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M2.macrophage-derived exosomes promote diabetic fracture healing by acting as an immunomodulator

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Bioactive Materials 2023年第10期28卷 273-283页

作者： Yili wang Qiushui Lin Hao Zhang Sicheng wang Jin Cui {3. hu Jinlong Liu Mengmeng Li Kun Zhang Fengjin Zhou Yingying Jing Zhen geng Jiacan Su Institute of Translational Medicin5 Shanghai UniversityShangha9200444China school of Medicin5 Shanghai UniversityShangha9200444China school of Life sciences Shanghai UniversityShangha9200444China Organoid Research Center Shanghai UniversityShangha9200444China National Center for Translational Medicine(Shanghai)Shu Branc8 Shanghai UniversityShangha9200444China Department of Spine Surgery First Affiliated Hospital of Naval Medical UniversityShangha9200433China Department of Orthopedics Shanghai Zhongye HospitalShangha9200941China Department of Orthopedics Traum1 Changhai HospitalSecond Military Medical UniversityShangha9200433China Department of Orthopedics Honghui HospitalXi’an Jiao Tong UniversityXi’an710000China Suzhou Innovation Center of Shanghai University Suzhou215000JiangsuChina Shaoxing Institute of Technology at Shanghai University Shaoxin7312000Zhejian7China Department of Orthopedics Xinhua HospitalShanghai Jiao Tong University School of Medicin5Shangha9200092China

Diabetes mellitus is a chronically inflamed disease that predisposes to delayed fracture *** play a key role in the process of fracture healing by undergoing polarization into either M1 or M2.subtypes,which respectively exhibit pro-inflammatory or anti-inflammatory ***,modulation of macrophage polarization to the M2.subtype is beneficial for fracture *** perform an important role in improving the osteoimmune microenvironment due to their extremely low immunogenicity and high *** this study,we extracted the M2.exosomes and used them to intervene the bone repair in diabetic *** results showed that M2.exosomes significantly modulate the osteoimmune microenvironment by decreasing the proportion of M1 macrophages,thereby accelerating diabetic fracture *** further confirmed that M2.exosomes induced the conversion of M1 macrophages into M2.macrophages by stimulating the PI3./AKT *** study offers a fresh perspective and a potential therapeutic approach for M2.exosomes to improve diabetic fracture healing.

关键词： M2.exosomes Diabetic fracture healing Osteoimmune microenvironment Macrophage polarization PI3./AKT signaling pathway

High HIV incidence epidemic among men who have sex with men in china: results from a multi-site cross-sectional study

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Infectious Diseases of Poverty 2016年第1期5卷 753-763页

作者： Jun-Jie Xu Wei-Ming Tang hua-Chun Zou Tanmay Mahapatra Qing-Hai hu {3.-Feng Fu Zhe wang Lin Lu Ming-hua Zhuang Xi Chen Ji-hua Fu yan-Qiu Yu Jin-Xin Lu Yong-Jun Jiang Wen-Qing {3. Xiao-Xu Han Hong Shang Key Laboratory of AIDS Immunology of National Health and Family Planning Commission Department of Laboratory MedicineThe First Affiliated HospitalChina Medical UniversityShenyang 110001People’s Republic of China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases HangzhouPeople’s Republic of China University of North Carolina at Chapel Hill Project-ChinaNo.2 Lujing RoadGuangzhou 510085People’s Republic of China Guangdong Provincial Center for Skin Diseases and STIs Control Guangzhou 510085People’s Republic of China Kirby Institute the University of New South WalesSydneyNSW 2052Australia Department of Epidemiology Fielding School of Public HealthUniversity of CaliforniaLos Angeles 90095USA Jiangsu Provincial Centers for Disease Control and Prevention NanjingChina He’nan Provincial Centers for Disease Control and Prevention ZhengzhouChina Yunnan Provincial Centers for Disease Control and Prevention KunmingChina Shanghai Municipal Centers for Disease Control and Prevention ShanghaiChina hu’nan Provincial Centers for Disease Control and Prevention ChangshaChina Shandong Provincial Centers for Disease Control and Prevention JinanChina

