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Real-world data on ALK rearrangement test in chinese advanced non-small cell lung cancer(RATICAL):a nationwide multicenter retrospective study

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Cancer Communications 2024年第9期44卷 992-1004页

作者： Lin Li Wencai Li ChunyanWu Yanfeng Xi Lei Guo yuan Ji Lili Jiang Ji Li Jingping Yun Gang Chen yuan Li Yueping Liu DianbinMu Yuchen Han Leina Sun Qingxin Xia Xiaodong Teng Nanying Che WeiWu Xueshan Qiu Chao Liu Xiaochu Yan Daiqiang Li Zhihong Zhang ZheWang Yujun Li ZhengWang Lingchuan Guo Xiu Nie Jingshu {2. Jianhua Zhou Jianming Ying Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Pathology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China Department of Pathology Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China Department of Pathology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of Pathology West China Hospital of Sichuan UniversityChengduSichuanP.R.China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Pathology Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Department of Pathology Shandong Cancer HospitalJinanShandongP.R.China Department of Pathology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Department of Pathology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Department of Pathology Bei

Background:Anaplastic lymphoma kinase(ALK)test in advanced non-small cell lung cancer(NSCLC)can help physicians provide target therapies for patients harboring ALK gene *** study aimed to investigate the real-world test patterns and positive rates of ALK gene rearrangements in advanced ***:In this real-world study(ChiCTR2.000302.6),patientswith advanced NSCLC who underwent an ALK rearrangement test in 30 medical centers in china between October 1,2.18 and December 31,2.19 were retrospectively *** training was conducted before the study was *** controls were performed at participating centers using immunohistochemistry(IHC)-*** positive ALK gene rearrangement rate and consistency rate were *** associated clinicopathological characteristics of ALK gene rearrangement were investigated as ***:The overall ALK gene rearrangement rate was 6.7%in 2.,689 patients with advanced NSCLC and 8.2.in 17,436 patients with advanced lung *** quality control analysis of IHC-VENTANA-D5F3 revealed an intrahospital consistency rate of 98.2.(879/895)and an inter-hospital consistency rate of 99.2.(646/651).IHC-VENTANA-D5F3 was used in 53.6%,real-time polymerase chain reaction(RT-PCR)in 2..4%,next-generation sequencing(NGS)in 18.3%,and fluorescence in-situ hybridization(FISH)in 15.9%in the adenocarcinoma *** specimens tested with multiple methods,the consistency rates confirmed by IHC-VENTANA-D5F3 were 98.0%(82./839)for FISH,98.7%(1,2.2.1,2.8)forNGS,and 91.3%(146/160)for *** overall ALK gene rearrangement rateswere higher in females,patients of≤35 years old,never smokers,tumor cellularity of>50,and metastatic specimens used for testing in the total NSCLC population and adenocarcinoma subgroup(all P<0.05).Conclusions:This study highlights the real-world variability and challenges of ALK test in advanced NSCLC,demonstrating a predominant use of IHCVENTANA-D5F3 with high co

关键词： anaplastic lymphoma kinase diagnosis gene fusion non-small cell lung cancer

2.15~2.2.年洞庭湖水质变化及驱动因子分析

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长江流域资源与环境 2024年第7期33卷 1576-1588页

作者：原丽格耿明明李峰谢永宏中国科学院亚热带农业生态研究所中国科学院亚热带农业生态过程重点实验室湖南长沙410125 中国科学院亚热带农业生态研究所洞庭湖湿地生态系统观测研究站湖南长沙410125 中国科学院大学北京100049

为了分析2.15~2.2.年(即湖南省政府开展了《洞庭湖生态环境专项整治三年行动计划(2.18-2.2.年)》前后)洞庭湖水质变化趋势及其关键驱动因子,选取总氮(total nitrogen,TN)、总磷(total phosphorus,TP)、高锰酸盐指数(chemical oxygen dem... 详细信息

