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Acta Pharmaceutica Sinica B 2021年第11期11卷 3527-3541页

作者： Xiaojiaoyang Li junde ge Yajing Li Yajie Cai Qi Zheng Nana Huang Yiqing Gu Qi Han Yunqian Li Rong Sun Runping Liu Beijing University of Chinese Medicine Beijing 100029China The Second Hospital of Shandong University Shandong UniversityJi'nan 250033China Advanced Medical Research Institute Shandong UniversityJi'nan 250012China

Nonalcoholic fatty liver disease(NAFLD)has become one of the most prominent causes of chronic liver diseases and ***,few therapy has been *** Bupleuri(RB)is the most frequently used herbal medicine for the treatment of liver *** the current study,we aim to systemically evaluate the therapeutic effects of saikosaponin A(SSa)and saikosaponin D(SSd),the major bioactive monomers in RB,against NAFLD and to investigate the underlying *** results demonstrated that both SSa and SSd improved diet-induced *** lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes,like Lipe and *** profoundly suppressed the fatty acid biosynthesis by downregulating Fasn and Acaca expression and promoted fatty acid degradation by inducing Acox1 and Cpt1 a *** analysis further predicted the implication of master transcription factors,including peroxisome proliferator-activated receptor alpha(PPARα),in the protective effects of SSa and *** results were further confirmed in vitro in mouse primary *** summary,our study uncoded the complicated mechanisms underlying the promising anti-steatosis activities of saikosaponins(SSs),and provided critical evidence inspiring the discovery of innovative therapies based on SSa and SSd for the treatment of NAFLD and related complications.

关键词： Saikosaponin Nonalcoholic fatty liver disease Lipidome Transcriptome Lipid metabolism

Quantum algorithms for matrix operations and linear systems of equations

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Communications in Theoretical Physics 2024年第3期76卷 100-112页

作者： Wentao Qi Alexandr I Zenchuk Asutosh Kumar junde Wu School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS ChernogolovkaRussia P.G.Department of Physics Gaya CollegeMagadh UniversityRampurGaya 823001India Harish-Chandra Research Institute HBNIChhatnag RoadJhunsiPrayagraj 211019India Vaidic and Modern Physics Research Centre Bhagal BhimBhinmalJalore 343029India

Fundamental matrix operations and solving linear systems of equations are ubiquitous in scientific *** the‘sender-receiver’model,we propose quantum algorithms for matrix operations such as matrix-vector product,matrix-matrix product,the sum of two matrices,and the calculation of determinant and inverse *** encode the matrix entries into the probability amplitudes of the pure initial states of *** applying proper unitary transformation to the complete quantum system,the desired result can be found in certain blocks of the receiver’s density *** quantum protocols can be used as subroutines in other quantum ***,we present an alternative quantum algorithm for solving linear systems of equations.

关键词： matrix operation systems of linear equations ‘sender-receiver’quantum computation model quantum algorithm

Research of Network Convergence-Oriented Open Service Platform Architecture

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Research of Network Convergence-Oriented Open Service Platfo...

Research on Interpolation Method for Missing Electricity Consumption Data

2010 IEEE 2nd Symposium on Web Society

作者： Xiaoshan ge,Meina Song,junde Song School of Computer,Beijing University of Posts and Telecommunications,Beijing,China

＜正＞By well defining API,the network convergenceoriented open service platform can open the functions of network to various service applications,which make the service layer is independent from lower layers of *** this paper,we describe the based architecture model of network convergence-oriented open service platform as six parts:service logic execution environment subsystem,service creation environment subsystem,service management environment subsystem,virtual home environment subsystem,service capability subsystem,network protocol adaptive *** this architecture,we can use the open API to develop more service without knowing the lower communication mechanism,which will make the network resource used more reasonable.

关键词： network converged open service open service platform

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Computers, Materials & Continua 2024年第2期78卷 2575-2591页

作者： junde Chen Jiajia Yuan Weirong Chen Adnan Zeb Md Suzauddola Yaser A.Nanehkaran Department of Electronic Commerce Xiangtan UniversityXiangtan411105China School of Information Engineering Yancheng Teachers UniversityYancheng224000China Department of Information and Electrical Engineering Ningde Normal UniversityNingde352100China College of Engineering Southern University of Science and TechnologyShenzhen518005China School of Informatics Xiamen UniversityXiamen361005China

Missing value is one of the main factors that cause dirty *** high-quality data,there will be no reliable analysis results and precise ***,the data warehouse needs to integrate high-quality data *** the power system,the electricity consumption data of some large users cannot be normally collected resulting in missing data,which affects the calculation of power supply and eventually leads to a large error in the daily power line loss *** the problem of missing electricity consumption data,this study proposes a group method of data handling(GMDH)based data interpolation method in distribution power networks and applies it in the analysis of actually collected electricity ***,the dependent and independent variables are defined from the original data,and the upper and lower limits of missing values are determined according to prior knowledge or existing data *** missing data are randomly interpolated within the upper and lower ***,the GMDH network is established to obtain the optimal complexity model,which is used to predict the missing data to replace the last imputed electricity consumption *** last,this process is implemented iteratively until the missing values do not *** a relatively small noise level(α=0.25),the proposed approach achieves a maximum error of no more than 0.605%.Experimental findings demonstrate the efficacy and feasibility of the proposed approach,which realizes the transformation from incomplete data to complete ***,this proposed data interpolation approach provides a strong basis for the electricity theft diagnosis and metering fault analysis of electricity enterprises.