Background:Recent upsurge of new HIV infections among men who have sex with men(MSM)is a major concern in *** of national-level information regarding the burden and predictors of this progressive epidemic of new infections called for a multi-centric,timely and comprehensive ***:Mixed methods were used to recruit MSM from seven cities in china between 2.12.and *** and established HIV infections were estimated by Western Blot and BED HIV-1 capture enzyme *** and herpes simplex virus-2.HSV-2.were also ***:A total of 4496 eligible MSM were *** majority was aged≤3. years(77.5%),migrants(60.3.),never married(69.8%),and played receptive role in anal sex(70.5%).The HIV prevalence was 9.9%,and 41.9%were recently infected,with sensitivity/specificity adjusted HIV incidence of 8.9(95%CI:7.6-10.2./100 *** prevalence of history HSV-2.and syphilis were 12.5%and 8.5%,*** HIV infection was associated with having multiple male partners(aOR=1.4,95%CI 1.1-1.9),recreational drug use(aOR=2.2.95%CI 1.6-3.0),anal bleeding(aOR=2.1,95%CI 1.4-3.0),syphilis infection(aOR=2.8,95%CI 1.9-4.3.and history HSV-2.infection(aOR={13.95%CI 1.5-3.3..Conclusion:High rate of recent HIV infection is potentially resulting in progressive deterioration of the overall HIV epidemic among MSM in *** interventions to address high-risk MSM including those having multiple partners,history of recreational drug use and syphilis or HSV-2.infection seemed to be the need of the hour.

关键词： Men who have sex with men(MSM) HIV Incidence BED HIV-1 capture enzyme immunoassay(BED-CEIA)

冬凌草甲素降低糖皮质激素诱导的大鼠股骨颈骨折风险

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中国临床研究 2020年第9期33卷 1159-1162页

作者：王申翟娟冯莉孙华北聂新法卢庆国戴成柏李剑吴相志徐国庆毛继玲李梅胡艳丽崔瑶耿以茹黄国强薛魁徐帅李迎乐耿庆贺广西医科大学研究生院广西南宁530000 徐州医科大学附属邳州医院中心实验室江苏徐州221300 徐州医科大学附属邳州医院骨科江苏徐州221300

目的观察冬凌草甲素(ORI)对糖皮质激素诱导的大鼠股骨颈骨折风险的影响。方法将3.只4月龄SPF级SD大鼠随机分为对照组(n=10)、地塞米松皮下注射组(DEX组,n=10)、地塞米松皮下注射+ORI补充组(DEX+ORI组,n=10)。对照组给予0.1 ml生理盐水... 详细信息

目的观察冬凌草甲素(ORI)对糖皮质激素诱导的大鼠股骨颈骨折风险的影响。方法将3.只4月龄SPF级SD大鼠随机分为对照组(n=10)、地塞米松皮下注射组(DEX组,n=10)、地塞米松皮下注射+ORI补充组(DEX+ORI组,n=10)。对照组给予0.1 ml生理盐水肌内注射;DEX组按照1 mg/kg剂量行肌内注射,每周2.。DEX+ORI组自DEX注射(同DEX组)的第1天起,即予以腹腔注射ORI(剂量2.mg/kg,每周2.)。上午8:00准时给药,共计8周。8周后,对所有大鼠进行血清学、骨密度、骨微形态学、生物力学检测,并比较各组间差异。结果与对照组比较,DEX组大鼠血清中Ⅰ型前胶原氨基末端前肽(P1NP)水平,腰椎、股骨、胫骨的骨密度,股骨干微形态指标(骨体积分数、骨小梁数目、骨小梁厚度)和生物力学指标(股骨颈极限载荷、刚度、骨折强度)均明显降低(P<0.05),血清Ⅰ型胶原羧基端肽(CTX-1)水平、骨小梁分离度、结构模式指数明显升高(P<0.05)。与DEX组比较,DEX+ORI组血清P1NP,腰椎、股骨、胫骨的骨密度,股骨干微形态指标(骨体积分数、骨小梁数目、骨小梁厚度)和生物力学指标(股骨颈极限载荷、刚度、骨折强度)明显升高(P<0.05)、血清CTX-1水平、骨小梁分离度、结构模式指数明显降低(P<0.05)。结论ORI能够有效预防糖皮质激素诱导的大鼠股骨颈骨折,增加骨强度和骨密度,有效降低股骨颈骨折风险。

