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Metallomics:An integrated biometal science

Science china chemistry 2009年第12期52卷 2055-2070页

作者： ge ruiguang1,2 & sun hongzhe1 1 department of chemistry and open laboratory of chemical biology,the university of hong kong,hong kong,china 2 laboratory of Integrative biology,College of Life Sciences,sun Yat-Sen university,Guangzhou 510006,china department of chemistry and open laboratory of chemical biology The University of Hong Kong Hong Kong China laboratory of Integrative biology College of Life Sciences Sun Yat-Sen University Guangzhou 510006 China

Metallomics is an emerging scientific area integrating the research fields related to the understanding of the molecular mechanisms of metal-associated life processes and the entirety of metal and metalloid species within a cell or tissue type. In metallomics,metalloproteins,metalloenzymes and other metal-containing biomolecules in a biological system are referred to as metallomes,similar to genomes and proteomes in genomics and proteomics,respectively. This review discusses the concept of metallomics with a focus on analytical techniques and methods,particularly the so-called hyphenated techniques which combine a high-resolution separation technique (gel electrophoresis/laser ablation,chromatography or capillary electrophoresis) with a highly sensitive detection method such as elemental (inductively coupled plasma,ICP) or molecular (electron spray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)) mass spectrometry,or nuclear X-ray fluorescence/absorption spectrometry. The applications of these advanced analytical methods in the identification of metallo-/phospho-/seleno-proteins,probing of relationships between structure and function of metal-loproteins,and study of clinically used metallodrugs will be selectively outlined,along with their advantages and limitations.

关键词： metallomics metallome metallodrug metalloprotein chemical speciation

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The Yin and Yang of the protein corona on the delivery journey of nanoparticles

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Nano Research 2023年第1期16卷 715-734页

作者： Yi-Feng Wang Yaxin Zhou JiaBei sun Xiaotong Wang Yaru Jia Kun ge Yan Yan Kenneth A.Dawson Shutao Guo Jinchao Zhang Xing-Jie Liang Guangdong Provincial Education department Key laboratory of Nano-Immunoregulation Tumor Microenvironment Guangzhou Key Laboratory for Research and Development of Nano-Biomedical Technology for Diagnosis and Therapythe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Chinese Academy of Sciences(CAS)Key laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China Key laboratory of Functional Polymer Materials of Ministry of Education State Key Laboratory of Medicinal Chemical Biology and Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China china National Institute of Food and Drug Control Beijing 100061China Key laboratory of Medicinal chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding 071002China Centre for BioNano Interactions School of ChemistrySchool of Biomolecular and Biomedical ScienceUniversity College DublinDublin D04V1W8Ireland

Nanoparticles-based drug delivery systems have attracted significant attention in biomedical fields because they can deliver loaded cargoes to the target site in a controlled ***,tremendous challenges must still be overcome to reach the expected targeting and therapeutic efficacy in *** challenges mainly arise because the interaction between nanoparticles and biological systems is complex and dynamic and is influenced by the physicochemical properties of the nanoparticles and the heterogeneity of biological ***,once the nanoparticles are injected into the blood,a protein corona will inevitably form on the *** protein corona creates a new biological identity which plays a vital role in mediating the bio–nano interaction and determining the ultimate ***,it is essential to understand how the protein corona affects the delivery journey of nanoparticles in vivo and what we can do to exploit the protein corona for better delivery *** this review,we first summarize the fundamental impact of the protein corona on the delivery journey of ***,we emphasize the strategies that have been developed for tailoring and exploiting the protein corona to improve the transportation behavior of nanoparticles in ***,we highlight what we need to do as a next step towards better understanding and exploitation of the protein *** hope these insights into the“Yin and Yang”effect of the protein corona will have profound implications for understanding the role of the protein corona in a wide range of nanoparticles.