关键词： Data interpolation GMDH electricity consumption data distribution system

Multi-Objective Rule System Based Control Model with Tunable Parameters for Swarm Robotic Control in Confined Environment

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Complex System Modeling and Simulation 2024年第1期4卷 33-49页

作者： Yuan Wang Lining Xing junde Wang Tao Xie Lidong Chen Beijing Institute of Advanced Studies College of Advanced Interdisciplinary StudiesNational University of Defense TechnologyBeijing 100084China Key Laboratory of Collaborative Intelligence Systems Ministry of EducationXidian UniversityXi’an 710071China

Enhancing the adaptability of Unmanned Aerial Vehicle(UAV)swarm control models to cope with different complex working scenarios is an important issue in this research *** achieve this goal,control model with tunable parameters is a widely adopted *** this article,an improved UAV swarm control model with tunable parameters namely Multi-Objective O-Flocking(MO O-Flocking)is *** MO O-Flocking model is a combination of a multi rule control system and a virtual-physical-law based control model with tunable *** achieve multi-objective parameter tuning,a multi-objective parameter tuning method namely Improved Strength Pareto Evolutionary Algorithm 2(ISPEA2)is *** experiment scenarios include six target orientation scenarios with different kinds of *** results show that both the ISPEA2 algorithm and MO O-Flocking control model have good performance in their experiment scenarios.

关键词： swarm robotics flocking model parameter tuning multi-objective optimization heuristics

SemID: Blind Image Inpainting with Semantic Inconsistency Detection

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Tsinghua Science and Technology 2024年第4期29卷 1053-1068页

作者： Xin Li Zhikuan Wang Chenglizhao Chen Chunfeng Tao Yuanbo Qiu junde Liu Baile Sun College of Computer Science and Technology China University of Petroleum(East China)Qingdao 266580China CNPC Oriental geophysical Exploration Co.Ltd. Baoding 072751China

Most existing image inpainting methods aim to fill in the missing content in the inside-hole region of the target image. However, the areas to be restored in realistically degraded images are unspecified. Previous studies have failed to recover the degradations due to the absence of the explicit mask indication. Meanwhile, inconsistent patterns are blended complexly with the image content. Therefore, estimating whether certain pixels are out of distribution and considering whether the object is consistent with the context is necessary. Motivated by these observations, a two-stage blind image inpainting network, which utilizes global semantic features of the image to locate semantically inconsistent regions and then generates reasonable content in the areas, is proposed. Specifically, the representation differences between inconsistent and available content are first amplified, iteratively predicting the region to be restored from coarse to fine. A confidence-driven inpainting network based on prediction masks is then used to estimate the information regarding missing regions. Furthermore, a multiscale contextual aggregation module is introduced for spatial feature transfer to refine the generated contents. Extensive experiments over multiple datasets demonstrate that the proposed method can generate visually plausible and structurally complete results that are particularly effective in recovering diverse degraded images.

关键词： blind image inpainting inconsistent pattern representation difference contextual aggregation

Containment control for heterogeneous multi-agent systems with time delay via an output regulation approach

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Journal of Measurement Science and Instrumentation 2022年第1期13卷 79-88页

作者： WEI Wenjun LÜJiahui Huang Julong ge junde School of Automation and Electrical Engineering Lanzhou Jiaotong University Lanzhou 730070 China Key Lab of Opti-Electronic Technology and Intelligent Control of Ministry of Education Lanzhou Jiaotong University Lanzhou 730070 China China Energy Engineering Group Gansu Electric Power Design Institute Co. Ltd. Lanzhou 730050 China

This paper presents the containment analysis and design of heterogeneous linear multi-agent systems(MAS)with time-delay under the output *** leaders are treated as exosystems and an modified output regulation error is designed,which can deal with more than one leader in containment control,then the containment problem will be turned into an output regulation problem.A novel analysis framework of the output regulation is proposed to design a dynamic state feedback control law for containment error and distributed observer when the agents cannot receive external system signal,which guarantees the convergence of all follower agents to the dynamic convex hull spanned by the *** system stability for time-delay containment is proved by the output regulation method instead of the Lyapunov ***,a numerical example is given to illustrate the validity of the theoretical results.