为了分析2.15~2.2.年(即湖南省政府开展了《洞庭湖生态环境专项整治三年行动计划(2.18-2.2.年)》前后)洞庭湖水质变化趋势及其关键驱动因子,选取总氮(total nitrogen,TN)、总磷(total phosphorus,TP)、高锰酸盐指数(chemical oxygen demand,CODMn)和氨氮(NH3-N)4项水质指标,分析了洞庭湖水质年际变化趋势及行动计划前后的水质特征;并通过水体污染指数w和综合污染指数γ评估了洞庭湖水质污染水平;最后结合水位、入湖径流等水文指标和污水处理率、畜禽排泄量等人为指标,深入揭示不同时期影响湖泊水质的关键驱动因子。结果表明:(1)研究期间,TN、TP和NH3-N浓度均呈显著下降趋势(显著性水平p2.水位、入湖流量、入湖泥沙量呈年际波动趋势;泥沙沉积量显著增加,由-152..2.10^(4) t/a增至12.1.7×10^(4) t/a。(3)畜禽排泄量、施肥量、污水处理率、水位和泥沙沉积量是影响洞庭湖水质变化的关键驱动因子。建议后续湖泊管理中继续加强外源污染物管控,同时合理改善洞庭湖水文条件,加强水文连通性。

关键词：洞庭湖水质驱动因子三年行动计划

Phytoliths as quantitative indicators for the reconstruction of past environmental conditions in china I:phytolith-based transfer functions

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Phytoliths as quantitative indicators for the reconstruction...

Kinematics and age constraints of deformation in a Late Carboniferous accretionary complex in Western Junggar,NW china

中国科学院地质与地球物理研究所2.06学术年会

作者： Hou-yuan Lu~(a,b,),Nai-Qin Wu~a,Xiang-Dong Yang~c,Hui Jiang~(d,e),Kam-biu Liu~f,Tung-Sheng Liu~a a institute of Geology and Geophysics,chinese academy of sciences,beijing 100029,china b institute of Tibetan Plateau research,chinese academy of sciences,beijing 100085,china c Nanjing institute of Geography and Limnology,chinese academy of sciences,Nanjing 210008,china d Department of Earth sciences,University of Aarhus,DK-8000 Aarhus C,Denmark e Laboratory of geographic Information Science,East china Normal University,200062 Shanghai,china f Department of Geography and Anthropology,Louisiana State University,Baton Rouge,LA 70803,USA

This study investigated the distribution of phytolith assemblages in china from surface soil samples at 2.3 sites along significant ecological and climatic gradients to develop transfer functions for quantitative reconstruction of *** correspondence analysis(CCA) and detrended correspondence analysis(DCA) were used to determine the main environmental variables influencing phytolith *** results reveal that mean annual precipitation(MAP) is the dominant variable controlling the spatial distribution of phytoliths, which accounts for 39%of the total *** annual temperature(MAT),relative humidity (Humi),and annual evaporation(VAP) are another three significant variables,accounting for 6%, 10%,and 5%respectively of the total variance in phytolith *** functions,based on WA-PLS(weighted averaging plus partial least squares),were developed for MAP(R= 0.90,root-mean-square-error of prediction(RMSEP)=148 mm),MAT(R=0.84,RMSEP= 2.52.),Humi(R=0.75,RMSEP=6.36%) and VAP(R=0.59,RMSEP=32. mm). Overall,our results confirm that phytoliths can provide reliable and robust estimates of MAP, MAT,Humi and ***,WA-PLS is a robust calibration method for quantitative palaeoenvironmental reconstruction based on phytolith data.

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Kinematics and age constraints of deformation in a Late Carb...

