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Mechanoresponsive MiR-138-5p Targets MACF1 to Inhibit Bone Formation

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医用生物力学 2019年第A1期34卷 72-73页

作者： zhihao chen Zhao Fan Liang Chao Lifang hu chen Lei Zhang Yan yin Chong Dijie Li Tian ye Wuxia Qiu Kewen Zhang Chaofei Yang Xiaona Li Li Yu Weiyi chen Zhang ge qian Airong Lab for Bone Metabolism Key Lab for Space Biosciences and BiotechnologyResearch Center for Special Medicine and Health Systems EngineeringNPU-UAB Joint Laboratory for Bone MetabolismSchool of Life SciencesNorthwestern Polytechnical UniversityXi’an710072China Northwestern Polytechnical University-Hong Kong Baptist UniversityJoint Rese arch Centre for Translational Medicine on Musculoskeletal Health in Space Xi’an710072China Institute forAdvancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityHong Kong College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan030024China

Mechanical stimuli play an essential role in maintaining bone remodeling and skeletal ***,bone can respond to the changes of mechanical condition to adjust its mass and *** studies discover that bedridden patients showed osteoporotic T-scores and low bone mineral density,and long-term immobilized patients presented reduced markers of bone ***,as bone formation mediated by osteoblast differentiation is a complex process,the underlying molecular mechanism of mechanical stimuli regulating bone formation is still *** evidences show that microRNAs(miRNAs)are involved in mechanical stimuli regulating bone formation or osteoblast ***,no direct evidence identifies mechanoresponsive miRNA in both human and animal bones,and clarifies its mechanoresponsive role under different mechanical conditions(*** unloading,reloading,loading).In the current study,we screened for differentially expressed miRNAs in bone specimens of bedridden patients with fractures,then identified that the expression of miR-138-5p,but not the other miRNAs,altered withbedridden time and was negatively correlated with the expression of the bone formation marker genes Alp(alkaline phosphatase).Moreover,miR-138-5p was up-regulated with reduced bone formation during unloading and down-regulated with increased bone formation during reloading in hind4imb unloaded *** addition,miR-138-5p was verified to be responsive to different mechanical unloading condition and cyclic mechanical stretch condition in primary osteogenic cells,*** in vitro data suggested that mechanoresponsive miR-138-5p directly targeted microtubule actin crosslinking factor 1(MACF1)to inhibit osteoblast *** vivo,we constructed an osteoblastic miR-138-5p transgenic mice model(TG138)with the Runx2promoter,and found that overexpression miR-138-5p supressed bone ***,osteoblast-targeted inhibition of miR-13

关键词： Mechanoresponse miR-138-5p MACF1 bone formation

Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the general Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study

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Biomedical and Environmental Sciences 2021年第1期34卷 9-18页

作者： Zhu Yuan Yue ZHENG Rui zhi WANG Gui Xia chen Li SHI Li Xin SU Qing XU Min XU Yu chen Yu Hong YU xue Feng YAN Li WANG Tian ge ZHAO zhi Yun QIN Gui Jun WAN Qin chen Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN ying Fen huO Ya Nan LI qiang ye Zhen ZHANG yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG hua Cong ZHAO Jia Jun chen Lu Lu MU Yi Ming TANG Xu Lei hu Ru ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR ChinaShanghai National Center for Translational MedicineRuijin Hospital.Shanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China The First Hospital of Jilin University Changchun 130021JinlinChina Qilu Hospital of Shandong University Jinan 250012ShandongChina Affiliated Hospital of Guiyang Medical College Guiyang 550004GuizhouChina Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200092China Tongji Hospital.Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030HubeiChina Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120GuangdongChina The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052HenanChina The Affiliated Hospital of Southwest Medical University Luzhou 646099SichuanChina Fujian Provincial Hospital Fujian Medical UniversityFuzhou 350001FujianChina Dalian Municipal Central Hospital Dalian 116003LiaoningChina The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000ZhejiangChina The First Affiliated Hospital of Guangxi Medical University Nanning 530021GuangxiChina Jiangxi Provincial People's Hospital Affiliated to Nanchang University Nanchang 330006JiangxiChina The Second Affiliated Hospital of Harbin Medical University Harbin 150086HeilongjiangChina Zhejiang Provincial Center for Disease Control and Prevention Hangzhou 310051ZhejiangChina Central Hospital of Shanghai Jiading District Shanghai 201800China Jiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing 210028JiangsuChina The First Affiliated Hospital of Anhui Medical University Hefei 230022AnhuiChina Karamay Municipal

Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains *** aimed to explore the associations between glycemic indices and SUA levels in the general Chinese *** The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid *** nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive *** A total of 30,941 men and 62,361 women were eligible for the current *** additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and *** thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women.

