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genes & Diseases 2024年第5期11卷 33-35页

作者： Zhibin Yan xiangyu Hong Qihao Lin Leijie Wang Gang Shao Chentao ge Ruilong Xia Caiyun Fu Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China College of Life Sciences China Jiliang UniversityHangzhouZhejiang 310018China

Increasing evidence highlight tachykinin receptors as a prominent player in hematological *** previously revealed the proto-oncogenic role of neurokinin-1 receptor(NK-1R)in acute myeloid leukemia(AML),1 whereas the role of neurokinin-2 receptor(NK-2R)has not been ***,we found NK-2R was significantly up-regulated in AML patients in The Cancer genome Atlas *** result was further confirmed in blood from AML patients and a range of human leukemia ***,we verified that blocking NK-2R by SR48968 markedly promoted cell death in human myeloid leukemia without cytotoxicity to normal ***,we uncovered that SR48968 induced cytotoxicity through necroptosis mediated by calcium overload-driven reactive oxygen species(ROS)*** summary,our results propose that NK-2R antagonist SR48968 may be used as a new therapeutic approach for myeloid leukemia.

关键词： myeloid antagonist markedly

Helicopter blades running elevation measurement using omnidirectional vision

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Chinese Journal of Aeronautics 2017年第6期30卷 1974-1984页

作者： Chengtao CAI xiangyu WENG College of Automation Harbin Engineering University Harbin 150001 China

Omnidirectional dynamic space parameters of high-speed rotating helicopter blades are precise 3 D vector description of the blades. In particular, the elevation difference is directly related to the aerodynamic performance and maneuverability of the helicopter. The state of the art detection techniques based on optics and common vision have several drawbacks, such as high demands on devices but poor extensibility, limited measurement range and fixed measurement position. In this paper, a novel approach of helicopter blades running elevation measurement is proposed based on omnidirectional vision. With the advantages of panoramic visual imaging integration, 360° field of view and rotation in-variance, high-resolution images of all rotating blades positions are obtained at one time. By studying the non-linear calibration and calculation model of omnidirectional vision system, aiming at solving the problem of inaccurate visual space mapping model,the omnidirectional and full-scale measurement of the elevation difference are finalized. Experiments are carried out on our multifunctional simulation blades test system and the practical blades test tower, respectively. The experimental results demonstrate the effectiveness of the proposed method and show that the proposed method can considerably reduce the complexity of measurement.

关键词： Full-scale measurement Helicopter blades elevation Non-linear calibration Omnidirectional vision Unified sphere model

A Deep Adaptive Learning Method for Rolling Bearing Fault Diagnosis Using Immunity

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Tsinghua Science and Technology 2019年第6期24卷 750-762页

作者： Yuling Tian xiangyu Liu the College of Information and Computer Taiyuan University of Technology

The extraction of rolling bearing fault features using traditional diagnostic methods is not sufficiently comprehensive and the features are often chosen subjectively and depend on human experience. In this paper, an improved deep convolutional process is used to extract a set of features adaptively. The hidden multi-layer feature of deep convolutional neural networks is also exploited to improve the extraction features. A deterministic detection of low-confidence samples is performed to ensure the reliability of the recognition results and to decrease the rate of false positives by evaluating the diagnosis of the deep convolutional neural network. To improve the efficiency of the continuous learning elements of the rolling bearing fault diagnosis, a clone learning strategy based on cloning and mutation operations is proposed. The experimental results show that the proposed deep convolutional neural network model can extract multiple rolling bearing fault features, improve classification and detection accuracy by reducing the false positive rate when diagnosing rolling bearing faults, and accelerate learning efficiency when using low-confidence rolling bearing fault samples.

关键词： deep learning fault diagnosis feature extraction clone selection strategy

Three-dimensional porous electrodes for direct formate fuel cells

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Science China(Technological Sciences) 2021年第4期64卷 705-718页

作者： SU xiangyu PAN ZheFei AN Liang Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SAR 999077China