First Record of Middle Eocene Elephant Ancestors’Footprints in the Gonjo Basin,East Tibet Plateau

中国科学院地质与地球物理研究所第11届（2.11年度）学术年会

作者： Ji’en Zhang~a,Wenjiao Xiao~(a,*),Chunming Han~a,Songjian Ao~(a,b),Chao yuan~c,Min Sun~d,Hongyan geng~d, Guochun Zhao~d,Qianqian Guo~(a,b),Chong Ma~b a State Key Laboratory of Lithospheric Evolution,{2. of Geology and Geophysics,chinese academy of sciences,beijing 10002.,china b Graduate University,chinese academy of sciences,beijing 100049,china c Key Laboratory of Isotope Geochronology and Geochemistry,Guangzhou {2. of Geochemistry,chinese academy of sciences,Guangzhou 510640,china d Department of Earth sciences,The University of Hong Kong,Hong Kong,china

The Karamay area,situated in the eastern part of Western Junggar,Southern Altaids,contains an ophiolitic melange with ultramafic rocks,gabbro,basalt,chert and limestone,which show typical block-in-matrix structures,and coherent turbidites and *** lithological associations are interpreted as incoherent and coherent series formed in an acaetionary *** the basis of detailed field mapping and analyses of the asymmetry of imbricate thrusts,duplexes,tilted structures,shear band cleavages,and the NW-verging inclined to overturned folds,we conclude that the overall movement in the accretionary complex was *** youngest tuff involved in the deformation contains detrital zircons that have a U-Pb age(LA-MCICP-MS) of 308±7 ***-Ar resistance furnace step-heating of amphibole separates from a diorite dike,which cuts the folded and imbricated rocks in the accretionary prism,yielded a plateau age of 307±2.***,the age of the deformation in the prism is tightly constrained at 307-308 Ma,implying that the deformation occurred in an extremely short time-span during SE-ward *** contemporaneous occurrence of Baogutu adakite,high-Mg,Sr-enriched and Y-poor dioritic dikes,Miaoergou charnockite,and Maliya mafic rocks,we further suggest the acaetionary complex was cut by near-trench volcanic rocks and plutons possibly due to interaction with a spreading ridge.

关键词： West Junggar Accretionary complex Melange Coheret unit Southern Altaids

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Journal of Earth Science 2024年第4期35卷 1224-1235页

作者： Asma Tahir Huazhou Yao Junaid Khan Yangui Li He Zhao Yue Yu Tang yuan institute of Geological Survey China University of GeosciencesWuhan430074China Wuhan Center China Geological SurveyWuhan430205China State Key Laboratory of Geological Processes and Mineral resources Wuhan430078China Chengdu Center China Geological SurveyChengdu610081China institute of geographic {2. and Natural resources research Chinese Academy of SciencesBeijing100101China

It is the first time that the fossil footprints of a group of Middle Eocene elephant ancestors have been discovered in the Gonjo Basin,East Tibet *** Gonjo Formation is attributed to the Middle Eocene Epoch(U-Pb age=44.7±1.2.Ma)and consists mainly of purplish-red,medium-to coarse-grained sandstones,siltstones interbedded with mudstones,and conglomerates with sedimentary structures like ripple marks,rip-up clasts,and trough-cross bedding,suggesting fluvial-lacustrine *** group of fossil footprints has a characteristic oval-concave shape,and the toe impressions are *** fossil footprints are overstepped with a pockmarked texture resembling Proboscipeda *** than 165 fossil footprints of the group are relatively well-preserved with different diameters,which is evidence of highly social behavior and trackmakers of different ages,including calves,juveniles,adolescents,and *** size frequency of the fossil footprints enabled us to deduce the body mass,shoulder height,and hip-height distribution of the trackmakers that crossed the East Tibet Plateau 44.7 Ma *** trackmakers comprised an estimated average hip-height of 111.8 cm,an average shoulder height of 172.8 cm for males/155.9 cm for females,and an average body mass of approximately 12.8.1 kg for males/907.8 kg for *** abundance of fossil footprints reveals that in the Middle Eocene Epoch,the environment was extraordinarily conducive for the elephant ancestors to live in the East Tibet region.

