sciences 2010年第4期22卷 627-634页

作者： Xiaohui Wang Xianghua Wen craig Criddle george Wells Jie Zhang yin Zhao Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China. Department of Civil and Environmental Engineering Jerry Yang & Akiko Yamazaki Environment & Energy Building Stanford University Stanford CA94305-4020 USA Beijing Drainage Group Co. Ltd. Beijing 100084 China

We investigated the communities of ammonia-oxidizing bacteria （AOB） in activated sludge collected from eight wastewater treatment systems using polymerase chain reaction （PCR） followed by terminal restriction fragment length polymorphism （T-RFLP）, cloning, and sequencing of the α-subunit of the ammonia monooxygenase gene （amoA）. The T-RFLP fingerprint analyses showed that different wastewater treatment systems harbored distinct AOB communities. However, there was no remarkable difference among the AOB T- RFLP profiles from different parts of the same system. The T-RFLP fingerprints showed that a full-scale wastewater treatment plant （WWTP） contained a larger number of dominant AOB species than a pilot-scale reactor. The source of influent affected the AOB community, and the WWTPs treating domestic wastewater contained a higher AOB diversity than those receiving mixed domestic and industrial wastewater. However, the AOB community structure was little affected by the treatment process in this study. Phylogenetic analysis of the cloned amoA genes clearly indicated that all the dominant AOB in the systems was closely related to Nitrosomonas spp. not to Nitrosospira spp. Members of the Nitrosomonas oligotropha and Nitrosomonas communis clusters were found in all samples, while members of Nitrosomonas europaea cluster occurred in some systems.

关键词： activated sludge ammonia-oxidizing bacteria T-RFLP amoA gene wastewater treatment plant

New insights into acquired endocrine resistance of breast cancer

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Cancer Drug Resistance 2019年第2期2卷 198-209页

作者： Ping Fan V.craig Jordan Department of Breast Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA.

The translational research strategy of targeting estrogen receptorα(ERα)positive breast cancer and then using long term anti-hormone adjuvant therapy(5-10 years)has reduced recurrences and ***,resistance continues to occur and improvements are required to build on the success of tamoxifen and aromatase inhibitors(AIs)established over the past 40 *** translational research has described the evolution of acquired resistance of breast cancer cell lines to long term estrogen deprivation that parallels clinical experience over ***,recent reports have identified mutations in the ERαobtained from the recurrences of AI treated *** mutations allow the ERαto activate without ligands and auto stimulate metastatic tumor ***,the new biology of estrogen-induced apoptosis in acquired resistant models in vitro and in vivo has been interrogated and applied to clinical *** and stress are emerging concepts occurring in the process of acquired resistance and estrogen-induced apoptosis with different *** this review,we will present progress in the understanding of acquired resistance,focus on stress and inflammatory responses in the development of acquired resistance,and consider approaches to create new treatments to improve the treatment of breast cancer with endocrine resistance.

关键词： Estrogen receptorα endocrine resistance endoplasmic reticulum stress estrogen-induced apoptosis breast cancer

Robotic surgery for multi-visceral resection in locally advanced colorectal cancer:Techniques,benefits and future directions

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Laparoscopic, Endoscopic and Robotic Surgery 2023年第4期6卷 123-126页

作者： Chahaya Gauci Praveen Ravindran Stephen Pillinger Andrew craig Lynch Australian Robotic Colorectal Surgery SydneyAustralia Sydney Medical School Unversity of Sydney.Sydney Australia St george and Sutherland Clinical School Uhriversity of New South Wules MedidneSydneyAustrulia College of Health and Medicine Australian National UnversityCanberraAustulia

Colorectal cancer accounts for 10%of diagnosed cancers globally and often presents as advanced disease,necessitating aggressive *** both younger and healthier elderly patients being diagnosed,as well as potentially the need for salvage therapy post total neoadjuvant treatment,surgical options for cure include pelvic *** typically performed via an open approach,there has been an increased utilisation of minimally invasive techniques including robotic *** smaller in-cisions,reduced postoperative pain,and quicker recovery time than open surgery,robotic techniques have demonstrated lower blood loss,shorter hospital stays,and reduced ***,the er-gonomic design of robotic systems provides surgeons with comfort during long procedures and increased *** also offers an increased opportunity for organ preservation and reconstruction whilst maintaining adequate oncological *** robotic technology continues to evolve and combines with artificial intelligence,it is poised to play an even more significant role in the management of complex colorectal cancer cases,improving survival and long-term outcomes.

关键词： Colorectal neoplasms Robotic surgical procedures Pelvic exenteration Multivisceral surgery Artificial intelligence

Introduction to the practice of statistics 7th ed.

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Introduction_to_the_Practice_of_Statistics_6 6th ed

2012年

作者： Bruce A. craig. george P. McCabe David S. Moore

来源：畅想之星图书光盘版（南... 评论

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Precision management of brain oedema after acute ischaemic stroke

2009年

作者： craig BLEyER

来源：畅想之星图书光盘版（南... 评论

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Precision Clinical Medicine 2022年第3期5卷 195-197页

作者： Simiao Wu craig S Anderson Department of Neurology West China HospitalSichuan UniversityChengdu 610041China Centre for Cerebrovascular Diseases West China HospitalSichuan UniversityChengdu 610041China The george Institute for Global Health Faculty of MedicineUniversity of New South WalesSydney NSW 2050Australia The george Institute for Global Health China Beijing 100600China

Dear Editor,Stroke is a leading cause of death and disability in the world,with acute ischaemic stroke accounting for∼70%of all cases.1 Some degree of brain oedema occurs in all cases of acute ischaemic stroke and,when severe,has major consequences on survivalfree of *** studies indicate an evolution of cytotoxic oedema,ionic oedema,and vasogenic oedema,2 which implies brain oedema is a dynamic process and explains the various terminology used,such as large hemispheric infarction,symptomatic infarct swelling,space-occupying infarction,or malignant middle cerebral artery(MCA)*** in manifestations and sequelae necessitates a new,precision medicine approach to individualizing prevention and treatment of brain oedema after stroke.

