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Application of exosome-derived noncoding RNAs in bone regeneration:Opportunities and challenges

World Journal of Stem Cells 2022年第7期14卷 473-489页

作者： Yuan-Zhong ren shan-shan Ding Ya-Ping Jiang Hui Wen Tao Li Department of Emergency Trauma Surgery Luoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyang 471000Henan ProvinceChina Department of geriatrics Luoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyang 471000Henan ProvinceChina Department of Oral Implantology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Joint Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

With advances in the fields of regenerative medicine,cell-free therapy has received increased *** have a variety of endogenous properties that provide stability for molecular transport across biological barriers to cells,as a form of cell-to-cell communication that regulates function and *** addition,exosomes are an important component of paracrine signaling in stemcell-based therapy and can be used as a stand-alone therapy or as a drug delivery *** remarkable potential of exosomes has paved the pathway for cell-free treatment in bone *** are enriched in distinct noncoding RNAs(ncRNAs),including microRNAs,long ncRNAs and circular *** ncRNAs have multiple *** expression of ncRNA in exosomes is associated with the regenerative potential and development of various diseases,such as femoral head osteonecrosis,myocardial infarction,and *** there is increasing evidence that exosome-derived ncRNAs(exoncRNAs)have the potential for bone regeneration,the detailed mechanisms are not fully ***,we review the biogenesis of exo-ncRNA and the effects of ncRNAs on angiogenesis and osteoblast-and osteoclast-related pathways in different ***,there are still many unsolved problems and challenges in the clinical application of ncRNA;for instance,production,storage,targeted delivery and therapeutic potency *** in exo-ncRNA methods and design will promote the development of therapeutics,revolutionizing the present landscape.

关键词： Exosomes Non-coding RNA Bone Osteogenesis Angiogenesis Osteoclasts

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An improved Gmapping algorithm based map construction method for indoor mobile robot

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High Technology Letters 2021年第3期27卷 227-237页

作者： Tao yong Jiang shan ren Fan Wang Tianmiao Gao He School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191P.R.China Research Institute of Aero-Engine Beihang UniversityBeijing 100191P.R.China

With the rapid development in the service,medical,logistics and other industries,and the increasing demand for unmanned mobile devices,mobile robots with the ability of independent mapping,localization and navigation capabilities have become one of the research *** accurate map construction is a prerequisite for a mobile robot to achieve autonomous localization and ***,the problems of blurring and missing the borders of obstacles and map boundaries are often faced in the Gmapping algorithm when constructing maps in complex indoor *** this pursuit,the present work proposes the development of an improved Gmapping algorithm based on the sparse pose adjustment(SPA)*** improved Gmapping algorithm is then applied to construct the map of a mobile robot based on single-line *** show that the improved algorithm could build a more accurate and complete map,reduce the number of particles required for Gmapping,and lower the hardware requirements of the platform,thereby saving and minimizing the computing resources.

关键词： complex indoor environment single-line Lidar map construction improved Gmapping algorithm sparse pose adjustment(SPA)optimization

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Constitutive Modeling for Elevated Temperature Flow Behavior of30Cr2Ni4MoV Ultra-super-critical Rotor Steel

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Journal of Iron and Steel Research International 2014年第5期21卷 521-526页

作者： Fei CHEN Fa-cai ren Zhen-shan CUI Xin-min LAI Institute of Forming Technology and Equipment Shanghai Jiao Tong University School of Mechanical Engineering Shanghai Jiao Tong University

In order to perform numerical simulation of forging and determine the hot deformation processing parameters for 30Cr2Ni4MoV steel, the compressive deformation behaviors of 30Cr2Ni4MoV steel were investigated at the temperatures from 970 to 1270 ℃ and strain rates from 0. 001 to 0.1 s-1 on a Gleeble-3500 thermo-mechanical simulator. The flow stress constitutive equations of the work hardening-dynamical recovery period and dynamical recrystallization period were established for 30Cr2Ni4MoV steel. The stress-strain curves of 30Cr2Ni4MoV steel predicted by the proposed model well agreed with experimental results, which confirmed that the proposed equations can be used to determine the hot deformation processing parameters for 30Cr2Ni4MoV steel.