The dual-layer electrode for fuel cells is typically prepared by binding discrete catalyst nanoparticles onto a diffusion *** a random packing forms a dense catalyst layer and thus creates a barrier for mass/ion transport,particularly for direct liquid fuel ***-dimensional porous electrodes,a thin nano-porous catalyst layer uniformly distributed on the matrix surface of a foam-like structure,are typically employed to improve the mass/ion *** a three-dimensional porous structure brings two critical advantages:(i)reduced mass/ion transport resistance for the delivery of the reactants via shortening the transport distance and(ii)enlarged electrochemical surface area,via reducing the dead pores,isolated particles and severe aggregations,for interfacial ***,the three-dimensional design is capable of fabricating binder-free electrodes,thereby eliminating the use of ionomers/binders and simplifying the fabrication *** this work,three types of three-dimensional porous electrode are fabricated,via different preparation methods,for direct formate fuel cells:(i)Pd/C nanoparticles coating on the nickel foam matrix surface(Pd-C/NF)via a dip-coating method,(ii)Pd nanoparticles depositing on the nickel foam matrix surface(Pd/NF)via reduction reaction deposition,and(iii)Pd nanoparticles embedding in the nickel foam matrix(Pd/(in)NF)via replacement reaction *** latter two are binder-free three-dimensional porous *** a comparison,a conventional dual-layer design,Pd/C nanoparticles painting on the nickel foam layer(Pd-C//NF),is also prepared via direct painting *** is shown that the use of the three-dimensional Pd-C/NF electrode as the anode in a direct formate fuel cell results in a peak power density of 45.0 mW cm^(-2)at 60℃,which is two times of that achieved by using a conventional dual-layer design(19.5 mW cm^(-2)).This performance improvement is mainly attributed to the unique three-dimensional structure

关键词： direct formate fuel cells dual-layer structure three-dimensional porous structure binder-free mass/ion transport electrochemical surface area

Fuzzy Set-Membership Filtering for Discrete-Time Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2022年第6期9卷 1026-1036页

作者： Jingyang Mao xiangyu Meng Derui Ding Department of Control Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Division of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA70803 USA IEEE School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourneVIC 3122Australia

In this article,the problem of state estimation is addressed for discrete-time nonlinear systems subject to additive unknown-but-bounded noises by using fuzzy set-membership ***,an improved T-S fuzzy model is introduced to achieve highly accurate approximation via an affine model under each fuzzy ***,compared to traditional prediction-based ones,two types of fuzzy set-membership filters are proposed to effectively improve filtering performance,where the structure of both filters consists of two parts:prediction and *** the locally Lipschitz continuous condition of membership functions,unknown membership values in the estimation error system can be treated as multiplicative noises with respect to the estimation ***-time recursive algorithms are given to find the minimal ellipsoid containing the true ***,the proposed optimization approaches are validated via numerical simulations of a one-dimensional and a three-dimensional discrete-time nonlinear systems.

关键词： Affine model membership functions set-membership filtering stability Takagi-Sugeno fuzzy modeling

A Review of Contact Electrification at Diversified Interfaces and Related Applications on Triboelectric Nanogenerator

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Nano-Micro Letters 2024年第1期16卷 106-130页

作者： Jun Hu Mitsumasa Iwamoto xiangyu Chen CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Physical Electronics Tokyo Institute of Technology2‑12‑1 S3‑33 O‑OkayamaMeguro‑KuTokyo 152‑8552Japan

The triboelectric nanogenerator(TENG)can effectively collect energy based on contact electrification(CE)at diverse interfaces,including solid–solid,liquid–solid,liquid–liquid,gas–solid,and gas–*** enables energy harvesting from sources such as water,wind,and *** this review,we provide an overview of the coexistence of electron and ion transfer in the CE *** elucidate the diverse dominant mechanisms observed at different interfaces and emphasize the interconnectedness and complementary nature of interface *** review also offers a comprehensive summary of the factors influencing charge transfer and the advancements in interfacial modification ***,we highlight the wide range of applications stemming from the distinctive characteristics of charge transfer at various ***,this review elucidates the future opportunities and challenges that interface CE may *** anticipate that this review can offer valuable insights for future research on interface CE and facilitate the continued development and industrialization of TENG.

关键词： Contact electrification Interfaces Triboelectric nanogenerators Diversified applications

The Structure of Vector Bundles on Non-primary Hopf Manifolds

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Chinese Annals of Mathematics,Series B 2020年第6期41卷 929-938页

作者： Ning GAN xiangyu ZHOU School of Sciences Jimei Uni vers计yXiamen 361021FujianChina Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

Let X be a Hopf manifold with non-Abelian fundamental group and E be a holomorphic vector bundle over X,with trivial pull-back to C^n-{0}.The authors show that there exists a line bundle L over X such that E■L has a nowhere vanishing *** is proved that in case dim(X)≥3,π*(E)is trivial if and only if E is filtrable by vector *** the structure theorem,the authors get the cohomology dimension of holomorphic bundle E over X with trivial pull-back and the vanishing of Chern class of E.