关键词： Proboscipeda enigmatica East Tibet Plateau Gonjo Formation fossil footprints fluvial-lacustrine

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农业生产的温室气体排放研究进展

山东农业大学学报（自然科学版） 2003年第2期34卷 311-314页

作者：李明峰董云社耿元波齐玉春中国科学院地理科学与资源研究所北京100101

农业生产是人类最重要的生产活动 ,是人类生活资料最根本的来源 ,特别是现代农业的发展 ,使农业生产力水平大幅度提高。但农业生产活动改变了地表大气、土壤和生物之间的物质循环和能量流动 ,也带来了一系列环境问题。本文着重阐述农业... 详细信息

农业生产是人类最重要的生产活动 ,是人类生活资料最根本的来源 ,特别是现代农业的发展 ,使农业生产力水平大幅度提高。但农业生产活动改变了地表大气、土壤和生物之间的物质循环和能量流动 ,也带来了一系列环境问题。本文着重阐述农业生产活动对大气CO2.、CH4、N2.O等温室气体的贡献 ,并通过对稻田生态系统、旱田生态系统、农业生产废弃物以及饲养业对温室气体CO2.、CH4、N2.O的产生、传输影响因子的综合分析 ,进一步了解农业生产与全球温室气体浓度增加之间的关系 ,及其在全球气候变暖中所起的作用 ,从而采取一系列相关措施来减少温室气体的排放。

关键词：农业生产温室气体气体排放碳氮循环地表大气土壤生物

Influencing Factors on Farming System Development in Shandong Province

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Asian Agricultural research 2010年第10期2卷 60-64页

作者： LIU Yan1,NING Tang-yuan1,ZHOU Xun-bo1,2.1.State Key Laboratory of Crop Biology,Shandong Key Laboratory of Crop Biology,Shandong Agricultural University,Taian 2.1018,china 2.Key Laboratory of Ecosystem Network Observation and Modeling,{2. of geographic sciences and Natural resources research,chinese academy of sciences,beijing 100101,china

The developmental situation of the farming system in Shandong Province is *** present,Shandong Province is at the semi-intensive,semi-commercial and semi-sufficiency level of farming *** coast and central Shandong agricultural zones are moving in the direction of modern farming system,having formed a preliminary new pattern of the coordinated development of grain,feedstuff,economic and other *** factors on the development of farming system in Shandong Province is analyzed,which are agricultural production condition and input level,population and food,policy measures,development of natural resources and regions,agricultural industrialization and urbanization level,and scientific and technological *** population will be within 100 million at the year 2.2.;per capita annual share of grain will be 475 kilograms;and there is great pressure on grain ***,we must change the pattern of agricultural development and accelerate the establishment of modern farming *** machinery,water conservancy projects,and chemical fertilizer application have greatly affected the development of farming *** of production conditions has promoted the adjustment of agricultural structure,increased the planting ratio of winter wheat-summer maize,and improved multiple-cropping *** of agricultural industrialization has promoted the transfer of rural labor force and the establishment of modern farming system;while the unbalanced development of cities has restricted the establishment of modern farming ***,the appropriate policy,scientific and rational regional distribution,and advanced science and technology can help to set up the modern farming system in Shandong Province.

