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Effects of connected automated vehicle on stability and energy consumption of heterogeneous traffic flow system

Chinese Physics B 2024年第3期33卷 291-301页

作者：申瑾赵建东刘华清姜锐余智鑫 School of Systems Science Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Transport Industry of Big Data Application Technologies for Comprehensive Transport Beijing Jiaotong UniversityBeijing 100044China School of Maritime and Transportation Ningbo UniversityNingbo 315000China

With the development of intelligent and interconnected traffic system,a convergence of traffic stream is anticipated in the foreseeable future,where both connected automated vehicle(CAV)and human driven vehicle(HDV)will *** order to examine the effect of CAV on the overall stability and energy consumption of such a heterogeneous traffic system,we first take into account the interrelated perception of distance and speed by CAV to establish a macroscopic dynamic model through utilizing the full velocity difference(FVD)***,adopting the linear stability theory,we propose the linear stability condition for the model through using the small perturbation method,and the validity of the heterogeneous model is verified by comparing with the FVD *** nonlinear theoretical analysis,we further derive the KdV-Burgers equation,which captures the propagation characteristics of traffic density ***,by numerical simulation experiments through utilizing a macroscopic model of heterogeneous traffic flow,the effect of CAV permeability on the stability of density wave in heterogeneous traffic flow and the energy consumption of the traffic system is *** analysis reveals emergent traffic *** experimental findings demonstrate that as CAV permeability increases,the ability to dampen the propagation of fluctuations in heterogeneous traffic flow gradually intensifies when giving system perturbation,leading to enhanced stability of the traffic ***,higher initial traffic density renders the traffic system more susceptible to congestion,resulting in local clustering effect and stop-and-go traffic ***,the total energy consumption of the heterogeneous traffic system exhibits a gradual decline with CAV permeability *** evidence has demonstrated the positive influence of CAV on heterogeneous traffic *** research contributes to providing theoretical guidance for future CAV applic

关键词： heterogeneous traffic flow CAV linear stability nonlinear stability energy consumption

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Omics-imaging signature-based nomogram to predict the progression-free survival of patients with hepatocellular carcinoma after transcatheter arterial chemoembolization

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World Journal of Clinical Cases 2024年第18期12卷 3340-3350页

作者： qing-Long Guan Hai-Xiao Zhang Jun-Peng Gu geng-Fei Cao Wei-Xin Ren Department of Interventional Radiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous regionChina Department of Interventional Radiology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830011Xinjiang Uygur Autonomous RegionChina

BACKGROUND Enhanced magnetic resonance imaging(MRI)is widely used in the diagnosis,treatment and prognosis of hepatocellular carcinoma(HCC),but it can not effectively reflect the heterogeneity within the tumor and evaluate the effect after *** imaging analysis of voxel changes can effectively reflect the internal heterogeneity of the tumor and evaluate the progression-free survival(PFS).AIM To predict the PFS of patients with HCC before operation by building a model with enhanced MRI *** Delineate the regions of interest(ROI)in arterial phase,portal venous phase and delayed phase of enhanced *** extracting the combinatorial features of ROI,the features are fused to obtain deep learning radiomics(DLR)_***'s test was used to evaluate the diagnostic performance of different typological features.K-M analysis was applied to assess PFS in different risk groups,and the discriminative ability of the model was evaluated using the *** Tumor diameter and diolame were independent factors influencing the prognosis of ***'s test revealed multi-phase combined radiomic features had significantly greater area under the curve values than did those of the individual phases(P<0.05).In deep transfer learning(DTL)and DLR,significant differences were observed between the multi-phase and individual phases feature sets(P<0.05).K-M survival analysis revealed a median survival time of high risk group and low risk group was 12.8 and 14.2 months,respectively,and the predicted probabilities of 6 months,1 year and 2 years were 92%,60%,40%and 98%,90%,73%,*** C-index was 0.764,indicating relatively good consistency between the predicted and observed *** and DLR have higher predictive value for 2-year PFS in *** Based on the multi-temporal characteristics of enhanced MRI and the constructed Nomograph,it provides a new strategy for predicting the PFS of transarterial chemoembolization treatment of HCC.

关键词： Magnetic resonance imaging Radiomics Deep learning Progression-free survival Transcatheter arterial chemoembolization Hepatocellular carcinoma

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Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice

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Zoological Research 2024年第5期45卷 1073-1087页

作者： Jing-Wei Ye Tanveer Abbas Jian-Teng Zhou Jing Chen Meng-Lei Yang Xiong-Heng huang huan Zhang Hui Ma Ao Ma Bo Xu Ghulam Murtaza qing-hua Shi Bao-Lu Shi Division of Reproduction and Genetics First Affiliated Hospital of University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at MicroscaleSchool of Basic Medical SciencesDivision of Life Sciences and MedicineBiomedical Sciences and Health Laboratory of Anhui ProvinceInstitute of Health and MedicineHefei Comprehensive National Science CenterUniversity of Science and Technology of ChinaHefeiAnhui 230026China Institute of Andrology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China

