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A GRB Follow-up System at the Xinglong Observatory and Detection of the High-Redshift GRB 060927

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chinese Journal of Astronomy and Astrophysics 2008年第6期8卷 693-699页

作者： Wei-Kang Zheng Jin-Song Deng Meng Zhai Li-Ping Xin Yu-Lei Qiu Jing wang Xiao-Meng Lu Jian-yan Wei Jing-Yao hu National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China graduate school of chinese academy of sciences Beijing 100049 China

A gamma-ray burst （GRB） optical photometric follow-up system at the Xinglong Observatory of National Astronomical Observatories of china （NAOC） has been constructed. It uses the 0.8-m Tsinghua-NAOC Telescope （TNT） and the 1-m EST telescope, and can au- tomatically respond to GRB Coordinates Network （GCN） alerts. Both telescopes slew relatively fast, being able to point to a new target field within - 1 min upon a request. Whenever available, the 2.16-m NAOC telescope is also used. In 2006 the system responded to 15 GRBs and detected seven early afterglows. In 2007 six GRBs have been detected among 18 follow- up observations. TNT observations of the second most distant GRB 060927 （z = 5.5） are shown, which started as early as 91 s after the GRB trigger. The afterglow was detected in the combined image of the first 19 × 20 s unfiltered exposures. This GRB follow-up system has joined the East-Asia GRB Follow-up Observation Network （EAFON）.

关键词： gamma-rays: bursts gamma-rays: observations telescopes

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Epigenetics and environmental health

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Frontiers of Medicine 2024年第4期18卷 571-596页

作者： Min Zhang Ting hu Tianyu Ma Wei huang yan wang Key Laboratory of Cancer and Microbiome State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China beijing Key Laboratory of Cancer Invasion and Metastasis Research Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCapital Medical UniversityBeijing100069China

Epigenetic modifications including DNA methylation,histone modifications,chromatin remodeling,and RNA modifications complicate gene regulation and heredity and profoundly impact various physiological and pathological *** recent years,accumulating evidence indicates that epigenetics is vulnerable to environmental changes and regulates the growth,development,and diseases of individuals by affecting chromatin activity and regulating gene *** exposure or induced epigenetic changes can regulate the state of development and lead to developmental disorders,aging,cardiovascular disease,Alzheimer's disease,cancers,and so ***,epigenetic modifications are *** use of specific epigenetic inhibitors targeting epigenetic changes in response to environmental exposure is useful in disease ***,we provide an overview of the role of epigenetics in various ***,we summarize the mechanism of epigenetic alterations induced by different environmental exposures,the influence of different environmental exposures,and the crosstalk between environmental variation epigenetics,and genes that are implicated in the body's ***,the interaction of multiple factors and epigenetics in regulating the initiation and progression of various diseases complicates clinical *** discuss some commonly used epigenetic drugs targeting epigenetic modifications and methods to prevent or relieve various diseases regulated by environmental exposure and epigenetics through diet.

关键词： epigenetics environmental exposure health prevention and therapy

MEIC-global-CO_(2):A new global CO_(2)emission inventory with highly-resolved source category and sub-country information

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Science china Earth sciences 2024年第2期67卷 450-465页

作者： Ruochong XU Dan TONG Qingyang XIAO Xinying QIN Cuihong CHEN Liu yan Jing CHENG Can CUI Hanwen hu Wenyu LIU Xizhe yan huaxuan wang Xiaodong LIU Guannan geng Yu LEI Dabo GUAN Kebin HE Qiang ZHANG Department of Earth System Science Ministry of Education Key Laboratory for Earth System ModelingInstitute for Global Change StudiesTsinghua UniversityBeijing100084China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China chinese academy of Environmental Planning Beijing100041China Institute for Carbon Neutrality Tsinghua UniversityBeijing100084China