关键词： Shandong Province Structure adjustment Regional de

中国土地流转的区域差异及其影响因素——基于2.03-2.13年农村固定观察点数据

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地理学报 2018年第3期73卷 487-502页

作者：王亚辉李秀彬辛良杰谈明洪蒋敏中国科学院地理科学与资源研究所中国科学院陆地表层格局与模拟重点实验室北京100101 中国科学院大学北京100049

土地流转是实现农业适度规模经营的必经之路,理解土地流转的空间差异及影响因素具有重要意义。基于2.03-2.13年农业部农村固定观察点系统的169511个住户样本,本文揭示了中国土地流转的区域差异,并采用Heckman两阶段模型识别土地流转区... 详细信息

土地流转是实现农业适度规模经营的必经之路,理解土地流转的空间差异及影响因素具有重要意义。基于2.03-2.13年农业部农村固定观察点系统的169511个住户样本,本文揭示了中国土地流转的区域差异,并采用Heckman两阶段模型识别土地流转区域差异的影响因素,旨在为促进土地流转提供科学参考。结果发现:(1)2.03-2.13年间,土地流转率从17.09%上升到2..1%,年均增幅近0.7个百分点;南方土地流转较为活跃,比如福建等地流转率超过30%,而北方土地流转率较低;(2.转入土地支付租金平均为2.3.74元/亩,55.05%的转入户并未支付租金;相反,转出土地获得租金为2.3.2.元/亩,52.63%的农户转出土地未获得租金;目前中国土地的"零租金"流转率超过50%;(3)土地质量、地理区位、交易费用、家庭及村庄特征等对土地流转的区域差异具有显著影响;土地质量和地理区位在平原地区的边际效应较大,但在丘陵和山区,交易成本已成为影响土地流转的重要因素。土地"零租金"流转的实质是土地资源错配的一种表现,丘陵和山区边际化及交易费用偏高降低了土地资源的潜在价值。政府应努力降低土地流转中面临的各类交易费用,建立健全土地流转的补偿机制,同时关注丘陵和山区的土地资产贬值和撂荒现象。

关键词：土地流转区域差异零租金影响因素 Heckman模型中国

Water-soluble chitosan promotes remediation of Pb-contaminated soil by Hylotelephium spectabile

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Frontiers of Environmental Science & Engineering 2024年第7期18卷 109-122页

作者： Bingxin Guo Yiwei Zhang Junxing Yang Tianwei Qian Junmei Guo Xiaona Liu yuan Jiao Tongbin Chen Guodi Zheng Wenjun Li Fei Qi College of Environmental Science and Engineering Taiyuan University of TechnologyShanxi Key Laboratory of Earth Surface Processes and Resource Ecological Security in Fenhe River BasinShanxi Engineering Research Center of Low Carbon Remediation for Water and Soil Pollution in Yellow River BasinJinzhong 030600China Center for Environmental Remediation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of chinese academy of sciences Beijing 100049China Shanxi Transportation Holding Ecological Environment Co. Ltd.Shanxi 030000China beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China

Water-soluble chitosan(WSC)has been studied for its ability to mobilize soil Pb and promote the phytoremediation by Hylotelephium spectabile in Pb-contaminated *** aimed to clarify the internal mechanism by which wSC impacts phytoremediation by examining plant growth and Pb accumulation performance of *** as well as the Pb form,functional groups,and mineral phases of Pb-contaminated *** effectively decreased soil pH and activated Pb migration in rhizosphere soils,with a considerable increase in water-soluble and acid-extractable Pb by 2.%-102.and 9%-65%,respectively,and a clear decreasing trend in reducible and oxidizable ***-transform infrared spectroscopy revealed a significant increase in amino and hydroxyl groups in the soil generated by *** coordination of Pb with amino and hydroxyl groups may play an important role in the formation of Pb complexes and activation of Pb in *** field trials,the application of WSC significantly increased Pb accumulation in *** by 12..44%,reaching 92.g/hm^(2..Moreover,the organic matter and nitrogen in the soils were increased by WSc,which improved the growth conditions of *** obvious growth inhibition was observed in either the pot or field ***,WSC is a promising chelating agent for mobilizing Pb in ***,WSC can be potentially used to boost ***-mediated phytoremediation of Pb-contaminatedfarmland.

关键词： Phytoremediation Pb-contaminated soil Water-soluble chitosan Hylotelephium spectabile Fourier transform infrared spectroscopy