关键词： 30Cr2Ni4MoV steel hot compression dynamical recrystallization flow stress

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Thermal simulation of basic volcanic fluid influence on different source rocks

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Chinese Journal Of geochemistry 2014年第2期33卷 168-172页

作者： LI Jiyan shan Xuanlong SUN Zhe XIE Xiaoting ren Yu Collage of Earth Sciences Jilin University Zhejiang geological Prospecting Institute of CHEM

Based on thermal simulation experiment, interactions between volcanic fluids and source rocks were studied. Gas generations in the dry system and fluid system under different temperatures were analyzed. The results showed that the various types of source rocks are similar in composition, containing gaseous C1-C5 hydrocarbons, H2 and CO2 whose gas yields increase with increasing temperature. The gas yield of source rocks of type is Ⅰ the highest, followed by type Ⅱ, and that of source rocks of type is Ⅲ the lowest, indicating that the yield of hydrocarbon gases is related to their hydrocarbon generating potential. Although the generating potential of type is Ⅲ the lowest, it can still be regarded as a useful gas source when it is buried deeply enough. The basic volcanic fluid restrains the generation of gaseous hydrocarbons in different types of source rocks, but promotes the generation of inorganic gases.

关键词：基性火山岩热模拟实验流体系统烃源岩相互作用干燥系统气体产率生烃潜力

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Evaluation of the Protective Efficacy of a Fused OmpK/Omp22 Protein Vaccine Candidate against Acinetobacter baumannii Infection in Mice

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Biomedical and Environmental Sciences 2018年第2期31卷 155-158页

作者： GUO San Jun ren shan XIE Yong En The Research Institute of Immunology and Molecular Biology North Sichuan Medical College

Acinetobocter baumannfi （A. Baumannii） is an emerging opportunistic pathogen responsible for hospital-acquired infections, and which now constitutes a sufficiently serious threat to public health to necessitate the development of an effective vaccine. In this study, a recombinant fused protein named OmpK/Omp22 and two individual proteins OmpK and Omp22 were obtained using recombinant expression and Ni-affinity purification. Groups of BALB/c mice were immunized with these proteins and challenged with a clinically isolated strain of A. boumonnii. The bacterial load in the blood, pathological changes in the lung tissue and survival rates after challenge were evaluated. Mice immunized with OmpK/Omp22 fused protein provided significantly greater protection against A. boumonnfi challenge than those immunized with either of the two proteins individually. The results provide novel clues for future design of vaccines against A. boumonnii.

关键词： Evaluation of the Protective Efficacy of a Fused OmpK/Omp22 Protein Vaccine Candidate against Acinetobacter baumannii Infection in Mice

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Solidification microstructure characteristics of Ti–44Al–4Nb–2Cr–0.1B alloy under various cooling rates during mushy zone

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Rare Metals 2016年第1期35卷 35-41页

作者： Peng Han Hong-Chao Kou Jie-ren Yang Guang Yang Jin-shan Li The State Key Laboratory of Solidification Processing Northwestern Polytechnical University

Beta-solidifying TiAl alloy has great potential in the field of aero-industry as a cast *** the present work,the influence of cooling rate during mushy zone on solidification behavior of Ti-44Al-4Nb-2Cr-0.1B alloy was investigated.A vacuum induction heating device combining with temperature control system was *** Ti-44Al-4Nb-2Cr-0.1B alloy solidified from superheated was melted to β phase with the cooling rates of 10,50,100,200,400 and 700 K·min^（-1）,*** show that with the increase in cooling rate from 10 to 700 K·min^（-1）,the colony size of α_2/γ lamella decreases from 1513 to48 urn and the solidification segregation significantly *** the content of residual B2 phase within α_2/γlamellar colony decreases with the increase in cooling *** addition,the alloy in local interdendritic regions would solidify in a hypo-peritectic way,which can be attributed to the solute redistribution and enrichment of Al element in solidification.

关键词： β-solidifying TiAl alloy Cooling rate Mushyzone Solidification microstructure

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A fuzzy risk assessment model used for assessing the introduction of African swine fever into Australia from overseas

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Artificial Intelligence in Agriculture 2023年第1期7卷 27-34页

作者： Hongkun Liu YongLin ren Huanhuan Chu Hu shan Kok Wai Wong College of Veterinary Medicine Qingdao Agriculture UniversityQingdaoPR China Murdoch University 90 South StreetMurdochWestern Australia 6150Australia

African swine fever(ASF)is a contagious and lethal hemorrhagic disease with a high case fatality *** 2007,ASF has been spreading into many countries,especially in Europe and *** that there is no effective vaccine and treatment to deal with ASF,prevention is an important way for a country to avoid the effects of the *** is currently ASF-free but the disease has been reported in many neighboring countries,such as Indonesia,Timor-Leste,and Papua New ***,it is necessary for Australia to maintain hypervigilance to prevent the ASF *** this paper,we propose the use of fuzzy concepts to establish a fuzzy risk assessment model to predict the ASF introduction risk in *** the analysis,the international passengers(IP)and international import trade(IIT)are concluded as the two main ASF introduction factors based on transmission features and past *** the established fuzzy risk assessment model based on the analysis of the 2019 and 2020 data,the risks of ASF introduction into Australia are considered to be *** model further deduced that the Asian region was the major source of potential ***,in order to validate the effectiveness of the established fuzzy risk assessment model,the qualitative data from the Department for Environment,Food&Rural Affairs of the United Kingdom was *** the validation results,it has shown that the results were consistent when the same data is adopted,and thus proved that the functionality of the established fuzzy risk assessment model for assessing the risk in Australia.