关键词： Hopf manifolds Holomorphic vector bundles Exact sequence Cohomology Filtration Chern class

Polycyclic aromatic hydrocarbons (PAHs) in a sediment core from Lake Taihu and their associations with sedimentary organic matter

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Journal of Environmental Sciences 2023年第7期129卷 79-89页

作者： Yong He xiangyu Wang Zhaobin Zhang College of Urban and Environmental Sciences Peking UniversityBeijing 100871China

Sediment core is the recorder of polycyclic aromatic hydrocarbon(PAH)pollutions and the associated sedimentary organic matter(SOM),acting as crucial supports for pollution control and environmental ***,the sedimentary records of PAHs and SOM in the past century in Lake Taihu,China,were reconstructed from a 50-cm sediment *** the one hand,the presence of PAHs ranged from 8.99 to 199.2 ng/***,PAHs declined with the depth increased,and the sedimentation history of PAHswas divided into two stages with a discontinuity at 20 cm *** composition,PAHs in the sediment core were dominated by three-ring PAHs(44.6%±9.1%,mean±standard deviation),and were followed by four-ring(27.0%±3.3%),and five-ring(12.1%±4.0%)*** toxicity assessment,the sedimentary records of benzo[a]pyrene-based toxic equivalency were well described by an exponential model with R-square of 0.95,and the environmental background toxic value was identified as 1.62 ng/*** the other hand,different components of SOM were successfully identified by n-alkanemarkers(pgenic and biogenic SOM(pgenic factors should attract more attentions as well as PAH emissions to reduce the impacts of PAHs.

关键词： Polycyclic aromatic hydrocarbons (PAHs) N-alkanes Sedimentary records Composition Toxicity assessment Lake Taihu

Chatter stability and precision during high-speed ultrasonic vibration cutting of a thin-walled titanium cylinder

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Chinese Journal of Aeronautics 2020年第12期33卷 3535-3549页

作者： Zhenlong PENG Deyuan ZHANG xiangyu ZHANG School of Mechanical Engineering and Automation Beihang UniversityBeijing 100083China Institute of Bionic and Micro-Nano Systems Beihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100083China

Titanium alloys are widely used in the aviation and aerospace industries due to their unique mechanical and physical ***,thin-walled titanium(Ti)cylinders have received increasing attention for their applications as rocket engine casings,aircraft landing gear,and aero-engine hollow shaft due to their observed improvement in the thrust-to-weight ***,the conventional cutting(CC)process is not appropriate for thin-walled Ti cylinders due to its low thermal conductivity,high strength,and low ***,high-speed ultrasonic vibration cutting(HUVC)assisted processing has recently proved highly effective for Ti-alloy *** this study,HUVC technology is employed to perform external turning of a thinwalled Ti cylinder,which represents a new application of ***,the kinematics,tool path,and dynamic cutting thickness of HUVC are ***,the phenomenon of mode-coupling chatter is analyzed to determine the effects and mechanism of HUVC by establishing a critical cutting thickness *** can increase the critical cutting thickness and effectively reduce the average cutting force,thus reducing the energy intake of the ***,comparison experiments are conducted between HUVC and CC *** results indicate that the diameter error rate is 10%or less for HUVC and 51%for the CC method due to a 40%reduction in the cutting *** addition,higher machining precision and better surface roughness are achieved during thin-walled Ti cylinder manufacturing using HUVC.

关键词： High-speed machining Minimum chip thickness Mode-coupling Thin-walled cylinder Ultrasonic vibration cutting

GMAT:A Graph Modeling Method for Group Preference Prediction

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 475-493页

作者： xiangyu Li Xunhua Guo Guoqing Chen International Business School Jinan UniversityZhuhai519070China School of Economics and Management Tsinghua UniversityBeijing100084China

Preference prediction is the building block of personalized services,and its implementation at the group level helps enterprises identify their target customers *** methods for preference prediction mainly focus on behavioral interactions to extract the associations between groups and products,ignoring the importance of other auxiliary records(e.g.,online reviews and social tags)in association *** paper proposes a novel method named GMAT for group preference prediction,aiming to collectively detect the sophisticated association patterns from user generated content(UGC)and behavioral *** doing so,we construct a tripartite graph to collaborate these two types of data,and design a deep-learning algorithm with mutual attention module for generating the contextualized representations of groups and *** experiments on two real-world datasets show that GMAT is superior to other baselines in terms of group preference ***,GMAT is able to improve prediction accuracy compared with its different variants,further verifying the proposed method’s effectiveness on association pattern detection.

关键词： Group preference UGC tripartite graph deep learning