CO_(2)emission inventory provides fundamental data for climate research and emission ***,most global CO_(2)emission inventories were developed with energy statistics from International Energy Agency(IEA)and were available at country level with limited source ***,as the first step toward a high-resolution and dynamic updated global CO_(2)emission database,we developed a data-driven approach to construct seamless and highly-resolved energy consumption data cubes for 208 countries/territories,797 sub-country administrative divisions in 29 countries,42 fuel types,and 52 sectors,with the fusion of activity data from 24 international statistics and 65 regional/local *** CO_(2)emissions from fossil fuel combustion and cement production in 1970–2021 were then estimated with highly-resolved source category(1,484 of total)and sub-country information(797 of total).Specifically,73%of global CO_(2)emissions in 2021 were estimated with sub-country information,providing considerably improved spatial resolution for global CO_(2)emission *** the support of detailed information,the dynamics of global CO_(2)emissions across sectors and fuel types were presented,representing the evolution of global economy and progress of climate *** differences of sectoral contribution were found across sub-country administrative divisions within a given country,revealing the uneven distribution of energy and economic structure among different *** estimates were generally consistent with existing databases at aggregated level for global total or large emitters,while large discrepancies were observed for middle and small *** database,named the Multiresolution Emission Inventory model for Climate and air pollution research(MEIC)is publicly available through http://*** with highly-resolved information and timely update,which provides an independent carbon emission accounting data source for climate rese

关键词： CO_(2)emissions Data-driven approach Highly-resolved source category Sub-country information

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Expression of MRP14 gene is frequently down-regulated in chinese human esophageal cancer

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Cell Research 2004年第1期14卷 46-53页

作者： Jie wang~(1*), yan CAI~(1*), Hao XU~1, Jun ZHAO~2, Xin XU~1, Ya Ling HAN~1, Zhi Xiong XU~1, Bao Sheng CHEN~1, Hai hu~1, Min WU~1, Ming Rong wang~(1**) ~1National Laboratory of Molecular Oncology, Cancer Institute (Hospital), chinese academy of Medical sciences, Peking University of Medical school, beijing 100021, china. ~2Department of Thoracic Surgery, Cancer Institute (Hospital), chinese academy of Medical sciences, Peking University of Medical school, beijing 100021, china. National Laboratory of Molecular Oncology Cancer Institute (Hospital) Chinese Academy of Medical Sciences Peking University of Medical School Beijing China Department of Thoracic Surgery Cancer Institute (Hospital) Chinese Academy of Medical Sciences Peking University of Medical School Beijing China

Migration inhibitory factor-related protein 14 (MRP14) is one of calcium-binding proteins, referred as S100A9. The heterodimeric molecule formed by MRP14 with its partner MRP8 (S100A8) is the major fatty acid carrier in neutrophils. The MRP8/14 complex has been also implicated in the intracellular transport of arachidonic acid and its precursors in keratinocytes. We show here the involvement of MRP14 in human esophageal cancer. In an initial study, mRNA differential display-reverse transcription polymerase chain reaction (DD-PCR) was performed with two esophageal carcinomas, one esophageal adenocarcinoma and matched normal adjacent mucosa. DD-PCR with the arbitrary primer OPA3 showed that one cDNA band was highly expressed in normal tissues, but disappeared or substantially decreased in tumor counterparts. It was later identified to be the 3’-end of migration inhibitory factor-related protein 14 (MRP14). Northern blotting, RT-PCR and Western blotting corroborated the down-regulation of MRP14 in 58/64 sq

关键词： esophagus carcinoma MRP14 S100A9.

Steric hindrance modulation of hexaazatribenzanthraquinone isomers for high-capacity and wide-temperature-range aqueous proton battery

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National Science Review 2024年第4期11卷 271-282页

作者： Mingsheng yang Yuxin Hao Bei wang yan wang Liping Zheng Rui Li huige Ma Xinyu wang Xiaoming Jing Hongwei Li Mengxiao Li Zhihui wang Yujie Dai Guangcun Shan Mingjun hu Jun Luo Jun yang school of Materials Science and Engineering Beihang University beijing Institute of Nanoenergy &Nanosystems Chinese Academy of Sciences Center on Nanoenergy Research School of Physical Science & TechnologyGuangxi University school of Chemistry and Chemical Engineering Center on Nanoenergy Research Guangxi University school of Instrumentation Science and Opto-electronics Engineering Beihang University ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of China