关键词： Risk assessment Fuzzy model African swine fever(ASF) ASF introduction Australia

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Transition of solidification path in nonequilibrium solidification of Ti–48Al–8Nb alloy

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Rare Metals 2016年第1期35卷 48-53页

作者： Tan He Rui Hu Jie-ren Yang Tie-Bang Zhang Jin-shan Li The State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical University

The solidification behavior of Ti-48Al-8Nb alloy under nonequilibrium solidification conditions was studied by electromagnetic levitation *** solidification conditions are different undercooling（△T）under the same cooling condition and different cooling methods at the same undercooling condition,*** different undercooling conditions,when the undercooling is above a critical value（△T＊≈211K）,a remarkable morphological transition from typical hypoperitectic solidification to a sole solidification of the（3 phase resulting in the suppression of the peritectic reaction *** melts with different cooling conditions at the same undercooling（△T≈85 K）,the melt was rapidly cooled by quenching them in cooling *** cooling rate increasing,a transition from β phase to peritectic α phase solidification mode is revealed for Ti-48Al-8Nb alloy.

关键词： TiAl alloy Undercooling Nonequilibriumsolidification Microstructure evolution

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Sintering flue gas desulfurization with different carbon materials modified by microwave irradiation

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Journal of Iron and Steel Research International 2017年第10期24卷 979-984页

作者： shan ren Fu-qiang Guo Qi Zhao Jie Yang Lu Yao Ming Kong College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Modification of metallurgical coke,biomass char and semi-coke was carried out using a microwave device with power of 450-850 W and irradiation time of 6-12 *** desulfurization rates of three carbon materials before and after modification were *** effects of microwave power and irradiation time on the pore texture and surface chemical characteristics of the three carbon materials were examined by SEM,BET and Fourier transform infrared spectroscopy（FTIR）.The results showed that the specific surface area,total pore volume and pore diameter of biomass char and semi-coke after irradiation decreased ***,the pore diameter turned small and the acidic functional groups on their surface decomposed,thereby the basicity of carbon surface increased by microwave *** optimal promotion of desulfurization rate of three carbon materials was semi-coke irradiated at 850 W for 9 min and the sulfur dioxide adsorption rate was up to 45%.

关键词： Microwave modification Carbon material Sintering flue gas Desulfurization

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Effect of Rare Earth and Cooling Process on Microstructure and Mechanical Properties of an Ultra-Cleaned X80 Pipeline Steel

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Acta Metallurgica Sinica(English Letters) 2021年第5期34卷 639-648页

作者： He Duan Yi-Yin shan Ke Yang Xian-Bo Shi Wei Yan Yi ren Institute of Metal Research Chinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China State Key Laboratory of Metal Materials and Application for Marine Equipment Anshan114009China

In order to explore the eff ect of a small amount of rare earth addition in ultra-cleaned pipeline steel and the influence of the cooling process on the tensile and impact properties,three API X80 pipeline steels were fabricated by varying RE addition and the cooling process at the same *** microstructures with different features for a low C high Nb microalloyed high-strength pipeline steel and the corresponding mechanical properties were *** results showed that even in the ultra-cleaned steel with O and S contents less than 10 ppm,the addition of RE would still cause an increase in the volume fraction of inclusions consisting of complicated RE oxysulfide and RE *** inclusions formed in the 112 ppm RE steel were harmful to the low temperature toughness,while few inclusions formed in the 47 ppm RE steel had almost no influence on the low temperature *** two RE additions had no effect on strength of the *** the finishing cooling temperature was increased and the cooling rate was decreased within a certain range,the volume fractions of polygonal ferrite and quasi-polygonal ferrite as well as the number density and size of martensite–austenite islands were *** such combined effect,the strength of the steels had almost no *** the finishing cooling temperature was increased from 481 to 584℃and the cooling rate was reduced from 20 to 13℃/s,for the steel with 112 ppm addition of RE,there was an obvious decrease in the low temperature *** reduced value(about 33 J)of the USE of steel consisted of two parts including the influence(about 18 J)of more inclusions formed due to 112 ppm addition of RE and the eff ect(about 15 J)of the lower high-angle grain boundaries.

关键词： Low temperature toughness Cooling process High-angle grain boundaries(HAGBs) Ductile–brittle transition temperature(DBTT) Rare earth Inclusions

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