关键词： protein corona nanoparticles biological identity drug delivery bio-nano interaction

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Intrinsic spin shielding effect in platinum-rare-earth alloy boosts oxygen reduction activity

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National Science Review 2023年第9期10卷 136-145页

作者： Siyuan Zhu Mingzi sun Bingbao Mei Liting Yang Yuyi Chu Zhaoping Shi Jingsen Bai Xian Wang Zheng Jiang Changpeng Liu Bolong Huang Junjie ge Wei Xing State Key laboratory of Electroanalytical chemistry Laboratory of Advanced Power Sources Changchun Institute of Applied Chemistry Chinese Academy of Sciences School of Applied chemistry and Engineering University of Science and Technology of China department of Applied biology and chemical Technology The Hong Kong Polytechnic University Shanghai Synchrotron Radiation Facility Zhangjiang National LaboratoryShanghai Advanced Research InstituteChinese Academy of Sciences Dalian National laboratory for Clean Energy Chinese Academy of Sciences

Oxygen reduction reactions(ORRs) involve a multistep proton-coupled electron process accompanied by the conversion of the apodictic spin *** the role of spin configurations of metals in the adsorption and desorption of oxygen intermediates during ORRs is critical for the design of efficient ORR ***,a platinum-rare-earth-metal-based alloy catalyst,Pt2Gd,is introduced to reveal the role of spin configurations in the catalytic activity of *** catalyst exhibits a unique intrinsic spin reconfiguration because of interactions between the Gd-4f and Pt-5d *** adsorption and desorption of the oxygen species are optimized by modifying the spin symmetry and electronic structures of the material for increased ORR *** Pt2Gd alloy exhibits a half-wave potential of 0.95 V and a superior mass activity of 1.5 A·mgPt-1in a 0.1 M HClO4electrolyte,as well as higher durability than conventional Pt/C *** calculations have proven that the spin shielding effect of Gd pairs increases the spin symmetry of Pt-5d orbitals and adsorption preferences toward spin-polarized intermediates to facilitate *** work clarifies the impact of modulating the intrinsic spin state of Pt through the interaction with the local high spin 4f orbital electrons in rare-earth metals,with the aim of boosting the spin-related oxygen reduction reaction,thus fundamentally contributing to the understanding of new descriptors that control ORR activity.

关键词： oxygen reduction reaction intermetallic compound spin effect rare-earth metal electrocatalysis

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Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan hongwen sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang Natàlia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China university of Chinese Academy of Sciences Beijing 100049China department of chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical university of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key laboratory of Environmental Theoretical chemistry South China Normal UniversityGuangzhouGuangdong 510006China department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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Functional Recovery with Electro-Acupuncture Stimulation in an Mecp2-Knockout Rat Model of Rett Syndrome

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Engineering 2022年第5期8卷 83-89页

作者： Yanhong sun Zhifang Chen Yi Xu Yuefang Zhang Zhilei ge Chenglie Lin Yi Zhou Fangfei Zhao Meiling Yan Xinyi Liu Ying Zhu Jimin Gao hongyi Li Lihua Wang Jun Hu Zilong Qiu Chunhai Fan Bioimaging Center Shanghai Synchrotron Radiation FacilityZhang Jiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Division of Physical biology CAS Key Laboratory of Interfacial Physics and TechnologyShanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China Institute of Neuroscience Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China School of laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhou 325035China School of chemistry and chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137China Cardiology department Beijing HospitalBeijing 100730China

Rett syndrome is a progressive neurodevelopmental disorder that lacks effective *** deep-brain stimulation can alleviate some symptoms in Rett model mice,this interventional manipula-tion requires deliberate surgical ***,we report that electro-acupuncture stimulation(EAS)can ameliorate symptoms of an Mecp2-knockout rat model of Rett syndrome from the remote acupoints Baihui(GV 20),Yongquan(KI 1),and Shenmen(HT 7).We find that EAS not only prolongs the survival time of Rett rats,but also improves their behavior ability,including locomotion,motor coordination,and social *** activation was observed in the substantia nigra of the midbrain,corpus striatum,and cerebral cortex of wild-type and Rett model rats,as reflected by the increased expression of the c-Fos ***,EAS provides a potential promising therapeutic tool for treating neurodevel-opmental diseases.

关键词： Neurodevelopmental disorder Electro-acupuncture stimulation Rett syndrome Motor function Social interaction

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