Organic materials with rich active sites are good candidates of high-capacity anodes in aqueous batteries,but commonly low utilization of active sites limits their ***,two isomers,symmetric and asymmetric hexaazatribenzanthraquinone（s-HATBAQ and a-HATBAQ）,with rich active sites have been synthesized in a controllable *** has been revealed for the first time that a sulfuric acid catalyst can facilitate the stereoselective formation of *** to the reduced steric hindrance in favor of proton insertion as well as the amorphous structure conducive to electrochemical dynamics,s-HATBAQ exhibits 1.5 times larger specific capacity than ***,the electrode of s-HATBAQ with50% reduced graphene oxide（s-HATBAQ-50%rGO） delivers a record high specific capacity of405 mAh g-1in ***,the assembled MnO2//s-HATBAQ-50%rGO aqueous proton full batteries show an exceptional cycling stability at 25℃ and can maintain ～92% capacity after1000 cycles at 0.5 A g-1at-80℃.This work demonstrates the controllable synthesis of isomers,showcases a wide-temperature-range prototype proton battery and highlights the significance of precise mole cular structure modulation in organic energy storage.

关键词： stereoisomers steric effect aqueous battery super cycling stability ultra-low temperature proton battery

SHR-A1811(antibody-drug conjugate)in advanced HER2-mutant non-small cell lung cancer:a multicenter,open-label,phase 1/2 study

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3483-3492页

作者： Ziming Li Zhengbo Song Wei Hong Nong yang Yongsheng wang Hong Jian Zibin Liang Sheng hu Min Peng yan Yu yan wang Zicong Jiao Kaijing Zhao Ke Song You Li Wei Shi Shun Lu Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiaotong University School of MedicineShanghai 200030China Phase I Clinical Trial Ward Zhejiang Cancer HospitalHangzhou 310000China Department of Thoracic Oncology Zhejiang Cancer HospitalHangzhou 310000China Department of Lung&Gastrointestinal Oncology Hunan Cancer HospitalChangsha 410031China Thoracic Oncology Ward/Cancer Center West China Hospital of Sichuan UniversityChengdu 610041China Department of Thoracic Oncology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 51900China Department of Medical Oncology Hubei Cancer HospitalWuhan 43000China Department of Oncology Renmin Hospital of Wuhan UniversityWuhan 430200China Department of Thoracic Medicine Harbin Medical University Cancer HospitalHarbin 150081China Department of Medical Oncology Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Geneplus-beijing CoLtd.Beijing 102206China Jiangsu Hengrui Pharmaceuticals Co.Ltd.Shanghai 200120China

A dose-escalation and expansion,phase 1/2 study(***,NCT04818333)was conducted to assess the novel antibodydrug conjugate SHR-A1811 in pretreated HER2-altered advanced non-small cell lung cancer(NSCLC).Here,we report results from the phase 1 *** who had previously failed or were intolerant to platinum-based chemotherapy were enrolled and received SHR-A1811 intravenously at doses of 3.2 to 8.0 mg/kg every 3 *** escalation followed a Bayesian logistic regression model that included overdose control,with subsequent selection of tolerable levels for dose ***,63 patients were enrolled,including 43 receiving a recommended dose for expansion of 4.8 mg/*** patients had HER2-mutant ***-limiting toxicity occurred in one patient in the 8.0 mg/kg dose ***≥3 treatment-related adverse events occurred in 29(46.0%)*** patient in the 6.4 mg/kg cohort died due to interstitial lung *** of April 11,2023,the 4.8 mg/kg cohort showed an objective response rate of 41.9%(95%Cl 27.0-57.9),and a disease control rate of 95.3%(95%Cl 84.2-99.4).The median duration of response was 13.7 months,with 13 of 18 responses *** median progression-free survival was 8.4 months(95%CI 7.1-15.0).SHR-A1811 demonstrated favourable safety and clinically meaningful efficacy in pretreated advanced HER2-mutantNSCLC.

关键词： SHR HER2 doses

Responses of a Nostoc sp. Stain Isolated from Desert to UV-B Radiation

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Responses of a Nostoc sp. Stain Isolated from Desert to UV-B...

