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Negative effects of long-term feeding of high-grain diets to lactating goats on milk fat production and composition by regulating gene expression and DNA methylation in the mammary gland

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Journal of Animal Science and Biotechnology 2018年第1期9卷 217-227页

作者： Ping Tian Yanwen Luo xian Li Jing Tian Shiyu Tao Canfeng Hua Yali geng Yingdong Ni Ruqian Zhao Key Laboratory of Animal Physiology&Biochemistry Nanjing Agricultural University College of Veterinary Medicine Northwest A and F University

Background： It is well known that feeding a high concentrate（HC） diet to lactating ruminants likely induces subacute ruminal acidosis（SARA） and leads to a decrease in milk fat production. However, the effects of feeding a HC diet for long periods on milk fatty acids composition and the mechanism behind the decline of milk fat still remains poorly understood. The aim of this study was to investigate the impact of feeding a HC diet to lactating dairy goats on milk fat yield and fatty acids composition with an emphasis on the mechanisms underlying the milk fat depression. Seventeen mid-lactating dairy goats were randomly allocated to three groups. The control treatment was fed a low-concentrate diet（35% concentrate, n = 5, LC） and there were two high-concentrate treatments（65% concentrate, HC）, one fed a high concentrate diet for a long period（19 wks, n = 7, HL）; one fed a high concentrate diet for a short period of time（4 wk, n = 5, HS）. Milk fat production and fatty acids profiles were measured. In order to investigate the mechanisms underlying the changes in milk fat production and composition,the gene expression involved in lipid metabolism and DNA methylation in the mammary gland were also ***： Milk production was increased by feeding the HC diet in the HS and HL groups compared with the LC diet（P 〈 0.01）, while the percentage of milk fat was lower in the HL（P 〈 0.05） but not in the HS group. The total amount of saturated fatty acids（SFA） in the milk was not changed by feeding the HC diet, whereas the levels of unsaturated fatty acids（UFA） and monounsaturated fatty acids（MUFA） were markedly decreased in the HL group compared with the LC group（P 〈 0.05）. Among these fatty acids, the concentrations of C15：0（P 〈 0.01）, C17：0（P 〈 0.01）, C17：1（P 〈 0.01）, C18：1 n-9 c（P 〈 0.05）, C18：3 n-3 r（P 〈 0.01） and C20：0（P 〈 0.01） were markedly lower in the HL group, and the concentrations of C20：0（P 〈 0.05） and C18：3 n-3 r（P 〈 0.01） were lower in the HS group compared

关键词： DNA methylation Gene expression Goat High concentrate diet Milk fat

Disaster reduction stick equipment: A method for monitoring and early warning of pipeline-landslide hazards

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Journal of Mountain Science 2019年第12期16卷 2687-2700页

作者： YAN Yan YANG Da-shen geng Dong-xian HU Sheng WANG Zi-ang HU Wang YIN Shu-yao Key Laboratory of High-Speed Railway Engineering Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Sinopec Marketing South China Branch Guangzhou510620China Analysis and Test Center of Sichuan Province Chengdu 610066China College of Urban and Environmental Sciences Northwest UniversityXi'an 710127China School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Oil and gas pipelines are of great importance in China,and pipeline security problems pose a serious threat to society and the *** safety has therefore become an integral part of the entire national *** are the most harmful type of pipeline accident,and have directed increasing public attention to safety *** some useful results have been obtained in the investigation and prevention of pipeline-landslide hazards,there remains a need for effective monitoring and early warning methods,especially when the complexity of pipeline-landslides is *** oil and gas pipeline-landslides typically occur in the superficial soil layers,monitoring instruments must be easy to install and must cause minimal disturbance to the surrounding soil and *** address the particular characteristics of pipelinelandslides,we developed a multi-parameter integrated monitoring system called disaster reduction stick *** this paper,we detail this monitoring and early warning system for pipeline-landslide hazards based on an on-site monitoring network and early warning *** functionality of our system was verified by its successful application to the Chongqing Loujiazhuang pipeline-landslide in *** results presented here provide guidelines for the monitoring,early warning,and prevention of pipeline geological hazards.

关键词： Pipeline landslide hazards Multi parameter integrated monitor Monitoring Early warning Pipeline landslide

A Dynamic Input- Output Model Solution

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Systems Science and Systems Engineering 1999年第3期9卷 290-298页

作者： geng xian\|min Xinjiang Petroleum Institute, Urumqi 830000, China

In this paper we research the homogeneous input output model of forward delay that lag is one production cycle. It is conformed that the necessary and sufficient conditions of economic balanced development are that the output vector geng xian\|min Xinjiang Petroleum Institute, Urumqi 830000, ChinaAbstract:\ In this paper we research the homogeneous input output model of forward delay that lag is one production cycle. It is conformed that the necessary and sufficient conditions of economic balanced development are that the output vector X(t) is the right positive characteristic vector of (I-A) -1 (A+B), and the input vector is AX(t). We also constitute the workable economic subset S-,when the output vector of the first production cycle is X(1), the economy will surely collapse.