关键词： edema acute prevention

裂缝型致密气藏和页岩气藏的流一固耦合机制分析

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海洋地质 2013年第1期29卷 31-32页

作者： george J. MORIDIS Jihoon KIM craig M. FREEMAN

本文通过数值模拟分析了页岩和致密砂岩这两种类型的裂缝型致密气藏的流一固耦合机制和过程。数学模型包括基于达西定律的多相流方程和有关储层流体热物理性质的准确描述。

关键词：致密气藏耦合机制裂缝型页岩数值模拟分析热物理性质致密砂岩储层流体

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机器人在结直肠手术中的作用

英国医学杂志中文版 2018年第11期21卷 643-652页

作者： Christina L Cheng craig Rezac 公磊(译) Colon and Rectal Clinic Swedish Medical Center1101Madison AvenueSte 510SeattleWA98104USA Virginia Hospital Center Physician Group 1625N George Mason DriveSte 334ArlingtonVA22205USA 北京清华长庚医院外科

研究支持结直肠手术使用腹腔镜途径。与开腹手术相比,腹腔镜手术减少了术后并发症发生率,缩短了住院时间,同时可以获得相同的肿瘤治疗效果。尽管如此,大部分结直肠手术仍然以开放手术方式进行。部分原因可能是腹腔镜手术存在技术挑战,... 详细信息

研究支持结直肠手术使用腹腔镜途径。与开腹手术相比,腹腔镜手术减少了术后并发症发生率,缩短了住院时间,同时可以获得相同的肿瘤治疗效果。尽管如此,大部分结直肠手术仍然以开放手术方式进行。部分原因可能是腹腔镜手术存在技术挑战,尤其是在像骨盆这样的狭窄腔隙中工作时。另外,现在一些文献对直肠癌腹腔镜手术的肿瘤治疗效果提出质疑。机器人手术被认为是一种可以克服这些挑战的微创治疗方式。它的优势是可以提供三维图像,使用可以扭曲的器械,并且具有计算机平台,可以做出流畅而且精准的动作。总体而言,目前的证据表明机器人技术在结直肠手术中是安全可行的,并且其短期和长期效果与腹腔镜手术相似。关于机器人手术的成本研究显示出了自相矛盾的结果,这是机器人应用的最大缺点之一。由于机器人技术是一项相对较新的技术,现在鲜有大规模高质量研究。这一领域发表的多数研究包括回顾性评论、案例匹配研究和国家数据库综述。还需要进行大型随机前瞻性研究来进一步支持其使用。

关键词：机器人手术直肠癌机器人技术治疗效果腹腔镜计算机平台机器人应用治疗方式

Characteristics,management and response to alteplase in China versus non-China participants of the ENCHANTED trial

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Stroke & Vascular Neurology 2017年第2期2卷 53-58页

作者： Lily Song Xia Wang Thompson Robinson Richard I Lindley Hisatomi Arima Pablo M Lavados Xiaoying Chen John Chalmers craig S Anderson The george Institute for Global Health at Peking University Health Science Center BeijingChina Department of Neurology 85 Hospital of People’s Liberation ArmyShanghaiChina The george Institute for Global Health The University of New South WalesSydneyAustralia Department of Cardiovascular Sciences and NIHR Biomedical Research Unit for Cardiovascular Sciences University of LeicesterLeicesterUK Department of Preventive Medicine and Public Health Faculty of MedicineFukuoka UniversityFukuokaJapan Clínica Alemana de Santiago Universidad del DesarrolloConcepciónChile Departamento de Ciencias Neurológicas Facultad de MedicinaUniversidad de ChileConcepciónChile Neurology Department Royal Prince Alfred HospitalSydneyAustralia

Background The characteristics of patients with acute ischaemic stroke(AIS)and their management vary across regions,which may influence *** examined for differential patterns of outcome between China and non-China participants of the ENhanced Control of Hypertension And Thrombolysis strokE stuDy(ENCHANTED),which tested different alteplase doses in *** ENCHANTED was an international,multicentre,open,blinded-endpoint trial of the effects of low-dose(0.6 mg/kg)versus standard-dose(0.9 mg/kg)intravenous alteplase on 90-day disability outcomes and symptomatic intracerebral haemorrhage(sICH)in 3310 patients with *** Participants(n=1419,48%)in China were younger,and more often male,hypertensive and with prior stroke and coronary artery disease,but less likely to have atrial fibrillation and use antihypertensive,antithrombotic and lipid-lowering agents,compared with non-China patients with *** China participants had more AIS due to large artery occlusion,were treated later and had differing ancillary management,there was no significant difference in 90-day modified Rankin scale scores 2–6(55.6% vs 47.8%;OR,adjusted for baseline and management factors 0.87(95%CI 0.71 to 1.07;p=0.20))and risk of sICH(Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria:1.4% vs 1.8%;p=0.12)compared with non-China *** was no heterogeneity in the treatment effects of low-dose versus standard-dose alteplase between China and non-China *** Patients with AIS recruited to the ENCHANTED trial in China had similar outcomes in response to thrombolysis treatment despite significantly differing demographic,clinical and management factors to patients with AIS in other regions.

关键词： hypertensive doses younger