关键词： heterogeneous multi-agent systems output regulation linear time-delay systems containment control

Study on the influence of pneumatic probe on the wake flow field of transonic turbine cascade

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Acta Mechanica Sinica 2024年第7期40卷 43-54页

作者： Qingdian Zhang Hongwei Ma Anqi Xiao Yingcun Liu junde Guo School of Energy and Power Engineering Beihang UniversityBeijing 102206China

The pneumatic probe is widely used for contact measurements in turbomachinery flow field ***,it inevitably interferes with the original flow field,leading to additional errors,particularly in wake flow fields or transonic regions with significant pressure *** study employed Reynolds-Averaged Navier-Stokes delete and high-fidelity numerical simulation to investigate the impact of an inserted pneumatic probe on the wake flow field of a transonic turbine blade and compared it to the baseline flow *** indicate that the probe causes the shock waves premature occurrence in the high subsonic wake region near the turbine blade trailing *** shock waves affect vortex shedding by thickening the boundary layer near the trailing edge and changing the shedding pattern from high-frequency-low-energy to *** addition,the extra flow loss is incurred,and the blade's heat transfer characteristic is *** research provides a reference for testing experiments in complex transonic flow fields,guiding experimental researchers to minimize instrument interference with the original flow field.

关键词： Pneumatic probe Wake flow field Transonic turbine cascade Shock wave High-fidelity numerical simulation

Validating the use of ROS-scavenging bacteria as probiotics to increase coral resilience to thermal stress

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Journal of Oceanology and Limnology 2024年第4期42卷 1242-1260页

作者： Xiaoyu TANG Qingsong YANG Ying ZHANG Hanzhang WANG Juan LING Haiyan SUN junde DONG Yanying ZHANG CAS Key Laboratory of Tropical Marine Bio-resources and Ecology South China Sea Institute of Oceanology(SCSIO)Guangzhou 510301China Ocean School Yantai UniversityYantai 264005China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Sanya National Marine Ecosystem Research Station and Key Laboratory of Tropical Marine Biotechnology of Hainan Province Sanya Institute of OceanologySCSIOSanya 572000China Institute of Deep-sea Science and Engineering Chinese Academy of SciencesSanya 572000China University of Chinese Academy of Sciences Beijing 100049China

Thermal stress causes the overproduction and toxic accumulation of reactive oxygen species(ROS),which seems to be correlated with coral bleaching and,ultimately,*** reduction of ROS concentration within the coral holobiont could minimize the effects of thermal stress and support efforts to reduce coral decline *** the current study,we explored the physiological responses of Pocillopora damicornis to ROS-scavenging bacteria inoculation as well as the microbiome restructuring that correlates with ***’s resilience to thermal stress after probiotic *** of corals with ROS-scavenging bacteria enhanced coral health and reduced ROS ***,the enhanced coral thermal resistance promoted by ROS-scavenging bacteria was also correlated with an overall coral microbiome *** addition,the complex network relationships between bacteria and Symbiodiniaceae in corals after ROS-scavenging bacteria inoculation contributed to corals’resilience to high ***,coral heat tolerance bacterial biomarkers,such as Myxococcota,were enriched in corals with added ROS-scavenging ***,our findings validate the selected ROS-scavenging bacteria as coral probiotics that could help corals resist thermal stress on a short ***,our data contribute to our understanding of the potential interactions between different members of the coral holobiont and the use of probiotics as tools to aid coral restoration efforts.

关键词： coral beneficial microorganisms for corals(BMCs) Symbiodiniaceae thermal stress coral bleaching

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谈实施《职业健康安全管理体系规范》

石油工业技术监督 2006年第8期22卷 63-64页

作者：葛军德中国石油兰州石化分公司计量部甘肃兰州730060

2004年3月,根据兰州石化公司QHSE推进办公室的安排,我们进行了全员危险源的辩识和评价工作,在与炼油3#计量站班组成员讨论的时候,大家一致认为3#计量站旁边的污水井时常散发出臭鸡蛋味,对本站员工的健康造成一定的危害,因此制定了相应... 详细信息

2004年3月,根据兰州石化公司QHSE推进办公室的安排,我们进行了全员危险源的辩识和评价工作,在与炼油3#计量站班组成员讨论的时候,大家一致认为3#计量站旁边的污水井时常散发出臭鸡蛋味,对本站员工的健康造成一定的危害,因此制定了相应的中毒事故应急预案,并定期举办应急预案演练.通过演练,找出应急预案的不足之处,不断完善,以减少在紧急状况下员工及财产受到的损失.

关键词：《职业健康安全管理体系规范》事故应急预案兰州石化公司评价工作 QHSE 计量站污水井危险源办公室演练