关键词： input output consumption coefficient matrix investment coefficient matrix irreducible nonnegative matrix maximum characteristic value

Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression

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Signal Transduction and Targeted Therapy 2023年第2期8卷 716-729页

作者： xiang-Peng Tan Yan He Jing Yang xian Wei You-Long Fan guo-geng Zhang Yi-Dong Zhu Zheng-Qiu Li Hua-Xin Liao Da-Jiang Qin Xin-Yuan Guan Bin Li The First Affiliated Hospital of Jinan University Jinan UniversityGuangzhouChina Key Laboratory of Biological Targeting Diagnosis Therapy and Rehabilitation of Guangdong Higher Education Institutes and Key Laboratory of Protein Modification and DegradationThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina MOE Key Laboratory of Tumor Molecular Biology and National Engineering Research Center of Genetic Medicine College of Life Science and TechnologyJinan UniversityGuangzhouChina School of Pharmacy Jinan UniversityGuangzhouChina Department of Clinical Oncology The University of Hong KongHong KongChina

Hepatocellular carcinoma(HCC)is one of the most common malignant *** of the underlying mechanism of HCC progression and exploration of new therapeutic drugs are urgently ***,a compound library consisting of 419 FDA-approved drugs was taken to screen potential anticancer drugs.A series of functional assays showed that desloratadine,an antiallergic drug,can repress proliferation in HCC cell lines,cell-derived xenograft(CDX),patient-derived organoid(PDO)and patient-derived xenograft(PDX)models.N-myristoyl transferase 1(NMT1)was identified as a target protein of desloratadine by drug affinity responsive target stability(DARTS)and surface plasmon resonance(SPR)*** of NMT1 expression enhanced but NMT1 knockdown suppressed tumor growth in vitro and in *** labeling and mass spectrometry analyses revealed that Visinin-like protein 3(VILIP3)was a new substrate of NMT1 in protein N-myristoylation modification,and high NMT1 or VILIP3 expression was associated with advanced stages and poor survival in ***,desloratadine binds to Asn-246 in NMT1 and inhibits its enzymatic activity,disrupting the NMT1-mediated myristoylation of the VILIP3 protein and subsequent NFκB/Bcl-2 ***,this study demonstrates that desloratadine may be a novel anticancer drug and that NMT1-mediated myristoylation contributes to HCC progression and is a potential biomarker and therapeutic target in HCC.

关键词： drugs VILI allergic

基于列线图预测模型的重症颅脑损伤继发应激性溃疡的影响因素分析

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现代生物医学进展 2024年第12期24卷 2361-2366页

作者：夏加庚樊友武李启贤辛恒钱正庭南京医科大学附属南京医院神经外科江苏南京210006

目的:探讨重症颅脑损伤(s TBI)继发应激性溃疡影响因素,并构建列线图预测模型。方法:选取2022年5月至2023年5月我院诊治的s TBI患者116例为研究对象,根据是否继发应激性溃疡分为发生组(n=35)和未发生组(n=81)。收集两组患者的临床资料,... 详细信息

目的:探讨重症颅脑损伤(s TBI)继发应激性溃疡影响因素,并构建列线图预测模型。方法:选取2022年5月至2023年5月我院诊治的s TBI患者116例为研究对象,根据是否继发应激性溃疡分为发生组(n=35)和未发生组(n=81)。收集两组患者的临床资料,采用单因素和多因素Logistic回归模型分析s TBI患者继发应激性溃疡的影响因素,构建列线图预测模型,采用受试者工作特征(ROC)曲线分析对s TBI患者继发应激性溃疡的预测价值。结果:s TBI继发应激性溃疡与入院时格拉斯哥昏迷评分法(GCS)评分、随机血糖水平、血红蛋白(Hb)、受伤至入院时间、胃泌素(GAS)等因素有关(P21,表明该模型具有较好的预测能力。决策分析显示,其阈值概率范围为0.03~0.93,且表现出净收益率大于0的特点,超过了两条无效线。结论:s TBI继发应激性溃疡与入院GCS评分、随机血糖水平、Hb、GAS密切相关,通过上述指标构建的列线图预测模型,可以提升预测s TBI患者继发应激性溃疡的发生风险,有助于临床早期干预和治疗。