关键词： Cross-sectional study Serum uric acid Glycemic index Glycemic status

A joint call for actions to advance taxonomy in China

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Zoological Systematics 2022年第3期47卷 188-197页

作者： Chaodong Zhu Arong Luo Ming Bai Michael COrr Zhonge Hou Siqin ge Jun chen Yibo hu Xuming Zhou gexia Qiao Hongzhi Kong Limin Lu Xiaohua Jin Lei Cai Xinli Wei Ruilin Zhao Wei Miao Qingfeng Wang Zhongli Sha qiang lin Meng Qu Jianping Jiang Jiatang Li Jing Che xuelong Jiang Xiaoyong chen Lianming Gao Zongxin Ren Chunlei Xiang Shixiao Luo Donghui Wu Dong Liu Yanqiong Peng Tao Su chenyang Cai Tianqi Zhu Wanzhi Cai Xingyue Liu hu Li huaijun xue Zhen ye xuexin chen Pu Tang Shujun Wei Hong Pang qiang Xie Feng Zhang Feng Zhang Xianjin Peng Aibing Zhang Taiping Gao Changfa Zhou chen Shao Libin Ma Zhaoming Wei Yunxia Luan Ziwei yin Wu Dai Cong Wei Xiaolei huang Jingxian Liu Xiangsheng chen Tianci Yi zhisheng Zhang Zhulidezi Aishan Qin Li Hongying hu CAS Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Mycology(SKLM) Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Aquatic Biodiversity and Conservation Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074China Department of Marine Organism Taxonomy&Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China State Key Laboratory of genetic Resources and Evolution&Yunnan Key Laboratory of Biodiversity and Ecological Security of Gaoligong Mountain Kunming Institute of ZoologyChinese Academy of SciencesKunming 650221China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Key Laboratory of Plant Resource Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650China CAS Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 66630

Taxonomy plays an important role in understanding the origin, evolution, and ecological functionality of biodiversity. There are large number of unknown species yet to be described by taxonomists, which together with their ecosystem services cannot be effectively protected prior to description. Despite this, taxonomy has been increasingly underrated insufficient funds and permanent positions to retain young talents. Further, the impact factordriven evaluation systems in China exacerbate this downward trend, so alternative evaluation metrics are urgently necessary. When the current generation of outstanding taxonomists retires,there will be too few remaining taxonomists left to train the next generation. In light of these challenges, all co-authors worked together on this paper to analyze the current situation of taxonomy and put out a joint call for immediate actions to advance taxonomy in China.

关键词： Endangered taxonomists morphology-based taxonomy integrative taxonomy capacity building systematics

First results on ^(76)ge neutrinoless double beta decay from CDEX-1 experiment

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Science China(Physics,Mechanics & Astronomy) 2017年第7期60卷 53-59页

作者： Li Wang qian Yue KeJun Kang JianPing cheng YuanJing Li TszKing Henry Wong ShinTed lin JianPing Chang JingHan chen QingHao chen Yunhua chen zhi Deng qiang Du hui Gong Li He QingJu He JinWei hu HanXiong huang TengRui huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li xueqian Li YuLan Li FongKay lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu Yucheng Wu HaoYang Xing yin Xu Tao xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng Xionghui Zeng zhi Zeng Lan Zhang Yunhua Zhang MingGang Zhao Wei Zhao JiFang Zhou Zuying Zhou JingJun Zhu WeiBin Zhu Zhonghua Zhu Key Laboratory of Particle and Radiation Imaging (Ministry of Education) and Department of Engineering Physics Tsinghua University Institute of Physics Academia Sinica School of Physical Science and Technology Sichuan University NUCTECH Company YaLong River Hydropower Development Company Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University

We report the first results on 76ge neutrinoless double beta decay from stage one of the China dark-matter experiment （CDEX）. A p-type point-contact high-purity germanium detector with a mass of 994g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304kgd has been analyzed over a wide spectral band from 500keV to 3MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039MeV energy range. The half-life of76ge neutrinoless double beta decay derived based on this result is 70v2〉6.4× 1022 yr （90%C.L.）. An upper limit on the effective Majorana-neutrino mass of 5.0eV has been achieved.