Crocus sativus *** anti-inflammatory effects and regulates the NLRP3–NF-κB pathway

中国海洋湖沼学会藻类学分会第七届会员大会暨第十四次学术讨论会

作者： wang Gao-hong~1 hu Chun-xiang~1 XIAO Yuan~(1,2) ZHANG De-lu~(1,2) LI Xiao-yan~(1,2) HAO Zong-jie~(1,2) LIU Yong-ding~(1*) 1.Institute of Hydrobiology,The chinese academy of sciences,Wuhan 430072 2.graduate school of the chinese academy of sciences,beijing 100049

It was found that UV-B radiation induced the production of ROS and degraded photosynthetic pigments in cells of a strain of Nostoc *** from desert,also,UV-B radiation inhibited photosynthetic activities and boosted lipid peroxidation and DNA *** Fast Chlorophyll Fluorescence Examination showed that,UV-B maybe attacks the photosystems of this strain of Nostoc via many *** exogenous chemicals(ascorbate acid,ASC;N-acetylcysteine,NAC), which was effective quencher to ROS,had obvious protective effects on photosynthesis,membrane and DNA under UV-B *** suggested that the cellular damage by UV-B radiation was functioned through attacking the cellular apparatus following the induction of production of ROS in cells.

关键词： Desert Nostoc sp. UV-B ROS photosynthesis

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Acupuncture and Herbal Medicine 2024年第3期4卷 375-385页

作者： Liang yang huanhua Xu Qian Hong Nuo Xu yan Zhang Rui Tao Shuai Li Zizheng Zhang Jiahao geng Zihan wang huizi hu yan Dong Zhaoyi Chu Bin Zheng Jinmiao Zhu Ming geng Yue Gao school of Chemistry and Pharmaceutical Engineering Hefei Normal UniversityHefeiChina National Key Laboratory for the Modernization of Classical and Famous Prescriptions of chinese Medicine Jiangxi University of Chinese MedicineNanchangChina huaihai Hospital Affiliated to Xuzhou Medical University/PLA 71st Group Military Hospital XuzhouChina beijing Institution of Radiation Medicine BeijingChina

Objective:This study aimed to evaluate the anti-inflammatory effects of petal and stamen extracts of saffron crocus(Crocus sativus)and explore the underlying ***:Local and systemic inflammation models were used to investigate the anti-inflammatory effects of ***.A xyleneinduced inflammation model or lipopolysaccharide(LPS)-induced inflammation model was used in this *** petal and stamen extracts were each administered to the mice in the xylene and LPS models by gavage for 14 d at 0.1 and 0.4 g/kg doses,***-linked immunosorbent assay(ELISA)was used to measure the concentrations of tumor necrosis factor(TNF)-αand interleukin(IL)-1βin mouse *** and eosin(H&E)staining was used to observe the pathological changes in the ear in the xylene-induced inflammation model and in the spleen in the LPS-induced inflammation ***-like receptor thermal protein domain associated protein 3(NLRP3)protein levels within the nuclear factor-kappa B(NF-κB)pathway were assessed using western ***264.7 cells were treated with LPS(5μg/mL)and LPS+***(0.05,0.1,and 0.2 mg/mL)for 24 h,and a Cell Counting Kit-8 was used to measure cell *** in NLRP3 and NF-κB levels were evaluated by western ***:Petal and stamen extracts of *** attenuated the anti-inflammatory effects in local or systemic inflammatory models and repaired pathological changes in the ear in the xylene-induced inflammation model and spleen in the LPS-induced inflammation *** extracts also decreased the concentrations of TNF-αand IL-1βin the mouse serum in the LPS-induced inflammation *** downregulated NLRP3 protein level through the NF-κB pathway and downregulated LC-3 and BECLIN1 in vivo and in *** Cyanide3-ChloroPhenylhydrazone(CCCP)weakened the effects of *** on the NLRP3–NF-κB ***:*** has anti-inflammatory effects and regulates the NLRP3-NF-κB pathway.