关键词：冬凌草甲素骨质疏松地塞米松股骨颈骨折风险 Ⅰ型前胶原氨基末端前肽 Ⅰ型胶原羧基端肽

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全国血流感染细菌耐药监测(BRICS)2.2.年度报告

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中华临床感染病杂志 2023年第1期16卷 33-47页

作者：陈云波嵇金如刘志盈应超群杨青孔海深王际亮丁卉茆海丰周义正金炎刘永云耿燕戴媛媛卢鸿张鹏黄颖黄东红强鑫华沈继录徐红云陈凤訇廖国林刘丹董海新宋江勤王璐曹俊敏张利侠李艳红宋迪静李卓尹佑东刘东华郭良刘强张保华徐荣董银樵虎淑妍梁坤鹏全博郑琳孟灵栾亮梁金花刘卫平胡雪飞田鹏鹏颜小平李爱云李健夏修三戚晓燕乔登嫣肖永红浙江大学医学院附属第一医院传染病诊治国家重点实验室杭州310003 感染性疾病诊治协同创新中心杭州310003 山东省胜利油田中心医院检验科东营257034 浙江省丽水市中心医院检验科 323000 江苏省连云港市第一人民医院检验科 222002 湖北省荆州市中心医院检验科 434020 山东省立医院检验科济南250021 山东省滨州医学院附属医院检验科烟台256603 西安交通大学第二附属医院检验科 710004 安徽省立医院检验科合肥230036 山西医科大学第一医院检验科太原030001 安徽省皖南医学院弋矶山医院检验科芜湖241001 安徽医科大学第一附属医院检验科合肥230022 福建医科大学附属第二医院检验科泉州362002 浙江省湖州市第一人民医院 313099 安徽医科大学第一附属医院北区检验科合肥230012 云南省第二人民医院检验科昆明650021 福建省莆田市第一医院检验科 351100 湖北省武汉市普仁医院检验科 430081 江西省九江市第一人民医院检验科 332000 山东省济宁医学院附属医院检验科 272000 湖北省天门市第一人民医院 431799 安徽省六安市人民医院检验科 237005 浙江省中医院检验科杭州310006 陕西省人民医院检验科西安710068 河南省安阳地区医院检验科 455000 浙江省海宁市人民医院检验科 314400 西安医学院第一附属医院检验科 710077 云南省盈江县人民医院检验科 679301 湖北省孝感市中心医院检验科 432009 福建省宁德市闽东医院检验科福安355000 河南大学淮河医院检验科开封475000 安徽省黄山市人民医院检验科 245000 江西省宜春市人民医院检验科 336000 安徽省天长人民医院检验科 239300 甘肃省庆阳市人民医院检验 745000 安徽省蚌埠医学院第二附属医院检验科 233040 湖北省荆州市第二人民医院检验科 530031 宁波大学医学院附属医院检验科 315211 兰州大学第一医院检验科 730099 中国人民解放军北部战区总医院检验科沈阳110015 黑龙江省牡丹江医学院附属红旗医院检验科 157011 内蒙古自治区人民医院呼和浩特737399 南昌大学第一附属医院检验科 330006 湖北省荆州市第一人民医院检验科 434000 四川省自贡市第三人民医院检验科 643000 浙江大学医学院附属妇产科医院检验科杭州310006 安徽省六安世立医院检验科 237000 安徽庐江县人民医院检验科巢湖231500 安徽省六安市儿童医院检验科 237008 甘肃省中医院检验科兰州730699

目的通过血流感染病原菌谱及其耐药性的监测,为临床血流感染治疗和合理用药提供参考。方法收集全国血流感染细菌耐药监测联盟(BRICS)成员单位2.2.年1至12.所有分离自血培养的病原菌,按美国临床和实验室标准化研究所(CLSI)推荐的稀释法... 详细信息