关键词： neutrinoless double beta decay CDEX point-contact germanium detector 76ge isotope

表达羧基端融合HA表位N蛋白的重组小反刍兽疫病毒的拯救及鉴定

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中国预防兽医学报 2013年第6期35卷 456-459页

作者：殷倩倩陈伟业胡倩倩温志远葛金英王喜军步志高中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室/农业部兽医公共卫生重点开放实验室黑龙江哈尔滨150001 安徽科技学院动物科学学院安徽凤阳233100 南京农业大学动物医学院江苏南京210095

为构建小反刍兽疫(PPR)标记疫苗,本研究以PPR病毒(PPRV)反向遗传操作系统为基础,将编码H A表位(YPYD VPDYA)的序列融合连接于PPRV感染性全长cD N A N基因的3'末端构建感染性克隆质粒pN g75/1-GFP/NHA,将其与辅助质粒pCAGGS-N、pCAGGS-P... 详细信息

为构建小反刍兽疫(PPR)标记疫苗,本研究以PPR病毒(PPRV)反向遗传操作系统为基础,将编码H A表位(YPYD VPDYA)的序列融合连接于PPRV感染性全长cD N A N基因的3'末端构建感染性克隆质粒pN g75/1-GFP/NHA,将其与辅助质粒pCAGGS-N、pCAGGS-P、pCAGGS-L共转染V ero细胞救获表达融合H A表位N蛋白的重组病毒rPPRV/GFP/NHA。W estern blot和间接免疫荧光试验表明融合H A表位的N蛋白获得正确表达;体外生长动力学试验分析表明rPPRV/G FP/N H A的生长最高滴度可达106.2TCID50/m L,能够满足标记疫苗的使用要求。本研究结果为进一步研制PPRV标记疫苗奠定基础。

关键词：小反刍兽疫病毒 N蛋白 HA表位标记疫苗

Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia(2021 Edition)

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Military Medical Research 2022年第5期9卷 515-533页

作者： Xian-Tao Zeng ying-hui Jin Tong-Zu Liu Fang-Ming chen De-Gang Ding Meng Fu Xin-Quan Gu Bang-Min Han Xing huang zhi Hou Wan-Li hu Xin-Li Kang Gong-hui Li Jian-Xing Li pei-Jun Li Chao-Zhao Liang Xiu-Heng Liu zhi-Yu Liu Chun-Xiao Liu Jiu-Min Liu Guang-Heng Luo Yi Luo Wei-Jun Qin Jian-Hong Qiu Jian-Xin Qiu xue-Jun Shang Ben-Kang Shi Fa Sun Guo-Xiang Tian ye Tian Feng Wang Feng Wang yin-huai Wang Yu-Jie Wang zhi-Ping Wang Zhong Wang qiang Wei Min-hui Xiao Wan-Hai Xu Fa-Xian Yi Chao-Yang Zhu qian-Yuan Zhuang Li-Qun Zhou Xiao-Feng Zou Nian-Zeng Xing Da-lin He Xing-huan Wang 无 Department of Urology Institute of UrologyZhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Urology Tianjin Third Central Hospital Affiliated To Nankai UniversityTianjin300170China Department of Urology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China Department of Urology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing102218China Department of Urology China-Japan Union Hospital of Jilin UniversityChangchun130033China Department of Urology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200080China Department of Urology Qinghai University Affiliated HospitalXi’ning810012China Department of Urology People’s Hospital of Hainan ProvinceHainan Affiliated Hospital of Hainan Medical University HaikouHaikou570311China Department of Urology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou310016China Department of Urology General Hospital of Ningxia Medical UniversityYinchuan750003China Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Urology Renmin Hospital of Wuhan UniversityWuhan430060China Department of Urology The Second Hospital of Dalian Medical UniversityDalian116023LiaoningChina Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou510282China Department of Urology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Urology Surgery Guizhou Province People’s HospitalGuiyang550002China Department of Urology Xijing Hospital of Air Force Military Medical UniversityXi’an710032China Department of Urology The 980St Hospital of the PLA Joint Logistics Support Force(Bethune International Peace Hospital of PLA)Shijiazhuang050082China Department of Urology

Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence-based guidelines, so we formed a working group of clinical experts and methodologists. The steering group members posed 31 questions relevant to the management of TUPKP for BPH covering the following areas: questions relevant to the perioperative period (preoperative, intraoperative, and postoperative) of TUPKP in the treatment of BPH, postoperative complications and the level of surgeons’ surgical skill. We searched the literature for direct evidence on the management of TUPKP for BPH, and assessed its certainty generated recommendations using the grade criteria by the European Association of Urology. Recommendations were either strong or weak, or in the form of an ungraded consensus-based statement. Finally, we issued 36 statements. Among them, 23 carried strong recommendations, and 13 carried weak recommendations for the stated procedure. They covered questions relevant to the aforementioned three areas. The preoperative period for TUPKP in the treatment of BPH included indications and contraindications for TUPKP, precautions for preoperative preparation in patients with renal impairment and urinary tract infection due to urinary retention, and preoperative prophylactic use of antibiotics. Questions relevant to the intraoperative period incorporated surgical operation techniques and prevention and management of bladder explosion. The application to different

关键词： Transurethral plasmakinetic resection of prostate Benign prostatic hyperplasia Recommendation Treatment Guideline

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-Yuan chen Jian-Jun chen Kun-Xin chen Li chen xue-Lei chen Xiao-Yan chen ying chen Norbert Christlieb Jia-Ru Chu chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-hui Hou Wen Hou Hong-Zhuan hu Ning-Sheng hu Zhong-Wen hu zhi-ying huo Lei Jia Fang-hua Jiang Xiang Jiang zhi-Bo Jiang ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-hua Li Chang-hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li yin-Bi Li ye-Ping Li Yuan Liang Chien-cheng lin Chao Liu gen-Rong Liu Guan-Qun Liu zhi-Gang Liu Wen-zhi Lu Yu Luo yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-yin Shen huo-Ming Shi Jing Song Yi-Han Song Ding-qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-zhi Wei Hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-hua Yang Hai-Feng Yang hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

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35例急性垂体瘤卒中的临床分析

中华神经医学杂志 2006年第9期5卷 955-956页

作者：葛培林陈谦学叶应湖陈坚王国安武汉大学人民医院神经外科武汉430060

急性垂体瘤卒中是一种危急状态．它往往表现为突发头痛、恶心、眼肌麻痹、视力视野的急剧下降．严重者可因垂体功能不足而危及生命。本科自1996至2004年共收冶了35例急性垂体瘤卒中患者，现将其临床表现、影像学资料、预后等作回顾性分... 详细信息

急性垂体瘤卒中是一种危急状态．它往往表现为突发头痛、恶心、眼肌麻痹、视力视野的急剧下降．严重者可因垂体功能不足而危及生命。本科自1996至2004年共收冶了35例急性垂体瘤卒中患者，现将其临床表现、影像学资料、预后等作回顾性分析，并探讨提高急性垂体瘤卒中诊断、治疗的方法。

关键词：垂体瘤垂体卒中

Towards a global One Health index: a potential assessment tool for One Health performance

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Infectious Diseases of Poverty 2022年第3期11卷 12-26页

作者： Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun yin Qin-Qin hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu huang Xiang-cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian yin Tian-ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min chen Nan Zhou Zi-Le cheng Yi Xie hui-Min Li Jin chen Zhao-Yu Guo Jia-Xin Feng lin Ai Jing-Bo xue qian ye Liz Grant Jun-Xia Song geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghaiPeople’s Republic of China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesShanghaiPeople’s Republic of China Shanghai Legislative Research Institute ShanghaiPeople’s Republic of China Zhuhai Branch ESPREBeijing Normal University Zhuhai CampusZhuhaiGuangdongPeople’s Republic of China Global Health Academy The University of EdinburghEdinburghUK Food and Agriculture Organization of the United Nations RomeItaly Global Academy of Agriculture and Food Systems The University of EdinburghEdinburghUK Swiss Tropical and Public Health Institute AllschwilSwitzerland University of Basel BaselSwitzerland

Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently ***:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the ***:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be ***:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the

关键词： Antimicrobial resistance Cell-like framework Climate change Food security Global One Health index(GOHI) Global performance assessment Governance Zoonotic diseases