关键词： Autophagy Crocus sativus L. Inflammatory NOD-like receptor thermal protein domain associated protein 3 Nuclear factor kappa B

The genetic load for hereditary hearing impairment in chinese population and its clinical implication

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Journal of Otology 2009年第2期4卷 98-105页

作者： wang Qiu-ju 1,2, RAO Shao-qi 1, 3, GUO Yu-fen 4, LI Qing-zhong 5, ZHAO hui 1, ZHAO Li-dong 1, YUAN hu 1, ZONG Liang 1, LIU Qiong 1, ZHAO Ya-li 6, wang Da-yong 1, HAN Ming-kun 1, JI Yu-bin 1, LI Jian-qiang 1, LAN Lan 1, yanG Wei-yan 1, SHEN yan 2,6, HAN Dong-yi 1 1 Department of Otorhinolaryngology-Head and Neck Surgery, and Institute of Otolaryngology, chinese People’s Liberation Army General Hospital, beijing, 100853 china 2 chinese National human Genome Center, beijing, 100176 china 3 Department of Medical Statistics and Epidemiology, school of Public Health, Sun Yat-Sen University, Guangzhou, 510080, china 4 Department of Otorhinolaryngology, Head and Neck Surgery, Second Hospital of Lanzhou University, Lanzhou 730030, china 5 Department of Otolaryngology, EYE & ENT hospital of Fudan University, Shanghai, 200031,china 6 Institute of Basic Medical sciences, chinese academy of Medical sciences and Peking Union Medical College, beijing, 100005 china Department of Otorhinolaryngology–Head and Neck Surgery and Institute of Otolaryngology Chinese People’s Liberation Army General Hospital Beijing 100853 China chinese National human Genome Center Beijing 100176 China Department of Medical Statistics and Epidemiology School of Public Health Sun Yat–Sen University Guangzhou 510080 China Department of Otorhinolaryngology Head and Neck Surgery Second Hospital of Lanzhou UniversityLanzhou 730030 China Department of Otolaryngology EYE & ENT hospital of Fudan University Shanghai 200031China Institute of Basic Medical sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China

Objective To understand the genetic load in the chinese population for improvement in diagnosis, prevention and rehabilitation of deafness. Methods DNA samples, immortalized cell lines as well as detailed clinical and audiometric data were collected through a national genetic resources collecting network. Two conventional genetic approaches were used in the studies. Linkage analysis in X chromosome and autosomes with microsatellite markers were performed in large families for gene mapping and positional cloning of novel genes. Candidate gene approach was used for screening the mtDNA 12SrRNA, GJB2 and SLC26A4 mutations in population -based samples. Results A total of 2,572 chinese hearing loss families or sporadic cases were characterized in the reported studies, including seven X-linked, one Y-linked, 28 large and multiplex autosomal dominant hearing loss families, 607 simplex autosomal recessive hereditary hearing loss families, 100 mitochondrial inheritance families, 147 GJB2 induced hearing loss cases, 230 cases with enlarged vestibular aqueduct (EVA) syndrome, 169 sporadic cases with auditory neuropathy, and 1,283 sporadic sensorineural hearing loss cases. Through linkage analysis or sequence analysis, two X-linked families were found transmitting two novel mutations in the POU3F4 gene, while another X -linked family was mapped onto a novel locus, nominated as AUNX1 (auditory neuropathy, X-linked locus 1). The only Y-linked family was mapped onto the DFNY1 locus(Y-linked locus 1, DFNY1). Eight of the 28 autosomal dominant families were linked to various autosomal loci. In population genetics studies, 2,567 familial cases and sporadic patients were subjected to mutation screening for three common hearing loss genes: mtDNA 12S rRNA 1555G, GJB2 and SLC26A4. The auditory neuropathy cases in our samples were screened for OTOF gene mutations. Conclusions These data show that the chinese population has a genetic load on hereditary hearing loss. Establishing personalize

关键词： Hereditary hea ring loss linkage analysis DFNY1 AUNX1 auditory neuropathy enlarged vestibular aqueduct senserineural hearing loss genetic epidemiology

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