Infertility represents a significant health concern,with sperm quantity and quality being crucial determinants of male ***(OAT)is characterized by reduced sperm motility,lower sperm concentration,and morphological abnormalities in sperm heads and *** variants in several genes have been implicated in OAT,its genetic etiologies and pathogenetic mechanisms remain inadequately *** this study,we identified a homozygous nonsense mutation(c.916C>T,***306*)in the coiled-coil domain containing 146(CCDC146)gene in an infertile male patient with *** mutation resulted in the production of a truncated CCDC146 protein(amino acids 1-305),retaining only two out of five coiled-coil *** validate the pathogenicity of the CCDC146 mutation,we generated a mouse model(Ccdc146^(mut/mut))with a similar mutation to that of the ***,the Ccdc146mut/mut mice exhibited infertility,characterized by significantly reduced sperm counts,diminished motility,and multiple defects in sperm heads and ***,the levels of axonemal proteins,including DNAH17,DNAH1,and SPAG6,were significantly reduced in the sperm of Ccdc146^(mut/mut) ***,both human and mouse CCDC146 interacted with intraflagellar transport protein 20(IFT20),but this interaction was lost in the mutated versions,leading to the degradation of *** study identified a novel deleterious homozygous nonsense mutation in CCDC146 that causes male infertility,potentially by disrupting axonemal protein *** findings offer valuable insights for genetic counseling and understanding the mechanisms underlying CCDC146 mutant-associated infertility in human males.

关键词： Oligoasthenoteratozoospermia Human infertility Sperm flagellum CCDC146 Intraflagellar transport IFT20

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马传染性贫血病毒美洲流行株与我国弱毒疫苗株鉴别诊断方法的研究

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中国病毒学 2006年第1期21卷 81-83页

作者：耿庆华王晓钧赵立平吕晓玲沈荣显相文华中国农业科学院哈尔滨兽医研究所黑龙江哈尔滨150001

In order to develop an assay to distinguish the infection of Equine infectious anemia virus(EIAV)American strains from Donkey-leukocyte attenuated virus(DLV)strain,eight primers were designed based on the comparison of complete sequences of four EIAV American strains and *** viral genome fragments were amplified and analyzed from donkey leucocytes by PCR using these eight *** primers from gag gene were selected to detect the differences between EIAV American strains and *** horses were inoculated with DLV and two with EIAV American strains,the Wyoming strain and the Argentina strain,*** fragments,675bp and 400bp,were amplified from DLV-infected cells,while only one segment of 675bp was obtained from cells inoculated with American *** results indicate that this nest multiplex PCR can be used to distinguish EIAV American strains from the donkey leucocyte-attenuated vaccine strain of EIAV.

关键词：马传染性贫血病毒巢式多重PCR 鉴别诊断

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Microstructure and ablation behavior of Zr-based ultra-high-temperature gradient composites

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 2889-2899页

作者： qing-hua LIU Tian TIAN Wei SUN Hong-bo ZHANG Xiang XIONG State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China National Key Laboratory of Science and Technology on High-strength Structural Materials Central South UniversityChangsha 410083China

To obtain high-performance Zr-based ultra-high-temperature composites,Zr-based ultra-high-temperature gradient composites were prepared by changing the laying method of the infiltrant via reactive melt *** effects of different infiltrant laying methods on the microstructure and ablative properties of Zr-based ultrahigh-temperature gradient composites were *** results showed that the gradient structure of the Zr-based ultrahigh-temperature gradient composites differed when the composition ratio of the infiltrant was *** the thicknesses of the Zr/Mo/Si layers were 6/4/12 mm and 8/2/12 mm,the SiMoZrC solid solution content in the samples increased and decreased along the infiltration direction,*** gradient samples were ablated in an oxyacetylene flame at 3000°C for 40 *** ablation resistance of the sample was the highest when the infiltrant was a powder and the thickness of the Zr/Mo/Si layer was 6/4/12 mm.

关键词： reactive melt infiltration ceramic-matrix composites gradient material microstructure ablation property

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A novel alternative for pyrogen detection based on a transgenic cell line

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1221-1229页

作者： qing He Chuan-Fei Yu Gang Wu Kai-Qin Wang Yong-Bo Ni Xiao Guo Zhi-Hao Fu Lan Wang De-Jiang Tan hua Gao Can Wang Gang Chen Xu-Hong Chen Bo Chen Jun-Zhi Wang National Institutes for Food and Drug Control BeijingChina School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyangChina Shanghai Institute for Food and Drug Control ShanghaiChina KeyMed Biosciences Inc. ChengduChina