目的通过血流感染病原菌谱及其耐药性的监测,为临床血流感染治疗和合理用药提供参考。方法收集全国血流感染细菌耐药监测联盟(BRICS)成员单位2.2.年1至12.所有分离自血培养的病原菌,按美国临床和实验室标准化研究所(CLSI)推荐的稀释法进行抗菌药物敏感性测定。采用WHONET 5.6进行分析统计。结果共收集51家成员单位11013.病原菌,其中革兰阳性菌为2.82.(2..3.),革兰阴性菌82.1株(74.7%)。前10位病原菌为大肠埃希菌4141株(3..6%)、肺炎克雷伯菌2.76株(18.9%)、金黄色葡萄球菌1078株(9.8%)、凝固酶阴性葡萄球菌697株(6.3.)、铜绿假单胞菌401株(3.6%)、屎肠球菌3.7株(3.6%)、鲍曼不动杆菌3.8株(2.8%)、粪肠球菌2.6株(2.7%)、阴沟肠杆菌2.6株(2.5%)和其他克雷伯菌属{13.(2.1%)。耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌流行率分别为2..3.和76.8%,未检测到对糖肽类和达托霉素耐药葡萄球菌属;金黄色葡萄球菌对头孢比罗的敏感率>95.0%。未检测到耐万古霉素肠球菌。产超广谱β-内酰胺酶大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌分别为49.6%、2..5%和3..0%;耐碳青霉烯类大肠埃希菌、肺炎克雷伯菌分别为2.2.和15.8%;7.9%耐碳青霉烯类肺炎克雷伯菌对头孢他啶/阿维巴坦耐药。头孢比罗对超广谱β-内酰胺酶阴性大肠埃希菌和肺炎克雷伯菌具有较强的抗菌活性。耐碳青霉烯类大肠埃希菌、肺炎克雷伯菌对氨曲南/阿维巴坦敏感性较高。鲍曼不动杆菌对碳青霉烯类的耐药率为60.0%,对多黏菌素B和替加环素耐药率低,分别为5.5%和4.5%;铜绿假单胞菌对碳青霉烯类的耐药率为18.9%。结论我国血流感染病原体以革兰阴性菌为主,且大肠埃希菌占1/3.MRSA的流行率呈进一步下降趋势,耐万古霉素肠球菌仍然处于较低水平;耐碳青霉烯肺炎克雷伯菌仍呈较高水平流行,但已有下降趋势,耐碳青霉烯类大肠埃希菌处于较低水平流行。

关键词：革兰氏阴性菌革兰氏阳性菌抗药性细菌血流感染全国范围耐药监测

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Search for hidden-charm tetraquark with strangeness in e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.

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Chinese Physics C 2023年第3期47卷 1-14页