关键词：重症颅脑损伤应激性溃疡影响因素预测价值

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烧结燃料粒度的优化实验研究

山东冶金 2024年第1期46卷 63-64,67页

作者：李保良贾宪张超民耿军亮辛渊敬业钢铁有限公司铁前管理中心河北平山050400

为研究燃料粒度对烧结指标的影响,通过烧结杯实验研究不同粒度燃料对烧结过程及烧结矿质量的影响。结果表明:燃料粒度越小,燃烧速度越快;降低燃料中3mm比例15%。

关键词：燃料粒度烧结杯实验烧结指标

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高炉煤气流监测装置及应用

山东冶金 2024年第2期46卷 47-49页

作者：贾宪辛渊李保良张超民耿军亮敬业钢铁有限公司铁前管理中心河北石家庄050000

介绍了一种高炉煤气流监测装置的结构及应用效果。通过对炉顶不同方向煤气流的温度检测与比值计算,实现对其发展程度和趋势的数据化精准判断,有效解决传统十字测温装置造成的料面拉沟问题,稳定了高炉煤气流分布,提高了煤气利用率。

关键词：高炉煤气流比值测温云台

应用血管内超声评估经导管主动脉瓣置换术中冠状动脉阻塞风险12例回顾分析

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中国实用内科杂志 2024年第5期44卷 409-414页

作者：刘娴王颖东梁振洋王耿荆全民韩雅玲李洋于杰盛宇贺王斌徐凯北部战区总医院心血管内科辽宁沈阳110016

目的研究血管内超声(intravascular ultrasound,IVUS)评估经导管主动脉瓣置换术(transcatheter aortic valve replacement,TAVR)术中冠状动脉阻塞风险的可行性。方法回顾性分析北部战区总医院自2020年4月至2023年11月12例经计算机断... 详细信息

目的研究血管内超声(intravascular ultrasound,IVUS)评估经导管主动脉瓣置换术(transcatheter aortic valve replacement,TAVR)术中冠状动脉阻塞风险的可行性。方法回顾性分析北部战区总医院自2020年4月至2023年11月12例经计算机断层扫描分析判断为冠状动脉阻塞风险高,接受TAVR治疗且术中应用IVUS评估冠状动脉开口堵塞可能性的患者。结果共纳入12例术前CT分析冠状动脉堵塞风险高的患者,三叶式主动脉瓣9例,二叶式主动脉瓣3例。24条冠状动脉中,其中3条冠状动脉在球囊扩张的同时对冠状动脉开口实施IVUS检查,11条冠状动脉在植入人工瓣膜后实施IVUS检查。5条冠状动脉经IVUS检查后被判定为堵塞风险高而植入冠状动脉支架。结论IVUS对于TAVR术中或术后冠状动脉堵塞的风险评价有重要意义,尤其是在人工瓣膜植入术后,能准确预测冠状动脉堵塞风险。

关键词：经导管主动脉瓣置换术血管内超声冠状动脉

Fluorescence and Photosensitizing Behavior of N-(p-Phenoxyphenyl)methacrylamide and Its Polymer

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Chemical Research in Chinese Universities 2002年第1期18卷 56-60页

作者： GAO Qing-yu LIU Zhi-gui GUAN Hui-li YANG geng-xu YU xian-da Laboratory of Lubrication and Functional Materials Henan UniversityKaifeng 475001P.R.China Lanzhou Institute of Chemistry and Physics Chinese Academy of ScienceLanzhou 730000P.R.China

A novel acrylic monomer bearing aromatic ethereality group N-(p -phenoxy-phenyl) methacrylamide(MAPOA) was synthesized and polymerized. The fluorescence spectra of MAPOA and its polymer were studied, showing that the polymer displays a stronger fluorescence than its monomer at the same chromophore concentration. The fluorescence of P(MAPOA) was quenched by adding electron deficiency monomers such as MMA, AN etc .. It is another example of showing the 'fluorescence structural self-quenching effect' as we reported previously, from which it is demonstrated again that this phenomenon is not an accidental one but a common effect for acrylic monomers bearing electon-donating chromophores. The photopolymerization of AN sensitized by MAPOA and P(MAPOA) was studied. The kinetic equation of the polymerization was obtained and represented as follows:  R _p∝ 0.38 × 0.78 , R _p∝ 0.33 × 0.71  The overall activation energies were determined to be E_ a =24\^22 kJ/mol(MAPOA) and E_ a =26\^31 kJ/mol  respectively. The fluorescence analysis of the resulted P(AN) showed that the sensitizer also entered into the P(AN) chains. A mechanism of the formation of a charge transfer complex and free radical initiation was suggested for the photopolymerization of AN sensitized by MAPOA and P(MAPOA).

关键词： N-(p -Phenoxy-phenyl)methacrylamide Fluorescence Structural self-quenching effect Acrylonitrile Photopolymerization