Pyrogen,often as a contaminant,is a key indicator affecting the safety of almost all parenteral drugs(including biologicals,chemicals,traditional Chinese medicines and medical devices).It has become a goal to completely replace the in vivo rabbit pyrogen test by using the in vitro pyrogen test based on the promoted‘reduction,replacement and refinement’principle,which has been highly considered by regulatory agencies from different *** used NF-κB,a central signalling molecule mediating inflammatory responses,as a pyrogenic marker and the monocyte line THP-1 transfected with a luciferase reporter gene regulated by NF-κB as an in vitro model to detect pyrogens by measuring the intensity of a fluorescence ***,we show that this test can quantitatively and sensitively detect endotoxin(lipopolysaccharide from different strains)and nonendotoxin(lipoteichoic acid,zymosan,peptidoglycan,lectin and glucan),has good stability in terms of NF-κB activity and cell phenotypes at 39 cell passages and can be applied to detect pyrogens in biologicals(group A&C meningococcal polysaccharide vaccine;basiliximab;rabies vaccine(Vero cells)for human use,freeze-dried;Japanese encephalitis vaccine(Vero cells),inactivated;insulin aspart injection;human albumin;recombinant human erythropoietin injection(CHO Cell)).The within-laboratory reproducibility of the test in three independent laboratories was 85%,80%and 80%and the interlaboratory reproducibility among laboratories was 83.3%,95.6%and 86.7%.The sensitivity(true positive rate)and specificity(true negative rate)of the test were 89.9%and 90.9%,*** summary,the test provides a novel alternative for pyrogen detection.

关键词： pyrogen rabbit replace

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Zika virus infection induces glycometabolic disorder in northern pig-tailed macaques

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Science China Life Sciences 2024年

作者： qing Li Ren-hua Yang Yan Hu Bei-Bei Tang Ying-Jie Jiang Chang-Bo Zheng Tian-Zhang Song State Key Laboratory of Genetic Evolution&Animal Models Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of Sciences School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University University of Chinese Academy of Sciences KIZ-SU Joint Laboratory of Animal Model and Drug Development College of Pharmaceutical SciencesSoochow University

Dear Editor,The Zika virus (ZIKV) was first identified in Africa in 1947 but remained relatively obscure for nearly 70 ***,from 2014 to 2016,ZIKV was introduced into Brazil from the Pacific Islands,leading to its rapid dissemination throughout the Americas (Fauci and Morens,2016).This mosquito-borne virus is distinguished by its capacity to cause congenital defects,as evidenced by the microcephaly epidemic in Brazil,and has been declared a Public Health Emergency of International Concern (Gulland,2016).

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多传感器在智能机器人中的应用研究

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自动化与仪器仪表 2010年第5期 55-57页

作者：耿庆华宋弘陈桂徐四川理工学院自动化与电子信息学院

介绍了一种使用多传感器快速测量智能机器人与障碍物之间距离的方法,使机器人不仅具备语音识别功能,而且能实现智能避障。本设计给出了相应的电路设计和软件设计方案。实验结果表明:设计方案可行,智能机器人工作稳定、可靠。

关键词： A/D转换智能避障红外测距传感器语音识别

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在场与超越在场:具身传播视域下Vlog的城市形象传播

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编辑之友 2024年第2期 75-80页

作者：杨清华湖南第一师范学院文学与新闻传播学院湖南长沙410205

Vlog自带补偿性媒介基因,凭借其外在的人格化、深度的交互性,弥补了传统媒介单一封闭的传播缺憾。Vlog的具身叙事围绕特定地理空间、社会空间展开,其中产生的多层次场景与丰富内涵想象,为城市形象认知与审美体验提供了多种可能,也为城... 详细信息

Vlog自带补偿性媒介基因,凭借其外在的人格化、深度的交互性,弥补了传统媒介单一封闭的传播缺憾。Vlog的具身叙事围绕特定地理空间、社会空间展开,其中产生的多层次场景与丰富内涵想象,为城市形象认知与审美体验提供了多种可能,也为城市形象传播提供议程、传达意象。具身场域下在场的显性表达实现了传者自我价值呈现与受众审美认同的双向建构,超越在场的社会表演与影像动员丰富了城市形象传播的话语意蕴。

关键词： Vlog 城市形象具身传播在场超越在场

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创译学研究之路径展中华译学之精髓——张佩瑶对中国译学发展之贡献

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上海翻译（中英文） 2024年第4期 82-88页

作者：邵庆华上海大学上海200444 同济大学上海200092

本文介绍了张佩瑶的译著成就和译学思想,以及她在翻译理论和实践方面的贡献,重点讨论了其在翻译实践中对“丰厚翻译”理论的创造性应用、首创的“推手”理论以及为构建中国翻译话语体系所作出的努力及在国内外所产生的影响。本文认为,... 详细信息

本文介绍了张佩瑶的译著成就和译学思想,以及她在翻译理论和实践方面的贡献,重点讨论了其在翻译实践中对“丰厚翻译”理论的创造性应用、首创的“推手”理论以及为构建中国翻译话语体系所作出的努力及在国内外所产生的影响。本文认为,张佩瑶是中国译学话语体系建构过程中最为杰出和有影响力的学者之一,为中国译学发展提供了新的视角和方法,促进了中西方翻译理论的交流和创新。

关键词：中国翻译话语丰厚翻译推手理论张佩瑶

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