作者：麦迪娜 M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso 安美儒安琪白羽 O.Bakina R.Baldini Ferroli I.Balossino Y.Ban V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi E.Bianco J.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann 蔡浩蔡啸 A.Calcaterra 曹国富曹宁 S.A.Cetin 常劲帆常万玲车国荣 G.Chelkov 陈琛陈超陈刚陈和生陈玛丽陈申见陈少敏 T.Chen 陈旭荣 X.T.Chen 陈元柏陈卓俊成伟帅 S.K.Choi 初晓 G.Cibinetto F.Cossio 崔佳佳代洪亮代建平 A.Dbeyssi R.E.de Boer D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇丁逸董静董燎原董明义董翔杜书先段宗欢 P.Egorov 范玉兰方建房双世方文兴方易 R.Farinelli L.Fava F.Feldbauer G.Felici 封常青冯俊华 K Fischer M.Fritsch C.Fritzsch 傅成栋高涵高原宁高扬 S.Garbolino I.Garzia 葛潘婷葛振武耿聪 E.M.Gersabeck A Gilman K.Goetzen 龚丽龚文煊 W.Gradl M.Greco 谷立民顾旻皓顾运厅关春懿郭爱强郭立波郭如盼郭玉萍 A.Guskov 韩文颖郝喜庆 F.A.Harris 何凯凯何康林 F.H.Heinsius C.H.Heinz 衡月昆 C.Herold 侯国一侯颖锐侯治龙胡海明 J.F.hu 胡涛胡誉黄光顺黄凯旋黄麟钦黄性涛黄燕萍黄震 T.hussain N Hüsken W.Imoehl M.Irshad J.Jackson S.Jaeger S.Janchiv E.Jang J.H.Jeong 纪全姬清平季晓斌季筱璐吉钰瑶贾泽坤蒋沛成姜赛赛江晓山 Y.Jiang 焦健斌焦铮金山金毅荆茂强 T.Johansson S.Kabana N.Kalantar-Nayestanaki 康晓琳康晓珅 R.Kappert M.Kavatsyuk 柯百谦 I.K.Keshk A.Khoukaz R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kühn J.J.Lane J.S.Lange P.Larin A.Lavania L.Lavezzi 雷天天雷祚弘 H.Leithoff M.Lellmann T.Lenz 李聪李翠李春花李澄李德民李飞李刚李慧李贺李海波李惠静 H.N.Li J.Q.Li 李静舒李井文李科 L.J Li 李龙科李蕾李明浩李培荣李素娴栗帅迎李腾李卫东李卫国李旭红李晓玲李晓宇李彦谷李振轩李紫源梁畅梁浩梁昊梁勇飞梁羽铁廖广睿廖龙洲 J.Libby A.Limphirat 林创新林德旭 T.Lin 刘北江刘成刘春秀 D.Liu 刘福虎刘芳刘峰 G.M.Liu H.Liu 刘宏邦刘怀民刘欢欢刘汇慧刘建北刘佳俊刘晶译刘凯刘魁勇刘珂刘亮刘露刘美宏刘佩莲刘倩刘树彬刘桐刘维克刘卫民刘翔刘英刘玉斌刘振安刘智青娄辛丑卢飞翔吕海江吕军光陆小玲卢宇卢云鹏卢泽辉罗成林罗民兴罗涛罗小兰吕晓睿吕翌丰马凤才马海龙马连良马明明马秋梅马润秋马瑞廷马骁妍马尧 F.E.Maas M.Maggiora S.Maldaner S.Malde Q.A.Malik A.Mangoni 冒亚军毛泽普 S.Marcello 孟召霞 J.G.Messchendorp G.Mezzadri H.Miao 闵天觉 R.E.Mitchell 莫晓虎 N.Yu.Muchnoi Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛艳 S.L.Olsen 欧阳群 S.Pacetti 潘祥潘越 A.Pathak 裴宇鹏 M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 S.Plura S.Pogodin V.Prasad 齐法制齐航漆红荣祁鸣齐天钰钱森钱文斌钱圳乔从丰秦佳佳秦丽清覃潇平秦小帅秦中华邱进发屈三强 K Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of PetrochemicalTechnology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania15213USA Central china Normal University Wuhan 430079China Central South University Changsha 410083China china Center of AdvancedScience and Technology Beijing 100190China china University of Geosciences Wuhan 430074China COMSATS University Islamabad LahoreCampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of NuclearPhysics SB RAS(BINP) Novosibirsk 630090Russia GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany GuangxiNormal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan NormalUniversity Xinxiang 453007China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000People's Republic of China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DAricaChile Jilin Univers

We report a search for a heavier partner of the recently observed Z_(cs)(3.85)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682.and 4.699 GeV with the BESIII *** Z_(cs)^('-) is of interest as it is expected to be a candidate for a hidden-charm and open-strange tetraquark.A partial-reconstruction technique is used to isolate K^(+)recoil-mass spectra,which are probed for a potential contribution from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ *** find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(412..5±0.7_(sat)±4.7_(syst.))MeV/c^(2..As the data set is limited in size,the upper limits are evaluated at the 90%confidence level on the product of the Born cross sections(σ^(Borm))and the branching fraction(B)of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assumptions of the Z_(cs)^('-) mass from 4.12. to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass *** upper limits of σ^(Born).B are found to be at the level of O(1)pb at each *** data samples are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.

关键词： electron-positron collision BESIl hadron spectroscopy tetraquark

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